Most cited papers from Alzheimer’s Research UK

Alzheimer’s Research UK

What are the most cited papers from Alzheimer’s Research UK?

The most cited paper from Alzheimer’s Research UK is "The Cellular Phase of Alzheimer’s Disease" (Bart De Strooper, Eric H. Karran, 2016), with 2,066 citations. Next come "Small molecules, big targets: drug discovery faces the protein–protein interaction challenge" (1,172) and "Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities" (1,167).

Published TypeFieldAccessAuthorsCitations

Showing 50 of 60 papers. Every paper with more than 68 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	The Cellular Phase of Alzheimer’s Disease Bart De Strooper, Eric H. Karran · Cell Open access	Feb 2016	2,066
2	Small molecules, big targets: drug discovery faces the protein–protein interaction challenge Duncan E. Scott, Andrew R. Bayly, Chris Abell et al. · Nature Reviews Drug Discovery ReviewOpen access	6 Apr 2016	1,172
3	Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities Fiona M. Menzies et al. · Neuron Open access	Mar 2017	1,167
4	The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis Charles E. Massie et al. · The EMBO Journal Open access	20 May 2011	645
5	Somatic mutations and clonal dynamics in healthy and cirrhotic human liver Simon F. Brunner, Nicola D. Roberts, Luke A. Wylie et al. · Nature Open access	23 Oct 2019	422
6	The amyloid cascade hypothesis: are we poised for success or failure? Eric H. Karran, Bart De Strooper · Journal of Neurochemistry Open access	3 Jun 2016	410
7	Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening Efrat Resnick et al. · Journal of the American Chemical Society Open access	7 May 2019	349
8	Passive Amyloid Immunotherapy Clears Amyloid and Transiently Activates Microglia in a Transgenic Mouse Model of Amyloid Deposition Donna M. Wilcock, Amyn M. Rojiani, Arnon Rosenthal et al. · Journal of Neuroscience Open access	7 Jul 2004	301
9	LightGBM: An Effective and Scalable Algorithm for Prediction of Chemical Toxicity–Application to the Tox21 and Mutagenicity Data Sets Jin Zhang, Dániel Mucs, Ulf Norinder et al. · Journal of Chemical Information and Modeling Open access	27 Sep 2019	282
10	A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease Eric H. Karran, John Hardy · Annals of Neurology Open access	23 May 2014	282
11	NOTUM from Apc-mutant cells biases clonal competition to initiate cancer Dustin James Flanagan et al. · Nature Open access	2 Jun 2021	263
12	Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice Eleni Maniati, Maud Bossard, Natalie Cook et al. · Journal of Clinical Investigation Open access	7 Nov 2011	254
13	Molecular and functional variation in iPSC-derived sensory neurons Jeremy Schwartzentruber, Stefanie Foskolou, Helena Kilpinen et al. · Nature Genetics Open access	10 Dec 2017	243
14	Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane Nils Frank, Jeremy Nugent, Bethany R. Shire et al. · Nature Open access	15 Sep 2022	241
15	A genetics-led approach defines the drug target landscape of 30 immune-related traits Hai Yan Fang et al. · Nature Genetics Open access	28 Jun 2019	239
16	Postmortem transcriptional profiling reveals widespread increase in inflammation in schizophrenia: a comparison of prefrontal cortex, striatum, and hippocampus among matched tetrads of controls with subjects diagnosed with schizophrenia, bipolar or major depressive disorder Thomas A. Lanz, Veronica Reinhart, Mark J. Sheehan et al. · Translational Psychiatry Open access	23 May 2019	227
17	Mild Cognitive Impairment: the Manchester consensus Ross A. Dunne et al. · Age and Ageing Open access	27 Oct 2020	225
18	Tip of the Iceberg: Assessing the Global Socioeconomic Costs of Alzheimer’s Disease and Related Dementias and Strategic Implications for Stakeholders Youssef Hanna El-Hayek, Ryan E. Wiley, Charles P. Khoury et al. · Journal of Alzheimer s Disease Open access	25 Jun 2019	225
19	Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia Francesco Paonessa, Lewis Evans, Ravi Solanki et al. · Cell Reports Open access	2019	213
20	Convergent somatic mutations in metabolism genes in chronic liver disease Stanley Ng et al. · Nature Open access	13 Oct 2021	203
21	Combined Inhibition of mTOR and CDK4/6 Is Required for Optimal Blockade of E2F Function and Long-term Growth Inhibition in Estrogen Receptor–positive Breast Cancer Chrysiis Michaloglou, Claire Crafter, Rasmus Siersbæk et al. · Molecular Cancer Therapeutics Open access	26 Feb 2018	194
22	New approaches for the treatment of Alzheimer’s disease Paul V. Fish, David Steadman, Elliott D. Bayle et al. · Bioorganic & Medicinal Chemistry Letters Open access	19 Nov 2018	185
23	Lipid Remodeling in Hepatocyte Proliferation and Hepatocellular Carcinoma Zoe Hall, Davide Chiarugi, Evelina Charidemou et al. · Hepatology Open access	27 May 2020	168
24	Antimalarial activity of primaquine operates via a two-step biochemical relay Grazia Camarda, Piyaporn Jirawatcharadech, Richard S. Priestley et al. · Nature Communications Open access	19 Jul 2019	162
25	Resolving the immune landscape of human prostate at a single-cell level in health and cancer Zewen Kelvin Tuong, Kevin W. Loudon, Brendan Berry et al. · Cell Reports Open access	Dec 2021	161
26	Microglial inflammation and phagocytosis in Alzheimer's disease: Potential therapeutic targets Sohaib Nizami, Hazel Hall‐Roberts, Sharat Warrier et al. · British Journal of Pharmacology Open access	11 Feb 2019	160
27	Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph Lorenza Magno, Christian B. Lessard, Marta Martins et al. · Alzheimer s Research & Therapy Open access	2 Feb 2019	151
28	Targeting the Small GTPase Superfamily through Their Regulatory Proteins Janine L. Gray, F. von Delft, Paul E. Brennan · Angewandte Chemie International Edition Open access	14 Mar 2019	148
29	The case for low-level BACE1 inhibition for the prevention of Alzheimer disease Eric McDade, Iryna Voytyuk, Paul S. S. Aisen et al. · Nature Reviews Neurology ReviewOpen access	21 Sep 2021	140
30	An Unbiased Approach to Identifying Tau Kinases That Phosphorylate Tau at Sites Associated with Alzheimer Disease Annalisa Cavallini, Suzanne Clare Brewerton, Amanda Bell et al. · Journal of Biological Chemistry Open access	24 Jun 2013	140
31	USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation Emma V. Rusilowicz-Jones et al. · Life Science Alliance Open access	7 Jul 2020	137
32	UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria Christel Brunschwig et al. · Antimicrobial Agents and Chemotherapy Open access	26 Jun 2018	136
33	Measuring intracellular pH in the heart using hyperpolarized carbon dioxide and bicarbonate: a 13C and 31P magnetic resonance spectroscopy study Marie Schroeder, Pawel Swietach, Helen J. Atherton et al. · Cardiovascular Research Open access	15 Dec 2009	131
34	Antiamyloid Therapy for Alzheimer's Disease — Are We on the Right Road? Eric H. Karran, John Hardy · New England Journal of Medicine	22 Jan 2014	126
35	A roadmap to advance dementia research in prevention, diagnosis, intervention, and care by 2025 James Pickett et al. · International Journal of Geriatric Psychiatry Open access	22 Feb 2018	120
36	Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia S. Picaud et al. · Science Advances Open access	7 Oct 2016	112
37	Could Conservative Iron Chelation Lead to Neuroprotection in Amyotrophic Lateral Sclerosis?© Caroline Moreau et al . 2018; Published by Mary Ann Liebert, Inc. This Open Access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is pr Caroline Moreau et al. · Antioxidants and Redox Signaling Open access	30 Dec 2017	109
38	Inhibiting p38 MAPK alpha rescues axonal retrograde transport defects in a mouse model of ALS Katherine L. Gibbs, Bernadett Kalmár, Elena R. Rhymes et al. · Cell Death and Disease Open access	22 May 2018	106
39	Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease Felicity Liew et al. · Nature Immunology Open access1,462 authors	Apr 2024	103
40	The structural basis of fatty acid elongation by the ELOVL elongases Laiyin Nie, Tomas C. Pascoa, Ashley C. W. Pike et al. · Nature Structural & Molecular Biology Open access	Jun 2021	103
41	Discovery of a PCAF Bromodomain Chemical Probe Moses Moustakim et al. · Angewandte Chemie International Edition Open access	14 Dec 2016	96
42	Discovery of an MLLT1/3 YEATS Domain Chemical Probe Moses Moustakim et al. · Angewandte Chemie International Edition Open access	6 Oct 2018	95
43	Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors Kanchan Devkota, Matthieu Schapira, Sumera Perveen et al. · SLAS DISCOVERY Open access	Jul 2021	90
44	Inhibiting Ca2+ channels in Alzheimer’s disease model mice relaxes pericytes, improves cerebral blood flow and reduces immune cell stalling and hypoxia Nils Korte, Anna Barkaway, Jack A. Wells et al. · Nature Neuroscience Open access	18 Sep 2024	89
45	Amyloidogenic processing of Alzheimer’s disease β-amyloid precursor protein induces cellular iron retention Andrew Tsatsanis, Bruce X. W. Wong, Adam P. Gunn et al. · Molecular Psychiatry	22 May 2020	86
46	Marked Age-Related Changes in Brain Iron Homeostasis in Amyloid Protein Precursor Knockout Mice Abdel Ali Belaidi, Adam P. Gunn, Bruce X. W. Wong et al. · Neurotherapeutics Open access	15 Aug 2018	84
47	Target 2035 – update on the quest for a probe for every protein Susanne Müller et al. · RSC Medicinal Chemistry Open access	3 Dec 2021	83
48	Implementing liquid biopsies into clinical decision making for cancer immunotherapy Dagmar Quandt et al. · Oncotarget Open access	24 Apr 2017	80
49	Systematic Investigation of the Permeability of Androgen Receptor PROTACs Duncan E. Scott, Timothy P. C. Rooney, Elliott D. Bayle et al. · ACS Medicinal Chemistry Letters Open access	8 Jun 2020	79
50	mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer David R. Driscoll, Saadia A. Karim, Makoto Sano et al. · Cancer Research Open access	6 Oct 2016	77

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.