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Most cited papers in Neuroscience

What are the most cited papers in Neuroscience?

The most cited paper in Neuroscience is "Human-level control through deep reinforcement learning" (Volodymyr Mnih, Koray Kavukcuoglu, David Lawrence Silver et al., 2015), with 31,206 citations. Next come "EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis" (25,692) and "A quantitative description of membrane current and its application to conduction and excitation in nerve" (23,507).

Showing 50 of 99 papers. Every paper with more than 7,550 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Human-level control through deep reinforcement learning Volodymyr Mnih, Koray Kavukcuoglu, David Lawrence Silver et al. · Nature 24 Feb 2015 31,206
2 EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis Arnaud Delorme, Scott Makeig · Journal of Neuroscience Methods 5 Feb 2004 25,692
3 A quantitative description of membrane current and its application to conduction and excitation in nerve Alan Lloyd Hodgkin, A. F. Huxley · The Journal of Physiology Open access 28 Aug 1952 23,507
4 The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia Stanley R. Kay, Abraham Fiszbein, Lewis A. Opler · Schizophrenia Bulletin Open access 1987 21,651
5 [Japanese version of the Neuropsychiatric Inventory--a scoring system for neuropsychiatric disturbance in dementia patients]. Nobutsugu Hirono, Etsuro Mori, Yoshitaka Ikejiri et al. · PubMed Mar 1997 20,864
6 Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults Vincent J. Felitti, Robert F. Anda, Dale F. Nordenberg et al. · American Journal of Preventive Medicine Open access May 1998 18,997
7 Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches Owen P. Hamill, Alain Marty, Erwin Neher et al. · Pflügers Archiv - European Journal of Physiology Aug 1981 18,543
8 The magical number seven, plus or minus two: Some limits on our capacity for processing information. George Miller · Psychological Review Mar 1956 17,806
9 A New Method for Measuring Daytime Sleepiness: The Epworth Sleepiness Scale Murray W. Johns · SLEEP Nov 1991 17,509
10 Automated Anatomical Labeling of Activations in SPM Using a Macroscopic Anatomical Parcellation of the MNI MRI Single-Subject Brain N. Tzourio-Mazoyer, Brigitte Landeau, Dimitri Papathanassiou et al. · NeuroImage Open access 2002 17,037
11 Neuropathological stageing of Alzheimer-related changes Heiko Braak, Eva Braak · Acta Neuropathologica Sep 1991 16,612
12 The Unity and Diversity of Executive Functions and Their Contributions to Complex “Frontal Lobe” Tasks: A Latent Variable Analysis Akira Miyake, Naomi P. Friedman, Michael J. Emerson et al. · Cognitive Psychology Aug 2000 15,905
13 An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest Rahul S. Desikan, Florent Ségonne, Bruce R. Fischl et al. · NeuroImage 14 Mar 2006 14,405
14 Advances in functional and structural MR image analysis and implementation as FSL Stephen M. Smith, Mark Jenkinson, Mark W. Woolrich et al. · NeuroImage 2004 14,361
15 Learning the parts of objects by non-negative matrix factorization Daniel D. Lee, H. Sebastian Seung · Nature Oct 1999 14,302
16 A New Depression Scale Designed to be Sensitive to Change Stuart Montgomery, Marie Åsberg · The British Journal of Psychiatry Apr 1979 14,132
17 Receptive fields, binocular interaction and functional architecture in the cat's visual cortex David Hunter Hubel, T. N. Wiesel · The Journal of Physiology Open access 1962 13,971
18 Control of goal-directed and stimulus-driven attention in the brain Maurizio Corbetta, Gordon L. Shulman · Nature reviews. Neuroscience Review Mar 2002 13,238
19 An Integrative Theory of Prefrontal Cortex Function Earl K. Miller, Jonathan D. Cohen · Annual Review of Neuroscience Review Mar 2001 13,094
20 A default mode of brain function Marcus E. Raichle, Ann Mary MacLeod, Abraham Z. Snyder et al. · Proceedings of the National Academy of Sciences Open access 16 Jan 2001 12,560
21 A feature-integration theory of attention Anne Treisman, Garry A. Gelade · Cognitive Psychology 1980 12,545
22 Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Harold P. Adams, Birgitte H. Bendixen, L. Jaap Kappelle et al. · Stroke Open access 1993 12,468
23 Complex brain networks: graph theoretical analysis of structural and functional systems Edward Thomas Bullmore, Olaf Sporns · Nature reviews. Neuroscience Review 4 Feb 2009 12,340
24 Complex network measures of brain connectivity: Uses and interpretations Mikail Rubinov, Olaf Sporns · NeuroImage 10 Oct 2009 12,245
25 Structure, function and diversity of the healthy human microbiome Curtis Huttenhower et al. · Nature Open access248 authors Jun 2012 12,195
26 FSL Mark Jenkinson, Christian F. Beckmann, Timothy E.J. Behrens et al. · NeuroImage Open access 16 Sep 2011 12,165
27 Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids Laura C. Green, David A. Wagner, Joseph A. Glogowski et al. · Analytical Biochemistry Oct 1982 12,147
28 The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine Robert F. Furchgott, John V. Zawadzki · Nature Nov 1980 12,123
29 The missing memristor found Dmitri B. Strukov, Gregory S. Snider, Duncan R. Stewart et al. · Nature 30 Apr 2008 11,715
30 AFNI: Software for Analysis and Visualization of Functional Magnetic Resonance Neuroimages Robert W. Cox · Computers and Biomedical Research Jun 1996 11,706
31 A synaptic model of memory: long-term potentiation in the hippocampus T.V.P. Bliss, Graham L. Collingridge · Nature 1993 11,655
32 Cortical Surface-Based Analysis Anders Martin Dale, Bruce R. Fischl, Martin I. Sereno · NeuroImage Feb 1999 11,631
33 FieldTrip: Open Source Software for Advanced Analysis of MEG, EEG, and Invasive Electrophysiological Data Robert Oostenveld, Pascal Henry Fries, Eric Maris et al. · Computational Intelligence and Neuroscience Open access 23 Dec 2010 11,541
34 A model of saliency-based visual attention for rapid scene analysis Laurent Itti, Christof Koch, Ernst Niebur · IEEE Transactions on Pattern Analysis and Machine Intelligence 1998 11,422
35 Pharmacological interventions for somatoform disorders in adults Maria Kleinstäuber, Michael Witthöft, Andrés Steffanowski et al. · Cochrane Database of Systematic Reviews Open access 7 Nov 2014 11,357
36 Staging of brain pathology related to sporadic Parkinson’s disease Heiko Braak, Kelly Del Tredici, Udo Rüb et al. · Neurobiology of Aging 28 Dec 2002 10,980
37 Hydrogen Peroxide is Scavenged by Ascorbate-specific Peroxidase in Spinach Chloroplasts Yoshiyuki Nakano, Kozi Asada · Plant and Cell Physiology Aug 1981 10,779
38 Deviations from michaelis-menten behaviour of plant glutamate dehydrogenase with ammonium as variable substrate Edwin Pahlich, Chr. Gerlitz · Phytochemistry 1980 10,703
39 Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. Andrew Jerome Hughes, S. E. Daniel, Linda Kilford et al. · Journal of Neurology Neurosurgery & Psychiatry Open access Mar 1992 10,504
40 The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease Marilyn S. Albert, Steven T. DeKosky, Dennis W. Dickson et al. · Alzheimer s & Dementia Open access 22 Apr 2011 10,419
41 FreeSurfer Bruce R. Fischl · NeuroImage Open access 10 Jan 2012 10,317
42 The Occurrence of Sleep-Disordered Breathing among Middle-Aged Adults Terry B Young, Mari Palta, Jerome A. Dempsey et al. · New England Journal of Medicine Open access 29 Apr 1993 10,268
43 Functional connectivity in the motor cortex of resting human brain using echo‐planar mri Bharat B. Biswal, F. Zerrin Yetkin, Victor M. Haughton et al. · Magnetic Resonance in Medicine Oct 1995 10,242
44 Determining optical flow Berthold K. P. Horn, Brian G. Schunck · Artificial Intelligence Open access Aug 1981 10,151
45 Tandem repeats finder: a program to analyze DNA sequences Gary Benson · Nucleic Acids Research Open access 1999 10,129
46 The organization of the human cerebral cortex estimated by intrinsic functional connectivity B.T. Thomas Yeo, Fenna M. Krienen, Jorge Sepulcre et al. · Journal of Neurophysiology Open access 9 Jun 2011 10,128
47 The Brain's Default Network Randy Lee Buckner, Jessica R. Andrews‐Hanna, Daniel L. Schacter · Annals of the New York Academy of Sciences Mar 2008 10,047
48 Statistical parametric maps in functional imaging: A general linear approach Karl John Friston, Andrew P. Holmes, Keith J. Worsley et al. · Human Brain Mapping 1994 9,877
49 The Mathematical Theory of Communication Claude E. Shannon, Warren Weaver, Norbert Wiener · Physics Today Sep 1950 9,856
50 A Neural Substrate of Prediction and Reward Wolfram Schultz, Peter Dayan, P. Read Montague · Science 14 Mar 1997 9,810

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.