Most cited papers from Daiichi-Sankyo (Japan)

Daiichi-Sankyo (Japan)

What are the most cited papers from Daiichi-Sankyo (Japan)?

The most cited paper from Daiichi-Sankyo (Japan) is "Edoxaban versus Warfarin in Patients with Atrial Fibrillation" (Robert Patrick Giugliano et al., 2013), with 5,195 citations. Next come "Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis" (2,809) and "Trastuzumab Deruxtecan in Previously Treated HER2-Low Advanced Breast Cancer" (2,702).

Published TypeFieldAccessAuthorsCitations

Showing 50 of 60 papers. Every paper with more than 493 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Edoxaban versus Warfarin in Patients with Atrial Fibrillation Robert Patrick Giugliano et al. · New England Journal of Medicine Open access	19 Nov 2013	5,195
2	Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis Gabriele Bergers, Rolf A. Brekken, Gerald McMahon et al. · Nature Cell Biology Open access	20 Sep 2000	2,809
3	Trastuzumab Deruxtecan in Previously Treated HER2-Low Advanced Breast Cancer Shanu Modi et al. · New England Journal of Medicine Open access	5 Jun 2022	2,702
4	Cytochrome P-450 Polymorphisms and Response to Clopidogrel Jessica L. Mega, Sandra L. Close, Stephen D. Wiviott et al. · New England Journal of Medicine Open access	22 Dec 2008	2,503
5	Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain Monica R. P. Elmore, Allison R. Najafi, Maya A. Koike et al. · Neuron Open access	Apr 2014	2,089
6	Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer Shanu Modi et al. · New England Journal of Medicine Open access	11 Dec 2019	2,026
7	Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis Landin F. Boring, Jennifa Gosling, Michael D. Cleary et al. · Nature	Aug 1998	1,983
8	Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma Gideon E. Bollag et al. · Nature Open access	Sep 2010	1,850
9	RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF Poulikos I. Poulikakos, Chao Zhang, Gideon E. Bollag et al. · Nature Open access	23 Feb 2010	1,849
10	Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy David Glenn DeNardo, Donal J. Brennan, Elton Rexhepaj et al. · Cancer Discovery Open access	8 Apr 2011	1,750
11	Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism Gary E. Raskob, Nick van Es, Peter B. Verhamme et al. · New England Journal of Medicine Open access	12 Dec 2017	1,633
12	Hyperactive Ras in developmental disorders and cancer Suzanne Schubbert, KEVIN M. SHANNON, Gideon E. Bollag · Nature reviews. Cancer Review	23 Mar 2007	1,600
13	High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells. Toyoshi Inoguchi, Pan Li, F. Umeda et al. · Diabetes Open access	Nov 2000	1,588
14	Drug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activities Go Saito, Joel A. Swanson, Kyung‐Dall Lee · Advanced Drug Delivery Reviews Review	Feb 2003	1,410
15	Trastuzumab Deruxtecan in Previously Treated HER2-Positive Gastric Cancer Kohei Shitara, Yung‐Jue Bang, Satoru Iwasa et al. · New England Journal of Medicine Open access	29 May 2020	1,352
16	CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth Takatsugu Ishimoto et al. · Cancer Cell Open access	Mar 2011	1,206
17	DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1 Yusuke Ogitani, Tetsuo Aida, Katsunobu Hagihara et al. · Clinical Cancer Research	29 Mar 2016	1,190
18	Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis Akari Suzuki et al. · Nature Genetics	27 Jun 2003	1,172
19	Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1 Hiroyuki Tamemoto, Takashi Kadowaki, Kazuyuki Tobe et al. · Nature	Nov 1994	1,095
20	In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses Yasushi Itoh et al. · Nature Open access	13 Jul 2009	1,082
21	Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model Elizabeth E. Spangenberg et al. · Nature Communications Open access	21 Aug 2019	1,038
22	Adiponectin Reduces Atherosclerosis in Apolipoprotein E-Deficient Mice Yoshihisa Okamoto, Shinji Kihara, Noriyuki Bob Ouchi et al. · Circulation	25 Nov 2002	1,038
23	Trastuzumab Deruxtecan in HER2 -Mutant Non–Small-Cell Lung Cancer Bob T. Li et al. · New England Journal of Medicine Open access	18 Sep 2021	1,025
24	Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses Jonathan B. Mitchem, Donal J. Brennan, Brett L. Knolhoff et al. · Cancer Research Open access	5 Dec 2012	959
25	ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogensis produced by Penicillium citrinum. Akira Endo, Masao Kuroda, Yoshio Tsujita · The Journal of Antibiotics Open access	1976	957
26	Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake Naoto Kubota et al. · Cell Metabolism Open access	Jul 2007	848
27	Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin Mark L. Kahn, Mayumi Nakanishi‐Matsui, Michael J. Shapiro et al. · Journal of Clinical Investigation Open access	15 Mar 1999	848
28	Identification of the Human Cytochrome P450 Enzymes Involved in the Two Oxidative Steps in the Bioactivation of Clopidogrel to Its Pharmacologically Active Metabolite Miho Kazui, Yumi Nishiya, Tomoko Ishizuka et al. · Drug Metabolism and Disposition	7 Oct 2009	835
29	Antitumor Activity and Safety of Trastuzumab Deruxtecan in Patients With HER2-Low–Expressing Advanced Breast Cancer: Results From a Phase Ib Study Shanu Modi, Haeseong Park, Rashmi Krishna Murthy et al. · Journal of Clinical Oncology Open access	14 Feb 2020	828
30	Competitive inhibition of 3‐hydroxy‐3‐methylglutaryl coenzyme a reductase by ML‐236A and ML‐236B fungal metabolites, having hypocholesterolemic activity Akira Endo, Masao Kuroda, Kazuhiko Tanzawa · FEBS Letters	31 Dec 1976	805
31	Polatuzumab Vedotin in Relapsed or Refractory Diffuse Large B-Cell Lymphoma Laurie Helen Sehn, Alex Francisco Herrera, Christopher R. Flowers et al. · Journal of Clinical Oncology Open access	6 Nov 2019	785
32	Bystander killing effect of DS ‐8201a, a novel anti‐human epidermal growth factor receptor 2 antibody–drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity Yusuke Ogitani, Katsunobu Hagihara, Masataka Oitate et al. · Cancer Science Open access	11 May 2016	750
33	Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology Elizabeth E. Spangenberg, Rafael J. Lee, Allison R. Najafi et al. · Brain Open access	26 Feb 2016	744
34	Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel John T. Brandt, Sandra L. Close, Stephen J. Iturria et al. · Journal of Thrombosis and Haemostasis Open access	27 Sep 2007	735
35	Osteoclast differentiation by RANKL and OPG signaling pathways Nobuyuki Udagawa, Masanori Koide, Midori Nakamura et al. · Journal of Bone and Mineral Metabolism	20 Oct 2020	707
36	Growth‐promoting activity of tissue inhibitor of metalloproteinases‐1 (TIMP‐1) for a wide range of cells A possible new growth factor in serum Taro Hayakawa, Kyoko Yamashita, Kazuhiko Tanzawa et al. · FEBS Letters Open access	17 Feb 1992	707
37	Electronic health records to facilitate clinical research Martín Cowie, Juuso Blomster, Lesley H. Curtis et al. · Clinical Research in Cardiology Open access	23 Aug 2016	692
38	Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome Christine M. Oslowski, Takashi Hara, Bryan O’Sullivan-Murphy et al. · Cell Metabolism Open access	Aug 2012	686
39	Edoxaban-based versus vitamin K antagonist-based antithrombotic regimen after successful coronary stenting in patients with atrial fibrillation (ENTRUST-AF PCI): a randomised, open-label, phase 3b trial Pascal Vranckx, Marco Valgimigli, Lars Eckardt et al. · The Lancet	3 Sep 2019	685
40	Trastuzumab deruxtecan versus trastuzumab emtansine in patients with HER2-positive metastatic breast cancer: updated results from DESTINY-Breast03, a randomised, open-label, phase 3 trial Sara A. Hurvitz et al. · The Lancet Open access	7 Dec 2022	683
41	Selective Suppression of Endothelial Cell Apoptosis by the High Molecular Weight Form of Adiponectin Hideki Kobayashi, Noriyuki Bob Ouchi, Shinji Kihara et al. · Circulation Research Open access	3 Feb 2004	658
42	Cytochrome P450 Genetic Polymorphisms and the Response to Prasugrel Jessica L. Mega, Sandra L. Close, Stephen D. Wiviott et al. · Circulation	5 May 2009	655
43	Effects of Extracranial–Intracranial Bypass for Patients With Hemorrhagic Moyamoya Disease Susumu Miyamoto et al. · Stroke Open access	25 Mar 2014	652
44	Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON–TIMI 38 trial: a pharmacogenetic analysis Jessica L. Mega, Sandra L. Close, Stephen D. Wiviott et al. · The Lancet Open access	31 Aug 2010	616
45	Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study Nicholas Arthur Butowski, Howard Colman, John de Groot et al. · Neuro-Oncology Open access	8 Oct 2015	602
46	A metabolic pathway for bile acid dehydroxylation by the gut microbiome Masanori Funabashi, Tyler L. Grove, Min Wang et al. · Nature Open access	17 Jun 2020	592
47	Measurement of the High–Molecular Weight Form of Adiponectin in Plasma Is Useful for the Prediction of Insulin Resistance and Metabolic Syndrome Kazuo Hara, Momoko Horikoshi, Toshimasa Yamauchi et al. · Diabetes Care Open access	26 May 2006	577
48	CSF1R Signaling Blockade Stanches Tumor-Infiltrating Myeloid Cells and Improves the Efficacy of Radiotherapy in Prostate Cancer Jingying Xu, Jemima Escamilla, Stephen Mok et al. · Cancer Research Open access	15 Feb 2013	575
49	A comparison of prasugrel and clopidogrel loading doses on platelet function: magnitude of platelet inhibition is related to active metabolite formation John T. Brandt, Christopher D. Payne, Stephen D. Wiviott et al. · American Heart Journal	15 Dec 2006	572
50	Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebo-controlled phase 2 study Armando Santoro et al. · The Lancet Oncology	19 Nov 2012	558

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.