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Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial
Yung‐Jue Bang, Eric Van Cutsem, Andrea Feyereislova et al. · The Lancet
Open access |
Aug 2010 |
7,405 |
| 2 |
Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer
Martine J Piccart et al. · New England Journal of Medicine
Open access |
20 Oct 2005 |
5,138 |
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International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma
William David Travis et al. · Journal of Thoracic Oncology
Open access |
20 Jan 2011 |
4,890 |
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Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): a phase 3, open-label, multicentre randomised controlled trial
Achim Rittmeyer et al. · The Lancet
Open access |
12 Dec 2016 |
4,817 |
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The 2015 World Health Organization Classification of Lung Tumors
William David Travis, Elisabeth M. Brambilla, Andrew Gordon Nicholson et al. · Journal of Thoracic Oncology
Open access |
21 Aug 2015 |
4,651 |
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MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling
Jeffrey A. Engelman, Kreshnik Zejnullahu, Tetsuya Mitsudomi et al. · Science
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26 Apr 2007 |
4,504 |
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Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer
Peter Schmid, Sylvia Adams, Hope S. Rugo et al. · New England Journal of Medicine
Open access |
20 Oct 2018 |
4,469 |
| 8 |
Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial
Tetsuya Mitsudomi et al. · The Lancet Oncology
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19 Dec 2009 |
4,130 |
| 9 |
ESMO consensus guidelines for the management of patients with metastatic colorectal cancer
Eric Van Cutsem et al. · Annals of Oncology
Open access |
5 Jul 2016 |
3,512 |
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Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia
Courtney Denton Dinardo et al. · New England Journal of Medicine
Open access |
12 Aug 2020 |
2,918 |
| 11 |
Alpelisib for PIK3CA -Mutated, Hormone Receptor–Positive Advanced Breast Cancer
Fabrice André, Eva M. Ciruelos, Gábor Rubovszky et al. · New England Journal of Medicine
Open access |
15 May 2019 |
2,660 |
| 12 |
Adjuvant Chemotherapy for Gastric Cancer with S-1, an Oral Fluoropyrimidine
Shinichi Sakuramoto, Mitsuru Sasako, Toshiharu Yamaguchi et al. · New England Journal of Medicine
Open access |
31 Oct 2007 |
2,547 |
| 13 |
Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial
Hansjochen Wilke, Kei Muro, Eric Van Cutsem et al. · The Lancet Oncology
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17 Sep 2014 |
2,505 |
| 14 |
Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2016 for the treatment of colorectal cancer
Japanese Society for Cancer of the Colon and Rectum et al. · International Journal of Clinical Oncology
Open access |
27 Mar 2017 |
2,496 |
| 15 |
Comprehensive genomic profiles of small cell lung cancer
Julie George et al. · Nature
Open access |
10 Jul 2015 |
2,448 |
| 16 |
Reduced Expression of the let-7 MicroRNAs in Human Lung Cancers in Association with Shortened Postoperative Survival
Junichi Takamizawa, Hiroyuki Konishi, Kiyoshi Yanagisawa et al. · Cancer Research
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Jun 2004 |
2,373 |
| 17 |
International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas
Masao Tanaka, Carlos Fernández-del Castillo, Volkan N. Adsay et al. · Pancreatology
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May 2012 |
2,359 |
| 18 |
Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial
Yoon‐Koo Kang et al. · The Lancet
Open access |
12 Oct 2017 |
2,317 |
| 19 |
International Consensus Guidelines for Management of Intraductal Papillary Mucinous Neoplasms and Mucinous Cystic Neoplasms of the Pancreas
Masao Tanaka, Suresh T. Chari, Volkan N. Adsay et al. · Pancreatology
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30 Nov 2005 |
2,051 |
| 20 |
Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer
Shanu Modi et al. · New England Journal of Medicine
Open access |
11 Dec 2019 |
2,026 |
| 21 |
Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer
Yojiro Hashiguchi et al. · International Journal of Clinical Oncology
Open access |
15 Jun 2019 |
2,012 |
| 22 |
Adjuvant Capecitabine for Breast Cancer after Preoperative Chemotherapy
Norikazu Masuda et al. · New England Journal of Medicine
Open access |
31 May 2017 |
1,947 |
| 23 |
S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial
Wasaburo Koizumi, Hiroyuki Narahara, Takuo Hara et al. · The Lancet Oncology
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22 Feb 2008 |
1,876 |
| 24 |
Fulvestrant plus palbociclib versus fulvestrant plus placebo for treatment of hormone-receptor-positive, HER2-negative metastatic breast cancer that progressed on previous endocrine therapy (PALOMA-3): final analysis of the multicentre, double-blind, phase 3 randomised controlled trial
Massimo Cristofanilli, Nicholas C. Turner, Igor Bondarenko et al. · The Lancet Oncology
Open access |
2 Mar 2016 |
1,870 |
| 25 |
Pembrolizumab plus chemotherapy versus placebo plus chemotherapy for previously untreated locally recurrent inoperable or metastatic triple-negative breast cancer (KEYNOTE-355): a randomised, placebo-controlled, double-blind, phase 3 clinical trial
Javier Cortés et al. · The Lancet
Open access227 authors |
Dec 2020 |
1,856 |
| 26 |
Safety and Efficacy of Pembrolizumab Monotherapy in Patients With Previously Treated Advanced Gastric and Gastroesophageal Junction Cancer
Charles S. Fuchs et al. · JAMA Oncology
Open access |
15 Mar 2018 |
1,835 |
| 27 |
Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas
Masao Tanaka, Carlos Fernández‐del Castillo, Terumi Kamisawa et al. · Pancreatology
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13 Jul 2017 |
1,816 |
| 28 |
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
Rainer Malik et al. · Nature Genetics
Open access428 authors |
12 Mar 2018 |
1,753 |
| 29 |
Palbociclib in Hormone-Receptor–Positive Advanced Breast Cancer
Nicholas C. Turner, Jungsil Ro, Fabrice André et al. · New England Journal of Medicine
Open access |
Jun 2015 |
1,606 |
| 30 |
Association analysis identifies 65 new breast cancer risk loci
Kyriaki Michailidou et al. · Nature
Open access362 authors |
20 Oct 2017 |
1,602 |
| 31 |
A Polycistronic MicroRNA Cluster, miR-17-92 , Is Overexpressed in Human Lung Cancers and Enhances Cell Proliferation
Yoji Hayashita, Hirotaka Osada, Yoshio Tatematsu et al. · Cancer Research
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Nov 2005 |
1,524 |
| 32 |
A Randomized Trial Comparing Postoperative Adjuvant Chemotherapy with Cisplatin and 5-Fluorouracil Versus Preoperative Chemotherapy for Localized Advanced Squamous Cell Carcinoma of the Thoracic Esophagus (JCOG9907)
Nobutoshi Ando, Hoichi Kato, Hiroyasu Igaki et al. · Annals of Surgical Oncology
Open access |
30 Aug 2011 |
1,459 |
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Coronavirus disease 2019 (COVID-19): A literature review
Harapan Harapan, Naoya Itoh, Amanda Yufika et al. · Journal of Infection and Public Health
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8 Apr 2020 |
1,451 |
| 34 |
Irinotecan plus Cisplatin Compared with Etoposide plus Cisplatin for Extensive Small-Cell Lung Cancer
Kazumasa Noda, Yutaka Nishiwaki, Masaaki Kawahara et al. · New England Journal of Medicine
Open access |
10 Jan 2002 |
1,376 |
| 35 |
Pembrolizumab versus paclitaxel for previously treated, advanced gastric or gastro-oesophageal junction cancer (KEYNOTE-061): a randomised, open-label, controlled, phase 3 trial
Kohei Shitara et al. · The Lancet
Open access158 authors |
4 Jun 2018 |
1,338 |
| 36 |
Overall Survival with Palbociclib and Fulvestrant in Advanced Breast Cancer
Nicholas C. Turner, Dennis J. Slamon, Jungsil Ro et al. · New England Journal of Medicine
Open access |
20 Oct 2018 |
1,321 |
| 37 |
Nivolumab versus chemotherapy in patients with advanced oesophageal squamous cell carcinoma refractory or intolerant to previous chemotherapy (ATTRACTION-3): a multicentre, randomised, open-label, phase 3 trial
Ken Kato, Byoung Chul Cho, Masanobu Takahashi et al. · The Lancet Oncology
Open access |
30 Sep 2019 |
1,262 |
| 38 |
Mutations of the Epidermal Growth Factor Receptor Gene in Lung Cancer
Takayuki Kosaka, Yasushi Yatabe, Hideki Endoh et al. · Cancer Research
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15 Dec 2004 |
1,237 |
| 39 |
Atezolizumab plus nab-paclitaxel as first-line treatment for unresectable, locally advanced or metastatic triple-negative breast cancer (IMpassion130): updated efficacy results from a randomised, double-blind, placebo-controlled, phase 3 trial
Peter Schmid, Hope S. Rugo, Sylvia Adams et al. · The Lancet Oncology
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27 Nov 2019 |
1,226 |
| 40 |
Randomized Phase III KEYNOTE-181 Study of Pembrolizumab Versus Chemotherapy in Advanced Esophageal Cancer
Takashi Kojima et al. · Journal of Clinical Oncology
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7 Oct 2020 |
1,199 |
| 41 |
Pembrolizumab plus Chemotherapy in Advanced Triple-Negative Breast Cancer
Javier Cortés, Hope S. Rugo, David W. Cescon et al. · New England Journal of Medicine
Open access |
20 Jul 2022 |
1,193 |
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EML4-ALK Mutations in Lung Cancer That Confer Resistance to ALK Inhibitors
Young Lim Choi, Manabu Soda, Yoshihiro Yamashita et al. · New England Journal of Medicine
Open access |
27 Oct 2010 |
1,192 |
| 43 |
Adjuvant chemotherapy of S-1 versus gemcitabine for resected pancreatic cancer: a phase 3, open-label, randomised, non-inferiority trial (JASPAC 01)
Katsuhiko Uesaka, Narikazu Boku, Akira Fukutomi et al. · The Lancet
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3 Jun 2016 |
1,145 |
| 44 |
Pembrolizumab for patients with PD-L1-positive advanced gastric cancer (KEYNOTE-012): a multicentre, open-label, phase 1b trial
Kei Muro, Hyun Cheol Chung, Veena Shankaran et al. · The Lancet Oncology
Open access |
3 May 2016 |
1,137 |
| 45 |
Large-scale genotyping identifies 41 new loci associated with breast cancer risk
Kyriaki Michailidou et al. · Nature Genetics
Open access222 authors |
27 Mar 2013 |
1,109 |
| 46 |
Neoadjuvant atezolizumab in combination with sequential nab-paclitaxel and anthracycline-based chemotherapy versus placebo and chemotherapy in patients with early-stage triple-negative breast cancer (IMpassion031): a randomised, double-blind, phase 3 trial
Elizabeth Ann Mittendorf, Hong Zhang, Carlos H. Barrios et al. · The Lancet
Open access |
20 Sep 2020 |
1,099 |
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Phase II Open-Label Study of Pembrolizumab in Treatment-Refractory, Microsatellite Instability–High/Mismatch Repair–Deficient Metastatic Colorectal Cancer: KEYNOTE-164
Dung Thi Le et al. · Journal of Clinical Oncology
Open access |
14 Nov 2019 |
1,038 |
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Capmatinib in MET Exon 14–Mutated or MET -Amplified Non–Small-Cell Lung Cancer
Jürgen Wolf et al. · New England Journal of Medicine
Open access |
2 Sep 2020 |
1,029 |
| 49 |
D2 Lymphadenectomy Alone or with Para-aortic Nodal Dissection for Gastric Cancer
Mitsuru Sasako, Takeshi Sano, Seiichiro Yamamoto et al. · New England Journal of Medicine
Open access |
30 Jul 2008 |
1,029 |
| 50 |
Mutations of the Epidermal Growth Factor Receptor Gene Predict Prolonged Survival After Gefitinib Treatment in Patients With Non–Small-Cell Lung Cancer With Postoperative Recurrence
Tetsuya Mitsudomi, Takayuki Kosaka, Hideki Endoh et al. · Journal of Clinical Oncology
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Mar 2005 |
960 |