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Institution · Cyprotex (United States)

Most cited papers from Cyprotex (United States)

Cyprotex (United States)

What are the most cited papers from Cyprotex (United States)?

The most cited paper from Cyprotex (United States) is "A newin vitromethod for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells" (James M. McKim, Don J. Keller, Joel R. Gorski, 2010), with 137 citations. Next come "Systematic evaluation of non-animal test methods for skin sensitisation safety assessment" (135) and "Cross-Site Reliability of Human Induced Pluripotent stem cell-derived Cardiomyocyte Based Safety Assays Using Microelectrode Arrays: Results from a Blinded CiPA Pilot Study" (134).

Showing 50 of 83 papers. Every paper is listed.

Most cited papers, sortable by citations and release date
#Paper
1 A newin vitromethod for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells James M. McKim, Don J. Keller, Joel R. Gorski · Cutaneous and Ocular Toxicology 24 May 2010 137
2 Systematic evaluation of non-animal test methods for skin sensitisation safety assessment Kerstin Bianca Reisinger et al. · Toxicology in Vitro Open access 30 Oct 2014 135
3 Cross-Site Reliability of Human Induced Pluripotent stem cell-derived Cardiomyocyte Based Safety Assays Using Microelectrode Arrays: Results from a Blinded CiPA Pilot Study Daniel C. Millard, Qianyu Dang, Hong Shi et al. · Toxicological Sciences Open access 26 Apr 2018 134
4 Tissue Distribution of Basic Drugs: Accounting for Enantiomeric, Compound and Regional Differences Amongst β-Blocking Drugs in Rat Trudy Rodgers, David E. Leahy, Malcolm Rowland · Journal of Pharmaceutical Sciences 27 Apr 2005 133
5 In Vitro Screening for Seizure Liability Using Microelectrode Array Technology Jenifer A. Bradley, Harry H. Luithardt, Monica R. Metea et al. · Toxicological Sciences 7 Feb 2018 100
6 Effects of carrageenan on cell permeability, cytotoxicity, and cytokine gene expression in human intestinal and hepatic cell lines James M. McKim, Heidi Baas, Gabriel P. Rice et al. · Food and Chemical Toxicology Open access 16 Jul 2016 96
7 Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization John F. Wambaugh, Barbara A. Wetmore, Caroline Ring et al. · Toxicological Sciences Open access 15 Sep 2019 75
8 High-Throughput Screening of Chemical Effects on Steroidogenesis Using H295R Human Adrenocortical Carcinoma Cells Agnes L. Karmaus, Colleen Toóle, Dayne L. Filer et al. · Toxicological Sciences Open access 18 Jan 2016 65
9 Using the concordance of in vitro and in vivo data to evaluate extrapolation assumptions Gregory S. Honda, Robert G. Pearce, Ly Pham et al. · PLoS ONE Open access 28 May 2019 55
10 Pre-validation of an in vitro skin irritation test for medical devices using the reconstructed human tissue model EpiDerm™ Helena Kanďárová, Jamin A. Willoughby, Wim H. de Jong et al. · Toxicology in Vitro Open access 10 Feb 2018 55
11 Automated QSPR through Competitive Workflow John Cartmell, Steven J. Enoch, Damjan Krstajić et al. · Journal of Computer-Aided Molecular Design Nov 2005 53
12 Toxicity assessments of nonsteroidal anti-inflammatory drugs in isolated mitochondria, rat hepatocytes, and zebrafish show good concordance across chemical classes Sashi Nadanaciva, Michael D. Aleo, Christopher J. Strock et al. · Toxicology and Applied Pharmacology 26 Jun 2013 51
13 Round robin study to evaluate the reconstructed human epidermis (RhE) model as an in vitro skin irritation test for detection of irritant activity in medical device extracts Wim H. de Jong et al. · Toxicology in Vitro Open access 8 Jan 2018 47
14 The common food additive carrageenan is not a ligand for Toll-Like- Receptor 4 (TLR4) in an HEK293-TLR4 reporter cell-line model James M. McKim, Paul C. Wilga, Jeffrey F. Pregenzer et al. · Food and Chemical Toxicology Open access 29 Jan 2015 36
15 Identification of Drug–Drug InteractionsIn Vitro: A Case Study Evaluating the Effects of Sofosbuvir and Amiodarone on hiPSC-Derived Cardiomyocytes Daniel C. Millard, Christopher J. Strock, Coby B. Carlson et al. · Toxicological Sciences 7 Aug 2016 34
16 Progress in Simulation Modelling for Pharmacokinetics David E. Leahy · Current Topics in Medicinal Chemistry Jul 2003 34
17 Screening for Neurotoxicity with Microelectrode Array Jenifer A. Bradley, Christopher J. Strock · Current Protocols in Toxicology 21 Dec 2018 33
18 Predicting Respiratory Toxicity Using a Human 3D Airway (EpiAirway™) Model Combined with Multiple Parametric Analysis Jamin A. Willoughby · Applied In Vitro Toxicology Mar 2015 26
19 CON4EI: EpiOcular™ Eye Irritation Test (EpiOcular™ EIT) for hazard identification and labelling of eye irritating chemicals Helena Kanďárová, Silvia Letašiová, Els Adriaens et al. · Toxicology in Vitro 8 Jul 2017 22
20 CON4EI: Bovine Corneal Opacity and Permeability (BCOP) test for hazard identification and labelling of eye irritating chemicals Sandra Verstraelen, Gareth Adam Maglennon, Karen Hollanders et al. · Toxicology in Vitro 30 Jun 2017 22
21 The novel fungal CYP51 inhibitor VT-1598 displays classic dose-dependent antifungal activity in murine models of invasive aspergillosis Edward P. Garvey, Joanne Sharp, Peter A. Warn et al. · Medical Mycology 22 Aug 2019 21
22 High-Content Positional Biosensor Screening Assay for Compounds to Prevent or Disrupt Androgen Receptor and Transcriptional Intermediary Factor 2 Protein–Protein Interactions Yun Hua, Tong Ying Shun, Christopher J. Strock et al. · Assay and Drug Development Technologies Open access Sep 2014 21
23 CON4EI: Selection of the reference chemicals for hazard identification and labelling of eye irritating chemicals Els Adriaens, Nathalie Alépée, Helena Kanďárová et al. · Toxicology in Vitro 28 Jun 2017 20
24 Evaluation of an In Vitro Human Dermal Sensitization Test for Use with Medical Device Extracts Kelly P. Coleman, Lori R. McNamara, Thomas P. Grailer et al. · Applied In Vitro Toxicology Jun 2015 19
25 CON4EI: Development of testing strategies for hazard identification and labelling for serious eye damage and eye irritation of chemicals Els Adriaens, Sandra Verstraelen, Nathalie Alépée et al. · Toxicology in Vitro 29 Sep 2017 17
26 CON4EI: CONsortium for in vitro Eye Irritation testing strategy - EpiOcular™ time-to-toxicity (EpiOcular ET-50) protocols for hazard identification and labelling of eye irritating chemicals Helena Kanďárová, Silvia Letašiová, Els Adriaens et al. · Toxicology in Vitro Sep 2017 15
27 CON4EI: SkinEthic™ Human Corneal Epithelium Eye Irritation Test (SkinEthic™ HCE EIT) for hazard identification and labelling of eye irritating chemicals An R. Van Rompay, Nathalie Alépée, Laurent Nardelli et al. · Toxicology in Vitro 16 Jun 2017 15
28 Relating Caco-2 permeability to molecular properties using block relevance analysis Timothy Potter, Giuseppe Ermondi, G. Newbury et al. · MedChemComm Open access 8 Dec 2014 14
29 CON4EI: Short Time Exposure (STE) test method for hazard identification and labelling of eye irritating chemicals Els Adriaens, Jamin A. Willoughby, Baptiste Meyer et al. · Toxicology in Vitro 9 Aug 2017 13
30 hERG block potencies for 5 positive control drugs obtained per ICH E14/S7B Q&As best practices: Impact of recording temperature and drug loss Claudia Alvarez Baron, Nicolas Thiebaud, Ming Ren et al. · Journal of Pharmacological and Toxicological Methods Open access 2 Jul 2022 12
31 Reprint of “CON4EI: Bovine Corneal Opacity and Permeability (BCOP) test for hazard identification and labelling of eye irritating chemicals” Sandra Verstraelen, Gareth Adam Maglennon, Karen Hollanders et al. · Toxicology in Vitro 27 Mar 2018 12
32 Inhibition of Hepatobiliary Transport Activity by the Antibacterial Agent Fusidic Acid: Insights into Factors Contributing to Conjugated Hyperbilirubinemia/Cholestasis Kimberly Lapham, Jonathan J. Novak, Lisa D. Marroquin et al. · Chemical Research in Toxicology 28 Sep 2016 12
33 1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum Yanran Lu, Chelsea A. Mann, Sheri Nolan et al. · ACS Medicinal Chemistry Letters Open access 9 May 2022 10
34 Reconfiguring the AR-TIF2 Protein–Protein Interaction HCS Assay in Prostate Cancer Cells and Characterizing the Hits from a LOPAC Screen Ashley T. Fancher, Yun Hua, Daniel P. Camarco et al. · Assay and Drug Development Technologies Open access 8 Sep 2016 10
35 High-Content Imaging in Human and Rat Hepatocytes Using the Fluorescent Dyes CLF and CMFDA Is Not Specific Enough to Assess BSEP/Bsep and/or MRP2/Mrp2 Inhibition by Cholestatic Drugs Luping Qiu, James E. Finley, Mohammed Taimi et al. · Applied In Vitro Toxicology Sep 2015 10
36 Impact of gut permeability on estimation of oral bioavailability for chemicals in commerce and the environment Gregory S. Honda, Elaina M. Kenyon, Sarah E. Davidson-Fritz et al. · ALTEX Open access 2024 9
37 Perspective: How complex in vitro models are addressing the challenges of predicting drug-induced liver injury Katrina A. Taylor, Rajendra Kumar Ram, Lorna C. Ewart et al. · Frontiers in Drug Discovery Open access 19 Feb 2025 8
38 Assays to Interrogate the Ability of Compounds to Inhibit the AF-2 or AF-1 Transactivation Domains of the Androgen Receptor Ashley T. Fancher, Yun Hua, Christopher J. Strock et al. · Assay and Drug Development Technologies Open access 10 Sep 2019 8
39 High-Content Screening Campaign to Identify Compounds That Inhibit or Disrupt Androgen Receptor-Transcriptional Intermediary Factor 2 Protein-Protein Interactions for the Treatment of Prostate Cancer Ashley T. Fancher, Yun Hua, Daniel P. Camarco et al. · Assay and Drug Development Technologies Open access Aug 2018 8
40 A physiome interoperability roadmap for personalized drug development Simon Thomas, Katherine Wolstencroft, Bernard de Bono et al. · Interface Focus Open access 19 Feb 2016 8
41 Development, optimization and standardization of an in vitro skin irritation test for medical devices using the reconstructed human tissue model epiderm Helena Kanďárová, J. Willoughby, W. de Jong et al. · Toxicology Letters 29 Sep 2015 7
42 High Content Positional Biosensor Assay to Screen for Compounds that Prevent or Disrupt Androgen Receptor and Transcription Intermediary Factor 2 Protein-Protein Interactions Yun Hua, Daniel P. Camarco, Christopher J. Strock et al. · Methods in molecular biology Book chapterOpen access 29 Oct 2017 7
43 CON4EI: Evaluation of QSAR models for hazard identification and labelling of eye irritating chemicals Lieve Geerts, Els Adriaens, Nathalie Alépée et al. · Toxicology in Vitro 21 Sep 2017 7
44 CON4EI: Slug Mucosal Irritation (SMI) test method for hazard identification and labelling of serious eye damaging and eye irritating chemicals Els Adriaens, Robert Guest, Jamin A. Willoughby et al. · Toxicology in Vitro 2 Sep 2017 7
45 Validation of the OptiSafe™ eye irritation test Neepa Y. Choksi, Stewart J. Lebrun, Minh Nguyen et al. · Cutaneous and Ocular Toxicology Open access 26 Jun 2020 6
46 Synthesis and Mechanism of Action of Group a Streptogramin Antibiotics That Overcome Resistance Qi Li, J. Pellegrino, D. John Lee et al. · ChemRxiv PreprintOpen access Jul 2019 5
47 Characterization of allosteric modulators that disrupt androgen receptor co-activator protein-protein interactions to alter transactivation–Drug leads for metastatic castration resistant prostate cancer Ashley T. Fancher, Yun Hua, David A. Close et al. · SLAS DISCOVERY Open access 6 Aug 2023 4
48 Reprint of “CON4EI: Selection of the reference chemicals for hazard identification and labelling of eye irritating chemicals” Els Adriaens, Nathalie Alépée, Helena Kanďárová et al. · Toxicology in Vitro 27 Mar 2018 4
49 Development, optimization and validation of an in vitro skin irritation test for medical devices using the reconstructed human tissue model EpiDerm Helena Kanďárová, Jamin A. Willoughby, Wim H. de Jong et al. · Toxicology Letters Sep 2016 3
50 High Content Screening Biosensor Assay to Identify Disruptors of p53–hDM2 Protein-Protein Interactions Yun Hua, Christopher J. Strock, Paul A. Johnston · Methods in molecular biology Book chapter 2015 3

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.