Most cited papers from Curis (United States)

Curis (United States)

What are the most cited papers from Curis (United States)?

The most cited paper from Curis (United States) is "Directed Differentiation of Embryonic Stem Cells into Motor Neurons" (Hynek Wichterle, Ivo Lieberam, Jeffery A. Porter et al., 2002), with 1,765 citations. Next come "A paracrine requirement for hedgehog signalling in cancer" (967) and "Sonic Hedgehog Is Required for Progenitor Cell Maintenance in Telencephalic Stem Cell Niches" (718).

Published TypeFieldAccessAuthorsCitations

Showing 50 of 60 papers. Every paper with more than 30 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Directed Differentiation of Embryonic Stem Cells into Motor Neurons Hynek Wichterle, Ivo Lieberam, Jeffery A. Porter et al. · Cell Open access	Aug 2002	1,765
2	A paracrine requirement for hedgehog signalling in cancer Robert L. Yauch, Stephen E. Gould, Suzie J. Scales et al. · Nature	27 Aug 2008	967
3	Sonic Hedgehog Is Required for Progenitor Cell Maintenance in Telencephalic Stem Cell Niches Robert P. Machold, Shigemi Hayashi, Michael L. Rutlin et al. · Neuron Open access	Sep 2003	718
4	Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation Fanxin Long, Xiaoyan M. Zhang, Seth J. Karp et al. · Development	15 Dec 2001	661
5	Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis Humphrey Hung‐Chang Yao, Wendy J. Whoriskey, Blanche Capel · Genes & Development Open access	Jun 2002	544
6	Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1+/−p53−/− mice Justyna T. Romer, Hiromichi Kimura, Susan M. Magdaleno et al. · Cancer Cell Open access	Sep 2004	523
7	Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists Maria D. Frank-Kamenetsky, Xiaoyan M. Zhang, Steve Bottega et al. · Journal of Biology Open access	6 Nov 2002	491
8	Desert hedgehog (Dhh) Gene Is Required in the Mouse Testis for Formation of Adult-Type Leydig Cells and Normal Development of Peritubular Cells and Seminiferous Tubules Ann M. Clark, Kristin K. Garland, Lonnie D. Russell · Biology of Reproduction	Dec 2000	441
9	GDC-0449—A potent inhibitor of the hedgehog pathway Kirk D. Robarge et al. · Bioorganic & Medicinal Chemistry Letters Open access	16 Aug 2009	388
10	Deregulation of Dorsoventral Patterning by FGF Confers Trilineage Differentiation Capacity on CNS Stem Cells In Vitro Limor Gabay, Sally Lowell, Lee L. Rubin et al. · Neuron Open access	Oct 2003	317
11	Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling KENGO FUKUSHIMA KUSANO et al. · Nature Medicine	23 Oct 2005	309
12	Identification of a small molecule inhibitor of the hedgehog signaling pathway: Effects on basal cell carcinoma-like lesions Juliet Anne Williams, Oivin M. Guicherit, Beatrice I. Zaharian et al. · Proceedings of the National Academy of Sciences Open access	4 Apr 2003	298
13	Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization Amel Gritli-Linde, Marianna Bei, Richard L. Maas et al. · Development	Dec 2002	297
14	Recovery from paralysis in adult rats using embryonic stem cells Deepa M. Deshpande, Yun‐Sook Kim, Tara L. Martinez et al. · Annals of Neurology	26 Jun 2006	274
15	Discovery of 7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDC-101) as a Potent Multi-Acting HDAC, EGFR, and HER2 Inhibitor for the Treatment of Cancer Xiong Cai, Hai-Xiao Zhai, Jing Wang et al. · Journal of Medicinal Chemistry Open access	9 Feb 2010	266
16	BMP-7 regulates chemokine, cytokine, and hemodynamic gene expression in proximal tubule cells1 Stephen E. Gould, Maria Day, Simon S. Jones et al. · Kidney International Open access	2002	260
17	Cancer Network Disruption by a Single Molecule Inhibitor Targeting Both Histone Deacetylase Activity and Phosphatidylinositol 3-Kinase Signaling Changgeng Qian, Cheng-Jung Lai, Rudi Bao et al. · Clinical Cancer Research	13 Jun 2012	244
18	Comparative biological responses to human Sonic, Indian, and Desert hedgehog Suji Pathi, Sylvia M. Pagán-Westphal, Darren P. Baker et al. · Mechanisms of Development Open access	Aug 2001	228
19	CUDC-101, a Multitargeted Inhibitor of Histone Deacetylase, Epidermal Growth Factor Receptor, and Human Epidermal Growth Factor Receptor 2, Exerts Potent Anticancer Activity Cheng-Jung Lai, Rudi Bao, Xu Tao et al. · Cancer Research Open access	13 Apr 2010	213
20	Safety, tolerability, and preliminary activity of CUDC-907, a first-in-class, oral, dual inhibitor of HDAC and PI3K, in patients with relapsed or refractory lymphoma or multiple myeloma: an open-label, dose-escalation, phase 1 trial Anas Younes, Jesús G. Berdeja, Manish R. Patel et al. · The Lancet Oncology Open access	2 Apr 2016	188
21	A Developmental Study of the Desert Hedgehog-Null Mouse Testis1 Fernando Pierucci‐Alves, Ann M. Clark, Lonnie D. Russell · Biology of Reproduction	Nov 2001	171
22	Hedgehog signaling controls dorsoventral patterning, blastema cell proliferation and cartilage induction during axolotl tail regeneration Esther Schnapp, Martin Kragl, Lee L. Rubin et al. · Development	27 Jun 2005	171
23	A Review of the Clinical Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Vedolizumab Maria Rosario, Nathanael L. Dirks, Catherine E. Milch et al. · Clinical Pharmacokinetics Open access	18 May 2017	158
24	Dual HDAC and PI3K Inhibitor CUDC-907 Downregulates MYC and Suppresses Growth of MYC-dependent Cancers Kaiming Sun, Ruzanna Atoyan, Mylissa A. Borek et al. · Molecular Cancer Therapeutics	15 Dec 2016	147
25	Cooperation between sonic hedgehog and fibroblast growth factor/MAPK signalling pathways in neocortical precursors Nicoletta Kessaris, Françoise Jamen, Lee L. Rubin et al. · Development Open access	16 Feb 2004	141
26	CUDC-907 in relapsed/refractory diffuse large B-cell lymphoma, including patients with MYC-alterations: results from an expanded phase I trial Yasuhiro Oki, Kevin R. Kelly, Ian W. Flinn et al. · Haematologica Open access	31 Aug 2017	137
27	Modulation of Hair Growth with Small Molecule Agonists of the Hedgehog Signaling Pathway Rudolph D. Paladini, Jacqueline Saleh, Changgeng Qian et al. · Journal of Investigative Dermatology Open access	23 Sep 2005	131
28	THE HEDGEHOG PATHWAY AND NEUROLOGICAL DISORDERS Tammy Dellovade, Justyna T. Romer, Tom Curran et al. · Annual Review of Neuroscience Review	7 Apr 2006	119
29	CUDC-305, a Novel Synthetic HSP90 Inhibitor with Unique Pharmacologic Properties for Cancer Therapy Rudi Bao, Cheng-Jung Lai, Hui Qu et al. · Clinical Cancer Research Open access	15 Jun 2009	114
30	Expression of bone morphogenetic protein receptors type-IA, -IB and -II correlates with tumor grade in human prostate cancer tissues. Isaac Yi Kim, Dong Hyeon Lee, Han Jong Ahn et al. · PubMed	Jun 2000	102
31	Motoneurons Derived from Embryonic Stem Cells Express Transcription Factors and Develop Phenotypes Characteristic of Medial Motor Column Neurons Prabakaran Soundararajan, Gareth Brian Miles, Lee L. Rubin et al. · Journal of Neuroscience Open access	22 Mar 2006	99
32	Treatment of a murine model of high-turnover renal osteodystrophy by exogenous BMP-7 Esther A. González, Richard Lund, Kévin Martin et al. · Kidney International Open access	Apr 2002	96
33	Therapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathy Nigel A. Calcutt, Karen L. Allendoerfer, Andrew P. Mizisin et al. · Journal of Clinical Investigation Open access	14 Feb 2003	93
34	Liposomal Packaging Generates Wnt Protein with In Vivo Biological Activity Nathan T. Morrell, Philipp Leucht, Ludan Zhao et al. · PLoS ONE Open access	12 Aug 2008	82
35	Activation of targetable inflammatory immune signaling is seen in myelodysplastic syndromes with SF3B1 mutations Gaurav S. Choudhary et al. · eLife Open access	13 Jul 2022	77
36	Discovery of CA-4948, an Orally Bioavailable IRAK4 Inhibitor for Treatment of Hematologic Malignancies Venkateshwar Rao Gummadi et al. · ACS Medicinal Chemistry Letters Open access	14 Oct 2020	68
37	Long‐acting forms of Sonic hedgehog with improved pharmacokinetic and pharmacodynamic properties are efficacious in a nerve injury model R. Blake Pepinsky, Renee I. Shapiro, Shaoshan Wang et al. · Journal of Pharmaceutical Sciences	Feb 2002	66
38	Fit‐for‐Purpose Biometric Monitoring Technologies: Leveraging the Laboratory Biomarker Experience Alan Godfrey, Benjamin Vandendriessche, Jessie P. Bakker et al. · Clinical and Translational Science Open access	8 Aug 2020	63
39	IFNα induces Fas expression and apoptosis in hedgehog pathway activated BCC cells through inhibiting Ras-Erk signaling Chengxin Li, Sumin Chi, Nonggao He et al. · Oncogene	Dec 2003	60
40	Targeting heat shock protein 90 with CUDC-305 overcomes erlotinib resistance in non–small cell lung cancer Rudi Bao, Cheng-Jung Lai, Da-Gong Wang et al. · Molecular Cancer Therapeutics	Dec 2009	58
41	Dual inhibition of HDAC and EGFR signaling with CUDC-101 induces potent suppression of tumor growth and metastasis in anaplastic thyroid cancer Lisa M. Zhang, Yaqin Zhang, Amit R. Mehta et al. · Oncotarget Open access	13 Apr 2015	58
42	VISTA expression and patient selection for immune-based anticancer therapy Alexander Stephen Martin, Michael Molloy, Andrey V. Ugolkov et al. · Frontiers in Immunology Open access	20 Feb 2023	57
43	CA-170, a first in class oral small molecule dual inhibitor of immune checkpoints PD-L1 and VISTA, demonstrates tumor growth inhibition in pre-clinical models and promotes T cell activation in Phase 1 study John D. Powderly, Manish R. Patel, Jina Lee et al. · Annals of Oncology Open access	Sep 2017	56
44	Fimepinostat (CUDC‐907) in patients with relapsed/refractory diffuse large B cell and high‐grade B‐cell lymphoma: report of a phase 2 trial and exploratory biomarker analyses Daniel Jeffrey Landsburg, Stefan Klaus Barta, Radhakrishnan Ramchandren et al. · British Journal of Haematology Open access	2 Aug 2021	48
45	Cooperative Effects of Sonic Hedgehog and NGF on Basal Forebrain Cholinergic Neurons Jennifer Reilly, Irina D. Karavanova, Kevin P. Williams et al. · Molecular and Cellular Neuroscience	2002	46
46	Bone Morphogenetic Protein-7 Modulates Genes that Maintain the Vascular Smooth Muscle Cell Phenotype in Culture Haimanti Dorai, T. Kuber Sampath · Journal of Bone and Joint Surgery	2001	45
47	Vedolizumab Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability Following Administration of a Single, Ascending, Intravenous Dose to Healthy Volunteers Maria Rosario, Timothy L. Wyant, Timothy S. Leach et al. · Clinical Drug Investigation	15 Jul 2016	44
48	An autoantigen profile of human A549 lung cells reveals viral and host etiologic molecular attributes of autoimmunity in COVID-19 Julia Y. Wang, Wei Zhang, Michael W. Roehrl et al. · Journal of Autoimmunity Open access	27 Apr 2021	42
49	Fecal Calprotectin Responses Following Induction Therapy With Vedolizumab in Moderate to Severe Ulcerative Colitis: A Post Hoc Analysis of GEMINI 1 Walter Reinisch, Brian L. Bressler, Rebecca I. Curtis et al. · Inflammatory Bowel Diseases Open access	5 Oct 2018	41
50	Clinical and research updates on the VISTA immune checkpoint: immuno-oncology themes and highlights Randolph J. Noelle, Janet Louise Lines, Lionel D. Lewis et al. · Frontiers in Oncology Open access	15 Sep 2023	36

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.