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Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial
Hansjochen Wilke, Kei Muro, Eric Van Cutsem et al. · The Lancet Oncology
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17 Sep 2014 |
2,505 |
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FGF-21 as a novel metabolic regulator
Alexei Kharitonenkov, Tatiyana L. Shiyanova, Anja Köester et al. · Journal of Clinical Investigation
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3 May 2005 |
2,126 |
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The Differential Efficacy of Pemetrexed According to NSCLC Histology: A Review of Two Phase III Studies
Giorgio V. Scagliotti, Nasser H. Hanna, Frank V. Fossella et al. · The Oncologist
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16 Feb 2009 |
694 |
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Social and Emotional Impairment in Children and Adolescents with ADHD and the Impact on Quality of Life
Peter M. Wehmeier, Alexander Schacht, Russell A. Barkley · Journal of Adolescent Health
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5 Jan 2010 |
631 |
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Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway
Michael M. F. Lahn, Stephan Herbertz, J. Scott Sawyer et al. · Drug Design Development and Therapy
Open access |
Aug 2015 |
552 |
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Fibroblast Growth Factor-21 Improves Pancreatic β-Cell Function and Survival by Activation of Extracellular Signal–Regulated Kinase 1/2 and Akt Signaling Pathways
Wolf Wente, Alexander M. Efanov, Martin B. Brenner et al. · Diabetes
Open access |
25 Aug 2006 |
499 |
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Necitumumab plus gemcitabine and cisplatin versus gemcitabine and cisplatin alone as first-line therapy in patients with stage IV squamous non-small-cell lung cancer (SQUIRE): an open-label, randomised, controlled phase 3 trial
Nick Thatcher, Fred R. Hirsch, Alexander Luft et al. · The Lancet Oncology
Open access |
4 Jun 2015 |
484 |
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A reference map of potential determinants for the human serum metabolome
Noam Bar et al. · Nature
Open access172 authors |
11 Nov 2020 |
470 |
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Insulin and Cortisol Promote Leptin Production in Cultured Human Fat Cells
Martin Wabitsch, Per Bo Jensen, Werner Friedrich Blum et al. · Diabetes
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Oct 1996 |
463 |
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Predictors and clinical consequences of non-adherence with antipsychotic medication in the outpatient treatment of schizophrenia
Diego Novick, Josep María Haro, David L. Suarez et al. · Psychiatry Research
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25 Feb 2010 |
454 |
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Effects of Once-Weekly Dosing of a Long-Acting Release Formulation of Exenatide on Glucose Control and Body Weight in Subjects With Type 2 Diabetes
Dennis S. Kim, Leigh MacConell, Dongliang Zhuang et al. · Diabetes Care
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25 May 2007 |
448 |
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The Effect of Adding Exenatide to a Thiazolidinedione in Suboptimally Controlled Type 2 Diabetes
Bernard Zinman, Byron J. Hoogwerf, Santiago Durán García et al. · Annals of Internal Medicine
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3 Apr 2007 |
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Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes
Lawrence Blonde, ERIC J. KLEIN, J. Han et al. · Diabetes Obesity and Metabolism
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18 Apr 2006 |
419 |
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Contribution of androgens to the gender difference in leptin production in obese children and adolescents.
Martin Wabitsch, W. F. P. Blum, Rainer Muche et al. · Journal of Clinical Investigation
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15 Aug 1997 |
365 |
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Dual EGFR-VEGF Pathway Inhibition: A Promising Strategy for Patients With EGFR-Mutant NSCLC
Xiuning Le, Monique B. Nilsson, Jonathan Wade Goldman et al. · Journal of Thoracic Oncology
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20 Oct 2020 |
346 |
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Levels of Leptin in Maternal Serum, Amniotic Fluid, and Arterial and Venous Cord Blood: Relation to Neonatal and Placental Weight
Ch. Schubring, W. Kiess, Piera Englaro et al. · The Journal of Clinical Endocrinology & Metabolism
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KRAS-Mutant non-small cell lung cancer: From biology to therapy
Irene Ferrer, Jon Zugazagoitia, Stephan Herbertz et al. · Lung Cancer
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20 Jul 2018 |
333 |
| 18 |
Duloxetine and pregabalin: High-dose monotherapy or their combination? The “COMBO-DN study” – a multinational, randomized, double-blind, parallel-group study in patients with diabetic peripheral neuropathic pain
Solomon Hailemariam Tesfaye, Stefan Wilhelm, Alberto García Lledó et al. · Pain
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31 May 2013 |
312 |
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Exenatide Augments First- and Second-Phase Insulin Secretion in Response to Intravenous Glucose in Subjects with Type 2 Diabetes
Frauke Fehse, MICHAEL E. TRAUTMANN, Jens Juul Holst et al. · The Journal of Clinical Endocrinology & Metabolism
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Nov 2005 |
302 |
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Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a trial
Arun Jayant Sanyal, Lee M. Kaplan, Juan P. Frías et al. · Nature Medicine
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10 Jun 2024 |
290 |
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Genotypes and phenotypes in children with short stature: clinical indicators of SHOX haploinsufficiency
Gudrun Rappold, W. F. Blum, Elena P. Shavrikova et al. · Journal of Medical Genetics
Open access |
20 Dec 2006 |
258 |
| 22 |
Effects of Tadalafil Treatment on Erectile Function Recovery Following Bilateral Nerve-sparing Radical Prostatectomy: A Randomised Placebo-controlled Study (REACTT)
Francesco Montorsi, Gerald B Brock, Jens-Uwe Stolzenburg et al. · European Urology
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12 Oct 2013 |
251 |
| 23 |
Testosterone Substitution Normalizes Elevated Serum Leptin Levels in Hypogonadal Men
Friedrich Jockenhövel, Werner Friedrich Blum, Elisabeth Vogel et al. · The Journal of Clinical Endocrinology & Metabolism
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Aug 1997 |
251 |
| 24 |
Leptin suppresses semi-starvation induced hyperactivity in rats: implications for anorexia nervosa
Cornelia Exner, Johannes Hebebrand, Helmut Remschmidt et al. · Molecular Psychiatry
Open access |
Sep 2000 |
240 |
| 25 |
Leptin levels in patients with anorexia nervosa are reduced in the acute stage and elevated upon short-term weight restoration
Johannes Hebebrand, Werner Friedrich Blum, Nikolaus Barth et al. · Molecular Psychiatry
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Jul 1997 |
230 |
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Atomoxetine and methylphenidate treatment in children with ADHD: A prospective, randomized, open-label trial
Regina Dittmann, D.S. Fouche, Christopher J. Kratochvil et al. · European Neuropsychopharmacology
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223 |
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Hepatic and glucagon-like peptide-1–mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors
Kyle W. Sloop et al. · Journal of Clinical Investigation
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Jun 2004 |
215 |
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Costs Associated With Treatment of Chronic Low Back Pain
Jihyung Hong, Catherine C. Reed, Diego Novick et al. · Spine
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4 Oct 2012 |
213 |
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Molecular and prognostic distinction between serous ovarian carcinomas of varying grade and malignant potential
Ivo M. Meinhold-Heerlein, Dirk Bauerschlag, Felix Hilpert et al. · Oncogene
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22 Nov 2004 |
208 |
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Diabetes at the crossroads: relevance of disease classification to pathophysiology and treatment
Richard David Leslie, Jerry P. Palmer, Nanette Cathrin Schloot et al. · Diabetologia
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24 Oct 2015 |
207 |
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Drug Liposome Partitioning as a Tool for the Prediction of Human Passive Intestinal Absorption
K. Balon, Bernd U. Riebesehl, Bernhard W. Müller · Pharmaceutical Research
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199 |
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Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases
Guillermo Barturen et al. · Arthritis & Rheumatology
Open access132 authors |
8 Dec 2020 |
196 |
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Identification of 70 calcium-sensing receptor mutations in hyper- and hypo-calcaemic patients: evidence for clustering of extracellular domain mutations at calcium-binding sites
Fadil M. Hannan et al. · Human Molecular Genetics
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14 Mar 2012 |
192 |
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Multilevel Network Meta-Regression for Population-Adjusted Treatment Comparisons
David Phillippo, Sofia Dias, A. E. Ades et al. · Journal of the Royal Statistical Society Series A (Statistics in Society)
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Jun 2020 |
186 |
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Non?stimulant medications in the treatment of ADHD
Tobias Banaschewski, Veit Roessner, R.W. Dittmann et al. · European Child & Adolescent Psychiatry
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Jul 2004 |
185 |
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Leptin Production and Release in the Duallyin VitroPerfused Human Placenta1
Knud Linnemann, Antoine Malek, Ruth Sager et al. · The Journal of Clinical Endocrinology & Metabolism
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Nov 2000 |
185 |
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Clozapine and Olanzapine Are Associated With Food Craving and Binge Eating
Michael Kluge, Andreas Schuld, Hubertus Himmerich et al. · Journal of Clinical Psychopharmacology
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178 |
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Gemcitabine and cisplatin in the treatment of advanced or metastatic pancreatic cancer
Volker Heinemann, Hansjochen Wilke, H.‐G. Mergenthaler et al. · Annals of Oncology
Open access |
Nov 2000 |
172 |
| 39 |
Low leptin levels predict amenorrhea in underweight and eating disordered females
Wolfgang Kopp, Werner Friedrich Blum, S von Prittwitz et al. · Molecular Psychiatry
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Jul 1997 |
172 |
| 40 |
Serum leptin levels increase rapidly after initiation of clozapine therapy
T. Brömel, Werner Friedrich Blum, Andreas Ziegler et al. · Molecular Psychiatry
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1998 |
170 |
| 41 |
Dexamethasone Induces an Acute and Sustained Rise in Circulating Leptin Levels in Normal Human Subjects
JOHN P. MIELL, P. Engloro, Werner Friedrich Blum · Hormone and Metabolic Research
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169 |
| 42 |
Nonparametric Analysis of Ordered Categorical Data in Designs with Longitudinal Observations and Small Sample Sizes
Edgar Brunner, Frank Langer · Biometrical Journal
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Oct 2000 |
165 |
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ATP-Sensitive K+ Channel–Dependent Regulation of Glucagon Release and Electrical Activity by Glucose in Wild-Type and SUR1−/− Mouse α-Cells
Jesper Gromada, Xiaosong Ma, Marianne Høy et al. · Diabetes
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Dec 2004 |
165 |
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Rates and predictors of remission and recovery during 3 years in 392 never‐treated patients with schizophrenia
Martin Lambert, Dieter Naber, Alexander Schacht et al. · Acta Psychiatrica Scandinavica
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4 Aug 2008 |
161 |
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Exenatide twice daily versus glimepiride for prevention of glycaemic deterioration in patients with type 2 diabetes with metformin failure (EUREXA): an open-label, randomised controlled trial
Baptist Gallwitz, Juan M. Sánchez‐Guzmán, Francesco Dotta et al. · The Lancet
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Jun 2012 |
160 |
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Glucose Stimulates Glucagon Release in Single Rat α-Cells by Mechanisms that Mirror the Stimulus-Secretion Coupling in β-Cells
Hervør Lykke Olsen, Sten S. Theander, Krister B. Bokvist et al. · Endocrinology
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5 Aug 2005 |
160 |
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Front-line treatment of advanced non-small-cell lung cancer with MTA (LY231514, Pemetrexed disodium, ALIMTA™ and cisplatin: A multicenter phase II trial
C. Manegold, Ulrich Gatzemeier, Joachim von Pawel et al. · Annals of Oncology
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Apr 2000 |
156 |
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Parathyroid hormone increases the concentration of insulin-like growth factor-I and transforming growth factor beta 1 in rat bone.
Johannes Pfeilschifter, F Laukhuf, B. Müller‐Beckmann et al. · Journal of Clinical Investigation
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Clinical and Pharmacokinetic Phase I Study of Multitargeted Antifolate (LY231514) in Combination With Cisplatin
Ralf Thödtmann, Henrik Depenbrock, Herlinde Dumez et al. · Journal of Clinical Oncology
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Oct 1999 |
151 |
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A review of hemolytic uremic syndrome in patients treated with gemcitabine therapy
Man C. Fung, Anna Maria Storniolo, Binh Vu Nguyen et al. · Cancer
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May 1999 |
150 |