| 1 |
Effective treatment of severe COVID-19 patients with tocilizumab
Xiaoling Xu, Mingfeng Han, Tiantian Li et al. · Proceedings of the National Academy of Sciences
Open access |
29 Apr 2020 |
2,800 |
| 2 |
Sintilimab plus a bevacizumab biosimilar (IBI305) versus sorafenib in unresectable hepatocellular carcinoma (ORIENT-32): a randomised, open-label, phase 2–3 study
Zhenggang Ren et al. · The Lancet Oncology
|
15 Jun 2021 |
1,154 |
| 3 |
The role of BCL-2 family proteins in regulating apoptosis and cancer therapy
Shanna Qian, Zhong Wei, Wanting Yang et al. · Frontiers in Oncology
Open access |
12 Oct 2022 |
1,002 |
| 4 |
Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders
Hua Jiang, Hongbin He, Yun Chen et al. · The Journal of Experimental Medicine
Open access |
11 Oct 2017 |
751 |
| 5 |
Camrelizumab plus rivoceranib versus sorafenib as first-line therapy for unresectable hepatocellular carcinoma (CARES-310): a randomised, open-label, international phase 3 study
Shukui Qin et al. · The Lancet
Open access138 authors |
24 Jul 2023 |
729 |
| 6 |
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade
Zhaolin Chen, Tianlu Shi, Lei Zhang et al. · Cancer Letters
|
24 Oct 2015 |
728 |
| 7 |
Systematic review and meta-analysis of mortality of patients infected with carbapenem-resistant Klebsiella pneumoniae
Liangfei Xu, Xiaoxi Sun, Xiaoling Ma · Annals of Clinical Microbiology and Antimicrobials
ReviewOpen access |
29 Mar 2017 |
698 |
| 8 |
Targeting PCDH20 gene by microRNA-122 confers 5-FU resistance in hepatic carcinoma.
Wei Wang, Wen Bin Liu, Da Huang et al. · PubMed
Open access |
2016 |
611 |
| 9 |
Toripalimab plus chemotherapy in treatment-naïve, advanced esophageal squamous cell carcinoma (JUPITER-06): A multi-center phase 3 trial
Zixian Wang et al. · Cancer Cell
Open access |
Mar 2022 |
592 |
| 10 |
METTL3 and ALKBH5 oppositely regulate m 6 A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes
Huiwen Song, Xing Feng, Heng Zhang et al. · Autophagy
Open access |
17 Mar 2019 |
554 |
| 11 |
Sintilimab versus placebo in combination with chemotherapy as first line treatment for locally advanced or metastatic oesophageal squamous cell carcinoma (ORIENT-15): multicentre, randomised, double blind, phase 3 trial
Zhihao Lü et al. · BMJ
Open access |
19 Apr 2022 |
508 |
| 12 |
Effect of First-Line Serplulimab vs Placebo Added to Chemotherapy on Survival in Patients With Extensive-Stage Small Cell Lung Cancer
Ying Cheng et al. · JAMA
Open access109 authors |
27 Sep 2022 |
497 |
| 13 |
Risk Factors for ERCP-Related Complications: A Prospective Multicenter Study
Peng Wang, Zhao‐Shen Li, Feng Liu et al. · The American Journal of Gastroenterology
|
18 Dec 2008 |
493 |
| 14 |
Air pollution and chronic airway diseases: what should people know and do?
Xuqin Jiang, Xiaodong Mei, Di Feng · PubMed
Open access |
2016 |
442 |
| 15 |
Adebrelimab or placebo plus carboplatin and etoposide as first-line treatment for extensive-stage small-cell lung cancer (CAPSTONE-1): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial
Jie Wang et al. · The Lancet Oncology
|
13 May 2022 |
433 |
| 16 |
Statins: a repurposed drug to fight cancer
Wen Jiang, Jin-Wei Hu, Xu-Ran He et al. · Journal of Experimental & Clinical Cancer Research
Open access |
24 Jul 2021 |
427 |
| 17 |
The Chinese Society of Clinical Oncology (CSCO) clinical guidelines for the diagnosis and treatment of nasopharyngeal carcinoma
Ling‐Long Tang et al. · 癌症:英文版
Open access |
26 Oct 2021 |
424 |
| 18 |
Genome-Wide Association Study in Asian Populations Identifies Variants in ETS1 and WDFY4 Associated with Systemic Lupus Erythematosus
Wanling Yang et al. · PLoS Genetics
Open access |
11 Feb 2010 |
409 |
| 19 |
Sintilimab Plus Chemotherapy for Unresectable Gastric or Gastroesophageal Junction Cancer
Jianming Xu et al. · JAMA
Open access |
5 Dec 2023 |
404 |
| 20 |
Efficacy and Safety of Sintilimab Plus Pemetrexed and Platinum as First-Line Treatment for Locally Advanced or Metastatic Nonsquamous NSCLC: a Randomized, Double-Blind, Phase 3 Study (Oncology pRogram by InnovENT anti-PD-1-11)
Yunpeng Yang et al. · Journal of Thoracic Oncology
Open access |
8 Aug 2020 |
404 |
| 21 |
Mitochondrial dysfunction in neurodegenerative diseases and drug targets via apoptotic signaling
Yuanbo Wu, Meiqiao Chen, Jielong Jiang · Mitochondrion
|
6 Jul 2019 |
400 |
| 22 |
Multiplexed Nanomaterial-Based Sensor Array for Detection of COVID-19 in Exhaled Breath
Benjie Shan et al. · ACS Nano
Open access |
18 Aug 2020 |
386 |
| 23 |
Weight Loss and Malnutrition in Patients with Parkinson's Disease: Current Knowledge and Future Prospects
Kai Ma, Nian Xiong, Yan Shen et al. · Frontiers in Aging Neuroscience
Open access |
18 Jan 2018 |
382 |
| 24 |
Perioperative Toripalimab Plus Chemotherapy for Patients With Resectable Non–Small Cell Lung Cancer
Shun Lü et al. · JAMA
Open access |
16 Jan 2024 |
380 |
| 25 |
Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma
Lu Jiang et al. · Nature Genetics
|
20 Jul 2015 |
380 |
| 26 |
Vitamin D alleviates lipopolysaccharide-induced acute lung injury via regulation of the renin-angiotensin system
Jun Mei Xu, Jialai Yang, Jian Chen et al. · Molecular Medicine Reports
Open access |
May 2017 |
366 |
| 27 |
2020 Chinese guidelines for ultrasound malignancy risk stratification of thyroid nodules: the C-TIRADS
Jianqiao Zhou et al. · Endocrine
239 authors |
21 Aug 2020 |
348 |
| 28 |
Tislelizumab plus chemotherapy versus placebo plus chemotherapy as first-line treatment for advanced or metastatic oesophageal squamous cell carcinoma (RATIONALE-306): a global, randomised, placebo-controlled, phase 3 study
Jianming Xu et al. · The Lancet Oncology
|
17 Apr 2023 |
339 |
| 29 |
Addiction related alteration in resting-state brain connectivity
Ning Ma, Ying Liu, Nan Li et al. · NeuroImage
Open access |
27 Aug 2009 |
327 |
| 30 |
Camrelizumab Plus Carboplatin and Paclitaxel as First-Line Treatment for Advanced Squamous NSCLC (CameL-Sq): A Phase 3 Trial
Shengxiang Ren et al. · Journal of Thoracic Oncology
Open access |
16 Dec 2021 |
326 |
| 31 |
Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors
Binqing Fu, Yonggang Zhou, Xiang Ni et al. · Immunity
Open access |
Dec 2017 |
320 |
| 32 |
The Ubiquitin Ligase Stub1 Negatively Modulates Regulatory T Cell Suppressive Activity by Promoting Degradation of the Transcription Factor Foxp3
Zuojia Chen et al. · Immunity
Open access |
Aug 2013 |
306 |
| 33 |
AENEAS: A Randomized Phase III Trial of Aumolertinib Versus Gefitinib as First-Line Therapy for Locally Advanced or MetastaticNon–Small-Cell Lung Cancer With EGFR Exon 19 Deletion or L858R Mutations
Shun Lü et al. · Journal of Clinical Oncology
Open access |
17 May 2022 |
302 |
| 34 |
The consensus on indications, conditioning regimen, and donor selection of allogeneic hematopoietic cell transplantation for hematological diseases in China—recommendations from the Chinese Society of Hematology
Lan‐Ping Xu, Chen Hu, Jing Chen et al. · Journal of Hematology & Oncology
Open access |
Mar 2018 |
300 |
| 35 |
Natural killer cells promote immune tolerance by regulating inflammatory T H 17 cells at the human maternal–fetal interface
Binqing Fu, X.C. Li, Rui Sun et al. · Proceedings of the National Academy of Sciences
Open access |
27 Dec 2012 |
297 |
| 36 |
High NKG2A expression contributes to NK cell exhaustion and predicts a poor prognosis of patients with liver cancer
Cheng Sun, Jing Xu, Qiang Huang et al. · OncoImmunology
Open access |
7 Dec 2016 |
291 |
| 37 |
Open-label, Multicenter, Phase II Study of RC48-ADC, a HER2-Targeting Antibody–Drug Conjugate, in Patients with Locally Advanced or Metastatic Urothelial Carcinoma
Xinan Sheng, Xieqiao Yan, Lin Wang et al. · Clinical Cancer Research
Open access |
27 Oct 2020 |
290 |
| 38 |
CT manifestations of coronavirus disease-2019: A retrospective analysis of 73 cases by disease severity
Kai-Cai Liu, Ping Xu, Wei‐Fu Lv et al. · European Journal of Radiology
Open access |
12 Mar 2020 |
285 |
| 39 |
Genome-wide analyses of non-syndromic cleft lip with palate identify 14 novel loci and genetic heterogeneity
Yanqin Yu et al. · Nature Communications
Open access |
24 Feb 2017 |
283 |
| 40 |
Regulation of glycolytic metabolism by autophagy in liver cancer involves selective autophagic degradation of HK2 (hexokinase 2)
Lin Jiao, Hai‐Liang Zhang, Dandan Li et al. · Autophagy
Open access |
5 Oct 2017 |
282 |
| 41 |
NLRP3: A promising therapeutic target for autoimmune diseases
Hui‐Hui Shen, Yuexin Yang, Xiang Ling Meng et al. · Autoimmunity Reviews
|
3 May 2018 |
278 |
| 42 |
Tucidinostat plus exemestane for postmenopausal patients with advanced, hormone receptor-positive breast cancer (ACE): a randomised, double-blind, placebo-controlled, phase 3 trial
Zefei Jiang et al. · The Lancet Oncology
|
27 Apr 2019 |
273 |
| 43 |
Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats
Liqin Tang, Wei Wei, Liming Chen et al. · Journal of Ethnopharmacology
|
5 May 2006 |
271 |
| 44 |
Chidamide in relapsed or refractory peripheral T cell lymphoma: a multicenter real-world study in China
Yuankai Shi et al. · Journal of Hematology & Oncology
Open access |
15 Mar 2017 |
259 |
| 45 |
Sintilimab plus bevacizumab biosimilar IBI305 and chemotherapy for patients with EGFR-mutated non-squamous non-small-cell lung cancer who progressed on EGFR tyrosine-kinase inhibitor therapy (ORIENT-31): first interim results from a randomised, double-blind, multicentre, phase 3 trial
Shun Lü et al. · The Lancet Oncology
|
28 Jul 2022 |
257 |
| 46 |
CD4+CD25+CD127low/− T Cells: A More Specific Treg Population in Human Peripheral Blood
Ning Yu, Xiaomei Li, Xiaomei Li et al. · Inflammation
|
30 Jun 2012 |
240 |
| 47 |
Biological control of insects in Brazil and China: history, current programs and reasons for their successes using entomopathogenic fungi
Zengzhi Li, Sérgio Batista Alves, Donald W. Roberts et al. · Biocontrol Science and Technology
|
14 Dec 2009 |
240 |
| 48 |
A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23
Yongzhe Li et al. · Nature Genetics
|
6 Oct 2013 |
240 |
| 49 |
Sugemalimab versus placebo, in combination with platinum-based chemotherapy, as first-line treatment of metastatic non-small-cell lung cancer (GEMSTONE-302): interim and final analyses of a double-blind, randomised, phase 3 clinical trial
Caicun Zhou, Ziping Wang, Yuping Sun et al. · The Lancet Oncology
|
15 Jan 2022 |
237 |
| 50 |
Development and validation of a prediction rule for estimating gastric cancer risk in the Chinese high-risk population: a nationwide multicentre study
Quan-cai Cai et al. · Gut
Open access |
29 Mar 2019 |
234 |