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FS118, a Bispecific Antibody Targeting LAG-3 and PD-L1, Enhances T-Cell Activation Resulting in Potent Antitumor Activity
Matthew Kraman, Mustapha Faroudi, Natalie L. Allen et al. · Clinical Cancer Research
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16 Apr 2020 |
113 |
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Alan Boyd, T. Geerling, W. J. Gregory et al. · Journal of the Operational Research Society
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6 Sep 2006 |
71 |
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FS222, a CD137/PD-L1 Tetravalent Bispecific Antibody, Exhibits Low Toxicity and Antitumor Activity in Colorectal Cancer Models
Matthew A. Lakins, Alexander Koers, Raffaella Giambalvo et al. · Clinical Cancer Research
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28 Apr 2020 |
67 |
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CD137/OX40 Bispecific Antibody Induces Potent Antitumor Activity that Is Dependent on Target Coengagement
Miguel A. Gaspar, John Pravin, Leonor Nunes Rodrigues et al. · Cancer Immunology Research
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9 Apr 2020 |
57 |
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A Phase 1 First-in-Human Study of FS118, a Tetravalent Bispecific Antibody Targeting LAG-3 and PD-L1 in Patients with Advanced Cancer and PD-L1 Resistance
Timothy Anthony Yap et al. · Clinical Cancer Research
Open access |
7 Nov 2022 |
53 |
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Quality of intervention delivery in a cluster randomised controlled trial: a qualitative observational study with lessons for fidelity
KAREN E. JAMES, Alan Quirk, Sue Patterson et al. · Trials
Open access |
17 Nov 2017 |
52 |
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A HER2-specific Modified Fc Fragment (Fcab) Induces Antitumor Effects Through Degradation of HER2 and Apoptosis
Kin-Mei Leung, Sarah Batey, Robert J. Rowlands et al. · Molecular Therapy
Open access |
3 Aug 2015 |
34 |
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Generation of Fcabs targeting human and murine LAG-3 as building blocks for novel bispecific antibody therapeutics
Katy L. Everett, Matthew Kraman, Francisca Wollerton et al. · Methods
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9 Sep 2018 |
31 |
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Mutant Lef1 controls Gata6 in sebaceous gland development and cancer
Bénédicte Oulès, Emanuel Rognoni, Esther Hoste et al. · The EMBO Journal
Open access |
18 Mar 2019 |
27 |
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Improving health care through community OR
Michael Walsh, Tony Hostick · Journal of the Operational Research Society
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8 Dec 2004 |
26 |
| 11 |
Stability assessment on a library scale: a rapid method for the evaluation of the commutability and insertion of residues in C-terminal loops of the CH3 domains of IgG1-Fc
Christoph Hasenhindl, Michael W. Traxlmayr, Gordana Wozniak‐Knopp et al. · Protein Engineering Design and Selection
Open access |
4 Sep 2013 |
21 |
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A carbohydrate-binding affinity ligand for the specific enrichment of glycoproteins
Chen Chen, Graziella El Khoury, Peiqing Zhang et al. · Journal of Chromatography A
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20 Mar 2016 |
18 |
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31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one
Andreas Lundqvist et al. · Journal for ImmunoTherapy of Cancer
Open access1,762 authors |
Nov 2016 |
11 |
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Efficacy and pharmacodynamic effect of anti-CD73 and anti-PD-L1 monoclonal antibodies in combination with cytotoxic therapy: observations from mouse tumor models
Brajesh Pratap Kaistha et al. · Cancer Biology & Therapy
Open access |
11 Jan 2024 |
10 |
| 15 |
Durable response of anaplastic thyroid carcinoma to FS118, a bispecific LAG-3/PD-L1 antibody, after checkpoint inhibitor progression: a case report
Maxwell Kroloff, Josefin-Beate Holz, Omer Stern et al. · Journal for ImmunoTherapy of Cancer
Open access |
Oct 2022 |
10 |
| 16 |
Biomarker Context-Of-Use: How Organizational Design Can Impact the Implementation of the Appropriate Biomarker Assay Strategy
Kyra J. Cowan et al. · Bioanalysis
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Jul 2022 |
9 |
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IFNγ Production by Functionally Reprogrammed Tregs Promotes Antitumor Efficacy of OX40/CD137 Bispecific Agonist Therapy
Charlotte J. Imianowski, Paula Kuo, Sarah K. Whiteside et al. · Cancer Research Communications
Open access |
12 Jul 2024 |
7 |
| 18 |
M9657 Is a Bispecific Tumor-Targeted Anti-CD137 Agonist That Induces MSLN-Dependent Antitumor Immunity without Liver Inflammation
Chunxiao Xu, Xueyuan Zhou, Lindsay Webb et al. · Cancer Immunology Research
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13 Dec 2023 |
7 |
| 19 |
1033TiP A first-in-human phase I study of FS120, an OX40/CD137 tetravalent bispecific antibody, in patients with advanced malignancies
K. Papadopoulos, Timothy Anthony Yap, Sarina Anne Piha-Paul et al. · Annals of Oncology
Open access |
Sep 2021 |
4 |
| 20 |
715 FS118, a tetravalent bispecific antibody targeting LAG-3 and PD-L1, induces LAG-3 shedding resulting in receptor downregulation by T cells via a novel mechanism of action
Michelle Morrow, Mustapha Faroudi, Krishnendu Chakraborty et al. · Regular and Young Investigator Award Abstracts
Conference paperOpen access |
Nov 2020 |
4 |
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Reverse immunology: From peptide sequence to tumor-killing human T-cell clones
Christophe Vanhaver, Mónica Gordón‐Alonso, Alexandre Bayard et al. · Methods in enzymology on CD-ROM/Methods in enzymology
Book chapterOpen access |
17 Jun 2019 |
4 |
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Antibodies as drugs—a Keystone Symposia report
Jennifer Cable et al. · Annals of the New York Academy of Sciences
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16 Nov 2022 |
3 |
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Pragmatic mAb lead molecule engineering from a developability perspective
Bertie Chi, Geoffrey De Oliveira, Tom Gallagher et al. · Biotechnology and Bioengineering
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29 Apr 2021 |
3 |
| 24 |
Improvement of Key Characteristics of Antibodies
Neil Brewis · Learning materials in biosciences
Book chapter |
30 Nov 2020 |
2 |
| 25 |
Crowdsourcing to Enhance Insights from Satellite Observations
Suvodeep Mazumdar, Stuart N. Wrigley, Fabio Ciravegna et al. · Earth systems data and models
Book chapter |
21 Dec 2017 |
2 |
| 26 |
The tetravalent, bispecific properties of FS118, an anti-LAG-3/PD-L1 antibody, mediate LAG-3 shedding from CD4+ and CD8+ tumor-infiltrating lymphocytes
Claire S. Reader, Wenjia Liao, Beatrice J. Potter-Landua et al. · Anti-Cancer Drugs
Open access |
17 Feb 2025 |
1 |
| 27 |
173P First-in-human study to evaluate the safety and clinical activity of FS222: A tetravalent bispecific antibody targeting PD-L1 and CD137, in patients with advanced solid tumors
G.A. De Velasco Oria, Elena Garralda, V. Moreno Garcia et al. · Immuno-Oncology Technology
Open access |
Dec 2022 |
1 |
| 28 |
165TiP A first-in-human phase I study of FS222, a CD137/PD-L1 tetravalent bispecific antibody, in patients with advanced malignancies
Elena Garralda, Ignacio Melero, Guillermo de Velasco et al. · Annals of Oncology
Open access |
Dec 2021 |
1 |
| 29 |
GNSSBio: Forest biomass retrieval based on GNSS ground receiver
Antonio Mollfulleda, Francisco Martín, S. Paloscia et al.
Conference paper |
Jul 2017 |
1 |
| 30 |
Characterisation of AMD Versal FPGA Transceivers Under Heavy-Ion Radiation
Alberto González Villafranca, Albert Ferrer Florit, Marti Farras Casas et al.
Conference paper |
2 Oct 2025 |
0 |
| 31 |
FS222, a CD137/PD-L1 Tetravalent Bispecific Antibody, Designed for Optimal CD137 Engagement Resulting in Potent Conditional T-Cell Activity
Matthew A. Lakins, Christel Séguy Veyssier, Jose M. Munoz-Olaya et al. · Current Cancer Drug Targets
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9 Oct 2025 |
0 |
| 32 |
SpaceFibre IP Cores for Fast Adoption of Next-Gen FPGA Communication Architectures
Alberto González Villafranca, Albert Ferrer Florit, Marti Farras Casas et al.
Conference paper |
Mar 2025 |
0 |
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Optimising TNFRSF agonism and checkpoint blockade with a novel CD137/PD-L1 bispecific antibody
Matthew A. Lakins, Jose M. Munoz-Olaya, D H Jones et al. · Annals of Oncology
Open access |
Dec 2018 |
0 |