Most cited papers from Arc Research Institute

Arc Research Institute

What are the most cited papers from Arc Research Institute?

The most cited paper from Arc Research Institute is "Simulating 500 million years of evolution with a language model" (Thomas Hayes et al., 2025), with 754 citations. Next come "Sequence modeling and design from molecular to genome scale with Evo" (511) and "How to build the virtual cell with artificial intelligence: Priorities and opportunities" (383).

Published TypeFieldAccessCitations

Showing 50 of 59 papers. Every paper with more than 29 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Simulating 500 million years of evolution with a language model Thomas Hayes et al. · Science	16 Jan 2025	754
2	Sequence modeling and design from molecular to genome scale with Evo Eric Nguyen, Michael Poli, Matthew G. Durrant et al. · Science Open access	14 Nov 2024	511
3	How to build the virtual cell with artificial intelligence: Priorities and opportunities Charlotte Bunne et al. · Cell Open access	Dec 2024	383
4	Improving prime editing with an endogenous small RNA-binding protein Jun Yan, Paul Oyler-Castrillo, Purnima Ravisankar et al. · Nature Open access	3 Apr 2024	257
5	Genome modeling and design across all domains of life with Evo 2 Garyk Brixi et al. · bioRxiv (Cold Spring Harbor Laboratory) PreprintOpen access	21 Feb 2025	222
6	Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome Matthew G. Durrant, Alison Fanton, Josh Tycko et al. · Nature Biotechnology Open access	10 Oct 2022	222
7	Nature of the Scrapie Agent R. A. Gibbons, GORDON D. HUNTER · Nature	Sep 1967	173
8	Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors Joseph M. Replogle, Jessica L. Bonnar, Angela N. Pogson et al. · eLife Open access	28 Dec 2022	166
9	Bridge RNAs direct programmable recombination of target and donor DNA Matthew G. Durrant, Nicholas Thomas Perry, James J. Pai et al. · Nature Open access	26 Jun 2024	158
10	Inactivation of the Scrapie Agent by Near Monochromatic Ultraviolet Light R Latarjet, Bernard Muel, D.A. Haig et al. · Nature	Sep 1970	149
11	Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection Scott B. Biering et al. · Nature Genetics Open access	25 Jul 2022	146
12	Genome modelling and design across all domains of life with Evo 2 Garyk Brixi et al. · Nature Open access	4 Mar 2026	138
13	The effects of rapid rearing and early calving on the subsequent performance of dairy heifers W. Little, Roger M Kay · Animal Science	Aug 1979	133
14	Biomni: A General-Purpose Biomedical AI Agent Kexin Huang et al. · bioRxiv (Cold Spring Harbor Laboratory) PreprintOpen access	2 Jun 2025	119
15	Towards multimodal foundation models in molecular cell biology Haotian Cui, Alejandro Tejada-Lapuerta, Maria Brbić et al. · Nature Open access	16 Apr 2025	112
16	A rare PRIMER cell state in plant immunity Tatsuya Nobori, Alexander Monell, Travis A. Lee et al. · Nature Open access	8 Jan 2025	110
17	Base-editing mutagenesis maps alleles to tune human T cell functions Ralf L. J. Schmidt, Carl C. Ward, Rama Dajani et al. · Nature Open access	13 Dec 2023	101
18	Transformers and genome language models Micaela Elisa Consens, C Dufault, Michael Wainberg et al. · Nature Machine Intelligence	13 Mar 2025	92
19	Pathogenesis of Mouse Scrapie: Patterns of Agent Replication in Different Parts of the CNS following Intraperitoneal Infection R.H. Kimberlin, Carol A Walker · Journal of the Royal Society of Medicine Open access	Aug 1982	92
20	Virtual Cell Challenge: Toward a Turing test for the virtual cell Yusuf Roohani et al. · Cell Open access	Jun 2025	90
21	Predicting cellular responses to perturbation across diverse contexts with State Abhinav Adduri et al. · Cell Open access	31 Aug 2026	86
22	Sequence modeling and design from molecular to genome scale with Evo Eric D. Nguyen, Michael Poli, Matthew G. Durrant et al. · bioRxiv (Cold Spring Harbor Laboratory) PreprintOpen access	27 Feb 2024	85
23	A search for new microorganisms in calf pneumonia by the inoculation of gnotobiotic calves L.H. Thomas, R.N. Gourlay, E. J. Stott et al. · Research in Veterinary Science Open access	Sep 1982	85
24	ENPP1 is an innate immune checkpoint of the anticancer cGAMP–STING pathway in breast cancer Songnan Wang, Volker Böhnert, Alby J. Joseph et al. · Proceedings of the National Academy of Sciences Open access	20 Dec 2023	82
25	Structural mechanism of bridge RNA-guided recombination Masahiro Hiraizumi, Nicholas Thomas Perry, Matthew G. Durrant et al. · Nature Open access	26 Jun 2024	75
26	Lineage-specific canonical and non-canonical activity of EZH2 in advanced prostate cancer subtypes Varadha Balaji Venkadakrishnan, Adam G. Presser, Richa Singh et al. · Nature Communications Open access	8 Aug 2024	74
27	Isolation of a Virus infecting a Strain of Mycoplasma laidlawii R.N. Gourlay · Nature	21 Mar 1970	74
28	Pathogenesis of mouse scrapie: Distribution of agent in the pulp and stroma of infected spleens Martin Clarke, R.H. Kimberlin · Veterinary Microbiology	Jul 1984	72
29	Highly efficient generation of isogenic pluripotent stem cell models using prime editing Hanqin Li, Oriol Busquets, Yogendra Kumar Verma et al. · eLife Open access	7 Sep 2022	69
30	Histopathological Similarities between Scrapie and Cuprizone Toxicity in Mice I.H. Pattison, Jean N. Jebbett · Nature	12 Mar 1971	69
31	PTER is a N-acetyltaurine hydrolase that regulates feeding and obesity Wei Wei et al. · Nature Open access	7 Aug 2024	67
32	Temporally distinct 3D multi-omic dynamics in the developing human brain Matthew G. Heffel et al. · Nature Open access	9 Oct 2024	66
33	Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle Robert Ietswaart, Brendan M. Smalec, Albert Xu et al. · Molecular Cell Open access	Jul 2024	66
34	Deep learning and CRISPR-Cas13d ortholog discovery for optimized RNA targeting Jingyi Wei, Peter Lotfy, Kian Faizi et al. · Cell Systems Open access	Dec 2023	66
35	A comparison of different models of the lactation curve in dairy cattle G. John Rowlands, Simon Lucey, A. M. Russell · Animal Science	Aug 1982	61
36	The magnitude and mechanisms of the uptake of milk precursors by the mammary gland J. L. Linzell · Proceedings of The Nutrition Society Open access	Mar 1968	61
37	A note on the individuality of the intake of drinking water by dairy cows W. Little, S.R. Shaw · Animal Science	Apr 1978	55
38	Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides Xueli Cao, Yu Xiao, Erin D. Huiting et al. · Molecular Cell Open access	15 Dec 2023	54
39	Generation of neutrophil chemoattractants by phagocytosing bovine mammary macrophages Neil Craven · Research in Veterinary Science	Nov 1983	51
40	Engineered CRISPR-Cas12a for higher-order combinatorial chromatin perturbations Chris C.‐S. Hsiung, Caroline M. Wilson, Nicholas A. Sambold et al. · Nature Biotechnology Open access	17 May 2024	50
41	Effects of restricting the water intake of dairy cows upon their milk yield, body weight and blood composition W. Little, B. F. Sansom, R. Manston et al. · Animal Science	Jun 1976	50
42	A role for IgM in the in vitro opsonisation of Staphylococcus aureus and Escherichia coli by bovine polymorphonuclear leucocytes M.R. Williams, A. W. Hill · Research in Veterinary Science	Jul 1982	49
43	scGPT-spatial: Continual Pretraining of Single-Cell Foundation Model for Spatial Transcriptomics Chloe Xueqi Wang, Haotian Cui, A. Zhang et al. · bioRxiv (Cold Spring Harbor Laboratory) PreprintOpen access	8 Feb 2025	47
44	Gnotobiotic Piglets Experimentally Infected with Neonatal Calf Diarrhoea Reovirus-Like Agent (Rotavirus) G.A. Hall, J. C. Bridger, R.L. Chandler et al. · Veterinary Pathology	May 1976	47
45	Calcium mobilisation in hypomagnesaemic cattle. Contreras Pa, R. Manston, Sansom Bf · PubMed	Jul 1982	43
46	IFITM proteins assist cellular uptake of diverse linked chemotypes Kevin Lou, Douglas R. Wassarman, Tangpo Yang et al. · Science Open access	8 Dec 2022	41
47	Multiplication of the Scrapie Agent D.A. Haig, Martin Clarke · Nature	Nov 1971	41
48	Identification of the extracellular membrane protein ENPP3 as a major cGAMP hydrolase and innate immune checkpoint Rachel Mardjuki, Songnan Wang, Jacqueline A. Carozza et al. · Cell Reports Open access	May 2024	40
49	The opsonic activity of bovine milk whey for the phagocytosis and killing by neutrophils of encapsulated and non-encapsulated Escherichia coli A. W. Hill, D.J.S. Heneghan, M.R. Williams · Veterinary Microbiology	Jun 1983	40
50	Calcium mobilisation in hypomagnesaemic cattle P.A. Contreras, R. Manston, B.F. Sansoni · Research in Veterinary Science	Jul 1982	36

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.