| 1 |
Radiotherapy to the primary tumour for newly diagnosed, metastatic prostate cancer (STAMPEDE): a randomised controlled phase 3 trial
Christopher Parker et al. · The Lancet
Open access |
21 Oct 2018 |
1,289 |
| 2 |
DEVELOPMENT OF A EUROPEAN MULTIMODEL ENSEMBLE SYSTEM FOR SEASONAL-TO-INTERANNUAL PREDICTION (DEMETER)
T. N. Palmer et al. · Bulletin of the American Meteorological Society
Open access |
Jun 2004 |
1,002 |
| 3 |
Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms
Samuel E. Jones et al. · Nature Communications
Open access |
29 Jan 2019 |
752 |
| 4 |
Focus Groups
Richard Antony Powell, Helen M. Single · International Journal for Quality in Health Care
|
1996 |
705 |
| 5 |
Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study
Nicholas Alexander Kennedy et al. · The Lancet. Gastroenterology & hepatology
Open access164 authors |
26 Feb 2019 |
696 |
| 6 |
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
Nicole M. Warrington et al. · Nature Genetics
Open access208 authors |
May 2019 |
664 |
| 7 |
Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary
Claus Franz Vogelmeier et al. · Archivos de Bronconeumología
|
23 Feb 2017 |
633 |
| 8 |
Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial
Michael C Böhm et al. · The Lancet
223 authors |
29 Mar 2020 |
598 |
| 9 |
Western Disturbances: A review
Ashok Priyadarshan Dimri, Dev Niyogi, Ana Paula Barros et al. · Reviews of Geophysics
|
8 Apr 2015 |
538 |
| 10 |
The North American Regional Climate Change Assessment Program: Overview of Phase I Results
Linda O. Mearns, R. W. Arritt, S. Biner et al. · Bulletin of the American Meteorological Society
Open access |
6 Mar 2012 |
492 |
| 11 |
Disease progression and treatment response in data-driven subgroups of type 2 diabetes compared with models based on simple clinical features: an analysis using clinical trial data
John Dennis, Beverley M. Shields, William Henley et al. · The Lancet Diabetes & Endocrinology
Open access |
29 Apr 2019 |
489 |
| 12 |
Vitamin D and Risk of Cognitive Decline in Elderly Persons
David J. Llewellyn · Archives of Internal Medicine
Open access |
12 Jul 2010 |
463 |
| 13 |
Characteristics of fetal anticonvulsant syndrome associated autistic disorder
AD Rasalam, H. Hailey, JHG Williams et al. · Developmental Medicine & Child Neurology
|
14 Jul 2005 |
461 |
| 14 |
A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II
Fiona E. Matthews et al. · Nature Communications
Open access |
19 Apr 2016 |
434 |
| 15 |
HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn’s Disease
Aleksejs Sazonovs et al. · Gastroenterology
Open access156 authors |
7 Oct 2019 |
423 |
| 16 |
Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank
Jessica Tyrrell, Samuel E. Jones, Robin N. Beaumont et al. · BMJ
Open access |
8 Mar 2016 |
415 |
| 17 |
Alagille syndrome: pathogenesis, diagnosis and management
Peter D. Turnpenny, Sian Ellard · European Journal of Human Genetics
Open access |
21 Sep 2011 |
405 |
| 18 |
Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array
Georgina Mansell, T.J. Gorrie-Stone, Yanchun Bao et al. · BMC Genomics
Open access |
14 May 2019 |
399 |
| 19 |
Mutations in the human Delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis
Michael P. Bulman, Kenro Kusumi, Timothy Mark Frayling et al. · Nature Genetics
|
Apr 2000 |
395 |
| 20 |
Cost733cat – A database of weather and circulation type classifications
Andreas Philipp, Judit Bartholy, Christoph Beck et al. · Physics and Chemistry of the Earth Parts A/B/C
Open access |
2010 |
382 |
| 21 |
Common genetic variants contribute to risk of rare severe neurodevelopmental disorders
Mari Niemi, Hilary C. Martin, Daniel L Rice et al. · Nature
Open access |
25 Sep 2018 |
354 |
| 22 |
Making new genetic diagnoses with old data: iterative reanalysis and reporting from genome-wide data in 1,133 families with developmental disorders
Caroline Fiona Wright, Jeremy F. McRae, Stephen Clayton et al. · Genetics in Medicine
Open access |
11 Jan 2018 |
353 |
| 23 |
Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour
Samuel E. Jones et al. · Nature Communications
Open access |
5 Apr 2019 |
339 |
| 24 |
Mutational spectrum in a worldwide study of 29,700 families with BRCA1 or BRCA2 mutations
Timothy Richard Rebbeck et al. · Human Mutation
Open access245 authors |
15 Feb 2018 |
325 |
| 25 |
The rediscovery of recovery: open to all
Glenn A. Roberts, Paul Wolfson · Advances in Psychiatric Treatment
Open access |
31 Dec 2003 |
322 |
| 26 |
Numbers of Salmonella enteritidis in the contents of naturally contaminated hens' eggs
T. J. Humphrey, A. L. Whitehead, Andrew Gawler et al. · Epidemiology and Infection
Open access |
Jun 1991 |
302 |
| 27 |
Multicenter Assessment of Neoadjuvant Chemotherapy for Muscle-invasive Bladder Cancer
Homayoun S. Zargar et al. · European Urology
Open access |
23 Sep 2014 |
298 |
| 28 |
SCOFF, the development of an eating disorder screening questionnaire
Laura S. Hill, Fiona Reid, JOHN FARNILL MORGAN et al. · International Journal of Eating Disorders
Open access |
2 Apr 2009 |
293 |
| 29 |
The clinical course and management of thoracic empyema
A.D. Ferguson, Richard J. Prescott, J.B. Selkon et al. · QJM
|
Apr 1996 |
292 |
| 30 |
Psychological factors that impact on women's experiences of first-time motherhood: a qualitative study of the transition
Ruth Darvill, Heather Skirton, Paul A Farrand · Midwifery
|
10 Sep 2008 |
286 |
| 31 |
On the variability of ENSO over the past six centuries
Rosanne D D'Arrigo, Edward R. Cook, Rob Wilson et al. · Geophysical Research Letters
Open access |
Feb 2005 |
282 |
| 32 |
From GOLD 0 to Pre-COPD
MeiLan King Han, Alvar G.N. Agustí, Bartolomé R. Celli et al. · American Journal of Respiratory and Critical Care Medicine
Open access |
19 Nov 2020 |
278 |
| 33 |
Sources of Campylobacter spp. Colonizing Housed Broiler Flocks during Rearing
S. A. Bull, V.M. Allen, Gil Domingue et al. · Applied and Environmental Microbiology
Open access |
2006 |
265 |
| 34 |
Salmonella enteritidis phage type 4 from the contents of intact eggs: a study involving naturally infected hens
T. J. Humphrey, Arthur Baskerville, S. L. Mawer et al. · Epidemiology and Infection
Open access |
Dec 1989 |
257 |
| 35 |
Initialized Earth System prediction from subseasonal to decadal timescales
Gerald A. Meehl et al. · Nature Reviews Earth & Environment
ReviewOpen access |
13 Apr 2021 |
249 |
| 36 |
Mutation of the LUNATIC FRINGE Gene in Humans Causes Spondylocostal Dysostosis with a Severe Vertebral Phenotype
Duncan Burnaby Sparrow, Gavin Chapman, Merridee A. Wouters et al. · The American Journal of Human Genetics
Open access |
7 Dec 2005 |
247 |
| 37 |
Percutaneous treatment options for acute pulmonary embolism: a clinical consensus statement by the ESC Working Group on Pulmonary Circulation and Right Ventricular Function and the European Association of Percutaneous Cardiovascular Interventions
Piotr Pruszczyk, Frederikus Klok Klok, Nils Kucher et al. · EuroIntervention
Open access |
Oct 2022 |
233 |
| 38 |
Satellite and In Situ Observations for Advancing Global Earth Surface Modelling: A Review
Gianpaolo Balsamo et al. · Remote Sensing
Open access |
14 Dec 2018 |
233 |
| 39 |
The role of hepatitis E virus testing in drug‐induced liver injury
Harry R. Dalton, H. J. Fellows, William Stableforth et al. · Alimentary Pharmacology & Therapeutics
|
7 Sep 2007 |
218 |
| 40 |
Vitamin K Deficiency Bleeding (VKDB) in Infancy
Rüdiger von Kries, Marlies Cornelissen, Andrew McNinch et al. · Thrombosis and Haemostasis
|
1999 |
206 |
| 41 |
Coronavirus pandemic and colorectal surgery: practical advice based on the Italian experience
Salomone Di Saverio, Francesco Pata, Gaetano Gallo et al. · Colorectal Disease
Open access |
31 Mar 2020 |
205 |
| 42 |
Chronic Obstructive Pulmonary Disease Biomarkers and Their Interpretation
Robert Andrew Stockley, David M.G. Halpin, Bartolomé R. Celli et al. · American Journal of Respiratory and Critical Care Medicine
Open access |
28 Dec 2018 |
204 |
| 43 |
Intraocular Pressure Monitoring Post Intravitreal Steroids: A Systematic Review
Weerawat Kiddee, Graham E. Trope, Lisa Sheng et al. · Survey of Ophthalmology
Review |
14 Jun 2013 |
195 |
| 44 |
Interplay between BRCA1 and RHAMM Regulates Epithelial Apicobasal Polarization and May Influence Risk of Breast Cancer
Christopher A. Maxwell et al. · PLoS Biology
Open access150 authors |
15 Nov 2011 |
194 |
| 45 |
Diabetes and Frailty: An Expert Consensus Statement on the Management of Older Adults with Type 2 Diabetes
William David Strain, Su Down, Pam Brown et al. · Diabetes Therapy
Open access |
8 Apr 2021 |
193 |
| 46 |
Monogenic diabetes: a gateway to precision medicine in diabetes
Haichen Zhang, Kevin Colclough, Anna L. Gloyn et al. · Journal of Clinical Investigation
Open access |
Feb 2021 |
193 |
| 47 |
HLA-DQA1–HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants
Graham Heap et al. · Nature Genetics
Open access |
14 Sep 2014 |
191 |
| 48 |
What is the evidence for the use of biologic or biosynthetic meshes in abdominal wall reconstruction?
Ferdin KÖckerling et al. · Hernia
Open access |
31 Jan 2018 |
181 |
| 49 |
Transatlantic distribution of the Alaskan White River Ash
Britta J.L. Jensen, Sean Pyne-O’Donnell, Gill Plunkett et al. · Geology
Open access |
19 Sep 2014 |
179 |
| 50 |
The colonization of broiler chickens withCampylobacter jejuni: some epidemiological investigations
T. J. Humphery, A. Henley, D. G. Lanning · Epidemiology and Infection
Open access |
Jun 1993 |
177 |