| 1 |
EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update
Josef S Smolen et al. · Annals of the Rheumatic Diseases
Open access |
25 Oct 2013 |
1,768 |
| 2 |
European League Against Rheumatism (EULAR) recommendations for the management of psoriatic arthritis with pharmacological therapies: 2015 update
Laure Gossec et al. · Annals of the Rheumatic Diseases
Open access |
10 Feb 2016 |
923 |
| 3 |
Secukinumab, a human anti-interleukin-17A monoclonal antibody, in patients with psoriatic arthritis (FUTURE 2): a randomised, double-blind, placebo-controlled, phase 3 trial
Iain B. McInnes, Philip J. Mease, Bruce W Kirkham et al. · The Lancet
|
2 Jul 2015 |
864 |
| 4 |
Efficacy and safety of procalcitonin guidance in reducing the duration of antibiotic treatment in critically ill patients: a randomised, controlled, open-label trial
Evelien de Jong et al. · The Lancet Infectious Diseases
Open access |
2 Mar 2016 |
847 |
| 5 |
Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia after 36 weeks' gestation (HYPITAT): a multicentre, open-label randomised controlled trial
Corine M. Koopmans et al. · The Lancet
|
4 Aug 2009 |
802 |
| 6 |
Single-agent bevacizumab or lomustine versus a combination of bevacizumab plus lomustine in patients with recurrent glioblastoma (BELOB trial): a randomised controlled phase 2 trial
Walter Taal et al. · The Lancet Oncology
|
14 Jul 2014 |
768 |
| 7 |
The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm
Anna Helgadóttir et al. · Nature Genetics
|
6 Jan 2008 |
730 |
| 8 |
Safety of synthetic and biological DMARDs: a systematic literature review informing the 2013 update of the EULAR recommendations for management of rheumatoid arthritis
Sofía Ramiro, Cécile Gaujoux-Viala, Jackie L Nam et al. · Annals of the Rheumatic Diseases
ReviewOpen access |
9 Jan 2014 |
712 |
| 9 |
Immunocytochemical detection and mapping of a cytokeratin 18 neo-epitope exposed during early apoptosis
Mathie P.G. Leers, Wendy K�lgen, Viveka Bj�rklund et al. · The Journal of Pathology
|
Apr 1999 |
643 |
| 10 |
Sequential versus combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (CAIRO): a phase III randomised controlled trial
Miriam Koopman, Ninja F. Antonini, Joep Douma et al. · The Lancet
|
Jul 2007 |
633 |
| 11 |
Human intestinal microbiota composition is associated with local and systemic inflammation in obesity
Froukje Jantina Verdam, Susana Fuentes, Charlotte de Jonge et al. · Obesity
Open access |
22 Mar 2013 |
610 |
| 12 |
Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial
Dominique Baeten et al. · The Lancet
|
12 Sep 2013 |
600 |
| 13 |
Risk factors for pelvic organ prolapse and its recurrence: a systematic review
Tineke F. M. Vergeldt, Mirjam Weemhoff, Joanna IntHout et al. · International Urogynecology Journal
ReviewOpen access |
12 May 2015 |
591 |
| 14 |
Defining analytical performance specifications: Consensus Statement from the 1st Strategic Conference of the European Federation of Clinical Chemistry and Laboratory Medicine
Sverre Sandberg, Callum G. Fraser, Andrea Rita Horvath et al. · Clinical Chemistry and Laboratory Medicine (CCLM)
Open access |
2015 |
558 |
| 15 |
Clinical use of biomarkers in breast cancer: Updated guidelines from the European Group on Tumor Markers (EGTM)
Michael Joe Duffy, Nadia Harbeck, M. Nap et al. · European Journal of Cancer
Open access |
28 Feb 2017 |
550 |
| 16 |
Induction versus expectant monitoring for intrauterine growth restriction at term: randomised equivalence trial (DIGITAT)
Kim E. Boers et al. · BMJ
Open access |
21 Dec 2010 |
538 |
| 17 |
Maintenance treatment with capecitabine and bevacizumab in metastatic colorectal cancer (CAIRO3): a phase 3 randomised controlled trial of the Dutch Colorectal Cancer Group
Lieke H. J. Simkens et al. · The Lancet
Open access |
10 Apr 2015 |
529 |
| 18 |
Radiographic findings following two years of infliximab therapy in patients with ankylosing spondylitis
Désirée M F M van der Heijde, Robert Landewé, Xenofon Baraliakos et al. · Arthritis & Rheumatism
|
29 Sep 2008 |
519 |
| 19 |
Effect of long-acting nifedipine on mortality and cardiovascular morbidity in patients with stable angina requiring treatment (ACTION trial): randomised controlled trial
Philip Alexander Poole-Wilson et al. · The Lancet
|
Sep 2004 |
518 |
| 20 |
Effect of Azithromycin Maintenance Treatment on Infectious Exacerbations Among Patients With Non–Cystic Fibrosis Bronchiectasis
Josje Altenburg, Casper S. de Graaff, Ymkje Stienstra et al. · JAMA
|
26 Mar 2013 |
503 |
| 21 |
A 6-Month, Placebo-Controlled Study Comparing Lung Function and Health Status Changes in COPD Patients Treated With Tiotropium or Salmeterol
James F. Donohue, Jan Arie van Noord, Eric D Bateman et al. · CHEST Journal
|
Jul 2002 |
472 |
| 22 |
Treating spondyloarthritis, including ankylosing spondylitis and psoriatic arthritis, to target: recommendations of an international task force
Josef S Smolen et al. · Annals of the Rheumatic Diseases
Open access |
8 Jun 2013 |
449 |
| 23 |
2010 Update of the international ASAS recommendations for the use of anti-TNF agents in patients with axial spondyloarthritis
Désirée M F M van der Heijde, Joachim Sieper, Walter P. Maksymowych et al. · Annals of the Rheumatic Diseases
|
3 May 2011 |
412 |
| 24 |
Assessment of Clinical Complete Response After Chemoradiation for Rectal Cancer with Digital Rectal Examination, Endoscopy, and MRI: Selection for Organ-Saving Treatment
Monique Maas, Doenja M. J. Lambregts, Patty J. Nelemans et al. · Annals of Surgical Oncology
Open access |
21 Jul 2015 |
391 |
| 25 |
Non-invasive assessment of local arterial pulse pressure: comparison of applanation tonometry and echo-tracking
Luc M. Van Bortel, Elisabeth J. Balkestein, Janneke J. van der Heijden-Spek et al. · Journal of Hypertension
Open access |
Jun 2001 |
383 |
| 26 |
Postcolonoscopy colorectal cancers are preventable: a population-based study
Chantal M. C. le Clercq, Mariëlle W.E. Bouwens, Eveline J. A. Rondagh et al. · Gut
|
6 Jun 2013 |
382 |
| 27 |
Consensus guidelines for lumbar puncture in patients with neurological diseases
Sebastiaan Engelborghs et al. · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
Open access |
2017 |
361 |
| 28 |
Treatment of Traumatic Thoracolumbar Spine Fractures: A Multicenter Prospective Randomized Study of Operative Versus Nonsurgical Treatment
Jan Siebenga, Vincent J. M. Leferink, Michiel J. M. Segers et al. · Spine
|
28 Nov 2006 |
361 |
| 29 |
State-of-the-art treatment of chronic leg ulcers: A randomized controlled trial comparing vacuum-assisted closure (V.A.C.) with modern wound dressings
Jeroen D. D. Vuerstaek, Tryfon Vainas, Jan Wuite et al. · Journal of Vascular Surgery
Open access |
27 Sep 2006 |
360 |
| 30 |
Higher disease activity leads to more structural damage in the spine in ankylosing spondylitis: 12-year longitudinal data from the OASIS cohort
Sofía Ramiro, Désirée M F M van der Heijde, Astrid M van Tubergen et al. · Annals of the Rheumatic Diseases
Open access |
9 May 2014 |
346 |
| 31 |
Comparison of tiotropium once daily, formoterol twice daily and both combined once daily in patients with COPD
Jan Arie van Noord, J-L. Aumann, Wim Janssens et al. · European Respiratory Journal
Open access |
29 Jul 2005 |
341 |
| 32 |
Laparoscopic peritoneal lavage or sigmoidectomy for perforated diverticulitis with purulent peritonitis: a multicentre, parallel-group, randomised, open-label trial
Sandra Vennix et al. · The Lancet
Open access155 authors |
21 Jul 2015 |
341 |
| 33 |
The Preventive Antibiotics in Stroke Study (PASS): a pragmatic randomised open-label masked endpoint clinical trial
Willeke F. Westendorp et al. · The Lancet
Open access |
19 Jan 2015 |
339 |
| 34 |
Tumor Markers in Breast Cancer – European Group on Tumor Markers Recommendations
Rafael Molina, Vivian Barak, Arie van Dalen et al. · Tumor Biology
|
2005 |
334 |
| 35 |
MRI lesions in the sacroiliac joints of patients with spondyloarthritis: an update of definitions and validation by the ASAS MRI working group
Walter P. Maksymowych et al. · Annals of the Rheumatic Diseases
Open access |
17 Aug 2019 |
319 |
| 36 |
EULAR definition of arthralgia suspicious for progression to rheumatoid arthritis
Hanna W. van Steenbergen et al. · Annals of the Rheumatic Diseases
Open access |
6 Oct 2016 |
319 |
| 37 |
Miss Rate of Lung Cancer on the Chest Radiograph in Clinical Practice
Lorentz G.B.A. Quekel, Alphons G.H. Kessels, Reginald Goei et al. · CHEST Journal
|
Mar 1999 |
317 |
| 38 |
Photodynamic therapy versus topical imiquimod versus topical fluorouracil for treatment of superficial basal-cell carcinoma: a single blind, non-inferiority, randomised controlled trial
Aimée HMM Arits, Klara Mosterd, Brigitte A.B. Essers et al. · The Lancet Oncology
|
14 May 2013 |
313 |
| 39 |
Obesity Due to Proopiomelanocortin Deficiency: Three New Cases and Treatment Trials with Thyroid Hormone and ACTH4–10
Heiko Krude, Heike Biebermann, Dirk Schnabel et al. · The Journal of Clinical Endocrinology & Metabolism
|
Oct 2003 |
309 |
| 40 |
De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health
Leah Eissing, Thomas Scherer, Klaus Tödter et al. · Nature Communications
Open access |
26 Feb 2013 |
303 |
| 41 |
“Components Separation Technique” for the Repair of Large Abdominal Wall Hernias
Tammo S. de Vries Reilingh, Harry van Goor, Camiel Rosman et al. · Journal of the American College of Surgeons
|
2003 |
299 |
| 42 |
Long-term survival and vascular event risk after transient ischaemic attack or minor ischaemic stroke: a cohort study
Iris van Wijk, L. Jaap Kappelle, Jan van Gijn et al. · The Lancet
|
Jun 2005 |
295 |
| 43 |
Influence of Phenotype at Diagnosis and of Other Potential Prognostic Factors on the Course of Inflammatory Bowel Disease
Mariëlle J. L. Romberg-Camps, Pieter C. Dagnelie, A D M Kester et al. · The American Journal of Gastroenterology
|
27 Jan 2009 |
293 |
| 44 |
Influence of smoking on incidence and prevalence of peripheral arterial disease
E.M. Willigendael, Joep A.W. Teijink, Marie-Louise E. L. Bartelink et al. · Journal of Vascular Surgery
Open access |
Dec 2004 |
290 |
| 45 |
Prognosis, disease progression, and treatment of atrial fibrillation patients during 1 year: follow-up of the Euro Heart Survey on Atrial Fibrillation
Robby Nieuwlaat, Martin H. Prins, Jean Yves Le Heuzey et al. · European Heart Journal
Open access |
20 Mar 2008 |
289 |
| 46 |
The relevance of intraventricular chemotherapy for leptomeningeal metastasis in breast cancer: a randomised study
Willem J. Boogerd, Martin J. van den Bent, Peter J. Koehler et al. · European Journal of Cancer
Open access |
18 Sep 2004 |
288 |
| 47 |
Differentiation between Cell Death Modes Using Measurements of Different Soluble Forms of Extracellular Cytokeratin 18
Gero Kramer, Hamdiye Erdal, Helena J. M. M. Mertens et al. · Cancer Research
|
Mar 2004 |
286 |
| 48 |
Radical Treatment of Non–Small-Cell Lung Cancer Patients with Synchronous Oligometastases: Long-Term Results of a Prospective Phase II Trial (Nct01282450)
Dirk De Ruysscher, Rinus Wanders, Angela van Baardwijk et al. · Journal of Thoracic Oncology
Open access |
15 Sep 2012 |
284 |
| 49 |
Effects of Tiotropium With and Without Formoterol on Airflow Obstruction and Resting Hyperinflation in Patients With COPD
Jan Arie van Noord, Joseph L. Aumann, Eduard Janssens et al. · CHEST Journal
|
Mar 2006 |
283 |
| 50 |
Tiotropium improves lung function in patients with severe uncontrolled asthma: A randomized controlled trial
Huib A.M. Kerstjens, Bernd G. Disse, Winfried Schröder-Babo et al. · Journal of Allergy and Clinical Immunology
|
19 Jun 2011 |
280 |