| 1 |
Towards the sustainable discovery and development of new antibiotics
Marcus Miethke et al. · Nature Reviews Chemistry
ReviewOpen access |
19 Aug 2021 |
1,192 |
| 2 |
Calcimimetics with potent and selective activity on the parathyroid calcium receptor
Edward F. Nemeth, Michael E. Steffey, Lance G. Hammerland et al. · Proceedings of the National Academy of Sciences
Open access |
31 Mar 1998 |
616 |
| 3 |
Molecular Cloning and Functional Expression of Human Parathyroid Calcium Receptor cDNAs
James E. Garrett, Irene V. Capuano, Lance G. Hammerland et al. · Journal of Biological Chemistry
Open access |
May 1995 |
504 |
| 4 |
Expression and Characterization of Inactivating and Activating Mutations in the Human Ca2+-sensing Receptor
Mei Bai, Steven J. Quinn, Sunita Trivedi et al. · Journal of Biological Chemistry
Open access |
Aug 1996 |
430 |
| 5 |
Controlled Dimerization of ErbB Receptors Provides Evidence for Differential Signaling by Homo- and Heterodimers
Senthil K. Muthuswamy, Michael Gilman, Joan S. Brugge · Molecular and Cellular Biology
Open access |
Oct 1999 |
367 |
| 6 |
Identification of a Peptide Toxin fromGrammostola spatulataSpider Venom That Blocks Cation-Selective Stretch-Activated Channels
Thomas M. Suchyna, JANICE H. JOHNSON, Katherine Hamer et al. · The Journal of General Physiology
Open access |
May 2000 |
352 |
| 7 |
Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats
Maxine Gowen, George B. Stroup, Robert A. Dodds et al. · Journal of Clinical Investigation
Open access |
Jun 2000 |
282 |
| 8 |
Short-Term Inhibition of Parathyroid Hormone Secretion by a Calcium-Receptor Agonist in Patients with Primary Hyperparathyroidism
Shonni J. Silverberg, Henry G. Bone, Thomas B. Marriott et al. · New England Journal of Medicine
|
20 Nov 1997 |
260 |
| 9 |
Platelet-Derived Growth Factor Induces Phosphorylation of Multiple JAK Family Kinases and STAT Proteins
Marie‐Luce Vignais, Henry B. Sadowski, Diane Watling et al. · Molecular and Cellular Biology
Open access |
Apr 1996 |
249 |
| 10 |
Calcilytic Compounds: Potent and Selective Ca2+Receptor Antagonists That Stimulate Secretion of Parathyroid Hormone
Edward F. Nemeth, Eric G. DelMar, William L. Heaton et al. · Journal of Pharmacology and Experimental Therapeutics
|
Oct 2001 |
238 |
| 11 |
Identification and localization of extracellular Ca2+-sensing receptor in rat intestine
Naibedya Chattopadhyay, Ivan Cheng, KIMBERLY V. ROGERS et al. · American Journal of Physiology-Gastrointestinal and Liver Physiology
|
1998 |
220 |
| 12 |
Efficacy and Safety of Human Parathyroid Hormone-(1–84) in Increasing Bone Mineral Density in Postmenopausal Osteoporosis
Anthony B. Hodsman, David A. Hanley, Mark P. Ettinger et al. · The Journal of Clinical Endocrinology & Metabolism
Open access |
Nov 2003 |
205 |
| 13 |
Heteropodatoxins: Peptides Isolated from Spider Venom that Block Kv4.2 Potassium Channels
Michael C. Sanguinetti, JANICE H. JOHNSON, Lance G. Hammerland et al. · Molecular Pharmacology
|
Mar 1997 |
197 |
| 14 |
Strategy for Identifying Repurposed Drugs for the Treatment of Cerebral Cavernous Malformation
Christopher C. Gibson, Weiquan Zhu, Chadwick T. Davis et al. · Circulation
Open access |
9 Dec 2014 |
186 |
| 15 |
The calcium-sensing receptor regulates mammary gland parathyroid hormone–related protein production and calcium transport
Joshua N. VanHouten, Pamela R. Dann, Grace McGeoch et al. · Journal of Clinical Investigation
|
14 Feb 2004 |
185 |
| 16 |
NPS R-568 halts or reverses osteitis fibrosa in uremic rats
Michihito Wada, Hiromi Ishii, Yoshihiro FURUYA et al. · Kidney International
Open access |
Feb 1998 |
151 |
| 17 |
Functional Consequences of Posttranslational Isomerization of Ser 46 in a Calcium Channel Toxin
Steven D. Heck, Chester J. Siok, Karen J. Krapcho et al. · Science
|
11 Nov 1994 |
147 |
| 18 |
Regulation of murine fetal-placental calcium metabolism by the calcium-sensing receptor.
Christopher S. Kovács, Chrystal L. Ho‐Pao, Joy L. Hunzelman et al. · Journal of Clinical Investigation
Open access |
15 Jun 1998 |
143 |
| 19 |
Defining a Noncarcinogenic Dose of Recombinant Human Parathyroid Hormone 1–84 in a 2-Year Study in Fischer 344 Rats
Jacquelin Jolette, Clynn E. Wilker, Susan Y. Smith et al. · Toxicologic Pathology
|
Dec 2006 |
142 |
| 20 |
β1 integrins and osteoclast function: Involvement in collagen recognition and bone resorption
Miep Helfrich, Stephen A. Nesbitt, Päivi T. Lakkakorpi et al. · Bone
|
Oct 1996 |
138 |
| 21 |
Calcimimetic NPS R-568 prevents parathyroid hyperplasia in rats with severe secondary hyperparathyroidism
Michihito Wada, Nobuo Nagano, Yoshihiro FURUYA et al. · Kidney International
Open access |
2000 |
135 |
| 22 |
MPC-6827: A Small-Molecule Inhibitor of Microtubule Formation That Is Not a Substrate for Multidrug Resistance Pumps
Shailaja Kasibhatla, Vijay R. Baichwal, Sui Xiong Cai et al. · Cancer Research
|
15 Jun 2007 |
130 |
| 23 |
Structure-Function Analysis of SH3 Domains: SH3 Binding Specificity Altered by Single Amino Acid Substitutions
Zhigang Weng, Richard J. Rickles, Sibo Feng et al. · Molecular and Cellular Biology
Open access |
Oct 1995 |
125 |
| 24 |
Amyloid-? proteins activate Ca2+-permeable channels through calcium-sensing receptors
Chianping Ye, Chrystal L. Ho‐Pao, Marie Kanazirska et al. · Journal of Neuroscience Research
|
Mar 1997 |
125 |
| 25 |
Expression of an extracellular calcium-sensing receptor in rat stomach
Ivan Cheng, Imtiaz Qureshi, Naibedya Chattopadhyay et al. · Gastroenterology
Open access |
1999 |
124 |
| 26 |
Allosteric Activation of the Ca2+ Receptor Expressed in Xenopus laevis Oocytes by NPS 467 or NPS 568
Lance G. Hammerland, James E. Garrett, Benjamin C.P. Hung et al. · Molecular Pharmacology
|
Jun 1998 |
123 |
| 27 |
Domains Determining Ligand Specificity for Ca2+ Receptors
Lance G. Hammerland, Karen J. Krapcho, James E. Garrett et al. · Molecular Pharmacology
|
Apr 1999 |
122 |
| 28 |
A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides
Kimberly C. Paul, Richard C. Krolewski, Edinson Lucumi Moreno et al. · Nature Communications
Open access |
16 May 2023 |
117 |
| 29 |
NPS R-568: A Type II Calcimimetic Compound that Acts on Parathyroid Cell Calcium Receptor of Rats to Reduce Plasma Levels of Parathyroid Hormone and Calcium
John Fox, Stacey H. Lowe, Barbara A. Petty et al. · Journal of Pharmacology and Experimental Therapeutics
|
Aug 1999 |
113 |
| 30 |
Calcimimetic Compounds: a Direct Approach to Controlling Plasma Levels of Parathyroid Hormone in Hyperparathyroidism
Edward F. Nemeth, John Fox · Trends in Endocrinology and Metabolism
Review |
Mar 1999 |
106 |
| 31 |
The Venus Fly Trap Domain of the Extracellular Ca2+-sensing Receptor Is Required for l-Amino Acid Sensing
Hee‐Chang Mun, Alison H. Franks, Emma L. Culverston et al. · Journal of Biological Chemistry
Open access |
Sep 2004 |
103 |
| 32 |
Coupling of Calcium Receptors to Inositol Phosphate and Cyclic AMP Generation in Mammalian Cells and Xenopus laevis Oocytes and Immunodetection of Receptor Protein by Region-Specific Antipeptide Antisera
Wenhan Chang, Stacy A. Pratt, Tsui‐Hua Chen et al. · Journal of Bone and Mineral Research
|
Apr 1998 |
95 |
| 33 |
Activation of the Calcium Receptor by a Calcimimetic Compound Halts the Progression of Secondary Hyperparathyroidism in Uremic Rats
JI CHIN, Scott C. Miller, Michihito Wada et al. · Journal of the American Society of Nephrology
|
May 2000 |
95 |
| 34 |
Enhanced Sensitivity to the HER1/Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Erlotinib Hydrochloride in Chemotherapy-Resistant Tumor Cell Lines
Qun Dai, Yi‐He Ling, Marie Lia et al. · Clinical Cancer Research
Open access |
15 Feb 2005 |
91 |
| 35 |
Dietary Vitamin D and Its Metabolites Non-Genomically Stabilize the Endothelium
Christopher C. Gibson, Chadwick T. Davis, Weiquan Zhu et al. · PLoS ONE
Open access |
15 Oct 2015 |
87 |
| 36 |
YY1 Facilitates the Association of Serum Response Factor with the c- fos Serum Response Element
Sridaran Natesan, Michael Gilman · Molecular and Cellular Biology
Open access |
Nov 1995 |
86 |
| 37 |
N-Linked Glycosylation of the Human Ca2+Receptor Is Essential for Its Expression at the Cell Surface
Gaofeng Fan, Paul K. Goldsmith, Regina M. Collins et al. · Endocrinology
|
May 1997 |
86 |
| 38 |
Agonists of the Ca2+-Sensing Receptor (CaR) Activate Nonselective Cation Channels in HEK293 Cells Stably Transfected with the Human CaR
Chianping Ye, KIMBERLY V. ROGERS, Mei Bai et al. · Biochemical and Biophysical Research Communications
|
Sep 1996 |
84 |
| 39 |
Genetic ancestry analysis on >93,000 individuals undergoing expanded carrier screening reveals limitations of ethnicity-based medical guidelines
Kristjan Eerik Kaseniit, Imran S. Haque, James D. Goldberg et al. · Genetics in Medicine
Open access |
28 Jun 2020 |
82 |
| 40 |
Disparate effects of mild, moderate, and severe secondary hyperparathyroidism on cancellous and cortical bone in rats with chronic renal insufficiency
Michael A. Miller, JI CHIN, Scott C. Miller et al. · Bone
|
Sep 1998 |
82 |
| 41 |
Cloning and Characterization of a Calcium-Sensing Receptor from the Hypercalcemic New Zealand White Rabbit Reveals Unaltered Responsiveness to Extracellular Calcium
Robert R. Butters, Naibedya Chattopadhyay, Palle Kjaerulff Nielsen et al. · Journal of Bone and Mineral Research
Open access |
Apr 1997 |
82 |
| 42 |
Aurora‐A over‐expression in high‐grade PIN lesions and prostate cancer
Holly McKlveen Buschhorn, Robert R. Klein, Susan M. Chambers et al. · The Prostate
|
7 Mar 2005 |
81 |
| 43 |
An orally active calcium-sensing receptor antagonist that transiently increases plasma concentrations of PTH and stimulates bone formation
Sanjay Kumar et al. · Bone
|
27 Sep 2009 |
80 |
| 44 |
A Novel Compound ARN-3236 Inhibits Salt-Inducible Kinase 2 and Sensitizes Ovarian Cancer Cell Lines and Xenografts to Paclitaxel
Jinhua Zhou, Albandri Alfraidi, Shu Zhang et al. · Clinical Cancer Research
Open access |
27 Sep 2016 |
78 |
| 45 |
Calcimimetic Compound NPS R-568 Stimulates Calcitonin Secretion But Selectively Targets Parathyroid Gland Ca2+ Receptor in Rats
John Fox, Stacey H. Lowe, Rebecca L. Conklin et al. · Journal of Pharmacology and Experimental Therapeutics
|
Aug 1999 |
77 |
| 46 |
Expression, Purification, and Biochemical Characterization of the Amino-terminal Extracellular Domain of the Human Calcium Receptor
Paul K. Goldsmith, Gao-Feng Fan, Kausik Kumar Ray et al. · Journal of Biological Chemistry
Open access |
Apr 1999 |
76 |
| 47 |
Daily intermittent decreases in serum levels of parathyroid hormone have an anabolic-like action on the bones of uremic rats with low-turnover bone and osteomalacia
Hiromi Ishii, M. Wada, Y Furuya et al. · Bone
|
Feb 2000 |
72 |
| 48 |
Clustering of Syk Is Sufficient To Induce Tyrosine Phosphorylation and Release of Allergic Mediators from Rat Basophilic Leukemia Cells
Victor M. Rivera, Joan S. Brugge · Molecular and Cellular Biology
Open access |
Mar 1995 |
70 |
| 49 |
Effects of daily treatment with parathyroid hormone 1–84 for 16 months on density, architecture and biomechanical properties of cortical bone in adult ovariectomized rhesus monkeys
Jack J. Fox, Michael A. Miller, M. K. Newman et al. · Bone
|
15 May 2007 |
69 |
| 50 |
Characterization and cloning of insecticidal peptides from the primitive weaving spider Diguetia canities
Karen J. Krapcho, Robert M. Kral, Bradford C. VanWagenen et al. · Insect Biochemistry and Molecular Biology
|
Oct 1995 |
68 |