Most cited papers from Centre for Life

Centre for Life

What are the most cited papers from Centre for Life?

The most cited paper from Centre for Life is "Spatio-temporal transcriptome of the human brain" (Hyo Jung Kang et al., 2011), with 2,233 citations. Next come "The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6" (1,750) and "Detecting gene–gene interactions that underlie human diseases" (1,388).

Published TypeFieldAccessAuthorsCitations

Showing 50 of 60 papers. Every paper with more than 300 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Spatio-temporal transcriptome of the human brain Hyo Jung Kang et al. · Nature Open access	Oct 2011	2,233
2	The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6 Haruhiko Akiyama, Marie‐Christine Chaboissier, James F. Martin et al. · Genes & Development Open access	Nov 2002	1,750
3	Detecting gene–gene interactions that underlie human diseases Heather Jane Cordell · Nature Reviews Genetics ReviewOpen access	12 May 2009	1,388
4	Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants Paul Robert Burton et al. · Nature Genetics Open access215 authors	21 Oct 2007	1,386
5	Survival in Duchenne muscular dystrophy: improvements in life expectancy since 1967 and the impact of home nocturnal ventilation Michelle Eagle, Simon Baudouin, Colin Chandler et al. · Neuromuscular Disorders	Dec 2002	1,016
6	Assessing salivary cortisol in large-scale, epidemiological research Emma Kristine Adam, Meena Kumari · Psychoneuroendocrinology	3 Aug 2009	937
7	Mitochondrial Dysfunction Accounts for the Stochastic Heterogeneity in Telomere-Dependent Senescence João F. Passos, Gabriele Christine Saretzki, Shaheda Sameena Ahmed et al. · PLoS Biology Open access	27 Apr 2007	799
8	Extracellular control of TGFβ signalling in vascular development and disease Peter ten Dijke, Helen M. Arthur · Nature Reviews Molecular Cell Biology Review	26 Sep 2007	776
9	Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination Edgar A. Otto et al. · Nature Genetics Open access	18 Jul 2003	658
10	DNA sequence and analysis of human chromosome 9 Sean Humphray et al. · Nature Open access148 authors	May 2004	656
11	Aberrant and Alternative Splicing in Cancer Julian P. Venables · Cancer Research	Nov 2004	643
12	Do Interventions Designed to Support Shared Decision-Making Reduce Health Inequalities? A Systematic Review and Meta-Analysis Marie‐Anne Durand, Lewis Carpenter, Hayley Dolan et al. · PLoS ONE ReviewOpen access	15 Apr 2014	637
13	Mutation of Celsr1 Disrupts Planar Polarity of Inner Ear Hair Cells and Causes Severe Neural Tube Defects in the Mouse John A. Curtin, Elizabeth Quint, Vicky Tsipouri et al. · Current Biology Open access	Jul 2003	635
14	NIPBL, encoding a homolog of fungal Scc2-type sister chromatid cohesion proteins and fly Nipped-B, is mutated in Cornelia de Lange syndrome Emma T. Tonkin, Tzu-Jou Wang, Steven Lisgo et al. · Nature Genetics	16 May 2004	606
15	Phylogenetic tree building in the genomic age Paschalia Kapli, Ziheng Yang, Maximilian J. Telford · Nature Reviews Genetics Review	18 May 2020	601
16	SOX9 is required for maintenance of the pancreatic progenitor cell pool Philip Allan Seymour, Kristine Freude, Man N. Tran et al. · Proceedings of the National Academy of Sciences Open access	2 Feb 2007	573
17	Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer Catherine M. Phelan et al. · Nature Genetics Open access420 authors	27 Mar 2017	566
18	In Vitro-Differentiated Embryonic Stem Cells Give Rise to Male Gametes that Can Generate Offspring Mice Karim Nayernia, Jessica Nolte, Hans Wilhelm Michelmann et al. · Developmental Cell Open access	Jul 2006	529
19	Diagnosis and management of vitamin D deficiency Simon H. S. Pearce, Tim D Cheetham · BMJ	11 Jan 2010	528
20	Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease Lyndsey Craven, Helen A. L. Tuppen, Gareth D. Greggains et al. · Nature Open access	13 Apr 2010	485
21	Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus Sébastien Jacquemont et al. · Nature Open access181 authors	30 Aug 2011	484
22	Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer ABCTB Investigators et al. · Nature Genetics Open access476 authors	23 Oct 2017	477
23	Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing the INTERVAL Study et al. · Nature Genetics Open access	Aug 2016	475
24	Revised 2017 international consensus on testing of ANCAs in granulomatosis with polyangiitis and microscopic polyangiitis Xavier Bossuyt et al. · Nature Reviews Rheumatology ReviewOpen access	14 Sep 2017	467
25	FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity Manuela Fanciulli, Penny J. Norsworthy, Enrico G. Petretto et al. · Nature Genetics Open access	21 May 2007	465
26	Refining genotype phenotype correlations in muscular dystrophies with defective glycosylation of dystroglycan Christian Godfrey et al. · Brain Open access	18 Sep 2007	446
27	An Aneuploid Mouse Strain Carrying Human Chromosome 21 with Down Syndrome Phenotypes Aideen O’Doherty, Sandra Ruf, Claire Mulligan et al. · Science Open access	22 Sep 2005	443
28	Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency Rachel Emma Dickinson et al. · Blood Open access	16 Jul 2011	436
29	A meta-analysis of genome-wide association studies identifies multiple longevity genes Joris Deelen et al. · Nature Communications ReviewOpen access	14 Aug 2019	417
30	Deeply conserved synteny resolves early events in vertebrate evolution Oleg Simakov, Ferdinand Marlétaz, Jia‐Xing Yue et al. · Nature Ecology & Evolution Open access	20 Apr 2020	412
31	C3 glomerulopathy — understanding a rare complement-driven renal disease Richard J. Smith, Gerald B. Appel, Anna M. Blom et al. · Nature Reviews Nephrology ReviewOpen access	28 Jan 2019	412
32	Collagen VI related muscle disorders AK Lampe, K M D Bushby · Journal of Medical Genetics Open access	Sep 2005	401
33	Mitochondrial genetics Patrick Francis Chinnery, Gavin Hudson · British Medical Bulletin Open access	22 May 2013	393
34	Downregulation of NANOG Induces Differentiation of Human Embryonic Stem Cells to Extraembryonic Lineages Louise Hyslop, Miodrag Stojković, Lyle Armstrong et al. · Stem Cells Open access	28 Jun 2005	393
35	Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk Fergus J. Couch et al. · PLoS Genetics Open access270 authors	27 Mar 2013	391
36	Homozygous Inactivation of Sox9 Causes Complete XY Sex Reversal in Mice1 Francisco Javier Barrionuevo, Stefan Bagheri‐Fam, Jürgen Klattig et al. · Biology of Reproduction	5 Oct 2005	381
37	Digenic mutations account for variable phenotypes in idiopathic hypogonadotropic hypogonadism Nelly Pitteloud et al. · Journal of Clinical Investigation Open access	19 Jan 2007	381
38	Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics Christoph Muus et al. · Nature Medicine ReviewOpen access235 authors	Mar 2021	379
39	Age-Related Meiotic Segregation Errors in Mammalian Oocytes Are Preceded by Depletion of Cohesin and Sgo2 Lisa Lister, Anna Kouznetsova, Louise Hyslop et al. · Current Biology Open access	Sep 2010	379
40	Effect of BRCA Mutations on Metastatic Relapse and Cause-specific Survival After Radical Treatment for Localised Prostate Cancer Elena Castro et al. · European Urology	6 Nov 2014	376
41	Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index Janine F. Felix et al. · Human Molecular Genetics Open access112 authors	24 Nov 2015	375
42	CD19 is essential for B cell activation by promoting B cell receptor–antigen microcluster formation in response to membrane-bound ligand David Depoil, Sebastian J. Fleire, Bebhinn Treanor et al. · Nature Immunology	2 Dec 2007	371
43	Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia Franck Lebrin, Samly Srun, Karine Raymond et al. · Nature Medicine	Apr 2010	367
44	The role of PI3K/AKT, MAPK/ERK and NFκβ signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis Lyle Armstrong, Owen R. Hughes, Sun Yung et al. · Human Molecular Genetics Open access	27 Apr 2006	366
45	Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease Louise Hyslop et al. · Nature Open access	7 Jun 2016	358
46	Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration Johanna M. Seddon, Yi Yu, Elizabeth Clarke Miller et al. · Nature Genetics Open access	15 Sep 2013	355
47	Hydroxyl radical is a significant player in oxidative DNA damage in vivo Barry B. Halliwell, Amitava Adhikary, Michael Dingfelder et al. · Chemical Society Reviews ReviewOpen access	2021	350
48	Mutations in VPS33B, encoding a regulator of SNARE-dependent membrane fusion, cause arthrogryposis–renal dysfunction–cholestasis (ARC) syndrome Paul Gissen et al. · Nature Genetics	28 Mar 2004	346
49	A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population EMBRACE et al. · Nature Genetics Open access185 authors	19 Sep 2010	344
50	Tumor risks and genotype–phenotype–proteotype analysis in 358 patients with germline mutations inSDHBandSDHD Christopher J. Ricketts et al. · Human Mutation Open access	3 Oct 2009	343

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.