| 1 |
Developing mRNA-vaccine technologies
Thomas Schlake, Andreas Theß, Mariola Fotin‐Mleczek et al. · RNA Biology
Open access |
12 Oct 2012 |
638 |
| 2 |
New Vaccine Technologies to Combat Outbreak Situations
Susanne Rauch, Edith Jasny, Kim E. Schmidt et al. · Frontiers in Immunology
Open access |
19 Sep 2018 |
598 |
| 3 |
Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: an open-label, non-randomised, prospective, first-in-human phase 1 clinical trial
Martin Alberer, Ulrike Gnad-Vogt, Henoch Sangjoon Hong et al. · The Lancet
|
25 Jul 2017 |
544 |
| 4 |
Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals
Andreas Theß, Stefanie E. Grund, Barbara L. Mui et al. · Molecular Therapy
Open access |
8 Jun 2015 |
528 |
| 5 |
Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection
Benjamin Petsch, Margit Schnee, Annette B. Vogel et al. · Nature Biotechnology
|
18 Nov 2012 |
470 |
| 6 |
Direct Injection of Protamine-protected mRNA: Results of a Phase 1/2 Vaccination Trial in Metastatic Melanoma Patients
Benjamin Weide, Steve Pascolo, Birgit Scheel et al. · Journal of Immunotherapy
|
21 May 2009 |
384 |
| 7 |
Messenger RNA-based Vaccines With Dual Activity Induce Balanced TLR-7 Dependent Adaptive Immune Responses and Provide Antitumor Activity
Mariola Fotin‐Mleczek, Katharina M. Duchardt, Christina Lorenz et al. · Journal of Immunotherapy
|
11 Dec 2010 |
339 |
| 8 |
Self-adjuvanted mRNA vaccination in advanced prostate cancer patients: a first-in-man phase I/IIa study
Hubert R Kübler, Birgit Scheel, Ulrike Gnad-Vogt et al. · Journal for ImmunoTherapy of Cancer
Open access |
13 Jun 2015 |
294 |
| 9 |
Effect of Recombinant Zoster Vaccine on Incidence of Herpes Zoster After Autologous Stem Cell Transplantation
Adriana Bastidas et al. · JAMA
Open access |
9 Jul 2019 |
269 |
| 10 |
Unmodified mRNA in LNPs constitutes a competitive technology for prophylactic vaccines
Johannes Lutz, Sandra Lazzaro, Mohamed Habbeddine et al. · npj Vaccines
Open access |
10 Oct 2017 |
263 |
| 11 |
Results of the First Phase I/II Clinical Vaccination Trial With Direct Injection of mRNA
Benjamin Weide, Jean‐Philippe Carralot, Anne Reese et al. · Journal of Immunotherapy
|
Feb 2008 |
263 |
| 12 |
Immunogenicity and safety of the adjuvanted recombinant zoster vaccine in adults with haematological malignancies: a phase 3, randomised, clinical trial and post-hoc efficacy analysis
Alemnew F. Dagnew et al. · The Lancet Infectious Diseases
Open access |
6 Aug 2019 |
261 |
| 13 |
Phase Ib evaluation of a self-adjuvanted protamine formulated mRNA-based active cancer immunotherapy, BI1361849 (CV9202), combined with local radiation treatment in patients with stage IV non-small cell lung cancer
Alexandros Papachristofilou et al. · Journal for ImmunoTherapy of Cancer
Open access |
8 Feb 2019 |
230 |
| 14 |
Intradermal Vaccinations With RNA Coding for TAA Generate CD8+ and CD4+ Immune Responses and Induce Clinical Benefit in Vaccinated Patients
Susanne Malaika Rittig, Maik Haentschel, Katrin J Weimer et al. · Molecular Therapy
Open access |
28 Dec 2010 |
224 |
| 15 |
A novel, disruptive vaccination technology
Karl‐Josef Kallen, Regina Heidenreich, Margit Schnee et al. · Human Vaccines & Immunotherapeutics
Open access |
6 Aug 2013 |
223 |
| 16 |
Visualization of early events in mRNA vaccine delivery in non-human primates via PET–CT and near-infrared imaging
Kevin E. Lindsay, Sushma M. Bhosle, Chiara Zurla et al. · Nature Biomedical Engineering
|
Apr 2019 |
222 |
| 17 |
An mRNA Vaccine Encoding Rabies Virus Glycoprotein Induces Protection against Lethal Infection in Mice and Correlates of Protection in Adult and Newborn Pigs
Margit Schnee, Annette B. Vogel, Daniel Voß et al. · PLoS neglected tropical diseases
Open access |
23 Jun 2016 |
218 |
| 18 |
A phase I/IIa study of the mRNA-based cancer immunotherapy CV9201 in patients with stage IIIB/IV non-small cell lung cancer
Martin Sebastian et al. · Cancer Immunology Immunotherapy
Open access |
15 Feb 2019 |
213 |
| 19 |
Proof-of-concept of a low-dose unmodified mRNA-based rabies vaccine formulated with lipid nanoparticles in human volunteers: A phase 1 trial
Cassandra Aldrich, Isabel Leroux‐Roels, Katell Bidet Huang et al. · Vaccine
Open access |
22 Jan 2021 |
210 |
| 20 |
Spontaneous cellular uptake of exogenous messenger RNA in vivo is nucleic acid-specific, saturable and ion dependent
Jochen Probst, Benjamin Weide, Birgit Scheel et al. · Gene Therapy
|
3 May 2007 |
210 |
| 21 |
Toll‐like receptor‐dependent activation of several human blood cell types by protamine‐condensed mRNA
Birgit Scheel, Regina Teufel, Jochen Probst et al. · European Journal of Immunology
|
15 Apr 2005 |
203 |
| 22 |
Immunogenicity and Safety of the Adjuvanted Recombinant Zoster Vaccine in Chronically Immunosuppressed Adults Following Renal Transplant: A Phase 3, Randomized Clinical Trial
Peter Vink et al. · Clinical Infectious Diseases
Open access |
28 Feb 2019 |
201 |
| 23 |
Adjuvant effects of a sequence-engineered mRNA vaccine: translational profiling demonstrates similar human and murine innate response
Darin Edwards, Edith Jasny, Heesik Yoon et al. · Journal of Translational Medicine
Open access |
3 Jan 2017 |
189 |
| 24 |
Efficacy and safety of the CVnCoV SARS-CoV-2 mRNA vaccine candidate in ten countries in Europe and Latin America (HERALD): a randomised, observer-blinded, placebo-controlled, phase 2b/3 trial
Peter G. Kremsner et al. · The Lancet Infectious Diseases
Open access177 authors |
23 Nov 2021 |
176 |
| 25 |
Spontaneous Formation of Nucleic Acid-based Nanoparticles Is Responsible for High Interferon-α Induction by CpG-A in Plasmacytoid Dendritic Cells
Miren Kerkmann, Lilian T. Costa, Christine E Richter et al. · Journal of Biological Chemistry
Open access |
26 Feb 2005 |
174 |
| 26 |
Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical model
Taihua Yang et al. · Journal of Hepatology
Open access |
25 Aug 2021 |
173 |
| 27 |
mRNA mediates passive vaccination against infectious agents, toxins, and tumors
Moritz Thran, Jean Mukherjee, Marion Pönisch et al. · EMBO Molecular Medicine
Open access |
9 Aug 2017 |
172 |
| 28 |
mRNA-based SARS-CoV-2 vaccine candidate CVnCoV induces high levels of virus-neutralising antibodies and mediates protection in rodents
Susanne Rauch, Nicole Roth, Kim Schwendt et al. · npj Vaccines
Open access |
16 Apr 2021 |
167 |
| 29 |
Messenger RNA-based vaccines
Steve Pascolo · Expert Opinion on Biological Therapy
|
Aug 2004 |
154 |
| 30 |
Protein expression from exogenous mRNA: Uptake by receptor-mediated endocytosis and trafficking via the lysosomal pathway
Christina Lorenz, Mariola Fotin‐Mleczek, Günter Dietmar Roth et al. · RNA Biology
Open access |
Jul 2011 |
151 |
| 31 |
Polarization of immunity induced by direct injection of naked sequence-stabilized mRNA vaccines
Jean‐Philippe Carralot, Jochen Probst, Ingmar Hoerr et al. · Cellular and Molecular Life Sciences
Open access |
Sep 2004 |
149 |
| 32 |
Immunostimulating capacities of stabilized RNA molecules
Birgit Scheel, Sybilla Braedel, Jochen Probst et al. · European Journal of Immunology
|
Feb 2004 |
141 |
| 33 |
Phase Ib study evaluating a self-adjuvanted mRNA cancer vaccine (RNActive®) combined with local radiation as consolidation and maintenance treatment for patients with stage IV non-small cell lung cancer
Martin Sebastian, Alexandros Papachristofilou, Christian Weiß et al. · BMC Cancer
Open access |
6 Oct 2014 |
141 |
| 34 |
Optimization of non-coding regions for a non-modified mRNA COVID-19 vaccine
Makda S. Gebre et al. · Nature
Open access |
18 Nov 2021 |
138 |
| 35 |
Safety and immunogenicity of an mRNA-lipid nanoparticle vaccine candidate against SARS-CoV-2
Peter G. Kremsner et al. · Wiener klinische Wochenschrift
Open access |
10 Aug 2021 |
135 |
| 36 |
mRNA as novel technology for passive immunotherapy
Thomas Schlake, Andreas Theß, Moritz Thran et al. · Cellular and Molecular Life Sciences
Open access |
17 Oct 2018 |
131 |
| 37 |
Phase 1 study of the ATR inhibitor berzosertib (formerly M6620, VX-970) combined with gemcitabine ± cisplatin in patients with advanced solid tumours
Mark Ross Middleton, Emma Jane Dean, Thomas R. Jeffry Evans et al. · British Journal of Cancer
Open access |
26 May 2021 |
127 |
| 38 |
A development that may evolve into a revolution in medicine: mRNA as the basis for novel, nucleotide-based vaccines and drugs
Karl‐Josef Kallen, Andreas Theß · Therapeutic Advances in Vaccines
Open access |
6 Nov 2013 |
127 |
| 39 |
A thermostable messenger RNA based vaccine against rabies
Lothar Stitz, Annette B. Vogel, Margit Schnee et al. · PLoS neglected tropical diseases
Open access |
7 Dec 2017 |
119 |
| 40 |
Therapeutic anti‐tumor immunity triggered by injections of immunostimulating single‐stranded RNA
Birgit Scheel, Steffen Aulwurm, Jochen Probst et al. · European Journal of Immunology
|
Oct 2006 |
109 |
| 41 |
Highly potent mRNA based cancer vaccines represent an attractive platform for combination therapies supporting an improved therapeutic effect
Mariola Fotin‐Mleczek, Kai Zanzinger, Regina Heidenreich et al. · The Journal of Gene Medicine
Open access |
20 Jan 2012 |
105 |
| 42 |
Phase 1 study of the ATR inhibitor berzosertib in combination with cisplatin in patients with advanced solid tumours
Geoffrey Ira Shapiro, Robert Wesolowski, Craig Devoe et al. · British Journal of Cancer
Open access |
26 May 2021 |
104 |
| 43 |
Phase 1 Assessment of the Safety and Immunogenicity of an mRNA- Lipid Nanoparticle Vaccine Candidate Against SARS-CoV-2 in Human Volunteers
Peter G. Kremsner et al. · medRxiv
PreprintOpen access |
9 Nov 2020 |
103 |
| 44 |
Self-adjuvanted mRNA vaccines induce local innate immune responses that lead to a potent and boostable adaptive immunity
Aleksandra Kowalczyk, Fatma Doener, Kai Zanzinger et al. · Vaccine
|
19 Jun 2016 |
102 |
| 45 |
Advances in RNA Vaccines for Preventive Indications: A Case Study of a Vaccine against Rabies
Nicole S. Armbruster, Edith Jasny, Benjamin Petsch · Vaccines
Open access |
27 Sep 2019 |
97 |
| 46 |
Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer
Sebastian M. Dieter et al. · Cell Reports
Open access |
Jul 2021 |
94 |
| 47 |
mRNA: A Novel Avenue to Antibody Therapy?
Thomas Schlake, Moritz Thran, Katja Fiedler et al. · Molecular Therapy
Open access |
5 Mar 2019 |
92 |
| 48 |
mRNA Cancer Vaccines
Katja Fiedler, Sandra Lazzaro, Johannes Lutz et al. · Recent results in cancer research/Recent Results in Cancer Research
Book chapter |
2016 |
86 |
| 49 |
Characterization of the ribonuclease activity on the skin surface
Jochen Probst, Sonja Brechtel, Birgit Scheel et al. · Genetic Vaccines and Therapy
Open access |
29 May 2006 |
86 |
| 50 |
A novel RNA‐based adjuvant combines strong immunostimulatory capacities with a favorable safety profile
Regina Heidenreich, Edith Jasny, Aleksandra Kowalczyk et al. · International Journal of Cancer
|
22 Dec 2014 |
83 |