Most cited papers from Children’s Institute

Children’s Institute

What are the most cited papers from Children’s Institute?

The most cited paper from Children’s Institute is "Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep" (Kenneth W. Liechty, Tippi C. MacKenzie, Aimen F. Shaaban et al., 2000), with 1,226 citations. Next come "De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly" (711) and "Meta-analysis of the diagnostic and clinical utility of genome and exome sequencing and chromosomal microarray in children with suspected genetic diseases" (654).

Published TypeFieldAccessAuthorsCitations

Showing 50 of 60 papers. Every paper with more than 179 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep Kenneth W. Liechty, Tippi C. MacKenzie, Aimen F. Shaaban et al. · Nature Medicine	Nov 2000	1,226
2	De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly Jeong Ho Lee, My N. Huynh, Jennifer L. Silhavy et al. · Nature Genetics Open access	24 Jun 2012	711
3	Meta-analysis of the diagnostic and clinical utility of genome and exome sequencing and chromosomal microarray in children with suspected genetic diseases Michelle M. Clark, Zornitza Stark, Lauge Farnaes et al. · npj Genomic Medicine ReviewOpen access	7 Jun 2018	654
4	Positive childhood experiences predict less psychopathology and stress in pregnant women with childhood adversity: A pilot study of the benevolent childhood experiences (BCEs) scale Angela J. Narayan, Luisa Maria Rivera, Rosemary E. Bernstein et al. · Child Abuse & Neglect	12 Oct 2017	557
5	Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission Smruthi Karthikeyan et al. · Nature Open access118 authors	7 Jul 2022	533
6	Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways Xiang Wang, Xinxin Chen, Wenqian Zhou et al. · Acta Pharmaceutica Sinica B Open access	19 Oct 2021	528
7	Mesenchymal stem cells: paradoxes of passaging Elisabeth H. Javazon, Kirstin J. Beggs, Alan W. Flake · Experimental Hematology Open access	May 2004	526
8	Infectious Entry Pathway of Adeno-Associated Virus and Adeno-Associated Virus Vectors Jeffrey S. Bartlett, Rose Wilcher, Richard Jude Samulski · Journal of Virology Open access	15 Mar 2000	520
9	Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure Georgios Karamanlidis, Chi Fung Lee, Lorena Garcia‐Menendez et al. · Cell Metabolism Open access	Aug 2013	481
10	Rapid whole-genome sequencing decreases infant morbidity and cost of hospitalization Lauge Farnaes, Amber Hildreth, Nathaly M. Sweeney et al. · npj Genomic Medicine Open access	29 Mar 2018	470
11	Results of the Dana-Farber Cancer Institute ALL Consortium Protocol 95-01 for children with acute lymphoblastic leukemia Albert Moghrabi, Donna Elise Levy, Barbara L. Asselin et al. · Blood Open access	26 Sep 2006	408
12	Characterization of Greater Middle Eastern genetic variation for enhanced disease gene discovery Eric M. Scott, Anason S. Halees, Yuval Itan et al. · Nature Genetics Open access	18 Jul 2016	401
13	Unsupervised Analysis of Transcriptomics in Bacterial Sepsis Across Multiple Datasets Reveals Three Robust Clusters Timothy E. Sweeney et al. · Critical Care Medicine Open access	14 Mar 2018	388
14	Extra-embryonic function of Rb is essential for embryonic development and viability Lizhao Wu, Alain de Bruin, Harold Ivan Saavedra et al. · Nature	Feb 2003	385
15	Psychological Functioning and Coping Among Mothers of Children With Autism: A Population-Based Study Guillermo Montes, Jill S. Halterman · PEDIATRICS	May 2007	381
16	Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder Dora C. Tărlungeanu et al. · Cell Open access	Dec 2016	376
17	A Randomized, Controlled Trial of the Analytic and Diagnostic Performance of Singleton and Trio, Rapid Genome and Exome Sequencing in Ill Infants Stephen F. Kingsmore et al. · The American Journal of Human Genetics Open access	26 Sep 2019	366
18	Sleep disturbance preceding completed suicide in adolescents. Tina R. Goldstein, Jeffrey A. Bridge, David A. Brent · Journal of Consulting and Clinical Psychology Open access	29 Jan 2008	365
19	CEC’s Standards for Classifying the Evidence Base of Practices in Special Education Bryan G. Cook, Virginia Buysse, Janette Kettmann Klingner et al. · Remedial and Special Education	6 Nov 2014	360
20	Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system Kim-Chew Lim, Ganesh Lakshmanan, Susan E. Crawford et al. · Nature Genetics	Jun 2000	344
21	A Comparison of High-Dose and Standard-Dose Epinephrine in Children with Cardiac Arrest Beatriz Perondi, Amélia G. Reis, Edison Ferreira de Paiva et al. · New England Journal of Medicine Open access	21 Apr 2004	325
22	Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures Joo Sang Lee et al. · Cell Open access	9 Aug 2018	309
23	Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation Hongda Li, Laura Paula Saucedo-Cuevas, José Ángel Regla-Nava et al. · Cell stem cell Open access	22 Aug 2016	308
24	Infection of Ciliated Cells by Human Parainfluenza Virus Type 3 in an In Vitro Model of Human Airway Epithelium Liqun Zhang, Alexander A. Bukreyev, Catherine Thompson et al. · Journal of Virology Open access	21 Dec 2004	308
25	Diagnosis of genetic diseases in seriously ill children by rapid whole-genome sequencing and automated phenotyping and interpretation Michelle M. Clark et al. · Science Translational Medicine Open access	24 Apr 2019	307
26	Patient care standards for primary mitochondrial disease: a consensus statement from the Mitochondrial Medicine Society Sumit Parikh et al. · Genetics in Medicine Open access	27 Jul 2017	303
27	Neutrophil elastase increasesMUC5ACmRNA and protein expression in respiratory epithelial cells Judith A. Voynow, Lisa R. Young, Yiqiong Wang et al. · American Journal of Physiology-Lung Cellular and Molecular Physiology	May 1999	278
28	Host gene expression classifiers diagnose acute respiratory illness etiology Ephraim L. Tsalik et al. · Science Translational Medicine Open access	20 Jan 2016	276
29	The relationship of meteorological conditions to the epidemic activity of respiratory syncytial virus Salim Yusuf, Giovanni Piedimonte, Alexander Auais et al. · Epidemiology and Infection Open access	8 Mar 2007	268
30	Quantitative PCR Assessments of Bacterial Species in Women with and without Bacterial Vaginosis Marcela Zozaya-Hinchliffe, Rebecca Lillis, David H. Martin et al. · Journal of Clinical Microbiology Open access	20 Mar 2010	266
31	Frequency and spectrum of central nervous system involvement in 193 children with haemophagocytic lymphohistiocytosis AnnaCarin Horne, Helena Trottestam, Maurizio Aricò et al. · British Journal of Haematology	10 Dec 2007	266
32	DIMINISHED INTERLEUKIN 6 (IL-6) PRODUCTION DURING SCARLESS HUMAN FETAL WOUND REPAIR Kenneth W. Liechty, N. Scott Adzick, Timothy M. Crombleholme · Cytokine Open access	Jun 2000	263
33	A community approach to mortality prediction in sepsis via gene expression analysis Timothy E. Sweeney et al. · Nature Communications Open access	9 Feb 2018	261
34	Project Baby Bear: Rapid precision care incorporating rWGS in 5 California children’s hospitals demonstrates improved clinical outcomes and reduced costs of care David Dimmock et al. · The American Journal of Human Genetics Open access	4 Jun 2021	259
35	Effects of Therapy in X-Linked Hypophosphatemic Rickets Charles F. Verge, ALBERT H. LAM, Judy M. Simpson et al. · New England Journal of Medicine Open access	26 Dec 1991	252
36	Acute-alcohol effects on the Experiential Discounting Task (EDT) and a question-based measure of delay discounting Brady A. Reynolds, Jerry B. Richards, Harriet de Wit · Pharmacology Biochemistry and Behavior	Feb 2006	251
37	Fetal wound repair results in scar formation in interleukin-10–deficient mice in a syngeneic murine model of scarless fetal wound repair Kenneth W. Liechty, Heung B. Kim, N. Scott Adzick et al. · Journal of Pediatric Surgery Open access	Jun 2000	250
38	Autism spectrum disorder: Parenting stress, family functioning and health-related quality of life. Norah L. Johnson, Marilyn Frenn, SUZANNE L. FEETHAM et al. · Families Systems & Health Open access	Sep 2011	242
39	Newborn Sequencing in Genomic Medicine and Public Health Jonathan S. Berg et al. · PEDIATRICS Open access	17 Jan 2017	238
40	Haematopoietic stem cell transplantation in haemophagocytic lymphohistiocytosis AnnaCarin Horne, Gritta Janka, Rudolph Maarten Egeler et al. · British Journal of Haematology	23 May 2005	236
41	Role of fibroblast growth factor receptors 1 and 2 in the ureteric bud Haotian Zhao, Heather Kegg, Sandy Grady et al. · Developmental Biology Open access	28 Sep 2004	231
42	Traumatic and stressful events in early childhood: Can treatment help those at highest risk? Chandra Ghosh Ippen, William W. Harris, Patricia Van Horn et al. · Child Abuse & Neglect Open access	Jul 2011	230
43	The NSIGHT1-randomized controlled trial: rapid whole-genome sequencing for accelerated etiologic diagnosis in critically ill infants Josh E Petrikin, Julie A. Cakici, Michelle M. Clark et al. · npj Genomic Medicine Open access	5 Feb 2018	227
44	Paternally inherited cis-regulatory structural variants are associated with autism William M. Brandler et al. · Science Open access	20 Apr 2018	225
45	Child perpetrators—children who molest other children: Preliminary findings Toni Cavanagh Johnson · Child Abuse & Neglect	1988	220
46	Structural airway abnormalities in infants and young children with cystic fibrosis Frederick R. Long, Roger S. Williams, Robert G. Castile · The Journal of Pediatrics	Feb 2004	210
47	Association of Childhood Autism Spectrum Disorders and Loss of Family Income Guillermo Montes, Jill S. Halterman · PEDIATRICS	Apr 2008	200
48	The plasma zinc/serum copper ratio as a biomarker in children with autism spectrum disorders Scott Faber, Gregory M. Zinn, John C. Kern et al. · Biomarkers	11 Mar 2009	198
49	Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors H. Stacy Nicholson, Cynthia S. Kretschmar, Mark Krailo et al. · Cancer	17 Aug 2007	196
50	Rapid whole genome sequencing and precision neonatology Joshua Erin Petrikin, Laurel K. Willig, Laurie D. Smith et al. · Seminars in Perinatology Open access	3 Nov 2015	195

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.