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Tumor Regression in Cancer Patients by Very Low Doses of a T Cell–Engaging Antibody
Ralf Christian Bargou, Eugen Leo, Gerhard Zugmaier et al. · Science
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14 Aug 2008 |
1,087 |
| 2 |
Targeted Therapy With the T-Cell–Engaging Antibody Blinatumomab of Chemotherapy-Refractory Minimal Residual Disease in B-Lineage Acute Lymphoblastic Leukemia Patients Results in High Response Rate and Prolonged Leukemia-Free Survival
Max S. Topp et al. · Journal of Clinical Oncology
Open access |
17 May 2011 |
921 |
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Frequent high-level expression of the immunotherapeutic target Ep-CAM in colon, stomach, prostate and lung cancers
Philip Went, Mohammad Vasei, Lukas Bubendorf et al. · British Journal of Cancer
Open access |
2006 |
390 |
| 4 |
Extremely potent, rapid and costimulation‐independent cytotoxic T‐cell response against lymphoma cells catalyzed by a single‐chain bispecific antibody
Torsten Dreier, Grit Lorenczewski, Christian Brandl et al. · International Journal of Cancer
Open access |
30 Jul 2002 |
359 |
| 5 |
Serial killing of tumor cells by cytotoxic T cells redirected with a CD19‐/CD3‐bispecific single‐chain antibody construct
Patrick Hoffmann, Robert Hofmeister, Klaus Brischwein et al. · International Journal of Cancer
Open access |
Feb 2005 |
351 |
| 6 |
IL-27 and IFN- α Signal via Stat1 and Stat3 and Induce T-Bet and IL-12R β 2 in Naive T Cells
Linda Hibbert, Stefan Pflanz, René de Waal Malefyt et al. · Journal of Interferon & Cytokine Research
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Sep 2003 |
321 |
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Combined transcriptome and genome analysis of single micrometastatic cells
Christoph A. Klein, Stefan Seidl, Karina Petat‐Dutter et al. · Nature Biotechnology
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Apr 2002 |
306 |
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Ripple pattern formation on silicon surfaces by low-energy ion-beam erosion: Experiment and theory
B. Ziberi, Frank Frost, Thomas Höche et al. · Physical Review B
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7 Dec 2005 |
220 |
| 9 |
Epitope distance to the target cell membrane and antigen size determine the potency of T cell-mediated lysis by BiTE antibodies specific for a large melanoma surface antigen
Claudia Bluemel, Susanne Hausmann, Petra Fluhr et al. · Cancer Immunology Immunotherapy
Open access |
22 Mar 2010 |
210 |
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Direct Genetic Analysis of Single Disseminated Cancer Cells for Prediction of Outcome and Therapy Selection in Esophageal Cancer
Nikolas Hendrik Stoecklein, Stefan Benedikt Hosch, Martin Bezler et al. · Cancer Cell
Open access |
May 2008 |
210 |
| 11 |
Overexpression of epithelial cell adhesion molecule (Ep-CAM) is an independent prognostic marker for reduced survival of patients with epithelial ovarian cancer
Gilbert Spizzo, Philip Went, Stephan Dirnhofer et al. · Gynecologic Oncology
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7 May 2006 |
204 |
| 12 |
T Cell Costimulus-Independent and Very Efficacious Inhibition of Tumor Growth in Mice Bearing Subcutaneous or Leukemic Human B Cell Lymphoma Xenografts by a CD19-/CD3- Bispecific Single-Chain Antibody Construct
Torsten Dreier, Patrick A. Baeuerle, Iduna Fichtner et al. · The Journal of Immunology
Open access |
Apr 2003 |
194 |
| 13 |
Strictly Target Cell-dependent Activation of T Cells by Bispecific Single-chain Antibody Constructs of the BiTE Class
Klaus Brischwein, Larissa Parr, Stefan Pflanz et al. · Journal of Immunotherapy
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Nov 2007 |
191 |
| 14 |
T cell-engaging BiTE antibodies specific for EGFR potently eliminate KRAS- and BRAF-mutated colorectal cancer cells
Ralf Lutterbuese, Tobias Raum, Roman Kischel et al. · Proceedings of the National Academy of Sciences
Open access |
28 Jun 2010 |
169 |
| 15 |
A revival of bispecific antibodies
Peter Kufer, Ralf Lutterbüse, Patrick A. Baeuerle · Trends in biotechnology
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3 Apr 2004 |
155 |
| 16 |
High-throughput generation and engineering of recombinant human antibodies
Barbara Krebs, Robert Rauchenberger, Silke U. Reiffert et al. · Journal of Immunological Methods
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Aug 2001 |
153 |
| 17 |
Efficient elimination of chronic lymphocytic leukaemia B cells by autologous T cells with a bispecific anti-CD19/anti-CD3 single-chain antibody construct
Anja Löffler, Michael Gruen, Christian Wuchter et al. · Leukemia
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May 2003 |
151 |
| 18 |
Complete remission after blinatumomab-induced donor T-cell activation in three pediatric patients with post-transplant relapsed acute lymphoblastic leukemia
Rupert Handgretinger, Gerhard Zugmaier, Guenter Henze et al. · Leukemia
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14 Oct 2010 |
147 |
| 19 |
The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses
José M.A. Moreira, Peter Scheipers, Poul Sørensen · BMC Cancer
Open access |
9 Nov 2003 |
143 |
| 20 |
The effect of dexamethasone on polyclonal T cell activation and redirected target cell lysis as induced by a CD19/CD3-bispecific single-chain antibody construct
Christian Brandl, Cornelia Haas, Sandrine d’Argouges et al. · Cancer Immunology Immunotherapy
Open access |
19 Feb 2007 |
137 |
| 21 |
An open-label, randomized phase II study of adecatumumab, a fully human anti-EpCAM antibody, as monotherapy in patients with metastatic breast cancer
Marcus Schmidt, Max Ernst Scheulen, Christian Dittrich et al. · Annals of Oncology
Open access |
24 Jul 2009 |
134 |
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Expression of IL‐27 in human Th1‐associated granulomatous diseases
Fréderique Larousserie, Stefan Pflanz, Aurore Coulomb L’Herminé et al. · The Journal of Pathology
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19 Jan 2004 |
133 |
| 23 |
Side-by-side analysis of five clinically tested anti-EpCAM monoclonal antibodies
Markus Münz, Alexander Murr, Majk Kvesic et al. · Cancer Cell International
Open access |
2 Nov 2010 |
123 |
| 24 |
T-cell activation and B-cell depletion in chimpanzees treated with a bispecific anti-CD19/anti-CD3 single-chain antibody construct
Bernd Schlereth, Cornelia Quadt, Torsten Dreier et al. · Cancer Immunology Immunotherapy
Open access |
19 Jul 2005 |
103 |
| 25 |
In vitro and in vivo activity of MT201, a fully human monoclonal antibody for pancarcinoma treatment
Stefanie Naundorf, Susanne Preithner, Petra Mayer et al. · International Journal of Cancer
Open access |
29 May 2002 |
101 |
| 26 |
Immunotherapy of lymphoma and leukemia with T-cell engaging BiTE antibody blinatumomab
Dirk Nagorsen, Ralf Christian Bargou, Dominik Rüttinger et al. · Leukemia & lymphoma/Leukemia and lymphoma
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2009 |
101 |
| 27 |
Application of a hexapole collision and reaction cell in ICP-MS Part II: Analytical figures of merit and first applications
Ines Feldmann, Norbert Jakubowski, Christoph Thomas et al. · Fresenius Journal of Analytical Chemistry
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14 Oct 1999 |
98 |
| 28 |
Highly ordered self-organized dot patterns on Si surfaces by low-energy ion-beam erosion
B. Ziberi, Frank Frost, Bernd Rauschenbach et al. · Applied Physics Letters
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12 Jul 2005 |
88 |
| 29 |
A Subset of Human Dendritic Cells in the T Cell Area of Mucosa-Associated Lymphoid Tissue with a High Potential to Produce TNF-α
Annegret de Baey, Ines Mende, Gustavo Bruno Baretton et al. · The Journal of Immunology
Open access |
May 2003 |
87 |
| 30 |
Highly Efficient Elimination of Colorectal Tumor-Initiating Cells by an EpCAM/CD3-Bispecific Antibody Engaging Human T Cells
Ines Herrmann, Patrick A. Baeuerle, Matthias Friedrich et al. · PLoS ONE
Open access |
18 Oct 2010 |
86 |
| 31 |
Potent Control of Tumor Growth by CEA/CD3-bispecific Single-chain Antibody Constructs That Are Not Competitively Inhibited by Soluble CEA
Ralf Lutterbuese, Tobias Raum, Roman Kischel et al. · Journal of Immunotherapy
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May 2009 |
78 |
| 32 |
W-Band Waveguide Bandpass Filters Fabricated by Micro Laser Sintering
Milan Salek, Xiaobang Shang, Robert C. Roberts et al. · IEEE Transactions on Circuits & Systems II Express Briefs
Open access |
10 Apr 2018 |
77 |
| 33 |
New Aspects of Laser Microdissection in Research and Routine
Renate Burgemeister · Journal of Histochemistry & Cytochemistry
Open access |
Mar 2005 |
70 |
| 34 |
Static-charging mitigation and contamination avoidance by selective carbon coating of TEM samples
Thomas Höche, Jürgen W. Gerlach, Tino Petsch · Ultramicroscopy
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7 Jul 2006 |
67 |
| 35 |
Epithelial tight junction proteins as potential antibody targets for pancarcinoma therapy
Sonja Offner, Armin Hekele, Ulrike Teichmann et al. · Cancer Immunology Immunotherapy
Open access |
16 Oct 2004 |
63 |
| 36 |
Antitumor Activity of an EpCAM/CD3-bispecific BiTE Antibody During Long-term Treatment of Mice in the Absence of T-cell Anergy and Sustained Cytokine Release
Maria Amann, Sandrine d’Argouges, Grit Lorenczewski et al. · Journal of Immunotherapy
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21 May 2009 |
62 |
| 37 |
Combined blockade of granulocyte-macrophage colony stimulating factor and interleukin 17 pathways potently suppresses chronic destructive arthritis in a tumour necrosis factor α-independent mouse model
Christine Plater-Zyberk, Leo A. B. Joosten, M.M. Helsen et al. · Annals of the Rheumatic Diseases
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22 May 2008 |
60 |
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Phenotype and function of human dendritic cells derived from M-DC8+ monocytes
Annegret de Baey, Ines Mende, Gert Riethmüeller et al. · European Journal of Immunology
Open access |
Jun 2001 |
59 |
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Rapamycin attenuates vascular wall inflammation and progenitor cell promoters after angioplasty
Thomas Georg Nührenberg, Rainer Voisard, Felicitas Fahlisch et al. · The FASEB Journal
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16 Nov 2004 |
56 |
| 40 |
Phase IB study of the EpCAM antibody adecatumumab combined with docetaxel in patients with EpCAM-positive relapsed or refractory advanced-stage breast cancer
Marcus Schmidt, Dominik Rüttinger, Martin Sebastian et al. · Annals of Oncology
Open access |
22 Feb 2012 |
54 |
| 41 |
Live Cell Catapulting and Recultivation
Monika Stich, Stefan Thalhammer, Renate Burgemeister et al. · Pathology - Research and Practice
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2003 |
54 |
| 42 |
Potent inhibition of local and disseminated tumor growth in immunocompetent mouse models by a bispecific antibody construct specific for Murine CD3
Bernd Schlereth, Petra Kleindienst, Iduna Fichtner et al. · Cancer Immunology Immunotherapy
Open access |
26 Sep 2005 |
54 |
| 43 |
Etching of CuInSe2 thin films—comparison of femtosecond and picosecond laser ablation
David Ruthe, Klaus Zimmer, Thomas Höche · Applied Surface Science
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15 May 2005 |
52 |
| 44 |
GM-CSF neutralisation suppresses inflammation and protects cartilage in acute streptococcal cell wall arthritis of mice
Christine Plater-Zyberk, Leo A. B. Joosten, M.M. Helsen et al. · Annals of the Rheumatic Diseases
Open access |
5 Oct 2006 |
49 |
| 45 |
Rapamycin Effects Transcriptional Programs in Smooth Muscle Cells Controlling Proliferative and Inflammatory Properties
Dietlind Zohlnhöfer, Thomas Georg Nührenberg, Franz‐Josef Neumann et al. · Molecular Pharmacology
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26 Mar 2004 |
49 |
| 46 |
Industrial freeform generation of microtools by laser micro sintering
Peter Regenfuß, Lars Hartwig, S. Klötzer et al. · Rapid Prototyping Journal
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26 Jan 2005 |
44 |
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EpCAM As a Target in Cancer Therapy
Olivier Gires, P.A. Bäuerle · Journal of Clinical Oncology
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13 Apr 2010 |
43 |
| 48 |
High Quality Half-cell Processing Using Thermal Laser Separation
Stefan Eiternick, Felix Kaule, Hans‐Ulrich Zühlke et al. · Energy Procedia
Conference paperOpen access |
Aug 2015 |
43 |
| 49 |
High Quality RNA Retrieved from Samples Obtained by Using LMPC (Laser Microdissection and Pressure Catapulting) Technology
Renate Burgemeister, Rainer Gangnus, B. G. A. ter Haar et al. · Pathology - Research and Practice
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2003 |
40 |
| 50 |
Therapeutic window of an EpCAM/CD3-specific BiTE antibody in mice is determined by a subpopulation of EpCAM-expressing lymphocytes that is absent in humans
Maria Amann, Matthias Friedrich, Petra Lutterbuese et al. · Cancer Immunology Immunotherapy
Open access |
Jul 2008 |
40 |