| 1 |
Intention-to-treat concept: A review
Sandeep Kumar Gupta · Perspectives in Clinical Research
Open access |
2011 |
1,992 |
| 2 |
Production of High-Titer Recombinant Adeno-Associated Virus Vectors in the Absence of Helper Adenovirus
Xiao Xiao, Juan Li, Richard Jude Samulski · Journal of Virology
Open access |
Mar 1998 |
1,387 |
| 3 |
Incidence, Reversal, and Prevention of Opioid-induced Respiratory Depression
Albert Dahan, Leon P.H.J. Aarts, Terry Smith · Anesthesiology
|
17 Dec 2009 |
641 |
| 4 |
Monitoring clinical changes in patients with heart failure: A comparison of methods
John A. Spertus, Eric David Peterson, Mark W. Conard et al. · American Heart Journal
|
Oct 2005 |
568 |
| 5 |
Nrf2-Deficient Mice Have an Increased Susceptibility to Dextran Sulfate Sodium–Induced Colitis
Tin Oo Khor, Mou‐Tuan Huang, Ki Han Kwon et al. · Cancer Research
|
15 Dec 2006 |
533 |
| 6 |
Accuracy of medicare claims-based diagnosis of acute myocardial infarction: estimating positive predictive value on the basis of review of hospital records
Yuka Kiyota, Sebastian Schneeweiß, Robert J. Glynn et al. · American Heart Journal
|
23 Jun 2004 |
531 |
| 7 |
Randomized trial of deep brain stimulation for Parkinson disease
Frances M. Weaver et al. · Neurology
Open access104 authors |
22 Jun 2012 |
455 |
| 8 |
Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents
Rassoul Dinarvand, Nima Sepehri, Manouchehri et al. · International Journal of Nanomedicine
Open access |
Apr 2011 |
451 |
| 9 |
Inhibition of 7,12-Dimethylbenz(a)anthracene-Induced Skin Tumorigenesis in C57BL/6 Mice by Sulforaphane Is Mediated by Nuclear Factor E2–Related Factor 2
Changjiang Xu, Mou‐Tuan Huang, Guoxiang Shen et al. · Cancer Research
Open access |
15 Aug 2006 |
385 |
| 10 |
Prevalence and Nature of Medication Administration Errors in Health Care Settings: A Systematic Review of Direct Observational Evidence
Richard Neil Keers, Steven David Williams, Jonathan Cooke et al. · Annals of Pharmacotherapy
Review |
Feb 2013 |
366 |
| 11 |
A randomized, double-blind, placebo-controlled trial of antidepressants in Parkinson disease
I Richard et al. · Neurology
Open access |
12 Apr 2012 |
340 |
| 12 |
Solid lipid nanoparticles: a review on recent perspectives and patents
Rishi Paliwal, Shivani Rai Paliwal, Rameshroo Kenwat et al. · Expert Opinion on Therapeutic Patents
|
31 Jan 2020 |
335 |
| 13 |
Identification of Cytochrome P450 2E1 as the Predominant Enzyme Catalyzing Human Liver Microsomal Defluorination of Sevoflurane, Isoflurane, and Methoxyflurane
Evan D. Kharasch, Kenneth E. Thummel · Anesthesiology
Open access |
Oct 1993 |
318 |
| 14 |
The Vanilloid Receptor TRPV1 Is Tonically Activated In Vivo and Involved in Body Temperature Regulation
Narender R. Gavva, Anthony W. Bannon, Sekhar Surapaneni et al. · Journal of Neuroscience
Open access |
28 Mar 2007 |
314 |
| 15 |
Potency Trends of Δ9-THC and Other Cannabinoids in Confiscated Marijuana from 1980–1997
MA ElSohly, Samir Anis Ross, Zlatko Mehmedic et al. · Journal of Forensic Sciences
|
2000 |
311 |
| 16 |
Practical approach to determining costs and frequency of adverse drug events in a health care network
Bonnie L. Senst, Louis E. Achusim, Robert Genest et al. · American Journal of Health-System Pharmacy
|
15 Jun 2001 |
310 |
| 17 |
Initial experiences with medicinal extracts of cannabis for chronic pain: Results from 34 ‘N of 1’ studies
William George Notcutt, Mario Price, Roy Miller et al. · Anaesthesia
|
16 Apr 2004 |
306 |
| 18 |
Cyclosporine Interacts with Mycophenolic Acid by Inhibiting the Multidrug Resistance-Associated Protein 2
Dennis Alexander Hesselink, Reinier M. van Hest, Ron A. A. Mathôt et al. · American Journal of Transplantation
|
5 Apr 2005 |
297 |
| 19 |
Characterization of functional receptors for somatostatin in rat pituitary cells in culture.
Agnes Schönbrunn, Hagop Tashjian · Journal of Biological Chemistry
Open access |
Sep 1978 |
293 |
| 20 |
Impact of interruptions and distractions on dispensing errors in an ambulatory care pharmacy
Elizabeth Allan Flynn, Kenneth N. Barker, J. Tyrone Gibson et al. · American Journal of Health-System Pharmacy
|
Jul 1999 |
291 |
| 21 |
Cost-Effectiveness of Intensive versus Standard Blood-Pressure Control
Adam Phillip Bress et al. · New England Journal of Medicine
Open access |
23 Aug 2017 |
290 |
| 22 |
Angiotensin-Converting Enzyme Inhibitor or Angiotensin II Type 1 Receptor Antagonist Therapy Is Associated with Prolonged Patient and Graft Survival after Renal Transplantation
Georg Heinze, Christa Mitterbauer, Heinz M. Regele et al. · Journal of the American Society of Nephrology
|
15 Feb 2006 |
276 |
| 23 |
Demonstration of a Genetic Therapeutic Index for Tumors Expressing Oncogenic BRAF by the Kinase Inhibitor SB-590885
Alastair J. King et al. · Cancer Research
Open access |
Dec 2006 |
265 |
| 24 |
A nanoparticle-incorporated STING activator enhances antitumor immunity in PD-L1–insensitive models of triple-negative breast cancer
Ning Hui Cheng, Rebekah Watkins-Schulz, Robert D. Junkins et al. · JCI Insight
Open access |
14 Nov 2018 |
257 |
| 25 |
Ethosomes: New Prospects in Transdermal Delivery
Biana Godin, Elka Touítou · Critical Reviews in Therapeutic Drug Carrier Systems
|
2003 |
256 |
| 26 |
Distribution of Gefitinib to the Brain Is Limited by P-glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2)-Mediated Active Efflux
Sagar Agarwal, Ramola Sane, Jose L. Gallardo et al. · Journal of Pharmacology and Experimental Therapeutics
Open access |
26 Apr 2010 |
255 |
| 27 |
Self-nanoemulsifying drug delivery system (SNEDDS) of the poorly water-soluble grapefruit flavonoid Naringenin: design, characterization,in vitroandin vivoevaluation
Abdul Wadood Khan, Sabna Kotta, Shahid Husain Ansari et al. · Drug Delivery
Open access |
10 Feb 2014 |
251 |
| 28 |
Prevalence of rheumatoid arthritis in France: 2001
Françis Guillemin, A Saraux, P Guggenbuhl et al. · Annals of the Rheumatic Diseases
Open access |
31 Mar 2005 |
240 |
| 29 |
GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet
Paula L. McClean, Nigel Irwin, Roslyn S. Cassidy et al. · American Journal of Physiology-Endocrinology and Metabolism
|
11 Sep 2007 |
239 |
| 30 |
Human Kidney Methoxyflurane and Sevoflurane Metabolism
Evan D. Kharasch, Douglas C. Hankins, Kenneth E. Thummel · Anesthesiology
Open access |
Mar 1995 |
231 |
| 31 |
Inhaled Tobramycin in Non—Cystic Fibrosis Patients with Bronchiectasis and Chronic Bronchial Infection with Pseudomonas Aeruginosa
M. Estrella Drobnic, Pilar Suñé, J Bruno Montoro et al. · Annals of Pharmacotherapy
|
23 Nov 2004 |
223 |
| 32 |
Low molecular weight heparin started before surgery as prophylaxis against deep vein thrombosis: 2500 versus 5000 Xal units in 2070 patients
David Bergqvist, Ulla Stina Burmark, Per Anders Flordal et al. · British journal of surgery
|
Apr 1995 |
220 |
| 33 |
Inhibition of Platelet Aggregation by Inhaled Nitric Oxide in Patients with Acute Respiratory Distress Syndrome
Charles Marc Samama, Mohamed Diaby, Jean-Luc Fellahi et al. · Anesthesiology
Open access |
Jul 1995 |
219 |
| 34 |
Improved drug loading and antibacterial activity of minocycline-loaded PLGA nanoparticles prepared by solid/oil/water ion pairing method
Rassoul Dinarvand, Tahereh Sadat Jafarzadeh Kashi, Eskandarion et al. · International Journal of Nanomedicine
Open access |
2012 |
217 |
| 35 |
Selection of a validated scale for measuring medication adherence
Stacey M. Lavsa, Ashley Holzworth, Nicole T. Ansani · Journal of the American Pharmacists Association
|
2011 |
216 |
| 36 |
Mechanisms Mediating the Vesicant Actions of Sulfur Mustard after Cutaneous Exposure
Michael P. Shakarjian, Diane E. Heck, Joshua P. Gray et al. · Toxicological Sciences
Open access |
15 Oct 2009 |
215 |
| 37 |
The Role of Hyaluronidase in the Treatment of Complications From Hyaluronic Acid Dermal Fillers
Maurizio Cavallini, Riccardo Gazzola, Marco Metalla et al. · Aesthetic Surgery Journal
|
Nov 2013 |
208 |
| 38 |
A Response Surface Analysis of Propofol–Remifentanil Pharmacodynamic Interaction in Volunteers
Steven E. Kern, Guoming Xie, Julia L. White et al. · Anesthesiology
|
19 May 2004 |
205 |
| 39 |
Combined Inhibitory Effects of Curcumin and Phenethyl Isothiocyanate on the Growth of Human PC-3 Prostate Xenografts in Immunodeficient Mice
Tin Oo Khor, Young-Sam Keum, Wen Lin et al. · Cancer Research
|
15 Jan 2006 |
204 |
| 40 |
Inhaled Nitric Oxide Reverses the Increase in Pulmonary Vascular Resistance Induced by Permissive Hypercapnia in Patients with Acute Respiratory Distress Syndrome
Louis Puybasset, Thomas E. Stewart, Jean‐Jacques Rouby et al. · Anesthesiology
|
Jun 1994 |
204 |
| 41 |
An innovative approach to integrated medicines management
Claire Scullin, Michael Scott, Anita Hogg et al. · Journal of Evaluation in Clinical Practice
|
28 Jul 2007 |
201 |
| 42 |
Antimicrobial activity of histones from hemocytes of the Pacific white shrimp
Séverine A. Patat, Ryan B. Carnegie, Celia Kingsbury et al. · European Journal of Biochemistry
Open access |
Dec 2004 |
200 |
| 43 |
PGC-1α is coupled to HIF-1α-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells
Kathleen O’Hagan, Sinéad Cocchiglia, Alexander V. Zhdanov et al. · Proceedings of the National Academy of Sciences
Open access |
28 Jan 2009 |
197 |
| 44 |
VBP15, a novel anti‐inflammatory and membrane‐stabilizer, improves muscular dystrophy without side effects
Christopher R. Heier et al. · EMBO Molecular Medicine
Open access |
9 Sep 2013 |
194 |
| 45 |
Sleep disruption in critically ill patients – pharmacological considerations
Richard S Bourne, GARY H. MILLS · Anaesthesia
Open access |
16 Mar 2004 |
192 |
| 46 |
Inhibition of lung tumor growth by complex pulmonary delivery of drugs with oligonucleotides as suppressors of cellular resistance
Olga B. Garbuzenko, Maha Saad, Vitaly P. Pozharov et al. · Proceedings of the National Academy of Sciences
Open access |
24 May 2010 |
186 |
| 47 |
Reliability and validity of the 4‐item perceived stress scale among pregnant women: Results from the OTIS antidepressants study
Fatiha Karam, Anick Bérard, Odile Sheehy et al. · Research in Nursing & Health
|
17 Apr 2012 |
184 |
| 48 |
Interactions of Warfarin with Garlic, Ginger, Ginkgo, or Ginseng: Nature of the Evidence
Leon PJ Vaes, Peter A. Chyka · Annals of Pharmacotherapy
|
Dec 2000 |
184 |
| 49 |
A Phase II Clinical Trial of Sorafenib in Androgen-Independent Prostate Cancer
William L. Dahut, Charity D. Scripture, Edwin Melencio Posadas et al. · Clinical Cancer Research
|
2008 |
180 |
| 50 |
Modulation of nuclear factor E2-related factor 2–mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin
Guoxiang Shen, Changjiang Xu, Rong Hu et al. · Molecular Cancer Therapeutics
Open access |
2006 |
180 |