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Most cited papers from Biotechnology Institute

What are the most cited papers from Biotechnology Institute?

The most cited paper from Biotechnology Institute is "Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2" (Evan K Bolyen et al., 2019), with 25,165 citations. Next come "Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences" (9,519) and "THE ROLE OF ROOT EXUDATES IN RHIZOSPHERE INTERACTIONS WITH PLANTS AND OTHER ORGANISMS" (4,713).

Showing 50 of 60 papers. Every paper with more than 802 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2 Evan K Bolyen et al. · Nature Biotechnology Open access112 authors 24 Jul 2019 25,165
2 Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences Morgan G. I. Langille, Jesse Zaneveld, J. Gregory Caporaso et al. · Nature Biotechnology Open access 25 Aug 2013 9,519
3 THE ROLE OF ROOT EXUDATES IN RHIZOSPHERE INTERACTIONS WITH PLANTS AND OTHER ORGANISMS HARSH PAL BAIS, Tiffany L. Weir, Laura G. Perry et al. · Annual Review of Plant Biology Review 31 Jan 2006 4,713
4 Molecular replacement with MOLREP Alexei A. Vagin, A. I. Teplyakov · Acta Crystallographica Section D Biological Crystallography 21 Dec 2009 3,727
5 Bandage: interactive visualization of de novo genome assemblies Ryan R. Wick, Mark B. Schultz, Justin Zobel et al. · Bioinformatics Open access 22 Jun 2015 3,373
6 The Treatment-Naive Microbiome in New-Onset Crohn’s Disease Dirk Gevers et al. · Cell Host & Microbe Open access Mar 2014 3,362
7 Closing yield gaps through nutrient and water management Nathaniel D. Mueller, James Gerber, Matt Johnston et al. · Nature 28 Aug 2012 2,876
8 Pervasive human-driven decline of life on Earth points to the need for transformative change Sandra M. Díaz et al. · Science Open access 12 Dec 2019 2,746
9 Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles Jan O. Lötvall, Andrew Francis Hill, Fred H. Hochberg et al. · Journal of Extracellular Vesicles Open access 2014 2,741
10 Engineering the third wave of biocatalysis Uwe T. Bornscheuer, Gjalt W. Huisman, Romas J. Kazlauskas et al. · Nature May 2012 2,648
11 The MARTINI Coarse-Grained Force Field: Extension to Proteins Luca Monticelli, Senthil Kumar Kandasamy, Xavier Périole et al. · Journal of Chemical Theory and Computation 16 Apr 2008 2,616
12 BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities Tianbo Liu, Yu‐Ting Lin, X. Wen et al. · Nucleic Acids Research Open access 2 Dec 2006 2,203
13 Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature Paul G. Arnison et al. · Natural Product Reports Open access 20 Nov 2012 2,136
14 Climate variation explains a third of global crop yield variability Deepak K. Ray, James Gerber, Graham K. MacDonald et al. · Nature Communications Open access 22 Jan 2015 2,060
15 The Genome Sequence of the Malaria Mosquito Anopheles gambiae Robert A. Holt et al. · Science 122 authors 3 Oct 2002 2,046
16 Shewanella secretes flavins that mediate extracellular electron transfer Enrico Marsili, Daniel B. Baron, Indraneel D. Shikhare et al. · Proceedings of the National Academy of Sciences Open access 3 Mar 2008 2,002
17 DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae John F. Heidelberg et al. · Nature Open access Aug 2000 1,915
18 Emerging Marine Diseases--Climate Links and Anthropogenic Factors C. Drew Harvell, Kiho Kim, JoAnn M. Burkholder et al. · Science 3 Sep 1999 1,845
19 Sodium/Calcium Exchange: Its Physiological Implications Mordecai P. Blaustein, William Jonathan Lederer · Physiological Reviews Review Jul 1999 1,749
20 Recent patterns of crop yield growth and stagnation Deepak K. Ray, Navin Ramankutty, Nathaniel D. Mueller et al. · Nature Communications Open access 18 Dec 2012 1,629
21 The Arabidopsis NPR1 Gene That Controls Systemic Acquired Resistance Encodes a Novel Protein Containing Ankyrin Repeats Hui Luo Cao, Jane Glazebrook, Joseph D. Clarke et al. · Cell Open access 1997 1,601
22 Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans Brian J. Haas et al. · Nature Open access Sep 2009 1,537
23 Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study Dae‐Wook Kang, James B. Adams, Ann Gregory et al. · Microbiome Open access 23 Jan 2017 1,415
24 Improving the forecast for biodiversity under climate change Mark C. Urban et al. · Science Open access 8 Sep 2016 1,340
25 Micro- and Nanostructured Surface Morphology on Electrospun Polymer Fibers Silke Megelski, Jean S. Stephens, D. Bruce Chase et al. · Macromolecules 27 Sep 2002 1,324
26 The Medicago genome provides insight into the evolution of rhizobial symbioses Nevin Dale Young et al. · Nature Open access124 authors 15 Nov 2011 1,319
27 Enterotypes in the landscape of gut microbial community composition Paul Igor Costea et al. · Nature Microbiology Open access 13 Dec 2017 1,261
28 HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS Udai Bhan Pandey, Zhiping Nie, Yakup Batlevi et al. · Nature Jun 2007 1,235
29 Criteria for Annotation of Plant MicroRNAs Blake C. Meyers et al. · The Plant Cell Open access Dec 2008 1,231
30 Regulation of an ATG7 - beclin 1 Program of Autophagic Cell Death by Caspase-8 Li Yu, Ajjai Shivaram Alva, Helen C. Su et al. · Science 10 May 2004 1,224
31 A Symbiotic View of Life: We Have Never Been Individuals Scott F. Gilbert, Jan Sapp, Alfred I. Tauber · The Quarterly Review of Biology Dec 2012 1,221
32 Root-Secreted Malic Acid Recruits Beneficial Soil Bacteria Thimmaraju Rudrappa, Kirk J. Czymmek, Paul W. Paré et al. · PLANT PHYSIOLOGY Open access 26 Sep 2008 1,185
33 Cohabiting family members share microbiota with one another and with their dogs Se Jin Song, Christian L. Lauber, Elizabeth K. Costello et al. · eLife Open access 16 Apr 2013 1,151
34 Arthropod relationships revealed by phylogenomic analysis of nuclear protein-coding sequences Jerome C. Regier, Jeffrey W. Shultz, Andreas Zwick et al. · Nature Feb 2010 1,051
35 Block Copolymer Assembly via Kinetic Control Honggang Cui, Zhiyun Chen, Sheng Zhong et al. · Science 2 Aug 2007 1,048
36 Autophagy: dual roles in life and death? Eric H. Baehrecke · Nature Reviews Molecular Cell Biology Review Jun 2005 995
37 Calculation of Protein-Ligand Binding Affinities Michael K. Gilson, Huan‐Xiang Zhou · Annual Review of Biophysics and Biomolecular Structure 3 Mar 2007 982
38 Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death Peter J. Mohler, Jean‐Jacques Schott, Anthony O. Gramolini et al. · Nature Feb 2003 965
39 Responsive Hydrogels from the Intramolecular Folding and Self-Assembly of a Designed Peptide Joel P. Schneider, Darrin J. Pochan, Bulent Ozbas et al. · Journal of the American Chemical Society 23 Nov 2002 949
40 Catalytic specificity of protein-tyrosine kinases is critical for selective signalling Zhou Songyang, Kermit L. Carraway, Michael J. Eck et al. · Nature Feb 1995 931
41 Minimum Information about a Biosynthetic Gene cluster Marnix H. Medema et al. · Nature Chemical Biology Open access154 authors 18 Aug 2015 927
42 Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites Alison N. Thorburn et al. · Nature Communications Open access 23 Jun 2015 924
43 American Gut: an Open Platform for Citizen Science Microbiome Research Daniel T. McDonald et al. · mSystems Open access168 authors 14 May 2018 921
44 Neuroendocrinology of reproduction in teleost fish Yonathan Zohar, José Antonio Muñoz‐Cueto, Abigail Elizur et al. · General and Comparative Endocrinology 24 Apr 2009 893
45 QIIME 2: Reproducible, interactive, scalable, and extensible microbiome data science Evan K Bolyen et al. PreprintOpen access109 authors 23 Oct 2018 892
46 Systematic improvement of amplicon marker gene methods for increased accuracy in microbiome studies Daryl M. Gohl, Pajau Vangay, John Garbe et al. · Nature Biotechnology 25 Jul 2016 891
47 More than one reason to rethink the use of peptides in vaccine design Anthony Wayne Purcell, James McCluskey, Jamie Rossjohn · Nature Reviews Drug Discovery Review May 2007 878
48 Autophagy Regulates Programmed Cell Death during the Plant Innate Immune Response Yule Liu, Michael H. Schiff, Kirk J. Czymmek et al. · Cell Open access May 2005 874
49 Environmental Escherichia coli : ecology and public health implications-a review Jeonghwan Jang, Hor‐Gil Hur, Michael Jay Sadowsky et al. · Journal of Applied Microbiology 6 Apr 2017 870
50 Global identification of microRNA–target RNA pairs by parallel analysis of RNA ends Marcelo A. German, Manoj Pillay, Dong‐Hoon Jeong et al. · Nature Biotechnology 9 Jun 2008 866

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.