| 1 |
Polyamine-Blocking Therapy Reverses Immunosuppression in the Tumor Microenvironment
Candace S. Hayes, Allyson C. Shicora, Martin P. Keough et al. · Cancer Immunology Research
Open access |
7 Oct 2013 |
169 |
| 2 |
Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma
Laura D. Gamble et al. · Science Translational Medicine
Open access |
30 Jan 2019 |
163 |
| 3 |
Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas
Aaminah Khan, Laura D. Gamble, Dannielle H. Upton et al. · Nature Communications
Open access |
12 Feb 2021 |
131 |
| 4 |
Polyamines drive myeloid cell survival by buffering intracellular pH to promote immunosuppression in glioblastoma
Jason M. Miska, Aida Rashidi, Catalina Lee-Chang et al. · Science Advances
Open access |
17 Feb 2021 |
118 |
| 5 |
AMXT-1501, a novel polyamine transport inhibitor, synergizes with DFMO in inhibiting neuroblastoma cell proliferation by targeting both ornithine decarboxylase and polyamine transport
Katherine Samal, Ping Zhao, Ann Kendzicky et al. · International Journal of Cancer
Open access |
2 Mar 2013 |
95 |
| 6 |
De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and determine T cell proliferation and function
Ruohan Wu, Xuyong Chen, Siwen Kang et al. · Science Advances
Open access |
16 Dec 2020 |
86 |
| 7 |
Polyamine blockade promotes antitumor immunity
Candace S. Hayes, Mark R. Burns, Susan K. Gilmour · OncoImmunology
Open access |
2014 |
37 |
| 8 |
Energy, Oxidative Stress, and Inflammation in the Colon
Richard F. Harty · Digestive Diseases and Sciences
Open access |
24 Aug 2013 |
14 |
| 9 |
Phase I/II clinical trial of 2‐difluoromethyl‐ornithine (DFMO) and a novel polyamine transport inhibitor (MQT 1426) for feline oral squamous cell carcinoma*
Katherine A. Skorupski, Thomas G. O’Brien, Teri A. Guerrero et al. · Veterinary and Comparative Oncology
Open access |
8 Mar 2011 |
13 |
| 10 |
The polyamine transporter ATP13A3 mediates difluoromethylornithine‐induced polyamine uptake in neuroblastoma
Mujahid Azfar, Weiman Gao, Chris Van den Haute et al. · Molecular Oncology
Open access |
21 Feb 2025 |
11 |
| 11 |
Polyamine depletion limits progression of acute leukaemia
Weiman Gao, Mawar Karsa, Lin Xiao et al. · International Journal of Cancer
Open access |
22 Feb 2025 |
8 |
| 12 |
Phase I dose-escalation trial of AMXT 1501 dicaprate plus difluoromethylornithine: a dual-agent approach targeting immunosuppressive polyamine metabolism
Sarina Anne Piha-Paul, Anthony W. Tolcher, Andrae Vandross et al. · ESMO Open
Open access |
Sep 2025 |
6 |
| 13 |
Interrogation of T Cell–enriched Tumors Reveals Prognostic and Immunotherapeutic Implications of Polyamine Metabolism
R. Alex Harbison, Rajeev Pandey, Michael Considine et al. · Cancer Research Communications
Open access |
27 Jun 2022 |
5 |
| 14 |
The polyamine transporter ATP13A3 mediates DFMO-induced polyamine uptake in neuroblastoma
Mujahid Azfar, Weiman Gao, Chris Van den Haute et al. · bioRxiv (Cold Spring Harbor Laboratory)
PreprintOpen access |
22 Feb 2024 |
4 |
| 15 |
Polyamine transport inhibition and cisplatin synergistically enhance tumor control through oxidative stress in murine head and neck cancer models
Abdul Yassin‐Kassab, Nathaniel S. Wang, Jackson R. Foley et al. · Oral Oncology Reports
Open access |
10 Nov 2023 |
2 |
| 16 |
DIPG-15. POLYAMINE PATHWAY INHIBITION IS A POTENT NOVEL THERAPEUTIC STRATEGY AGAINST DIFFUSE INTRINSIC PONTINE GLIOMA
Aaminah Khan, Laura D. Gamble, Dannielle H. Upton et al. · Neuro-Oncology
Open access |
Dec 2020 |
1 |
| 17 |
ID #95 Dual polyamine pathway blockade synergises with irinotecan to eradicate MYC-driven medulloblastoma
Aaminah Khan, Anjana Gopalakrishnan, Jie Liu et al. · Neuro-Oncology Pediatrics
Open access |
23 Jun 2026 |
0 |
| 18 |
OS05.6.A POLYAMINE PATHWAY BLOCKADE SENSITISES MYC-DRIVEN MEDULLOBLASTOMA TO CHEMOTHERAPY
Aadil Khan, Athira Perunelly Gopalakrishnan, Jie Liu et al. · Neuro-Oncology
Open access |
Oct 2025 |
0 |
| 19 |
266 Decoding the role of polyamine metabolism on anti-tumor immunity in head and neck cancer
Richard Alexander Harbison, William J. Andrews, Michael W. Mikula et al. · Journal of Clinical and Translational Science
Open access |
Apr 2023 |
0 |
| 20 |
Polyamine transport inhibition with AMXT-1501 synergizes with cisplatin in HNSCC
A. Yassin-Kassab, R.A. Harbison, N. Wang et al. · European Journal of Cancer
Open access |
Oct 2022 |
0 |
| 21 |
RARE-02. POLYAMINE PATHWAY INHIBITION IS A POTENT NOVEL THERAPEUTIC STRATEGY AGAINST DIFFUSE INTRINSIC PONTINE GLIOMA
Aaminah Khan, Laura D. Gamble, Dannielle H. Upton et al. · Neuro-Oncology
Open access |
Jun 2021 |
0 |
| 22 |
De novo synthesis and salvage pathway coordinately regulates polyamine homeostasis and determines T cell proliferation and function
Ruohan Wu, Xuyong Chen, Siwen Kang et al. · bioRxiv (Cold Spring Harbor Laboratory)
PreprintOpen access |
30 Apr 2020 |
0 |
| 23 |
853 Mechanical Characteristic Evaluation of Earthquake-proof Reinforced Member by using FEM Stress Analysis
Yoshitaka KOSUGE, Jyo SHIMURA, Kazuyuki MINEO et al. · The Proceedings of Yamanashi District Conference
Conference paperOpen access |
2010 |
0 |
| 24 |
152 Analytical Research on Strength Characteristic of Earthquake-proof Reinforced Member
Yoshitaka KOSUGE, Satoru KAMIYAMA, Jyo SHIMURA et al. · The Proceedings of Yamanashi District Conference
Conference paperOpen access |
2009 |
0 |
| 25 |
Microarray analysis in TNBS colitis: invivo effect of combination therapy with Nacetylcysteine and mesalamine on colonic tissue gene expression.
Samir Malhotra, Hanumantha R. Ancha, John D. Briggs et al. · Inflammatory Bowel Diseases
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Dec 2008 |
0 |