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Institution · Charles River Laboratories (Netherlands)

Most cited papers from Charles River Laboratories (Netherlands)

Charles River Laboratories (Netherlands)

What are the most cited papers from Charles River Laboratories (Netherlands)?

The most cited paper from Charles River Laboratories (Netherlands) is "Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index" (Jagath R. Junutula et al., 2008), with 1,386 citations. Next come "Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease" (842) and "Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System" (659).

Showing 50 of 61 papers. Every paper with more than 66 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index Jagath R. Junutula et al. · Nature Biotechnology 20 Jul 2008 1,386
2 Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease Jin‐Kuk Kim et al. · New England Journal of Medicine Open access 9 Oct 2019 842
3 Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System Bob Thoolen, Robert R. Maronpot, Takanori Harada et al. · Toxicologic Pathology Open access Dec 2010 659
4 Uptake, Whole-Body Distribution, and Depuration of Nanoplastics by the Scallop Pecten maximus at Environmentally Realistic Concentrations Maya Al-Sid-Cheikh, Steve Rowland, Karen A. Stevenson et al. · Environmental Science & Technology Open access 20 Nov 2018 398
5 Histological and Ultrastructural Evaluation of the Effects of a Radiofrequency-Based Nonablative Dermal Remodeling Device Brian D. Zelickson, David A. Kist, Eric F. Bernstein et al. · Archives of Dermatology Feb 2004 385
6 Collagen‐platelet rich plasma hydrogel enhances primary repair of the porcine anterior cruciate ligament Martha Meaney Murray, Kurt P. Spindler, Eduardo Lima de Abreu et al. · Journal of Orthopaedic Research® 9 Oct 2006 322
7 The Inflammasome Sensor, NLRP3, Regulates CNS Inflammation and Demyelination via Caspase-1 and Interleukin-18 Sushmita Jha, Siddharth Y. Srivastava, W. June Brickey et al. · Journal of Neuroscience Open access 24 Nov 2010 312
8 Chemical enhancement of percutaneous absorption in relation to stratum corneum structural alterations T. Marjukka Suhonen, Joke A. Bouwstra, Arto O. Urtti · Journal of Controlled Release May 1999 311
9 The (Pro)renin Receptor/ATP6AP2 is Essential for Vacuolar H + -ATPase Assembly in Murine Cardiomyocytes Kenichiro Kinouchi, Atsuhiro Ichihara, Motoaki Sano et al. · Circulation Research Open access 23 Jun 2010 303
10 Proliferative and Nonproliferative Lesions of the Rat and Mouse Male Reproductive System Dianne M. Creasy, Axel Bube, Eveline de Rijk et al. · Toxicologic Pathology Aug 2012 252
11 Engineered antibody-drug conjugates with defined sites and stoichiometries of drug attachment Charlotte Fenton McDonagh, Eileen Turcott, Lori Westendorf et al. · Protein Engineering Design and Selection Open access 18 Apr 2006 242
12 Swine as Models in Experimental Surgery M. Michael Swindle, Alison C. Smith, Bradley J. S. Hepburn · Journal of Investigative Surgery 1988 224
13 Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells Nadia Vié, Virginie Copois, Caroline Mollévi et al. · Molecular Cancer Open access 25 Jan 2008 224
14 Towards sustainable flood risk management in the Rhine and Meuse river basins: synopsis of the findings of IRMA‐SPONGE A. Hooijer, Frans Klijn, Bas Pedroli et al. · River Research and Applications Open access May 2004 208
15 Nest Building as an Indicator of Health and Welfare in Laboratory Mice Brianna N. Gaskill, Alicia Z. Karas, Joseph Paul Garner et al. · Journal of Visualized Experiments Open access 23 Dec 2013 192
16 STP Position Paper Brad N. Bolon, Robert H. Garman, Ingrid D. R. Pardo et al. · Toxicologic Pathology Open access 7 Mar 2013 191
17 Developmental and reproductive toxicology studies in nonhuman primates Gary J. Chellman, Jeanine L. Bussiere, Norbert Makori et al. · Birth Defects Research Part B Developmental and Reproductive Toxicology Dec 2009 159
18 Transgenic Mice Expressing a Truncated Form of the High Mobility Group I-C Protein Develop Adiposity and an Abnormally High Prevalence of Lipomas Paola Arlotta, Albert Tai, Guidalberto Manfioletti et al. · Journal of Biological Chemistry Open access May 2000 155
19 Formation, Clearance, Deposition, Pathogenicity, and Identification of Biopharmaceutical-related Immune Complexes Jennifer L. Rojko, Mark Gordon Evans, Shari A. Price et al. · Toxicologic Pathology 3 Apr 2014 150
20 Mouse lymphoma thymidine kinase gene mutation assay: Follow‐up meeting of the international workshop on Genotoxicity testing—Aberdeen, Scotland, 2003—Assay acceptance criteria, positive controls, and data evaluation Martha M. Moore et al. · Environmental and Molecular Mutagenesis 30 Jun 2005 143
21 Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington’s disease Xiao‐Hong Lu et al. · Science Translational Medicine 24 Dec 2014 140
22 Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies Diana W. Shineman, Guriqbal S. Basi, Jennifer L. Bizon et al. · Alzheimer s Research & Therapy Open access 2011 137
23 Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation. Jeff Ceci, Christos Patriotis, Christos Tsatsanis et al. · Genes & Development Open access 15 Mar 1997 137
24 A theoretical investigation of generalized voters for redundant systems P.R. Lorczak, A. K. Caglayan, Dave E. Eckhardt Conference paper 7 Jan 2003 136
25 Phagocytosis of Wnt inhibitor SFRP4 by late wound macrophages drives chronic Wnt activity for fibrotic skin healing Denise L. Gay, Giulia Ghinatti, Christian Fernando Guerrero‐Juarez et al. · Science Advances Open access 20 Mar 2020 131
26 Toxicity of copper oxide and basic copper carbonate nanoparticles after short-term oral exposure in rats Wim H. de Jong, Eveline de Rijk, Alessandro Bonetto et al. · Nanotoxicology Open access 19 Nov 2018 131
27 Modeling the dynamics of spring-driven oscillating-foil propulsion Karen A. Harper, M.D. Berkemeier, Sheryl M. Grace · IEEE Journal of Oceanic Engineering Jul 1998 130
28 Phosphodiesterase 10A Inhibition Improves Cortico-Basal Ganglia Function in Huntington’s Disease Models Vahri Beaumont et al. · Neuron Open access Dec 2016 123
29 C-Reactive Protein as a Prognostic Marker After Lacunar Stroke Mitchell S.V. Elkind et al. · Stroke Open access277 authors 13 Feb 2014 117
30 Synaptosome Proteomics Fengju Bai, Frank A. Witzmann · Sub-cellular biochemistry/Subcellular biochemistry Book chapterOpen access 2007 114
31 Cutaneous Delivery of a Live, Attenuated Chimeric Flavivirus Vaccines against Japanese Encephalitis (ChimeriVaxTM-JE) in Non-Human Primates Cheryl H. Dean, Jason B. Alarcon, Andrea M. Waterston et al. · Human Vaccines Open access May 2005 113
32 Histone Deacetylase Inhibitors Stimulate Histone H3 Lysine 4 Methylation in Part Via Transcriptional Repression of Histone H3 Lysine 4 Demethylases Po-Hsien Huang, Chun-Han Chen, Chih-Chien Chou et al. · Molecular Pharmacology Open access 20 Oct 2010 111
33 Production of levan by Bacillus licheniformis NS032 in sugar beet molasses-based medium G.D. Gojgic-Cvijovic, Dragica M. Jakovljević, Branka Lončarević et al. · International Journal of Biological Macromolecules Open access 3 Oct 2018 106
34 Romosozumab Improves Bone Mass and Strength While Maintaining Bone Quality in Ovariectomized Cynomolgus Monkeys Michael S. Ominsky, Steven K. Boyd, Aurore Varela et al. · Journal of Bone and Mineral Research Open access 10 Nov 2016 106
35 Proliferative and Nonproliferative Lesions of the Rat and Mouse Mammary, Zymbal’s, Preputial, and Clitoral Glands Daniel G. Rudmann, Robert D. Cardiff, Luc Chouinard et al. · Toxicologic Pathology Aug 2012 106
36 Methods for Volumetric Reconstruction of Visual Scenes Greg Slabaugh, W. Bruce Culbertson, Thomas Malzbender et al. · International Journal of Computer Vision 22 Jan 2004 103
37 Palladium(II)-Catalysed Oxidation of Alkenes Tom D. Sheppard, Sam E. Mann, Laure Benhamou · Synthesis 26 Aug 2015 102
38 Downstream changes in the composition, numbers and biomass of bottom fauna in the Tees below Cow Green Reservoir and in an unregulated tributary Maize Beck, in the first five years after impoundment Patrick D. Armitage · Hydrobiologia Apr 1978 100
39 The use of prediction to assess macroinvertebrate response to river regulation Patrick D. Armitage, R.J.M. Gunn, M.T. Furse et al. · Hydrobiologia 1987 99
40 Preparation of Animals for Research--Issues to Consider for Rodents and Rabbits Laura A Conour, Kathleen A. Murray, Marilyn J. Brown · ILAR Journal 2006 98
41 An ASO therapy for Angelman syndrome that targets an evolutionarily conserved region at the start of the UBE3A-AS transcript Scott V. Dindot et al. · Science Translational Medicine 22 Mar 2023 97
42 Manual Restraint and Common Compound Administration Routes in Mice and Rats Elton Machholz, Guy B Mulder, Casimira Ruiz et al. · Journal of Visualized Experiments Open access 26 Sep 2012 95
43 Classification and reporting of severity experienced by animals used in scientific procedures: FELASA/ECLAM/ESLAV Working Group report David W. Smith, David Anderson, Anne‐Dominique A. Y. Degryse et al. · Laboratory Animals Open access 23 Jan 2018 89
44 In vivo distribution of carotenoids in different anatomical locations of human skin: comparative assessment with two different Raman spectroscopy methods Maxim E. Darvin, Joachim W. Fluhr, Peter J. Caspers et al. · Experimental Dermatology Open access 24 Jul 2009 89
45 The effects of mine drainage and organic enrichment on benthos in the river nent system, Northern Pennines Patrick D. Armitage · Hydrobiologia Sep 1980 85
46 Drug screening and genome editing in human pancreatic cancer organoids identifies drug-gene interactions and candidates for off-label therapy Christian Hirt et al. · Cell Genomics Open access Feb 2022 84
47 Quantification Assays for Total and Polyglutamine-Expanded Huntingtin Proteins Douglas Macdonald, Michela Tessari, Ivette Boogaard et al. · PLoS ONE Open access 9 May 2014 78
48 Skeletal health: primate model of postmenopausal osteoporosis S. Y. Smith, Jacquelin Jolette, Charles H. Turner · American Journal of Primatology 2 Jun 2009 76
49 Murine Noroviruses Bind Glycolipid and Glycoprotein Attachment Receptors in a Strain-Dependent Manner Stefan Taube, Jeffrey W. Perry, Eoghan McGreevy et al. · Journal of Virology Open access 23 Mar 2012 76
50 Botulinum a toxin for spasmodic torticollis: Multiple vs single injection points per muscle Gary Edward Borodic, L. Bruce Pearce, Karen L. Smith et al. · Head & Neck 1992 76

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.