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Most cited papers from Conaris

Conaris

What are the most cited papers from Conaris?

The most cited paper from Conaris is "Efficacy of Sterile Fecal Filtrate Transfer for Treating Patients With Clostridium difficile Infection" (Stephan Johannes Ott, Georg H. Waetzig, Ateequr Rehman et al., 2016), with 729 citations. Next come "Increased Tryptophan Metabolism Is Associated With Activity of Inflammatory Bowel Diseases" (606) and "Sarcoidosis is associated with a truncating splice site mutation in BTNL2" (487).

Showing 50 of 70 papers. Every paper is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Efficacy of Sterile Fecal Filtrate Transfer for Treating Patients With Clostridium difficile Infection Stephan Johannes Ott, Georg H. Waetzig, Ateequr Rehman et al. · Gastroenterology Open access 18 Nov 2016 729
2 Increased Tryptophan Metabolism Is Associated With Activity of Inflammatory Bowel Diseases Susanna Nikolaus, Berenice Schulte, Natalie Al-Massad et al. · Gastroenterology Open access 19 Aug 2017 606
3 Sarcoidosis is associated with a truncating splice site mutation in BTNL2 Ruta Valentonyte et al. · Nature Genetics 27 Feb 2005 487
4 Genetic variation in DLG5 is associated with inflammatory bowel disease Monika Stoll, Brit Corneliussen, Christine M. Costello et al. · Nature Genetics Open access 11 Apr 2004 471
5 The IL-6/sIL-6R complex as a novel target for therapeutic approaches Stefan Rose‐John, Georg H. Waetzig, Jürgen Scheller et al. · Expert Opinion on Therapeutic Targets 27 Apr 2007 364
6 Metabolic Functions of Gut Microbes Associate With Efficacy of Tumor Necrosis Factor Antagonists in Patients With Inflammatory Bowel Diseases Konrad Aden et al. · Gastroenterology Open access 18 Jul 2019 279
7 Therapeutic Interleukin-6 Trans-signaling Inhibition by Olamkicept (sgp130Fc) in Patients With Active Inflammatory Bowel Disease Stefan Schreiber et al. · Gastroenterology Open access 2 Mar 2021 266
8 Transsignaling of Interleukin-6 Crucially Contributes to Atherosclerosis in Mice Harald Schuett, René Oestreich, Georg H. Waetzig et al. · Arteriosclerosis Thrombosis and Vascular Biology 11 Nov 2011 248
9 Transgenic blockade of interleukin 6 transsignaling abrogates inflammation Björn Rabe, Athena Chalaris, Ulrike May et al. · Blood 8 Nov 2007 244
10 The balance of interleukin (IL)-6, IL-6·soluble IL-6 receptor (sIL-6R), and IL-6·sIL-6R·sgp130 complexes allows simultaneous classic and trans-signaling Paul Baran, Selina Hansen, Georg H. Waetzig et al. · Journal of Biological Chemistry Open access 20 Mar 2018 235
11 Dissection of the Inflammatory Bowel Disease Transcriptome Using Genome-Wide cDNA Microarrays Christine M. Costello, Nancy Mah, Robert Häsler et al. · PLoS Medicine Open access 18 Aug 2005 232
12 Inhibition of Classic Signaling Is a Novel Function of Soluble Glycoprotein 130 (sgp130), Which Is Controlled by the Ratio of Interleukin 6 and Soluble Interleukin 6 Receptor Christoph Garbers, Wolfgang Maximilian Thaiss, Gareth Wyn Jones et al. · Journal of Biological Chemistry Open access 12 Oct 2011 210
13 Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model* Tanja Barkhausen, Thomas Tschernig, Philip C Rosenstiel et al. · Critical Care Medicine 18 Feb 2011 169
14 Distinct Effects of IL-6 Classic and Trans -Signaling in Bone Fracture Healing Katja Prystaz, Kathrin Kaiser, Anna Kovtun et al. · American Journal Of Pathology Open access 13 Nov 2017 141
15 Proteolytic Cleavage Governs Interleukin-11 Trans-signaling Juliane Lokau, Rebecca Nitz, Maria Agthe et al. · Cell Reports Open access Feb 2016 133
16 An Interleukin-6 Receptor-dependent Molecular Switch Mediates Signal Transduction of the IL-27 Cytokine Subunit p28 (IL-30) via a gp130 Protein Receptor Homodimer Christoph Garbers, Björn Spudy, Samadhi Aparicio-Siegmund et al. · Journal of Biological Chemistry Open access 4 Dec 2012 131
17 A short isoform of NOD2/CARD15, NOD2-S, is an endogenous inhibitor of NOD2/receptor-interacting protein kinase 2-induced signaling pathways Philip C Rosenstiel, Klaus Huse, Andreas Till et al. · Proceedings of the National Academy of Sciences 21 Feb 2006 117
18 Soluble tumor necrosis factor (TNF) receptor‐1 induces apoptosis via reverse TNF signaling and autocrine transforming growth factor‐β1 Georg H. Waetzig, Philip C Rosenstiel, Alexander Arlt et al. · The FASEB Journal 28 Oct 2004 113
19 Inhibition of IL‐6 signaling significantly reduces primary tumor growth and recurrencies in orthotopic xenograft models of pancreatic cancer Freya A. Goumas, Reinhild Holmer, Jan‐Hendrik Egberts et al. · International Journal of Cancer 21 Jan 2015 111
20 Interleukin-6: a villain in the drama of pancreatic cancer development and progression Reinhild Holmer, Freya A. Goumas, Georg H. Waetzig et al. · Hepatobiliary & pancreatic diseases international Aug 2014 110
21 Targeted Microbiome Intervention by Microencapsulated Delayed-Release Niacin Beneficially Affects Insulin Sensitivity in Humans Daniela Fangmann et al. · Diabetes Care Open access 6 Dec 2017 107
22 Different Soluble Forms of the Interleukin-6 Family Signal Transducer gp130 Fine-tune the Blockade of Interleukin-6 Trans-signaling Janina Wolf, Georg H. Waetzig, Athena Chalaris et al. · Journal of Biological Chemistry Open access 24 May 2016 94
23 Genome-Wide Expression Profiling Identifies an Impairment of Negative Feedback Signals in the Crohn’s Disease-Associated NOD2 Variant L1007fsinsC Susanne Billmann-Born, Andreas Till, Alexander Arlt et al. · The Journal of Immunology 19 Feb 2011 89
24 Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses Larissa Lamertz, Franziska Rummel, Robin Polz et al. · Science Signaling 2 Oct 2018 88
25 The Met-196 → Arg Variation of Human Tumor Necrosis Factor Receptor 2 (TNFR2) Affects TNF-α-induced Apoptosis by Impaired NF-κB Signaling and Target Gene Expression Andreas Till, Philip C Rosenstiel, Anja Krippner‐Heidenreich et al. · Journal of Biological Chemistry Open access Dec 2004 88
26 Hitting a complex target: an update on interleukin-6 trans-signalling Georg H. Waetzig, Stefan Rose‐John · Expert Opinion on Therapeutic Targets Feb 2012 83
27 Suppression of Map Kinases Inhibits Microglial Activation and Attenuates Neuronal Cell Death Induced by α-Synuclein Protofibrils Henrik Wilms, Philip C Rosenstiel, Marina Romero‐Ramos et al. · International Journal of Immunopathology and Pharmacology Oct 2009 81
28 Pharmacological inhibition of IL-6 trans-signaling improves compromised fracture healing after severe trauma Kathrin Kaiser, Katja Prystaz, Anna Vikman et al. · Naunyn-Schmiedeberg s Archives of Pharmacology Open access Mar 2018 74
29 Structure-guided Optimization of the Interleukin-6 Trans-signaling Antagonist sgp130 Stephanie Tenhumberg, Georg H. Waetzig, Athena Chalaris et al. · Journal of Biological Chemistry Open access 24 Jul 2008 72
30 N-Linked Glycosylation Is Essential for the Stability but Not the Signaling Function of the Interleukin-6 Signal Transducer Glycoprotein 130 Georg H. Waetzig, Athena Chalaris, Philip C Rosenstiel et al. · Journal of Biological Chemistry Open access 14 Nov 2009 65
31 Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis Jan Sodenkamp, Georg H. Waetzig, Jürgen Scheller et al. · Immunobiology 20 Jan 2012 64
32 Evaluation of interleukin-6 and its soluble receptor components sIL-6R and sgp130 as markers of inflammation in inflammatory bowel diseases Susanna Nikolaus, Georg H. Waetzig, Sven Butzin et al. · International Journal of Colorectal Disease Open access 11 May 2018 62
33 A role for membrane-bound CD147 in NOD2-mediated recognition of bacterial cytoinvasion Andreas Till, Philip C Rosenstiel, Karen Bräutigam et al. · Journal of Cell Science 6 Feb 2008 54
34 Tocilizumab does not block interleukin-6 (IL-6) signaling in murine cells Juliane Lokau, Florian Kleinegger, Yvonne Garbers et al. · PLoS ONE Open access 4 May 2020 50
35 The IL-6-neutralizing sIL-6R-sgp130 buffer system is disturbed in patients with type 2 diabetes Samadhi Aparicio-Siegmund, Yvonne Garbers, Charlotte M. Flynn et al. · American Journal of Physiology-Endocrinology and Metabolism Open access 25 Jun 2019 49
36 Analysis of NOD2-mediated Proteome Response to Muramyl Dipeptide in HEK293 Cells Dieter H. Weichart, Johan Gobom, Sina Klopfleisch et al. · Journal of Biological Chemistry Open access 29 Oct 2005 49
37 Interleukin-6 trans-signaling increases the expression of carcinoembryonic antigen-related cell adhesion molecules 5 and 6 in colorectal cancer cells Reinhild Holmer, Georg H. Wätzig, Sanjay Tiwari et al. · BMC Cancer Open access Dec 2015 46
38 Alternative Intronic Polyadenylation Generates the Interleukin-6 Trans-signaling Inhibitor sgp130-E10 Jan Sommer, Christoph Garbers, Janina Wolf et al. · Journal of Biological Chemistry Open access 28 Jun 2014 45
39 Essential role of neutrophil mobilization in concanavalin A-induced hepatitis is based on classic IL-6 signaling but not on IL-6 trans-signaling Sven Malchow, Wolfgang Maximilian Thaiss, Nathalie Jänner et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease Open access 3 Dec 2010 37
40 Constitutively Active Mutant gp130 Receptor Protein from Inflammatory Hepatocellular Adenoma Is Inhibited by an Anti-gp130 Antibody That Specifically Neutralizes Interleukin 11 Signaling Jürg M. Sommer, Timo Effenberger, Elena Volpi et al. · Journal of Biological Chemistry Open access 20 Apr 2012 37
41 Classic IL-6R signalling is dispensable for intestinal epithelial proliferation and repair Konrad Aden, Alexandra Breuer, Ateequr Rehman et al. · Oncogenesis Open access 21 Nov 2016 36
42 Activation of NF-?B in intestinal epithelial cells by E. coli strains isolated from the colonic mucosa of IBD patients Stefan Schreiber, Katia La Ferla, Dirk Seegert · International Journal of Colorectal Disease 21 Apr 2004 35
43 Constitutively Active Mutant gp130 Receptor Protein from Inflammatory Hepatocellular Adenoma Is Inhibited by an Anti-gp130 Antibody That Specifically Neutralizes Interleukin 11 Signaling Jan Sommer, Timo Effenberger, Elena Volpi et al. · Journal of Biological Chemistry Open access 7 Mar 2012 34
44 Mutations in Craniosynostosis Patients Cause Defective Interleukin-11 Receptor Maturation and Drive Craniosynostosis-like Disease in Mice Maria Agthe, Julian Brügge, Yvonne Garbers et al. · Cell Reports Open access Oct 2018 34
45 Selective inhibition of IL-6 trans-signaling by a miniaturized, optimized chimeric soluble gp130 inhibits T H 17 cell expansion Denise Heise, Alicia Derrac Soria, Selina Hansen et al. · Science Signaling 17 Aug 2021 33
46 Mitogen‐activated protein kinases in chronic intestinal inflammation — targeting ancient pathways to treat modern diseases Georg H. Waetzig, Stefan Schreiber · Alimentary Pharmacology & Therapeutics Open access Jul 2003 30
47 RAID3 - An interleukin-6 receptor-binding aptamer with post-selective modification-resistant affinity Florian Mittelberger, Cindy Meyer, Georg H. Waetzig et al. · RNA Biology Open access 2 Sep 2015 28
48 Case Report: Arterial Wall Inflammation in Atherosclerotic Cardiovascular Disease is Reduced by Olamkicept (sgp130Fc) Dominik Maria Schulte, Georg H. Waetzig, Harald Schuett et al. · Frontiers in Pharmacology Open access 9 Jun 2022 26
49 A soluble form of the interleukin-6 family signal transducer gp130 is dimerized via a C-terminal disulfide bridge resulting from alternative mRNA splicing Janina Wolf, Georg H. Waetzig, Torsten Michael Reinheimer et al. · Biochemical and Biophysical Research Communications 22 Jan 2016 15
50 Nicotinamide modulates gut microbial metabolic potential and accelerates recovery in mild-to-moderate COVID-19 Stefan Schreiber et al. · Nature Metabolism Open access 12 May 2025 12

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.