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The Translation of Cell-Based Therapies: Clinical Landscape and Manufacturing Challenges
Thomas R.J. Heathman, Alvin William Nienow, Mark McCall et al. · Regenerative Medicine
Open access |
2015 |
303 |
| 2 |
In vitro fibrillogenesis of collagen type I in varying ionic and pH conditions
J. Robin Harris, Andrei Soliakov, Richard James Lewis · Micron
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30 Mar 2013 |
117 |
| 3 |
Hybrid modeling for quality by design and PAT‐benefits and challenges of applications in biopharmaceutical industry
Moritz von Stosch, Steven Davy, Kjell François et al. · Biotechnology Journal
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8 May 2014 |
104 |
| 4 |
Characterization of human mesenchymal stem cells from multiple donors and the implications for large scale bioprocess development
Thomas R.J. Heathman, Qasim A. Rafiq, Alexander K.C. Chan et al. · Biochemical Engineering Journal
Open access |
4 Jul 2015 |
93 |
| 5 |
Anything but Conventional Chromatography Approaches in Bioseparation
Ana Cecília A. Roque, Ana Sofia Pina, Ana Margarida Azevedo et al. · Biotechnology Journal
Open access |
25 Apr 2020 |
89 |
| 6 |
Expansion, harvest and cryopreservation of human mesenchymal stem cells in a serum‐free microcarrier process
Thomas R.J. Heathman, Veronica A. M. Glyn, Andrew Picken et al. · Biotechnology and Bioengineering
Open access |
28 Feb 2015 |
89 |
| 7 |
Site-Specific PEGylation at Histidine Tags
Yuehua Cong et al. · Bioconjugate Chemistry
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16 Jan 2012 |
83 |
| 8 |
Scale‐Down Model Development in ambr systems: An Industrial Perspective
Viktor Sandner, Leon P. Pybus, Graham A. McCreath et al. · Biotechnology Journal
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23 Oct 2018 |
65 |
| 9 |
Generation and Characterization of Multipotent Stem Cells from Established Dermal Cultures
Rebecca P. Hill, Karl Gledhill, Aaron Ions Gardner et al. · PLoS ONE
Open access |
30 Nov 2012 |
62 |
| 10 |
Microbially induced calcium carbonate precipitation through CO2 sequestration via an engineered Bacillus subtilis
Katie A. Gilmour, Prakriti Sharma Ghimire, Jennifer Wright et al. · Microbial Cell Factories
Open access |
10 Jun 2024 |
58 |
| 11 |
Laterally fluorinated liquid crystals containing the 2,2′‐bithiophene moiety
Avtar Singh Matharu, Stephen J. Cowling, G. Wright · Liquid Crystals
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Apr 2007 |
47 |
| 12 |
Serum-free process development: improving the yield and consistency of human mesenchymal stromal cell production
Thomas R.J. Heathman, Alexandra Stolzing, Claire Fabian et al. · Cytotherapy
Open access |
29 Sep 2015 |
46 |
| 13 |
Scalability and process transfer of mesenchymal stromal cell production from monolayer to microcarrier culture using human platelet lysate
Thomas R.J. Heathman, Alexandra Stolzing, Claire Fabian et al. · Cytotherapy
Open access |
10 Mar 2016 |
45 |
| 14 |
Agitation and aeration of stirred-bioreactors for the microcarrier culture of human mesenchymal stem cells and potential implications for large-scale bioprocess development
Thomas R.J. Heathman, Alvin William Nienow, Qasim A. Rafiq et al. · Biochemical Engineering Journal
Open access |
25 Apr 2018 |
44 |
| 15 |
High-yield vesicle-packaged recombinant protein production from E. coli
Tara A. Eastwood, Karen Baker, Bree R. Streather et al. · Cell Reports Methods
Open access |
Feb 2023 |
39 |
| 16 |
Engineering the flagellar type III secretion system: improving capacity for secretion of recombinant protein
Charlotte A. Green, Nitin S. Kamble, Elizabeth K. Court et al. · Microbial Cell Factories
Open access |
18 Jan 2019 |
39 |
| 17 |
Multivariate Data Analysis Methodology to Solve Data Challenges Related to Scale‐Up Model Validation and Missing Data on a Micro‐Bioreactor System
Stephen Goldrick, Viktor Sandner, Matthew Cheeks et al. · Biotechnology Journal
Open access |
16 Oct 2019 |
31 |
| 18 |
Development of a process control strategy for the serum-free microcarrier expansion of human mesenchymal stem cells towards cost-effective and commercially viable manufacturing
Thomas R.J. Heathman, Alvin William Nienow, Qasim A. Rafiq et al. · Biochemical Engineering Journal
Open access |
21 Oct 2018 |
20 |
| 19 |
Enzymatic hydrolysis of bovine hide and recovery of collagen hydrolysate in aqueous two-phase systems
Pitchaivelu Selvakumar, Tau Chuan Ling, Anthony D Covington et al. · Separation and Purification Technology
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6 Feb 2012 |
20 |
| 20 |
Microbioreactor for lower cost and faster optimisation of protein production
Mayur Parekh, abdulaziz ali, Zulfiqur Ali et al. · The Analyst
Open access |
2020 |
19 |
| 21 |
Rapid screening of cellular stress responses in recombinant Pichia pastoris strains using metabolite profiling
Gregory D. Tredwell, Rochelle Aw, Bryn Edwards-Jones et al. · Journal of Industrial Microbiology & Biotechnology
Open access |
3 Feb 2017 |
19 |
| 22 |
Human hair follicle dermal sheath and papilla cells support keratinocyte growth in monolayer coculture
Rebecca P. Hill, Aaron Ions Gardner, Heather Crawford et al. · Experimental Dermatology
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2 Feb 2013 |
19 |
| 23 |
The accurate measurement of second virial coefficients using self-interaction chromatography: Experimental considerations
Amanda Quigley, Jerry Y. Y. Heng, John M. Liddell et al. · European Journal of Pharmaceutics and Biopharmaceutics
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25 Apr 2013 |
19 |
| 24 |
Study of pH-triggered heteroaggregation and gel formation within mixed dispersions
Dave Hui, Mohammed Nawaz, Daniel P. Morris et al. · Journal of Colloid and Interface Science
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29 May 2008 |
19 |
| 25 |
Partitioning of haemoglobin and bovine serum albumin from whole bovine blood using aqueous two-phase systems
Pitchaivelu Selvakumar, Tau Chuan Ling, Simon G. Walker et al. · Separation and Purification Technology
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6 Mar 2012 |
19 |
| 26 |
Analysis of fouling and breakthrough of process related impurities during depth filtration using confocal microscopy
Maria Parau, Thomas F. Johnson, James R. Pullen et al. · Biotechnology Progress
Open access |
17 Jan 2022 |
18 |
| 27 |
Screening Naturally Occurring Phenolic Antioxidants for Their Suitability as Additives to CHO Cell Culture Media Used to Produce Monoclonal Antibodies
Luis Toronjo‐Urquiza, David C. James, Tibor Nagy et al. · Antioxidants
Open access |
3 Jun 2019 |
18 |
| 28 |
The use of catechins in Chinese hamster ovary cell media for the improvement of monoclonal antibody yields and a reduction of acidic species
Luis Toronjo‐Urquiza, Adelina E. Acosta‐Martin, David C. James et al. · Biotechnology Progress
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17 Feb 2020 |
17 |
| 29 |
Coupling picodroplet microfluidics with plate imaging for the rapid creation of biomanufacturing suitable cell lines with high probability and improved multi‐step assurance of monoclonality
Leon P. Pybus, Devika Kalsi, Joe Matthews et al. · Biotechnology Journal
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11 Oct 2021 |
16 |
| 30 |
Inkjet printable aqueous composite dye–polymer nanoparticles
Jonathan Henry Wilson, Roy Bradbury, Tom Annable et al. · Dyes and Pigments
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21 Apr 2012 |
16 |
| 31 |
A metric for predicting perceptual blackness
Stephen Westland, TLV Cheung, OR Lozman · Color and Imaging Conference
Conference paperOpen access |
2006 |
15 |
| 32 |
Integration of host strain bioengineering and bioprocess development using ultra‐scale down studies to select the optimum combination: An antibody fragment primary recovery case study
Jean P. Aucamp, Richard Davies, Damien Hallet et al. · Biotechnology and Bioengineering
Open access |
16 May 2014 |
15 |
| 33 |
Porous Platform Inks for Fast and High‐Resolution 3D Printing of Stationary Phases for Downstream Processing
Mariachiara Conti, Jodie A. Symington, James R. Pullen et al. · Advanced Materials Technologies
Open access |
27 Jul 2023 |
14 |
| 34 |
Resveratrol addition to Chinese hamster ovary cell culture media: The effect on cell growth, monoclonal antibody synthesis, and its chemical modification
Luis Toronjo‐Urquiza, Adelina E. Acosta‐Martin, David C. James et al. · Biotechnology Progress
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19 Nov 2019 |
14 |
| 35 |
The use of MEG-based brain computer interface for classification of wrist movements in four different directions
Noha I. Sabra, Manal Abdel Wahed
Conference paper |
Apr 2011 |
13 |
| 36 |
Clinical usefulness of temporal subtraction method in screening digital chest radiography with a mobile computed radiography system
Yasuo Sasaki, Katsumi Abe, Makiko Tabei et al. · Radiological Physics and Technology
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17 Dec 2010 |
13 |
| 37 |
Purification of monoclonal antibodies using novel 3D printed ordered stationary phases
Mariachiara Conti, Deirdre Boland, Carmen Heeran et al. · Journal of Chromatography A
Open access |
4 Apr 2024 |
12 |
| 38 |
Intravenous access in children
James D. Bennett, Mary Cheung · Paediatrics and Child Health
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9 Apr 2020 |
12 |
| 39 |
Cross-interaction chromatography as a rapid screening technique to identify the stability of new antibody therapeutics
Sarah Hedberg, Jonathan Rapley, Jonathan M. Haigh et al. · European Journal of Pharmaceutics and Biopharmaceutics
Open access |
11 Oct 2018 |
12 |
| 40 |
Effect of Dose Reduction on the Ability of Digital Mammography to Detect Simulated Microcalcifications
Mari Yakabe, Shuji Sakai, Hidetake Yabuuchi et al. · Journal of Imaging Informatics in Medicine
Open access |
4 May 2009 |
12 |
| 41 |
Deciphering molecular drivers of lactate metabolic shift in mammalian cell cultures
Mauro Torres, Ellie Hawke, Robyn Hoare et al. · Metabolic Engineering
Open access |
5 Dec 2024 |
11 |
| 42 |
Dissecting cell death pathways in fed‐batch bioreactors
David A. Mentlak, John Albert Raven, Tessa Moses et al. · Biotechnology Journal
Open access |
Dec 2023 |
11 |
| 43 |
A workflow for the development of template-assisted membrane crystallization downstream processing for monoclonal antibody purification
Nazer Rajoub, Charline J. J. Gerard, Elvira Pantuso et al. · Nature Protocols
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11 Sep 2023 |
11 |
| 44 |
Micro scale self-interaction chromatography of proteins: A mAb case-study
Sarah Hedberg, Jerry Y. Y. Heng, Daryl R. Williams et al. · Journal of Chromatography A
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16 Dec 2015 |
11 |
| 45 |
A modular and multi‐functional purification strategy that enables a common framework for manufacturing scale integrated and continuous biomanufacturing
Leon P. Pybus, Charles T. Heise, Tibor Nagy et al. · Biotechnology Progress
Open access |
18 Mar 2024 |
8 |
| 46 |
Self-Interaction Chromatography of mAbs: Accurate Measurement of Dead Volumes
Sarah Hedberg, Jerry Y. Y. Heng, Daryl R. Williams et al. · Pharmaceutical Research
Open access |
12 Aug 2015 |
8 |
| 47 |
Simple recombinant monoclonal antibody production from Escherichia coli
Karen Baker, Tara A. Eastwood, Esther García et al. · Open Biology
Open access |
Feb 2025 |
7 |
| 48 |
Evaluating 3D-printed bioseparation structures using multi-length scale tomography
Thomas F. Johnson, Mariachiara Conti, Francesco Iacoviello et al. · Analytical and Bioanalytical Chemistry
Open access |
31 Jul 2023 |
7 |
| 49 |
Depth filter material process interaction in the harvest of mammalian cells
Maria Parau, James R. Pullen, Daniel G. Bracewell · Biotechnology Progress
Open access |
12 Feb 2023 |
7 |
| 50 |
Preclinical and phase I clinical studies of KW-2450, a dual IGF-1R/IR tyrosine kinase inhibitor, in combination with lapatinib and letrozole
Hiroshi Umehara, Yoshimi Maekawa, Fumito Koizumi et al. · Therapeutic Advances in Medical Oncology
Open access |
2018 |
6 |