| 1 |
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial
Rafael Rosell et al. · The Lancet Oncology
Open access |
30 Jan 2012 |
5,563 |
| 2 |
Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome
Alain Combes et al. · New England Journal of Medicine
Open access |
23 May 2018 |
2,451 |
| 3 |
High versus Low Blood-Pressure Target in Patients with Septic Shock
Pierre Asfar et al. · New England Journal of Medicine
Open access |
18 Mar 2014 |
1,248 |
| 4 |
Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study
Federico Cappuzzo, Tudor–Eliade Ciuleanu, Lilia V. Stelmakh et al. · The Lancet Oncology
Open access |
21 May 2010 |
1,194 |
| 5 |
Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label, phase 3 trial
Gérard Zalcman et al. · The Lancet
|
22 Dec 2015 |
980 |
| 6 |
Eosinophilic granulomatosis with polyangiitis (Churg‐Strauss): Clinical characteristics and long‐term followup of the 383 patients enrolled in the French Vasculitis Study Group cohort
Cloé Comarmond et al. · Arthritis & Rheumatism
|
8 Oct 2012 |
937 |
| 7 |
Executive summary of the KDIGO 2021 Guideline for the Management of Glomerular Diseases
Brad H. Rovin et al. · Kidney International
Open access |
20 Sep 2021 |
823 |
| 8 |
Venetoclax plus LDAC for newly diagnosed AML ineligible for intensive chemotherapy: a phase 3 randomized placebo-controlled trial
Andrew H. Wei et al. · Blood
Open access |
27 Mar 2020 |
774 |
| 9 |
Antineutrophil Cytoplasmic Antibodies and the Churg–Strauss Syndrome
R. Sablé-Fourtassou, Pascal Cohen, Alfred Mahr et al. · Annals of Internal Medicine
|
Nov 2005 |
688 |
| 10 |
Azathioprine or Methotrexate Maintenance for ANCA-Associated Vasculitis
Christian Pagnoux, Alfred Mahr, Mohamed Amine Hamidou et al. · Yearbook of Medicine
|
24 Dec 2008 |
674 |
| 11 |
Targeted Temperature Management for Cardiac Arrest with Nonshockable Rhythm
Jean-Baptiste Lascarrou et al. · New England Journal of Medicine
Open access |
2 Oct 2019 |
669 |
| 12 |
Epidemiology of Weaning Outcome according to a New Definition. The WIND Study
Gaëtan Beduneau, Tài Pham, Frédérique Schortgen et al. · American Journal of Respiratory and Critical Care Medicine
|
14 Sep 2016 |
651 |
| 13 |
Whipple's Disease
Florence Fenollar, Xavier Puéchal, Didier Raoult · New England Journal of Medicine
|
4 Jan 2007 |
643 |
| 14 |
First-line rituximab combined with short-term prednisone versus prednisone alone for the treatment of pemphigus (Ritux 3): a prospective, multicentre, parallel-group, open-label randomised trial
P. Joly et al. · The Lancet
|
22 Mar 2017 |
622 |
| 15 |
Maintenance therapy with pemetrexed plus best supportive care versus placebo plus best supportive care after induction therapy with pemetrexed plus cisplatin for advanced non-squamous non-small-cell lung cancer (PARAMOUNT): a double-blind, phase 3, randomised controlled trial
Luis G Paz-Ares, Filippo de Marinis, Mircea Dediu et al. · The Lancet Oncology
Open access |
16 Feb 2012 |
617 |
| 16 |
Enteral versus parenteral early nutrition in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group study (NUTRIREA-2)
Jean Reignier et al. · The Lancet
115 authors |
8 Nov 2017 |
592 |
| 17 |
Carboplatin and weekly paclitaxel doublet chemotherapy compared with monotherapy in elderly patients with advanced non-small-cell lung cancer: IFCT-0501 randomised, phase 3 trial
Élisabeth Quoix et al. · The Lancet
|
13 Aug 2011 |
578 |
| 18 |
Eradication of Hepatitis C Virus Infection in Patients With Cirrhosis Reduces Risk of Liver and Non-Liver Complications
Pierre Nahon et al. · Gastroenterology
Open access |
16 Sep 2016 |
540 |
| 19 |
Comorbidities of COPD
Arnaud Cavailles, Graziella Brinchault-Rabin, Adrien Dixmier et al. · European Respiratory Review
Open access |
29 Nov 2013 |
523 |
| 20 |
Randomized Trial Comparing a Web-Mediated Follow-up With Routine Surveillance in Lung Cancer Patients
Fabrice Denis, Claire Lethrosne, Nicolas Pourel et al. · JNCI Journal of the National Cancer Institute
Open access |
15 Feb 2017 |
519 |
| 21 |
Membranous nephropathy
Pierre Marie Ronco, Laurence H. Beck, Hanna Dêbiec et al. · Nature Reviews Disease Primers
Review |
30 Sep 2021 |
476 |
| 22 |
Nivolumab or nivolumab plus ipilimumab in patients with relapsed malignant pleural mesothelioma (IFCT-1501 MAPS2): a multicentre, open-label, randomised, non-comparative, phase 2 trial
Arnaud Scherpereel et al. · The Lancet Oncology
Open access |
16 Jan 2019 |
458 |
| 23 |
Denosumab versus zoledronic acid in bone disease treatment of newly diagnosed multiple myeloma: an international, double-blind, double-dummy, randomised, controlled, phase 3 study
Noopur S Raje, Evangelos Terpos, Wolfgang Willenbacher et al. · The Lancet Oncology
|
9 Feb 2018 |
450 |
| 24 |
Inefficacy of infliximab in primary Sjögren's syndrome: Results of the randomized, controlled trial of remicade in primary Sjögren's syndrome (TRIPSS)
Xavier Mariette, Philippe Ravaud, Serge Daniel Steinfeld et al. · Arthritis & Rheumatism
|
Apr 2004 |
437 |
| 25 |
Interleukin-1 receptor antagonist (anakinra) treatment in patients with systemic-onset juvenile idiopathic arthritis or adult onset Still disease: preliminary experience in France
Thierry Lequerré, Pierre Quartier, David Rosellini et al. · Annals of the Rheumatic Diseases
Open access |
19 Oct 2007 |
406 |
| 26 |
Personalised mechanical ventilation tailored to lung morphology versus low positive end-expiratory pressure for patients with acute respiratory distress syndrome in France (the LIVE study): a multicentre, single-blind, randomised controlled trial
Jean‐Michel Constantin et al. · The Lancet Respiratory Medicine
Open access |
6 Aug 2019 |
402 |
| 27 |
Treatment of Churg‐Strauss syndrome without poor‐prognosis factors: A multicenter, prospective, randomized, open‐label study of seventy‐two patients
Camillo Ribi, Pascal Cohen, Christian Pagnoux et al. · Arthritis & Rheumatism
Open access |
31 Jan 2008 |
335 |
| 28 |
Prospective Evaluation of Magnetic Resonance Imaging and [ 18 F]Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography at Diagnosis and Before Maintenance Therapy in Symptomatic Patients With Multiple Myeloma Included in the IFM/DFCI 2009 Trial: Results of the IMAJEM Study
Philippe Moreau et al. · Journal of Clinical Oncology
Open access |
7 Jul 2017 |
329 |
| 29 |
Plant-based diets to manage the risks and complications of chronic kidney disease
Juan Jesús Carrero, Ailema González-Ortíz, Carla María Avesani et al. · Nature Reviews Nephrology
ReviewOpen access |
11 Jun 2020 |
322 |
| 30 |
Safety and Efficacy of Immune Checkpoint Inhibitors in Patients With Cancer and Preexisting Autoimmune Disease: A Nationwide, Multicenter Cohort Study
Alice Tison et al. · Arthritis & Rheumatology
Open access |
5 Aug 2019 |
321 |
| 31 |
Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial
William W. Busse et al. · The Lancet Respiratory Medicine
460 authors |
8 Nov 2018 |
316 |
| 32 |
Epidemiology of adult Still's disease: estimate of the incidence by a retrospective study in west France.
G Magadur-Joly, Éric Billaud, J.-H. Barrier et al. · Annals of the Rheumatic Diseases
Open access |
Jul 1995 |
313 |
| 33 |
Hyperoxia and hypertonic saline in patients with septic shock (HYPERS2S): a two-by-two factorial, multicentre, randomised, clinical trial
Pierre Asfar et al. · The Lancet Respiratory Medicine
|
15 Feb 2017 |
311 |
| 34 |
Efficacy of ketogenic diet in severe refractory status epilepticus initiating fever induced refractory epileptic encephalopathy in school age children (FIRES)
Rima Nabbout, Michel Mazzuca, Philippe Hubert et al. · Epilepsia
|
31 Aug 2010 |
311 |
| 35 |
Early-onset invasive aspergillosis and other fungal infections in patients treated with ibrutinib
David Ghez, Anne Calleja, Caroline A. Protin et al. · Blood
|
Feb 2018 |
309 |
| 36 |
Risk Factors for Bullous Pemphigoid in the Elderly: A Prospective Case–Control Study
Sylvie Bastuji‐Garin, P. Joly, Pauline Lemordant et al. · Journal of Investigative Dermatology
Open access |
14 Oct 2010 |
303 |
| 37 |
Vasculitides associated with malignancies: Analysis of sixty patients
Olivier Fain et al. · Arthritis Care & Research
|
29 Nov 2007 |
299 |
| 38 |
Sleep Apnea–Specific Hypoxic Burden, Symptom Subtypes, and Risk of Cardiovascular Events and All-Cause Mortality
Wojciech Trzepizur, Margaux Blanchard, Timothée Ganem et al. · American Journal of Respiratory and Critical Care Medicine
|
14 Oct 2021 |
296 |
| 39 |
Drug-specific risk of non-tuberculosis opportunistic infections in patients receiving anti-TNF therapy reported to the 3-year prospective French RATIO registry
Dominique Salmon‐Céron, Florence Tubach, Olivier Lortholary et al. · Annals of the Rheumatic Diseases
|
21 Dec 2010 |
286 |
| 40 |
Comparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury (AKIKI 2): a multicentre, open-label, randomised, controlled trial
Stèphane Gaudry et al. · The Lancet
Open access |
Apr 2021 |
285 |
| 41 |
VTD is superior to VCD prior to intensive therapy in multiple myeloma: results of the prospective IFM2013-04 trial
Philippe Moreau et al. · Blood
Open access |
21 Mar 2016 |
280 |
| 42 |
Symptoms of Anxiety, Depression, and Peritraumatic Dissociation in Critical Care Clinicians Managing Patients with COVID-19. A Cross-Sectional Study
Élie Azoulay et al. · American Journal of Respiratory and Critical Care Medicine
Open access |
31 Aug 2020 |
279 |
| 43 |
Efficient strategy for the molecular diagnosis of intellectual disability using targeted high-throughput sequencing
Claire E. Redin et al. · Journal of Medical Genetics
Open access |
28 Aug 2014 |
277 |
| 44 |
Eprodisate for the Treatment of Renal Disease in AA Amyloidosis
Laura M. Dember, Philip Nigel Hawkins, Bouke P. C. Hazenberg et al. · New England Journal of Medicine
|
6 Jun 2007 |
274 |
| 45 |
Low versus standard calorie and protein feeding in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group trial (NUTRIREA-3)
Jean Reignier et al. · The Lancet Respiratory Medicine
Open access161 authors |
20 Mar 2023 |
270 |
| 46 |
High-flow nasal cannula oxygen during endotracheal intubation in hypoxemic patients: a randomized controlled clinical trial
Mickaël Vourc’h, Pierre Asfar, Christelle Volteau et al. · Intensive Care Medicine
Open access |
13 Apr 2015 |
265 |
| 47 |
Pembrolizumab Plus Ipilimumab or Placebo for Metastatic Non–Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score ≥ 50%: Randomized, Double-Blind Phase III KEYNOTE-598 Study
Michael Joseph Boyer et al. · Journal of Clinical Oncology
Open access |
29 Jan 2021 |
261 |
| 48 |
Adalimumab for steroid sparing in patients with giant-cell arteritis: results of a multicentre randomised controlled trial
Raphaèle Séror, Gabriel Baron, Eric HACHULLA et al. · Annals of the Rheumatic Diseases
|
29 Jul 2013 |
255 |
| 49 |
Effect of Influenza Vaccination of Nursing Home Staff on Mortality of Residents: A Cluster‐Randomized Trial
Magali Lemaître, Thierry Meret, Monique Rothan‐Tondeur et al. · Journal of the American Geriatrics Society
|
4 Aug 2009 |
254 |
| 50 |
Treatment of polyarteritis nodosa and microscopic polyangiitis with poor prognosis factors: A prospective trial comparing glucocorticoids and six or twelve cyclophosphamide pulses in sixty‐five patients
Loïc Guillevin, Pascal Cohen, Alfred Mahr et al. · Arthritis Care & Research
|
7 Feb 2003 |
253 |