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ARCHES: A Randomized, Phase III Study of Androgen Deprivation Therapy With Enzalutamide or Placebo in Men With Metastatic Hormone-Sensitive Prostate Cancer
Andrew J. Armstrong, Russell Zelig Szmulewitz, Daniel Peter Petrylak et al. · Journal of Clinical Oncology
Open access |
22 Jul 2019 |
1,239 |
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Efficacy and Tolerability of Mirabegron, a β3-Adrenoceptor Agonist, in Patients with Overactive Bladder: Results from a Randomised European–Australian Phase 3 Trial
Vik Khullar, G. Amarenco, J.C. Angulo et al. · European Urology
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6 Nov 2012 |
429 |
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Enzalutamide in Men with Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer: Extended Analysis of the Phase 3 PREVAIL Study
Tomasz M. Beer et al. · European Urology
Open access |
29 Jul 2016 |
426 |
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Physiologically Based Pharmacokinetic Model Qualification and Reporting Procedures for Regulatory Submissions: A Consortium Perspective
Mohamad Shebley et al. · Clinical Pharmacology & Therapeutics
Open access |
10 Jan 2018 |
390 |
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Immunogenicity of Recombinant Adenovirus Serotype 35 Vaccine in the Presence of Pre-Existing Anti-Ad5 Immunity
Dan H. Barouch, Maria Grazia Pau, Jerome H. H. V. Custers et al. · The Journal of Immunology
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May 2004 |
388 |
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Randomized Double-blind, Active-controlled Phase 3 Study to Assess 12-Month Safety and Efficacy of Mirabegron, a β3-Adrenoceptor Agonist, in Overactive Bladder
Christopher Reginald Chapple, Steven A. Kaplan, David Mitcheson et al. · European Urology
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6 Nov 2012 |
361 |
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Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia, hyperlipidemia, hepatic steatosis, oxidative stress, inflammation, and obesity in type 2 diabetic mice
Atsuo Tahara, Eiji Kurosaki, Masanori Yokono et al. · European Journal of Pharmacology
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23 May 2013 |
317 |
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Efficacy and safety of enzalutamide versus bicalutamide for patients with metastatic prostate cancer (TERRAIN): a randomised, double-blind, phase 2 study
Neal D. Shore, Simon Chowdhury, Arnauld A. Villers et al. · The Lancet Oncology
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13 Jan 2016 |
289 |
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Comparative Efficacy and Safety of Medical Treatments for the Management of Overactive Bladder: A Systematic Literature Review and Mixed Treatment Comparison
Khaled Maman, Samuel Aballéa, Jameel Nazir et al. · European Urology
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21 Nov 2013 |
258 |
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A Phase III, Randomized, Double-blind, Parallel-group, Placebo-controlled, Multicentre Study to Assess the Efficacy and Safety of the β3 Adrenoceptor Agonist, Mirabegron, in Patients With Symptoms of Overactive Bladder
Sender Herschorn, Jack Barkin, David Manuel Castro-Diaz et al. · Urology
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13 Jun 2013 |
249 |
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Combination Treatment with Mirabegron and Solifenacin in Patients with Overactive Bladder: Efficacy and Safety Results from a Randomised, Double-blind, Dose-ranging, Phase 2 Study (Symphony)
Paul Abrams, Con J. Kelleher, David R. Staskin et al. · European Urology
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19 Feb 2014 |
247 |
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Humanistic and economic burden of painful diabetic peripheral neuropathy in Europe: A review of the literature
Cathelijne Alleman, Kirsten Y Westerhout, Marja Hensen et al. · Diabetes Research and Clinical Practice
Open access |
5 May 2015 |
234 |
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Efficacy and Tolerability of Mirabegron Compared with Antimuscarinic Monotherapy or Combination Therapies for Overactive Bladder: A Systematic Review and Network Meta-analysis
Con J. Kelleher, Zalmaï Hakimi, Richard M. Zur et al. · European Urology
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23 Apr 2018 |
228 |
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The Novel Tuberculosis Vaccine, AERAS-402, Induces Robust and Polyfunctional CD4+ and CD8+ T Cells in Adults
Brian Abel et al. · American Journal of Respiratory and Critical Care Medicine
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18 Feb 2010 |
227 |
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Mirabegron for the treatment of overactive bladder: a prespecified pooled efficacy analysis and pooled safety analysis of three randomised, double‐blind, placebo‐controlled, phase III studies
Victor W. Νitti, V. Khullar, Philip E.V. van Kerrebroeck et al. · International Journal of Clinical Practice
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21 May 2013 |
213 |
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Persistence and Adherence with Mirabegron versus Antimuscarinic Agents in Patients with Overactive Bladder: A Retrospective Observational Study in UK Clinical Practice
Christopher Reginald Chapple, Jameel Nazir, Zalmaï Hakimi et al. · European Urology
Open access |
11 Feb 2017 |
209 |
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Extensions to the Visual Predictive Check to facilitate model performance evaluation
Teun M. Post, Jan I. Freijer, Bart A. Ploeger et al. · Journal of Pharmacokinetics and Pharmacodynamics
Open access |
15 Jan 2008 |
206 |
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Phase 3, Randomized, Double-Blind, Active-Comparator (Darbepoetin Alfa) Study of Oral Roxadustat in CKD Patients with Anemia on Hemodialysis in Japan
Tadao Akizawa, Manabu Iwasaki, Yusuke Yamaguchi et al. · Journal of the American Society of Nephrology
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3 Jun 2020 |
205 |
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SGLT2 selective inhibitor ipragliflozin reduces body fat mass by increasing fatty acid oxidation in high-fat diet-induced obese rats
Masanori Yokono, Toshiyuki Takasu, Yuka Hayashizaki et al. · European Journal of Pharmacology
Open access |
31 Jan 2014 |
198 |
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Effect of enzalutamide on health-related quality of life, pain, and skeletal-related events in asymptomatic and minimally symptomatic, chemotherapy-naive patients with metastatic castration-resistant prostate cancer (PREVAIL): results from a randomised, phase 3 trial
Yohann Loriot, Kurt Miller, Cora Nanette Sternberg et al. · The Lancet Oncology
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16 Apr 2015 |
192 |
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Efficacy and Safety of Mirabegron Add-on Therapy to Solifenacin in Incontinent Overactive Bladder Patients with an Inadequate Response to Initial 4-Week Solifenacin Monotherapy: A Randomised Double-blind Multicentre Phase 3B Study (BESIDE)
Marcus John Drake, Christopher Reginald Chapple, Adil Esen et al. · European Urology
Open access |
8 Mar 2016 |
186 |
| 22 |
RUBY-1: a randomized, double-blind, placebo-controlled trial of the safety and tolerability of the novel oral factor Xa inhibitor darexaban (YM150) following acute coronary syndrome
Philippe Gabríel Steg, Shamir R. Mehta, J. Wouter Jukema et al. · European Heart Journal
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30 Aug 2011 |
185 |
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Capsaicin 8% Patch in Painful Diabetic Peripheral Neuropathy: A Randomized, Double-Blind, Placebo-Controlled Study
David Martin Simpson, Jessica Robinson‐Papp, Joanna T Van et al. · Journal of Pain
Open access |
16 Oct 2016 |
180 |
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Efficacy and safety of combinations of mirabegron and solifenacin compared with monotherapy and placebo in patients with overactive bladder ( SYNERGY study)
Sender Herschorn, Christopher Reginald Chapple, Paul Abrams et al. · British Journal of Urology
Open access |
18 Apr 2017 |
176 |
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Signs and Symptoms of Detrusor Underactivity: An Analysis of Clinical Presentation and Urodynamic Tests From a Large Group of Patients Undergoing Pressure Flow Studies
Andrew Gammie, Mathilde Kaper, Caroline A. Dorrepaal et al. · European Urology
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29 Aug 2015 |
169 |
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Five-year Survival Prediction and Safety Outcomes with Enzalutamide in Men with Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer from the PREVAIL Trial
Andrew J. Armstrong, Ping Lin, Bertrand F. TOMBAL et al. · European Urology
Open access |
9 Jun 2020 |
168 |
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Pharmacokinetic Drug Interaction Studies with Enzalutamide
Jacqueline A. Gibbons, Michiel S. de Vries, Walter J. J. Krauwinkel et al. · Clinical Pharmacokinetics
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30 Apr 2015 |
161 |
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Adenovirus types 5 and 35 seroprevalence in AIDS risk groups supports type 35 as a vaccine vector
Stefan Kostense, Wouter Koudstaal, Mieke Sprangers et al. · AIDS
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May 2004 |
155 |
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National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) Symptom Evaluation in Multinational Cohorts of Patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome
Florian Wagenlehner, J. W. Olivier van Till, Vittorio Magri et al. · European Urology
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2 Nov 2012 |
154 |
| 30 |
Proarrhythmic Safety of Repeat Doses of Mirabegron in Healthy Subjects: A Randomized, Double-Blind, Placebo-, and Active-Controlled Thorough QT Study
Marek Malík, E. Marcel van Gelderen, J H Lee et al. · Clinical Pharmacology & Therapeutics
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14 Nov 2012 |
152 |
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Roxadustat for the treatment of anaemia in chronic kidney disease patients not on dialysis: a Phase 3, randomized, open-label, active-controlled study (DOLOMITES)
Jonathan Barratt, Branislav Andrić, Avtandil Tataradze et al. · Nephrology Dialysis Transplantation
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Jun 2021 |
150 |
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Clinical Pharmacokinetic Studies of Enzalutamide
Jacqueline A. Gibbons, Taoufik Ouatas, Walter J. J. Krauwinkel et al. · Clinical Pharmacokinetics
Open access |
27 Apr 2015 |
144 |
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Randomised, Multicentre, Placebo-controlled, Double-blind Crossover Study Investigating the Effect of Solifenacin and Oxybutynin in Elderly People with Mild Cognitive Impairment: The SENIOR Study
Adrian Wagg, Mark C Dale, Reiner Tretter et al. · European Urology
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11 Jan 2013 |
138 |
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A phase II dose-ranging study of mirabegron in patients with overactive bladder
On behalf of the Dragon Investigator Group, Christopher Reginald Chapple, Vladimír Dvořák et al. · International Urogynecology Journal
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7 Mar 2013 |
136 |
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The impact of acute kidney injury by serum creatinine or urine output criteria on major adverse kidney events in cardiac surgery patients
Priyanka Priyanka, Alexander Zarbock, Junichi Izawa et al. · Journal of Thoracic and Cardiovascular Surgery
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8 Jan 2020 |
135 |
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Solifenacin in the treatment of urgency and other symptoms of overactive bladder: results from a randomized, double‐blind, placebo‐controlled, rising‐dose trial
Linda Cardozo, Elke E. Heßdörfer, Rodolfo Milani et al. · British Journal of Urology
Open access |
6 Oct 2008 |
132 |
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Real-world persistence and adherence to oral antimuscarinics and mirabegron in patients with overactive bladder (OAB): a systematic literature review
Gillian Yeowell, Philip Smith, Jameel Nazir et al. · BMJ Open
ReviewOpen access |
Nov 2018 |
129 |
| 38 |
Effects of sodium-glucose cotransporter 2 selective inhibitor ipragliflozin on hyperglycaemia, oxidative stress, inflammation and liver injury in streptozotocin-induced type 1 diabetic rats
Atsuo Tahara, Eiji Kurosaki, Masanori Yokono et al. · Journal of Pharmacy and Pharmacology
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18 Feb 2014 |
126 |
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Roxadustat for the treatment of anemia in chronic kidney disease patients not on dialysis: a Phase 3, randomized, double-blind, placebo-controlled study (ALPS)
Evgeny V. Shutov, Władysław Sułowicz, Ciro Esposito et al. · Nephrology Dialysis Transplantation
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24 Feb 2021 |
124 |
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Antitumour Activity and Safety of Enzalutamide in Patients with Metastatic Castration-resistant Prostate Cancer Previously Treated with Abiraterone Acetate Plus Prednisone for ≥24 weeks in Europe
Johann Sebastian De Bono, Simon Chowdhury, Susan Feyerabend et al. · European Urology
Open access |
23 Aug 2017 |
120 |
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Minimizing Patient Burden Through the Use of Historical Subject-Level Data in Innovative Confirmatory Clinical Trials: Review of Methods and Opportunities
Jessica Lim, Rosalind J. Walley, Jiacheng Yuan et al. · Therapeutic Innovation & Regulatory Science
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18 Jun 2018 |
119 |
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Efficacy and safety of enzalutamide in patients 75 years or older with chemotherapy-naive metastatic castration-resistant prostate cancer: results from PREVAIL
Julie N. Graff, G. Baciarello, Andrew J. Armstrong et al. · Annals of Oncology
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18 Nov 2015 |
118 |
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Capsaicin 8% Patch Versus Oral Neuropathic Pain Medications for the Treatment of Painful Diabetic Peripheral Neuropathy: A Systematic Literature Review and Network Meta-analysis
Floortje E. van Nooten, M. Treur, Krystallia Pantiri et al. · Clinical Therapeutics
ReviewOpen access |
30 Mar 2017 |
117 |
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Efficacy and safety of ipragliflozin in patients with type 2 diabetes inadequately controlled on metformin: a dose‐finding study
John P.H. Wilding, Ele Ferrannini, Vivian Andrew Fonseca et al. · Diabetes Obesity and Metabolism
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19 Nov 2012 |
117 |
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Long-term Safety and Efficacy of Mirabegron and Solifenacin in Combination Compared with Monotherapy in Patients with Overactive Bladder: A Randomised, Multicentre Phase 3 Study (SYNERGY II)
Christian Gratzke, Rob van Maanen, Christopher Reginald Chapple et al. · European Urology
Open access |
Jun 2018 |
112 |
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Roxadustat for the Maintenance Treatment of Anemia in Patients with End-Stage Kidney Disease on Stable Dialysis: A European Phase 3, Randomized, Open-Label, Active-Controlled Study (PYRENEES)
Botond Szabolcs Csiky, Michael Schömig, Ciro Esposito et al. · Advances in Therapy
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19 Sep 2021 |
111 |
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Pharmacological profile of ipragliflozin (ASP1941), a novel selective SGLT2 inhibitor, in vitro and in vivo
Atsuo Tahara, Eiji Kurosaki, Masanori Yokono et al. · Naunyn-Schmiedeberg s Archives of Pharmacology
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3 Dec 2011 |
110 |
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Capsaicin 8% patch repeat treatment plus standard of care (SOC) versus SOC alone in painful diabetic peripheral neuropathy: a randomised, 52-week, open-label, safety study
Aaron I. Vinik, Serge Perrot, Etta Johanna Vinik et al. · BMC Neurology
Open access |
Dec 2016 |
108 |
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A dose escalation study of YM150, an oral direct factor Xa inhibitor, in the prevention of venous thromboembolism in elective primary hip replacement surgery
Bengt I. Eriksson, Alexander G.G. Turpie, Michael Rud Lassen et al. · Journal of Thrombosis and Haemostasis
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23 Jul 2007 |
108 |
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Capsaicin 8% patch versus oral pregabalin in patients with peripheral neuropathic pain
Maija L. Haanpää, G. Cruccu, Turo J Nurmikko et al. · European Journal of Pain
Open access |
19 Nov 2015 |
107 |