| 1 |
Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation
Ivica Letunić, Peer Bork · Nucleic Acids Research
Open access |
12 Apr 2021 |
12,232 |
| 2 |
Interactive Tree Of Life (iTOL) v4: recent updates and new developments
Ivica Letunić, Peer Bork · Nucleic Acids Research
Open access |
25 Mar 2019 |
6,592 |
| 3 |
Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees
Ivica Letunić, Peer Bork · Nucleic Acids Research
Open access |
19 Apr 2016 |
5,530 |
| 4 |
eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses
Jaime Huerta‐Cepas, Damian Szklarczyk, Davide Heller et al. · Nucleic Acids Research
Open access |
26 Oct 2018 |
5,477 |
| 5 |
eggNOG-mapper v2: Functional Annotation, Orthology Assignments, and Domain Prediction at the Metagenomic Scale
Carlos P. Cantalapiedra, Ana Hernández-Plaza, Ivica Letunić et al. · Molecular Biology and Evolution
Open access |
30 Sep 2021 |
5,074 |
| 6 |
Interactive Tree of Life (iTOL) v6: recent updates to the phylogenetic tree display and annotation tool
Ivica Letunić, Peer Bork · Nucleic Acids Research
Open access |
2 Apr 2024 |
4,591 |
| 7 |
The repertoire of mutational signatures in human cancer
Ludmil B. Alexandrov et al. · Nature
Open access1,384 authors |
5 Feb 2020 |
3,854 |
| 8 |
Pan-cancer analysis of whole genomes
Lauri A. Aaltonen et al. · Nature
Open access1,324 authors |
5 Feb 2020 |
3,360 |
| 9 |
InterPro in 2022
Typhaine Paysan‐Lafosse et al. · Nucleic Acids Research
Open access |
9 Nov 2022 |
2,650 |
| 10 |
The InterPro protein families and domains database: 20 years on
Matthias Blum et al. · Nucleic Acids Research
Open access |
23 Oct 2020 |
2,459 |
| 11 |
SMART: recent updates, new developments and status in 2020
Ivica Letunić, Supriya Khedkar, Peer Bork · Nucleic Acids Research
Open access |
6 Oct 2020 |
2,404 |
| 12 |
20 years of the SMART protein domain annotation resource
Ivica Letunić, Peer Bork · Nucleic Acids Research
Open access |
29 Sep 2017 |
2,245 |
| 13 |
SMART: recent updates, new developments and status in 2015
Ivica Letunić, Tobias Doerks, Peer Bork · Nucleic Acids Research
Open access |
9 Oct 2014 |
1,834 |
| 14 |
InterPro in 2017—beyond protein family and domain annotations
ROBERT FINN et al. · Nucleic Acids Research
Open access |
27 Oct 2016 |
1,598 |
| 15 |
InterPro in 2019: improving coverage, classification and access to protein sequence annotations
Alex Mitchell et al. · Nucleic Acids Research
Open access |
22 Oct 2018 |
1,557 |
| 16 |
The SIDER database of drugs and side effects
Michael Kuhn, Ivica Letunić, Lars Juhl Jensen et al. · Nucleic Acids Research
Open access |
19 Oct 2015 |
1,514 |
| 17 |
The evolutionary history of 2,658 cancers
Moritz Gerstung et al. · Nature
Open access1,441 authors |
5 Feb 2020 |
1,149 |
| 18 |
InterPro: the protein sequence classification resource in 2025
Matthias Blum et al. · Nucleic Acids Research
Open access |
23 Oct 2024 |
1,084 |
| 19 |
Patterns of somatic structural variation in human cancer genomes
Yilong Li et al. · Nature
Open access1,411 authors |
5 Feb 2020 |
1,005 |
| 20 |
Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
Isidro Cortés-Ciriano et al. · Nature Genetics
Open access1,407 authors |
5 Feb 2020 |
793 |
| 21 |
Analyses of non-coding somatic drivers in 2,658 cancer whole genomes
Esther Rheinbay et al. · Nature
Open access1,621 authors |
5 Feb 2020 |
674 |
| 22 |
Statin therapy is associated with lower prevalence of gut microbiota dysbiosis
Sara Vieira‐Silva et al. · Nature
Open access108 authors |
6 May 2020 |
534 |
| 23 |
Genomic basis for RNA alterations in cancer
PCAWG Transcriptome Core Group et al. · Nature
Open access1,461 authors |
5 Feb 2020 |
425 |
| 24 |
The landscape of viral associations in human cancers
Marc Zapatka et al. · Nature Genetics
Open access1,355 authors |
5 Feb 2020 |
412 |
| 25 |
eggNOG 6.0: enabling comparative genomics across 12 535 organisms
Ana Hernández-Plaza, Damian Szklarczyk, Jorge Botas et al. · Nucleic Acids Research
Open access |
24 Oct 2022 |
378 |
| 26 |
iPath3.0: interactive pathways explorer v3
Youssef Darzi, Ivica Letunić, Peer Bork et al. · Nucleic Acids Research
Open access |
11 Apr 2018 |
327 |
| 27 |
Microbiome and metabolome features of the cardiometabolic disease spectrum
Sébastien Fromentin et al. · Nature Medicine
Open access |
Feb 2022 |
306 |
| 28 |
Positioning hydrogen atoms by optimizing hydrogen-bond networks in protein structures
Rob W W Hooft, Chris Sander, Gerrit Vriend · Proteins Structure Function and Bioinformatics
|
Dec 1996 |
305 |
| 29 |
Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology
Antonio Molinaro et al. · Nature Communications
Open access110 authors |
18 Nov 2020 |
288 |
| 30 |
Activation of Blood Coagulation After Cardiac Arrest Is Not Balanced Adequately by Activation of Endogenous Fibrinolysis
Bernd Walter Böttiger, J. Motsch, Hubert Bohrer et al. · Circulation
|
Nov 1995 |
260 |
| 31 |
Towards the biogeography of prokaryotic genes
Luis Pedro Coelho et al. · Nature
Open access |
15 Dec 2021 |
253 |
| 32 |
Combinatorial, additive and dose-dependent drug–microbiome associations
Sofia Kirke Forslund et al. · Nature
Open access119 authors |
8 Dec 2021 |
247 |
| 33 |
A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns
Wei Jiao et al. · Nature Communications
Open access1,385 authors |
5 Feb 2020 |
246 |
| 34 |
Integrative pathway enrichment analysis of multivariate omics data
Marta Paczkowska et al. · Nature Communications
Open access1,460 authors |
5 Feb 2020 |
243 |
| 35 |
Overexpression of the Transcription Factor GROWTH-REGULATING FACTOR5 Improves Transformation of Dicot and Monocot Species
Jixiang Kong, Susana Martin‐Ortigosa, John J. Finer et al. · Frontiers in Plant Science
Open access |
12 Oct 2020 |
207 |
| 36 |
Use cases, best practice and reporting standards for metabolomics in regulatory toxicology
Mark R. Viant, Timothy M. D. Ebbels, Richard D. Beger et al. · Nature Communications
Open access |
10 Jul 2019 |
204 |
| 37 |
Landscape of mobile genetic elements and their antibiotic resistance cargo in prokaryotic genomes
Supriya Khedkar, Georgy Smyshlyaev, Ivica Letunić et al. · Nucleic Acids Research
Open access |
11 Mar 2022 |
195 |
| 38 |
Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis
Joana Carlevaro-Fita et al. · Communications Biology
Open access1,462 authors |
5 Feb 2020 |
195 |
| 39 |
proGenomes: a resource for consistent functional and taxonomic annotations of prokaryotic genomes
Daniel R. Mende, Ivica Letunić, Jaime Huerta‐Cepas et al. · Nucleic Acids Research
Open access |
17 Oct 2016 |
161 |
| 40 |
Influenza Vaccination Is Associated With a Reduced Risk of Stroke
Armin Grau, Beate Fischer, Cordula Barth et al. · Stroke
Open access |
10 Jun 2005 |
145 |
| 41 |
Genomic footprints of activated telomere maintenance mechanisms in cancer
Lina Sieverling et al. · Nature Communications
Open access1,414 authors |
5 Feb 2020 |
143 |
| 42 |
Divergent mutational processes distinguish hypoxic and normoxic tumours
Vinayak Bhandari et al. · Nature Communications
Open access1,328 authors |
5 Feb 2020 |
143 |
| 43 |
Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism
Eugeni Belda et al. · Gut
Open access |
11 Jan 2022 |
141 |
| 44 |
Sex differences in oncogenic mutational processes
Constance H. Li et al. · Nature Communications
Open access1,376 authors |
28 Aug 2020 |
130 |
| 45 |
Pathway and network analysis of more than 2500 whole cancer genomes
Matthew A. Reyna et al. · Nature Communications
Open access1,454 authors |
5 Feb 2020 |
120 |
| 46 |
PTMcode v2: a resource for functional associations of post-translational modifications within and between proteins
Pablo Mínguez, Ivica Letunić, Luca Parca et al. · Nucleic Acids Research
Open access |
31 Oct 2014 |
115 |
| 47 |
proGenomes2: an improved database for accurate and consistent habitat, taxonomic and functional annotations of prokaryotic genomes
Daniel R. Mende, Ivica Letunić, Oleksandr M. Maistrenko et al. · Nucleic Acids Research
Open access |
18 Oct 2019 |
107 |
| 48 |
SPIRE: a Searchable, Planetary-scale mIcrobiome REsource
Thomas Schmidt, Anthony Fullam, Pamela Ferretti et al. · Nucleic Acids Research
Open access |
11 Oct 2023 |
96 |
| 49 |
proGenomes3: approaching one million accurately and consistently annotated high-quality prokaryotic genomes
Anthony Fullam et al. · Nucleic Acids Research
Open access |
21 Nov 2022 |
91 |
| 50 |
Whole Blood DNA Methylation Signatures of Diet Are Associated With Cardiovascular Disease Risk Factors and All-Cause Mortality
Jiantao Ma et al. · Circulation Genomic and Precision Medicine
Open access |
11 Jun 2020 |
89 |