| 1 |
Gemcitabine alone or in combination with cisplatin in patients with biliary tract cancer: a comparative multicentre study in Japan
Takuji Okusaka, Kohei Nakachi, Akira Fukutomi et al. · British Journal of Cancer
Open access |
13 Jul 2010 |
757 |
| 2 |
Ramucirumab plus erlotinib in patients with untreated, EGFR-mutated, advanced non-small-cell lung cancer (RELAY): a randomised, double-blind, placebo-controlled, phase 3 trial
Kazuhiko Nakagawa et al. · The Lancet Oncology
Open access131 authors |
4 Oct 2019 |
619 |
| 3 |
Robust Central Reduction of Amyloid-β in Humans with an Orally Available, Non-Peptidic β-Secretase Inhibitor
Patrick C. May et al. · Journal of Neuroscience
Open access |
16 Nov 2011 |
373 |
| 4 |
Safety Profile of Baricitinib in Patients with Active Rheumatoid Arthritis with over 2 Years Median Time in Treatment
Josef S Smolen, Mark C. Genovese, Tsutomu Takeuchi et al. · The Journal of Rheumatology
Open access |
15 Sep 2018 |
260 |
| 5 |
Efficacy and safety of tirzepatide monotherapy compared with dulaglutide in Japanese patients with type 2 diabetes (SURPASS J-mono): a double-blind, multicentre, randomised, phase 3 trial
Nobuya Inagaki, Masakazu Takeuchi, Tomonori Oura et al. · The Lancet Diabetes & Endocrinology
Open access |
30 Jul 2022 |
226 |
| 6 |
Glucagon-Like Peptide 1 Receptor Agonist or Bolus Insulin With Optimized Basal Insulin in Type 2 Diabetes
Michaëla Diamant, Michael Albrecht Nauck, Rimma M. Shaginian et al. · Diabetes Care
|
11 Jul 2014 |
226 |
| 7 |
Efficacy and safety of ixekizumab treatment for Japanese patients with moderate to severe plaque psoriasis, erythrodermic psoriasis and generalized pustular psoriasis: Results from a 52‐week, open‐label, phase 3 study ( UNCOVER ‐J)
Hidehisa Saeki, Hidemi Nakagawa, Ko Nakajo et al. · The Journal of Dermatology
Open access |
11 Oct 2016 |
195 |
| 8 |
Prevalence, burden, and clinical management of migraine in China, Japan, and South Korea: a comprehensive review of the literature
Takao Takeshima, Qi Wan, Yanlei Zhang et al. · The Journal of Headache and Pain
Open access |
Dec 2019 |
176 |
| 9 |
Impact of caring for persons with Alzheimer’s disease or dementia on caregivers’ health outcomes: findings from a community based survey in Japan
Amir Goren, William S. Montgomery, Kristin Kahle‐Wrobleski et al. · BMC Geriatrics
Open access |
10 Jun 2016 |
159 |
| 10 |
Diabetes in Japan: a review of disease burden and approaches to treatment
Susan E. Neville, Kristina Secnik Boye, William S. Montgomery et al. · Diabetes/Metabolism Research and Reviews
|
30 Sep 2009 |
157 |
| 11 |
Pharmacogenomics of gemcitabine: can genetic studies lead to tailor-made therapy?
Hideki Ueno, Kendo Kiyosawa, Nahoko Kaniwa · British Journal of Cancer
Open access |
26 Jun 2007 |
157 |
| 12 |
The Role of Descending Inhibitory Pathways on Chronic Pain Modulation and Clinical Implications
Mikwang Kwon, Murat Altın, Héctor Dueñas et al. · Pain Practice
|
20 Nov 2013 |
153 |
| 13 |
Effects of teriparatide on bone mineral density and bone turnover markers in Japanese subjects with osteoporosis at high risk of fracture in a 24-month clinical study: 12-Month, randomized, placebo-controlled, double-blind and 12-month open-label phases
Akimitsu Miyauchi, Toshio Matsumoto, Toshitsugu Sugimoto et al. · Bone
|
25 May 2010 |
147 |
| 14 |
Guidelines for the use of biochemical markers of bone turnover in osteoporosis (2004)
Yoshiki Nishizawà, Toshitaka Nakamura, Hiroaki Ohta et al. · Journal of Bone and Mineral Metabolism
|
4 Mar 2005 |
138 |
| 15 |
Efficacy and safety of open‐label ixekizumab treatment in Japanese patients with moderate‐to‐severe plaque psoriasis, erythrodermic psoriasis and generalized pustular psoriasis
Hidehisa Saeki, Hidemi Nakagawa, Taeko Ishii et al. · Journal of the European Academy of Dermatology and Venereology
|
30 Oct 2014 |
132 |
| 16 |
Safety and efficacy of tirzepatide as an add-on to single oral antihyperglycaemic medication in patients with type 2 diabetes in Japan (SURPASS J-combo): a multicentre, randomised, open-label, parallel-group, phase 3 trial
Takashi Kadowaki, Rina Chin, Akichika Ozeki et al. · The Lancet Diabetes & Endocrinology
Open access |
30 Jul 2022 |
129 |
| 17 |
Randomised, double-blind, placebo-controlled study of olanzapine in patients with bipolar I depression
Mauricio F. Tohen, David McDonnell, Michael G. Case et al. · The British Journal of Psychiatry
Open access |
24 Aug 2012 |
129 |
| 18 |
Efficacy and Safety of Baricitinib in Japanese Patients with Active Rheumatoid Arthritis Receiving Background Methotrexate Therapy: A 12-week, Double-blind, Randomized Placebo-controlled Study
Yoshiya Tanaka, Kahaku Emoto, Zhihong Cai et al. · The Journal of Rheumatology
Open access |
Feb 2016 |
124 |
| 19 |
Residual symptoms and disease burden among patients with rheumatoid arthritis in remission or low disease activity: a systematic literature review
Masato Ishida, Yuki Kuroiwa, Emiko Yoshida et al. · Modern Rheumatology
ReviewOpen access |
18 Dec 2017 |
120 |
| 20 |
Efficacy and Safety of Two Doses of Pemetrexed Supplemented with Folic Acid and Vitamin B12 in Previously Treated Patients with Non-Small Cell Lung Cancer
Yuichiro Ohe, Yukito Ichinose, Kazuhiko Nakagawa et al. · Clinical Cancer Research
|
Jul 2008 |
120 |
| 21 |
Donanemab (LY3002813) Phase 1b Study in Alzheimer's Disease: Rapid and Sustained Reduction of Brain Amyloid Measured by Florbetapir F18 Imaging
Stephen Loucian Lowe, Cynthia Duggan Evans, Sergey Shcherbinin et al. · The Journal of Prevention of Alzheimer s Disease
Open access |
15 Sep 2021 |
117 |
| 22 |
Safety and Immunogenicity of LY3415244, a Bispecific Antibody Against TIM-3 and PD-L1, in Patients With Advanced Solid Tumors
Matthew David Hellmann, Nicoletta Bivi, Boris Calderón et al. · Clinical Cancer Research
Open access |
13 Jan 2021 |
113 |
| 23 |
A randomized, double-blind, phase II study of ramucirumab plus docetaxel vs placebo plus docetaxel in Japanese patients with stage IV non-small cell lung cancer after disease progression on platinum-based therapy
Kiyotaka Yoh, Yukio Hosomi, Kazuo Kasahara et al. · Lung Cancer
Open access |
19 Jul 2016 |
113 |
| 24 |
Identification of peak bone mass QTL in a spontaneously osteoporotic mouse strain
Motoyuki Shimizu, Keiichi Higuchi, Beth Bennett et al. · Mammalian Genome
|
Feb 1999 |
110 |
| 25 |
Real-world effectiveness of teriparatide on fracture reduction in patients with osteoporosis and comorbidities or risk factors for fractures: Integrated analysis of 4 prospective observational studies
Bente Lomholt Langdahl, Stuart L. Silverman, Saeko Fujiwara et al. · Bone
Open access |
20 Jul 2018 |
109 |
| 26 |
Burden of Migraine in Japan: Results of the ObserVational Survey of the Epidemiology, tReatment, and Care Of MigrainE (OVERCOME [Japan]) Study
Yasuhiko Matsumori, Kaname Ueda, Mika Komori et al. · Neurology and Therapy
Open access |
3 Dec 2021 |
107 |
| 27 |
Phase 1 study of galunisertib, a TGF-beta receptor I kinase inhibitor, in Japanese patients with advanced solid tumors
Yutaka Fujiwara, Hiroshi Nokihara, Yasuhide Yamada et al. · Cancer Chemotherapy and Pharmacology
|
2 Nov 2015 |
100 |
| 28 |
Once‐weekly glucagon‐like peptide‐1 receptor agonist dulaglutide is non‐inferior to once‐daily liraglutide and superior to placebo in J apanese patients with type 2 diabetes: a 26‐week randomized phase III study
Jun‐ichiro Miyagawa, Masato Odawara, Toshinari Takamura et al. · Diabetes Obesity and Metabolism
Open access |
14 Jul 2015 |
98 |
| 29 |
Real-world treatment patterns and patient-reported outcomes in episodic and chronic migraine in Japan: analysis of data from the Adelphi migraine disease specific programme
Kaname Ueda, Wenyu Ye, Louise Lombard et al. · The Journal of Headache and Pain
Open access |
7 Jun 2019 |
96 |
| 30 |
Infections in baricitinib clinical trials for patients with active rheumatoid arthritis
Kevin L. Winthrop, Masayoshi Harigai, Mark C. Genovese et al. · Annals of the Rheumatic Diseases
Open access |
11 Aug 2020 |
94 |
| 31 |
PINP as an aid for monitoring patients treated with teriparatide
Mika Tsujimoto, Peiqi Chen, Akimitsu Miyauchi et al. · Bone
|
18 Dec 2010 |
93 |
| 32 |
Subgroup analyses of the safety and efficacy of ramucirumab in Japanese and Western patients in RAINBOW: a randomized clinical trial in second-line treatment of gastric cancer
Kohei Shitara et al. · Gastric Cancer
Open access |
28 Oct 2015 |
87 |
| 33 |
Randomized, Double-blind, Placebo-controlled Phase III Trial of Duloxetine Monotherapy in Japanese Patients With Chronic Low Back Pain
Shin‐ichi Konno, Natsuko Oda, Toshimitsu Ochiai et al. · Spine
Open access |
25 May 2016 |
85 |
| 34 |
Phase I study of LY2181308, an antisense oligonucleotide against survivin, in patients with advanced solid tumors
Maki Tanioka, Hiroshi Nokihara, Noboru Yamamoto et al. · Cancer Chemotherapy and Pharmacology
|
15 Nov 2010 |
85 |
| 35 |
Efficacy and Safety Profile of Exenatide Once Weekly Compared With Insulin Once Daily in Japanese Patients With Type 2 Diabetes Treated With Oral Antidiabetes Drug(s): Results From a 26-Week, Randomized, Open-Label, Parallel-Group, Multicenter, Noninferiority Study
Nobuya Inagaki, Yoshihito Atsumi, Tomonori Oura et al. · Clinical Therapeutics
|
9 Aug 2012 |
85 |
| 36 |
Tadalafil once daily for lower urinary tract symptoms suggestive of benign prostatic hyperplasia: A randomized placebo‐ and tamsulosin‐controlled 12‐week study in A sian men
Osamu Yokoyama, Masaki Yoshida, Sae Chul Kim et al. · International Journal of Urology
|
7 Sep 2012 |
84 |
| 37 |
Comprehensive population-based survey of migraine in Japan: results of the ObserVational Survey of the Epidemiology, tReatment, and Care Of MigrainE (OVERCOME [Japan]) study
Koichi Hirata, Kaname Ueda, Mika Komori et al. · Current Medical Research and Opinion
Open access |
25 Aug 2021 |
83 |
| 38 |
Efficacy and safety of once‐weekly dulaglutide in combination with sulphonylurea and/or biguanide compared with once‐daily insulin glargine in J apanese patients with type 2 diabetes: a randomized, open‐label, phase III , non‐inferiority study
Eiichi Araki, Nobuya Inagaki, Yukio Tanizawa et al. · Diabetes Obesity and Metabolism
Open access |
14 Jul 2015 |
82 |
| 39 |
Concomitant Coronary Atheroma Regression and Stabilization in Response to Lipid-Lowering Therapy
Flavio Giuseppe Biccirè et al. · Journal of the American College of Cardiology
Open access |
26 Aug 2023 |
80 |
| 40 |
Potentials and limitations of nonclinical safety assessment for predicting clinical adverse drug reactions: correlation analysis of 142 approved drugs in Japan
Chihiro Tamaki, Takashi Nagayama, Masamichi Hashiba et al. · The Journal of Toxicological Sciences
Open access |
2013 |
80 |
| 41 |
Empagliflozin Induces Transient Diuresis Without Changing Long-Term Overall Fluid Balance in Japanese Patients With Type 2 Diabetes
Atsutaka Yasui, Ganghyuck Lee, Tetsuaki Hirase et al. · Diabetes Therapy
Open access |
27 Feb 2018 |
79 |
| 42 |
The Effect of Discontinuing Treatment With Blosozumab: Follow-up Results of a Phase 2 Randomized Clinical Trial in Postmenopausal Women With Low Bone Mineral Density
Christopher P. Recknor, Robert R. Recker, Charles Benson et al. · Journal of Bone and Mineral Research
Open access |
24 Feb 2015 |
77 |
| 43 |
Increased Risk of Acute Pancreatitis in Patients with Type 2 Diabetes: An Observational Study Using a Japanese Hospital Database
Hisashi Urushihara, Masanori Taketsuna, Ying Liu et al. · PLoS ONE
Open access |
27 Dec 2012 |
75 |
| 44 |
An individualized GH dose regimen for long-term GH treatment in Japanese patients with adult GH deficiency
Kazuo Chihara, Ekaterina B Koledova, Akira Shimatsu et al. · European Journal of Endocrinology
|
Jul 2005 |
72 |
| 45 |
Overexpression of IQGAP1 in advanced colorectal cancer correlates with poor prognosis—critical role in tumor invasion
Hiroyuki Hayashi, Kazuki Nabeshima, Mikiko Aoki et al. · International Journal of Cancer
|
23 Oct 2009 |
66 |
| 46 |
Long‐term efficacy and safety of ixekizumab in Japanese patients with erythrodermic or generalized pustular psoriasis: subgroup analyses of an open‐label, phase 3 study ( UNCOVER ‐J)
Yukari Okubo, Tomotaka Mabuchi, Keiji Iwatsuki et al. · Journal of the European Academy of Dermatology and Venereology
Open access |
14 Oct 2018 |
63 |
| 47 |
Alzheimer’s disease severity and its association with patient and caregiver quality of life in Japan: results of a community-based survey
William S. Montgomery, Amir Goren, Kristin Kahle‐Wrobleski et al. · BMC Geriatrics
Open access |
14 Jun 2018 |
63 |
| 48 |
Epidemiology, associated burden, and current clinical practice for the diagnosis and management of Alzheimer’s disease in Japan
William S. Montgomery, Kaname Ueda, Margaret Jorgensen et al. · ClinicoEconomics and Outcomes Research
Open access |
Dec 2017 |
63 |
| 49 |
Lifestyle-Related Metabolic Disorders, Osteoporosis, and Fracture Risk in Asia: A Systematic Review
Toshitsugu Sugimoto, Masayo Sato, Francis C. Dehle et al. · Value in Health Regional Issues
ReviewOpen access |
4 Dec 2015 |
63 |
| 50 |
Pharmacokinetics, Pharmacodynamics, Tolerability, and Safety of Exenatide in Japanese Patients With Type 2 Diabetes Mellitus
Prajakti A. Kothare, Helle Linnebjerg, Yoshitaka Isaka et al. · The Journal of Clinical Pharmacology
|
Dec 2008 |
63 |