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Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1 H -indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate
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Soluble CTLA-4 as a favorable predictive biomarker in metastatic melanoma patients treated with ipilimumab: an Italian melanoma intergroup study
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Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy
Bruno Mattiello Gomes et al. · Molecular Cancer Therapeutics
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Restoration of T-cell Effector Function, Depletion of Tregs, and Direct Killing of Tumor Cells: The Multiple Mechanisms of Action of a-TIGIT Antagonist Antibodies
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PPAR gamma agonist leriglitazone improves frataxin-loss impairments in cellular and animal models of Friedreich Ataxia
Laura Rodríguez‐Pascau, Elena Britti, Pablo Calap-Quintana et al. · Neurobiology of Disease
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7 Nov 2020 |
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Tryptophan 2,3-Dioxygenase Expression Identified in Human Hepatocellular Carcinoma Cells and in Intratumoral Pericytes of Most Cancers
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Decreased pool of mesenchymal stem cells is associated with altered chemokines serum levels in atrophic nonunion fractures
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Development of PPARγ Agonists for the Treatment of Neuroinflammatory and Neurodegenerative Diseases: Leriglitazone as a Promising Candidate
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6 Feb 2023 |
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Natividad Cuende, Rachele Ciccocioppo, Miguel Forte et al. · Cytotherapy
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8 May 2022 |
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Did Osteoblastic Cell Therapy Improve the Prognosis of Pre-fracture Osteonecrosis of the Femoral Head? A Randomized, Controlled Trial
Jean‐Philippe Hauzeur, Chantal Lechanteur, Étienne Baudoux et al. · Clinical Orthopaedics and Related Research
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Cannabidiol ameliorates mitochondrial disease via PPARγ activation in preclinical models
Emma Puighermanal et al. · Nature Communications
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4 Sep 2024 |
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Safety and feasibility of an endoluminal-suturing device for endoscopic gastric reduction (with video)
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Inhibition of ENT1 relieves intracellular adenosine-mediated T cell suppression in cancer
Theodore J. Sanders, Christopher S. Nabel, Margreet Brouwer et al. · Nature Immunology
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12 May 2025 |
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Microenvironment Tumor Metabolic Interactions Highlighted by qMSI: Application to the Tryptophan-Kynurenine Pathway in Immuno-Oncology
Rima Ait-Belkacem, Vanesa Bol, Gregory R. Hamm et al. · SLAS DISCOVERY
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30 May 2017 |
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Value of a radiographic score for the assessment of healing of nailed femoral and tibial shaft fractures: A retrospective preliminary study
Vasiliki Perlepe, Andrea Cerato, Dan Constantin Putineanu et al. · European Journal of Radiology
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8 Nov 2017 |
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Discovery, Optimization, and Preclinical Pharmacology of EP652, a METTL3 Inhibitor with Efficacy in Liquid and Solid Tumor Models
Guillaume Dutheuil, Killian Oukoloff, Julien Korac et al. · Journal of Medicinal Chemistry
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30 Jan 2025 |
25 |
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Does Adjunction of Autologous Osteoblastic Cells Improve the Results of Core Decompression in Early-stage Femoral Head Osteonecrosis? A Double-blind, Randomized Trial
Marc Jayankura, Thierry Thomas, Lothar Seefried et al. · Clinical Orthopaedics and Related Research
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24 Mar 2023 |
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TIGIT inhibition and lenalidomide synergistically promote antimyeloma immune responses after stem cell transplantation in mice
Simone A. Minnie, Olivia G. Waltner, Kathleen S. Ensbey et al. · Journal of Clinical Investigation
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13 Dec 2022 |
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Microscope-Based Automated Quantification of Liver Fibrosis in Mice Using a Deep Learning Algorithm
Yuval Ramot, Ameya Deshpande, Virginia Morello et al. · Toxicologic Pathology
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26 Mar 2021 |
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Percutaneous administration of allogeneic bone-forming cells for the treatment of delayed unions of fractures: a pilot study
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26 Jun 2021 |
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Mitochondrial modulation with leriglitazone as a potential treatment for Rett syndrome
Uliana Musokhranova, C. J. Alejos Grau, Cristina Vergara et al. · Journal of Translational Medicine
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26 Oct 2023 |
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The olfactory receptor Olfr78 promotes differentiation of enterochromaffin cells in the mouse colon
Gilles Dinsart, Morgane Leprovots, Anne Lefort et al. · EMBO Reports
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15 Dec 2023 |
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Radiprodil, a selective GluN2B negative allosteric modulator, rescues audiogenic seizures in mice carrying the GluN2A(N615S) mutation
Ilaria Bertocchi, Lorenzo Cifarelli, Alessandra Oberto et al. · British Journal of Pharmacology
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26 Mar 2024 |
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The antitumoral effects of chemerin are independent from leukocyte recruitment and mediated by inhibition of neoangiogenesis
Ingrid Dubois-Vedrenne, Diana Al Delbany, Olivier De Henau et al. · Oncotarget
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25 Aug 2021 |
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Target exposure and pharmacodynamics study of the indoleamine 2,3-dioxygenase-1 (IDO-1) inhibitor epacadostat in the CT26 mouse tumor model
Lauranne Poncelet, Rima Ait-Belkacem, Reece G. Marillier et al. · Journal of Pharmaceutical and Biomedical Analysis
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22 Mar 2019 |
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PPAR Gamma Agonist Leriglitazone Recovers Alterations Due to Pank2-Deficiency in hiPS-Derived Astrocytes
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6 Jan 2023 |
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Inhaled dry powder cisplatin increases antitumour response to anti-PD1 in a murine lung cancer model
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6 Dec 2022 |
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3 May 2021 |
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In Vivo Validation of a Less Invasive Gastrostimulator
Laurent Lonys, Anne Vanhoestenberghe, Vincent Huberty et al. · Artificial Organs
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Nov 2017 |
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Increased regulatory activity of intestinal innate lymphoid cells type 3 (ILC3) prevents experimental autoimmune encephalomyelitis severity
Milica N. Lazarević, Goran Stegnjaić, Bojan Jevtić et al. · Journal of Neuroinflammation
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18 Jan 2024 |
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Establishing Best Practice for the Application and Support of Solubility Purge Factors
Michael J. Burns, Ian X. Andrews, Jens-Christoph Baumann et al. · Organic Process Research & Development
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14 Mar 2023 |
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15 Jan 2004 |
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Safety and efficacy of a single intra-articular injection of a novel enhanced protein solution (JTA-004) compared to hylan G-F 20 in symptomatic knee osteoarthritis: a randomized, double-blind, controlled phase II/III study
Marie Bettonville, Marc Léon, Joëlle Margaux et al. · BMC Musculoskeletal Disorders
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19 Oct 2021 |
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A Mesenchymal‐Epithelial Transition Factor‐Agonistic Antibody Accelerates Cirrhotic Liver Regeneration and Improves Mouse Survival Following Partial Hepatectomy
Kuai Ma, Weitao Que, Xin Hu et al. · Liver Transplantation
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16 Sep 2021 |
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Preclinical tolerance evaluation of the addition of a cisplatin-based dry powder for inhalation to the conventional carboplatin-paclitaxel doublet for treatment of non-small cell lung cancer
Selma Chraibi, Rémi Rosière, E. De Prez et al. · Biomedicine & Pharmacotherapy
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16 May 2021 |
8 |
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Treatment of osteonecrosis of the femoral head with implantation of autologous bone-marrow cells: Five-year follow-up
Valérie Gangji, Michel Toungouz, M. Lambermont et al. · Bone
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7 Apr 2007 |
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Ferroptosis-armed dendritic cell vaccines for glioma immunotherapy
Mariia Saviuk et al. · Nature Communications
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7 May 2026 |
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Epigenetic MLH1 silencing concurs with mismatch repair deficiency in sporadic, naturally occurring colorectal cancer in rhesus macaques
Simon Deycmar et al. · Journal of Translational Medicine
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19 Mar 2024 |
6 |
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A new small molecule DHODH-inhibitor [KIO-100 (PP-001)] targeting activated T cells for intraocular treatment of uveitis — A phase I clinical trial
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17 Oct 2022 |
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Pulmonary and renal tolerance of cisplatin-based regimens combining intravenous and endotracheal routes for lung cancer treatment in mice
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27 Feb 2021 |
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22 Oct 2019 |
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Discovery of UCB9386: A Potent, Selective, and Brain-Penetrant Nuak1 Inhibitor Suitable for In Vivo Pharmacological Studies
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26 Nov 2024 |
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Proceedings of the ISCT scientific signature series symposium, “Advances in cell and gene therapies for lung diseases and critical illnesses”
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22 May 2022 |
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PPARγ activation by leriglitazone counteracts neurodegeneration and neuroinflammation in a disease-relevant mouse model of COASY dysfunction
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13 Apr 2026 |
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Accelerating Neoantigen Discovery: A High-Throughput Approach to Immunogenic Target Identification
Lena Pfitzer, Gitta Boons, Lien Lybaert et al. · Vaccines
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15 Aug 2025 |
4 |
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Amelioration of Central Nervous System Autoimmunity Through FFAR2 Agonism Is Associated With Changes in Gut Microbiota
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28 Feb 2025 |
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Evaluation of a xenogeneic vascular endothelial growth factor-2 vaccine in two preclinical metastatic tumor models in mice
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3 Aug 2017 |
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Jieyi Xiong et al. · Nucleic Acids Research
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13 Nov 2025 |
3 |