Institution · Discovery Institute
Most cited papers from Discovery Institute
What are the most cited papers from Discovery Institute?
The most cited paper from Discovery Institute is "Metascape provides a biologist-oriented resource for the analysis of systems-level datasets" (Yingyao Zhou, Bin Zhou, Lars Pache et al., 2019), with 16,072 citations. Next come "The Immune Landscape of Cancer" (6,328) and "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)" (6,023).
Showing 50 of 59 papers. Every paper with more than 774 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Metascape provides a biologist-oriented resource for the analysis of systems-level datasets Yingyao Zhou, Bin Zhou, Lars Pache et al. · Nature Communications | 3 Apr 2019 | 16,072 |
| 2 | The Immune Landscape of Cancer Vésteinn Thórsson et al. · Immunity | Apr 2018 | 6,328 |
| 3 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) Daniel J. Klionsky et al. · Autophagy | 2 Jan 2016 | 6,023 |
| 4 | Large-scale analysis of the yeast proteome by multidimensional protein identification technology Michael P. Washburn, Dirk Andreas Wolters, John R. Yates · Nature Biotechnology | Mar 2001 | 4,806 |
| 5 | Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling Nobuhiko Kayagaki et al. · Nature | 16 Sep 2015 | 3,790 |
| 6 | Cellular Senescence: Defining a Path Forward Vassilis G. Gorgoulis et al. · Cell | Oct 2019 | 3,322 |
| 7 | Mapping genomic loci implicates genes and synaptic biology in schizophrenia Vassily Vladimirovich Trubetskoy et al. · Nature | 8 Apr 2022 | 2,894 |
| 8 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 Daniel J. Klionsky et al. · Autophagy | 2 Jan 2021 | 2,743 |
| 9 | Mechanisms, regulation and functions of the unfolded protein response Claudio Hetz, Kezhong Zhang, Randal J. Kaufman · Nature Reviews Molecular Cell Biology | 26 May 2020 | 2,740 |
| 10 | Comprehensive Characterization of Cancer Driver Genes and Mutations Matthew H. Bailey et al. · Cell | Apr 2018 | 2,560 |
| 11 | Reactive astrocyte nomenclature, definitions, and future directions Carole Escartin et al. · Nature Neuroscience | 15 Feb 2021 | 2,503 |
| 12 | The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro Leon Caly, Julian D Druce, Mike G Catton et al. · Antiviral Research | 3 Apr 2020 | 2,278 |
| 13 | Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Toshiyuki Miyashita, Stanisław Krajewski, Maryla Krajewska et al. · PubMed | Jun 1994 | 2,164 |
| 14 | Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity Ludovico Cantuti‐Castelvetri et al. · Science | 20 Oct 2020 | 2,038 |
| 15 | Protein misfolding in the endoplasmic reticulum as a conduit to human disease Miao Wang, Randal J. Kaufman · Nature | 2016 | 1,673 |
| 16 | Molecular definitions of autophagy and related processes Lorenzo Galluzzi et al. · The EMBO Journal | 8 Jun 2017 | 1,670 |
| 17 | Orchestrated Transcription of Key Pathways in Arabidopsis by the Circadian Clock Stacey L. Harmer, John B. Hogenesch, Marty Straume et al. · Science | 15 Dec 2000 | 1,667 |
| 18 | Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics Patrycja Puchalska, Peter A. Crawford · Cell Metabolism | Feb 2017 | 1,652 |
| 19 | Autophagy in major human diseases Daniel J. Klionsky et al. · The EMBO Journal | 30 Aug 2021 | 1,608 |
| 20 | Ligand Binding to Integrins Edward F. Plow, Thomas A. Haas, Li Zhang et al. · Journal of Biological Chemistry | Jul 2000 | 1,360 |
| 21 | Cytoplasmic chromatin triggers inflammation in senescence and cancer Zhixun Dou et al. · Nature | Oct 2017 | 1,349 |
| 22 | Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth Hengli Tang, Christy Hammack, Sarah C. Ogden et al. · Cell stem cell | 5 Mar 2016 | 1,343 |
| 23 | Autophagy in healthy aging and disease Yahyah Aman, Tomas Schmauck‐Medina, Malene Hansen et al. · Nature Aging | 12 Aug 2021 | 1,335 |
| 24 | Organ targeting In vivo using phage display peptide libraries Renata Pasqualini, Erkki I. Ruoslahti · Nature | Mar 1996 | 1,236 |
| 25 | SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2 Thomas Mandel Clausen et al. · Cell | 14 Sep 2020 | 1,210 |
| 26 | NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria Zhenyu Zhong, Atsushi Umemura, Elsa Sánchez‐López et al. · Cell | Feb 2016 | 1,199 |
| 27 | Fibrillin, a new 350-kD glycoprotein, is a component of extracellular microfibrils. Lynn Y. Sakai, Douglas R. Keene, Eva Olsson Engvall · The Journal of Cell Biology | Dec 1986 | 1,154 |
| 28 | DNA methylation aging clocks: challenges and recommendations Christopher G. Bell et al. · Genome biology | 25 Nov 2019 | 1,146 |
| 29 | Symbol Nomenclature for Graphical Representations of Glycans Ajit P Varki et al. · Glycobiology | 5 Nov 2015 | 1,118 |
| 30 | Transforming growth factor-beta in disease: the dark side of tissue repair. Wayne A. Border, Erkki Ruoslahti · Journal of Clinical Investigation | Jul 1992 | 1,115 |
| 31 | Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain Blue B. Lake, Song Chen, Brandon Chin Sos et al. · Nature Biotechnology | 11 Dec 2017 | 1,106 |
| 32 | Dopamine: Functions, Signaling, and Association with Neurological Diseases Marianne Klein, Daniella Sabino Battagello, Ariel R. Cardoso et al. · Cellular and Molecular Neurobiology | 16 Nov 2018 | 1,094 |
| 33 | BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis Kate S. McArthur et al. · Science | 22 Feb 2018 | 1,071 |
| 34 | A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation Alexandra Grubman, Gabriel Chew, John F. Ouyang et al. · Nature Neuroscience | 25 Nov 2019 | 1,067 |
| 35 | Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy Parinaz Fozouni et al. · Cell | 4 Dec 2020 | 1,063 |
| 36 | Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease Tiantian Guo, Denghong Zhang, Yuzhe Zeng et al. · Molecular Neurodegeneration | 16 Jul 2020 | 1,062 |
| 37 | SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse Frank Koopmans et al. · Neuron | 3 Jun 2019 | 1,060 |
| 38 | Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) Andrea Cossarizza et al. · European Journal of Immunology | Oct 2019 | 1,014 |
| 39 | Metabolic Flexibility in Health and Disease Bret H. Goodpaster, Lauren Marie Sparks · Cell Metabolism | May 2017 | 996 |
| 40 | Towards environmental systems biology of Shewanella James K. Fredrickson, Margaret F. Romine, Alexander S. Beliaev et al. · Nature Reviews Microbiology | 7 Jul 2008 | 976 |
| 41 | Anti-cancer activity of targeted pro-apoptotic peptides H. Michael Ellerby, Wadih Arap, Lisa Ellerby et al. · Nature Medicine | Sep 1999 | 940 |
| 42 | Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity Kristen M. Turner et al. · Nature | 8 Feb 2017 | 933 |
| 43 | Activation and allosteric modulation of a muscarinic acetylcholine receptor Andrew C. Kruse, Aaron M. Ring, Aashish Manglik et al. · Nature | 19 Nov 2013 | 930 |
| 44 | The AMPA Receptor Code of Synaptic Plasticity Graham H. Diering, Richard L. Huganir · Neuron | Oct 2018 | 929 |
| 45 | A simplified laminin nomenclature Monique Aumailley, Leena Bruckner‐Tuderman, William G. Carter et al. · Matrix Biology | 25 Jun 2005 | 929 |
| 46 | Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding Shashank Tripathi et al. · Cell Host & Microbe | Dec 2015 | 928 |
| 47 | Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly Hongjie Li et al. · Science | 3 Mar 2022 | 898 |
| 48 | A genome-scale shRNA resource for transgenic RNAi in Drosophila Jian-Quan Ni, Rui Zhou, Benjamin Czech et al. · Nature Methods | 3 Apr 2011 | 896 |
| 49 | Clostridium difficile infection Wiep Klaas Smits, Dena Lyras, Dana Borden Lacy et al. · Nature Reviews Disease Primers | 7 Apr 2016 | 893 |
| 50 | Comparative cellular analysis of motor cortex in human, marmoset and mouse Trygve E. Bakken et al. · Nature | 6 Oct 2021 | 874 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.