Most cited papers from Bitop (Germany)

Bitop (Germany)

What are the most cited papers from Bitop (Germany)?

The most cited paper from Bitop (Germany) is "Extremolytes: natural compounds from extremophiles for versatile applications" (Georg Lentzen, Thomas L. Schwarz, 2006), with 341 citations. Next come "Animal models and the prediction of efficacy in clinical trials of analgesic drugs: A critical appraisal and call for uniform reporting standards" (293) and "A blueprint of ectoine metabolism from the genome of the industrial producer Halomonas elongata DSM 2581 T" (279).

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Showing 50 of 54 papers. Every paper is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Extremolytes: natural compounds from extremophiles for versatile applications Georg Lentzen, Thomas L. Schwarz · Applied Microbiology and Biotechnology	6 Sep 2006	341
2	Animal models and the prediction of efficacy in clinical trials of analgesic drugs: A critical appraisal and call for uniform reporting standards Andrew S.C. Rice, Dorothy Cimino-Brown, James C. Eisenach et al. · Pain	24 Sep 2008	293
3	A blueprint of ectoine metabolism from the genome of the industrial producer Halomonas elongata DSM 2581 T Karin Schwibbert, Alberto Marı́n-Sanguino, Irina Bagyan et al. · Environmental Microbiology Open access	16 Sep 2010	279
4	Rational Design of Inhibitors of HIV-1 TAR RNA through the Stabilisation of Electrostatic “Hot Spots” Ben J. Davis, Mohammad Farzad Afshar, Gabriele Varani et al. · Journal of Molecular Biology	8 Jan 2004	159
5	Ectoine and hydroxyectoine inhibit aggregation and neurotoxicity of Alzheimer's β‐amyloid Mathumai Kanapathipillai, Georg Lentzen, Michael R. Sierks et al. · FEBS Letters Open access	8 Aug 2005	146
6	The effect of compatible solute ectoines on the structural organization of lipid monolayer and bilayer membranes Rakesh Kumar Harishchandra, Stephanie Wulff, Georg Lentzen et al. · Biophysical Chemistry	12 Feb 2010	120
7	Ectoine-Containing Cream in the Treatment of Mild to Moderate Atopic Dermatitis: A Randomised, Comparator-Controlled, Intra-Individual Double-Blind, Multi-Center Trial Alessandra Marini, K. Reinelt, Jean Krutmann et al. · Skin Pharmacology and Physiology	16 Aug 2013	104
8	Compatible solutes: Thermodynamic properties and biological impact of ectoines and prolines Christoph Held, Thorsten Neuhaus, Gabriele Sadowski · Biophysical Chemistry	4 Aug 2010	95
9	Neutrons describe ectoine effects on water H-bonding and hydration around a soluble protein and a cell membrane Giuseppe Zaccaı̈, Irina Bagyan, Jérôme Combet et al. · Scientific Reports Open access	16 Aug 2016	89
10	Novel effects of ectoine, a bacteria-derived natural tetrahydropyrimidine, in experimental colitis H Abdel-Aziz, Walaa Wadie, Dalaal M. Abdallah et al. · Phytomedicine	28 Feb 2013	76
11	Recovery of neutrophil apoptosis by ectoine: a new strategy against lung inflammation Ulrich Sydlik, Henrike Peuschel, Adnana Paunel‐Görgülü et al. · European Respiratory Journal Open access	25 Oct 2012	69
12	Ectoine in the Treatment of Irritations and Inflammations of the Eye Surface Andreas Bilstein, Anja Heinrich, Anna Rybachuk et al. · BioMed Research International Open access	2021	65
13	Inhibition of β-amyloid peptide aggregation and neurotoxicity by α-d-mannosylglycerate, a natural extremolyte Jungki Ryu, Mathumai Kanapathipillai, Georg Lentzen et al. · Peptides	11 Jan 2008	53
14	Reduction of neutrophilic lung inflammation by inhalation of the compatible solute ectoine: a randomized trial with elderly individuals Klaus Unfried, Ursula Krämer, Ulrich Sydlik et al. · International Journal of COPD Open access	Oct 2016	51
15	Treatment of Allergic Rhinitis with Ectoine Containing Nasal Spray and Eye Drops in Comparison with Azelastine Containing Nasal Spray and Eye Drops or with Cromoglycic Acid Containing Nasal Spray Nina Werkhäuser, Andreas Bilstein, Uwe Sonnemann · Journal of Allergy Open access	Jun 2014	48
16	Topical Ectoine Application in Children and Adults to Treat Inflammatory Diseases Associated with an Impaired Skin Barrier: A Systematic Review Marion Kauth, О. В. Трусова · Dermatology and Therapy ReviewOpen access	17 Jan 2022	44
17	Compatible solutes: Ectoine and hydroxyectoine improve functional nanostructures in artificial lung surfactants Rakesh Kumar Harishchandra, Amit Kumar Sachan, Andreas Kerth et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes Open access	22 Aug 2011	39
18	Potential applications of stress solutes from extremophiles in protein folding diseases and healthcare Carla D. Jorge, Nuno Borges, Irina Bagyan et al. · Extremophiles	12 Apr 2016	34
19	Ectoine lozenges in the treatment of acute viral pharyngitis: a prospective, active-controlled clinical study Van‐Anh Dao, Sabrina Overhagen, Andreas Bilstein et al. · European Archives of Oto-Rhino-Laryngology Open access	9 Feb 2019	33
20	Effect of ectoine, hydroxyectoine and β-hydroxybutyrate on the temperature and pressure stability of phospholipid bilayer membranes of different complexity Marius Herzog, Mridula Dwivedi, Rakesh Kumar Harishchandra et al. · Colloids and Surfaces B Biointerfaces	16 Mar 2019	27
21	Efficacy and tolerability of an ectoine mouth and throat spray compared with those of saline lozenges in the treatment of acute pharyngitis and/or laryngitis: a prospective, controlled, observational clinical trial Dörte Müller, Torben Lindemann, Kija Shah‐Hosseini et al. · European Archives of Oto-Rhino-Laryngology Open access	28 Apr 2016	27
22	Meta-Analysis of the Efficacy of Ectoine Nasal Spray in Patients with Allergic Rhinoconjunctivitis Andrea Eichel, Andreas Bilstein, Nina Werkhäuser et al. · Journal of Allergy ReviewOpen access	11 May 2014	27
23	Effectiveness, Tolerability, and Safety of Ectoine-Containing Mouthwash Versus Those of a Calcium Phosphate Mouthwash for the Treatment of Chemotherapy-Induced Oral Mucositis: A Prospective, Active-Controlled, Non-interventional Study Van‐Anh Dao, Andreas Bilstein, Sabrina Overhagen et al. · Oncology and Therapy Open access	9 May 2018	25
24	Bacteria-Derived Compatible Solutes Ectoine and 5α-Hydroxyectoine Act as Intestinal Barrier Stabilizers to Ameliorate Experimental Inflammatory Bowel Disease H Abdel-Aziz, Walaa Wadie, Olaf Scherner et al. · Journal of Natural Products	28 May 2015	24
25	Noninterventional Open-Label Trial Investigating the Efficacy and Safety of Ectoine Containing Nasal Spray in Comparison with Beclomethasone Nasal Spray in Patients with Allergic Rhinitis Uwe Sonnemann, Marcus Johannes Möller, Andreas Bilstein · Journal of Allergy Open access	28 May 2014	23
26	Effects of ectoine containing nasal spray and eye drops on symptoms of seasonal allergic rhinoconjunctivitis Anne Marie Salapatek, Nina Werkhäuser, Basma Ismail et al. · Clinical and Translational Allergy Open access	Mar 2021	22
27	Treatment of Rhinitis Sicca Anterior with Ectoine Containing Nasal Spray Uwe Sonnemann, Olaf Scherner, Nina Werkhäuser · Journal of Allergy Open access	13 Apr 2014	22
28	Signalling-Dependent Adverse Health Effects of Carbon Nanoparticles Are Prevented by the Compatible Solute Mannosylglycerate (Firoin) In Vitro and In Vivo Andrea Autengruber, Ulrich Sydlik, Matthias Kroker et al. · PLoS ONE Open access	21 Nov 2014	19
29	Ectoine-Containing Inhalation Solution versus Saline Inhalation Solution in the Treatment of Acute Bronchitis and Acute Respiratory Infections: A Prospective, Controlled, Observational Study Binh-Hai Tran, Van‐Anh Dao, Andreas Bilstein et al. · BioMed Research International Open access	31 Jan 2019	18
30	Validation of Crashworthiness Simulation and Design Methods by Testing of a Scaled Composite Helicopter Frame Section Christof Kindervater, Dlr, Matthew David et al. Conference paper	3 May 2011	17
31	Revision and reannotation of the Halomonas elongata DSM 2581 T genome Friedhelm Pfeiffer, Irina Bagyan, Gabriela Alfaro‐Espinoza et al. · MicrobiologyOpen Open access	27 Mar 2017	16
32	Ectoine as a natural component of food: detection in red smear cheeses Julia Klein, Thomas L. Schwarz, Georg Lentzen · Journal of Dairy Research	26 Oct 2007	16
33	Ectoin®, a Novel, Non-Drug, Extremophile-Based Device, Relieves Allergic Rhinoconjunctivitis Symptoms in Patients in an Environmental Exposure Chamber Model A. Salapatek, M. Bates, Andreas Bilstein et al. · Journal of Allergy and Clinical Immunology Open access	Feb 2011	13
34	The Effectiveness of the Bacteria Derived Extremolyte Ectoine for the Treatment of Allergic Rhinitis Andreas Bilstein, Nina Werkhäuser, Anna Rybachuk et al. · BioMed Research International Open access	2021	12
35	Observational study investigating Ectoin® Rhinitis Nasal Spray as natural treatment option of acute rhinosinusitis compared to treatment with Xylometazoline Nina Werkhäuser, Andreas Bilstein, Kathrin Mahlstedt et al. · European Archives of Oto-Rhino-Laryngology Open access	4 Jun 2021	10
36	Complex transitions between dihydrate and anhydrate forms of ectoine – unexpected behavior of a highly hygroscopic compatible solute in the solid state W.M. Hützler, Estelle Mossou, Ronnald Vollrath et al. · CrystEngComm	25 Nov 2019	8
37	Multifunctional Tryptophan-synthesizing Enzyme Thomas L. Schwarz, Katharina Uthoff, Claudia Klinger et al. · Journal of Biological Chemistry Open access	Apr 1997	6
38	The use of a hollow fiber membrane module in sample conditioning prior to electrophoresis Thomas L. Schwarz, Susanne Sindern, Peter Bartholmes et al. · Electrophoresis	1994	5
39	Purification of unstable proteins from Halobacterium salinarium crude cell extracts: combined cell disruption and desalting by a hollow-fiber membrane module as an access to perform ion-exchange chromatography Kerstin Heesche‐Wagner, Thomas L. Schwarz, Peter Bartholmes et al. · Journal of Chromatography A	Sep 1995	5
40	Reduction of chronic lung inflammation by inhalation of the compatible solute ectoine: a population-based intervention study with elderly individuals Klaus Unfried, Ursula Krämer, Ulrich Sydlik et al. · Pneumologie	23 Feb 2017	3
41	The pyrostatins A and B do not inhibit N-acetyl-ß-D-glucosaminidase Daniel Appel, Georg Lentzen · Journal of Enzyme Inhibition and Medicinal Chemistry Open access	19 Mar 2009	3
42	Safety and efficacy of ectoine inhalation solution in patients with inflammation and airway obstruction: The EFECT study Roman Berndt, Ulrich Sydlik, Andreas Bilstein et al. · European Respiratory Journal	Sep 2012	2
43	A directed approach to the selection of bacteria with enhanced catabolic activity Kerstin Heesche‐Wagner, Thomas L. Schwarz, Martin Kaufmann · Letters in Applied Microbiology	6 Mar 2001	2
44	Effectiveness of Ectoin lozenges on oropharyngeal allergic symptoms Rawan Khachouk, Ursula Pieper‐Fürst, Cengizhan Açıkel et al. · Clinical and Translational Allergy Open access	2022	1
45	The compatible solute ectoine prevents neutrophilic lung inflammation induced by environmental model nanoparticles in vivo Klaus Unfried, Ulrich Sydlik, Henrike Peuschel et al. · Toxicology Letters	8 May 2010	1
46	Umwelttechnik Peter Bartholmes, M. Kaufmann, Thomas A. Schwarz Book chapter	1996	0
47	Paradigma Peter Bartholmes, M. Kaufmann, Thomas Schwarz Book chapter	1996	0
48	Umweltgifte Peter Bartholmes, M. Kaufmann, Thomas A. Schwarz Book chapter	1996	0
49	Evolution Peter Bartholmes, M. Kaufmann, Thomas Schwarz Book chapter	1996	0
50	ArtEv-Verfahren Peter Bartholmes, M. Kaufmann, Thomas A. Schwarz Book chapter	1996	0

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.