| 1 |
Colchicine in Patients with Chronic Coronary Disease
Stefan Mark Nidorf et al. · New England Journal of Medicine
Open access |
31 Aug 2020 |
2,252 |
| 2 |
Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer (EORTC 10981-22023 AMAROS): a randomised, multicentre, open-label, phase 3 non-inferiority trial
Mila Donker et al. · The Lancet Oncology
Open access |
15 Oct 2014 |
1,891 |
| 3 |
A Step-up Approach or Open Necrosectomy for Necrotizing Pancreatitis
Hjalmar C. van Santvoort et al. · New England Journal of Medicine
Open access |
21 Apr 2010 |
1,726 |
| 4 |
Guillain–Barré syndrome: pathogenesis, diagnosis, treatment and prognosis
Bianca van den Berg, Christa Walgaard, Judith Drenthen et al. · Nature Reviews Neurology
Review |
15 Jul 2014 |
1,100 |
| 5 |
Invasive aspergillosis in patients admitted to the intensive care unit with severe influenza: a retrospective cohort study
Alexander F. A. D. Schauwvlieghe et al. · The Lancet Respiratory Medicine
Open access |
31 Jul 2018 |
927 |
| 6 |
Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia after 36 weeks' gestation (HYPITAT): a multicentre, open-label randomised controlled trial
Corine M. Koopmans et al. · The Lancet
|
4 Aug 2009 |
802 |
| 7 |
Diagnosis of Guillain-Barre syndrome and validation of Brighton criteria
Christiaan Fokke, B. van den Berg, Judith Drenthen et al. · Brain
|
26 Oct 2013 |
801 |
| 8 |
Laparoscopy in Combination with Fast Track Multimodal Management is the Best Perioperative Strategy in Patients Undergoing Colonic Surgery
Malaika Sanne Vlug, Jan Wind, Markus W. Hollmann et al. · Annals of Surgery
|
19 May 2011 |
761 |
| 9 |
A Conservative and Minimally Invasive Approach to Necrotizing Pancreatitis Improves Outcome
Hjalmar C. van Santvoort et al. · Gastroenterology
Open access |
10 Jul 2011 |
748 |
| 10 |
Endoscopic or Surgical Step-Up Approach for Infected Necrotising Pancreatitis: A Multicentre Randomised Trial
Sandra van Brunschot et al. · The Lancet
Open access |
3 Nov 2017 |
743 |
| 11 |
Frailty screening methods for predicting outcome of a comprehensive geriatric assessment in elderly patients with cancer: a systematic review
Marije Emilie Hamaker, J.M. Jonker, Sophia E de Rooij et al. · The Lancet Oncology
Review |
28 Sep 2012 |
647 |
| 12 |
A prospective validation of the HEART score for chest pain patients at the emergency department
Barbra E. Backus, A. Jacob Six, Johannes C. Kelder et al. · International Journal of Cardiology
Open access |
7 Mar 2013 |
590 |
| 13 |
Simplified diagnostic management of suspected pulmonary embolism (the YEARS study): a prospective, multicentre, cohort study
Tom van der Hulle et al. · The Lancet
|
23 May 2017 |
552 |
| 14 |
36th International Symposium on Intensive Care and Emergency Medicine
R. M. Bateman et al. · Critical Care
Open access2,440 authors |
Apr 2016 |
531 |
| 15 |
Early Outcome After Off-Pump Versus On-Pump Coronary Bypass Surgery
Diederik van Dijk, Arno Pieter Nierich, Erik W.L. Jansen et al. · Circulation
Open access |
9 Oct 2001 |
524 |
| 16 |
Use of a peripheral perfusion index derived from the pulse oximetry signal as a noninvasive indicator of perfusion
Alexandre Pinto Lima, Peter Beelen, Jan Bakker · Critical Care Medicine
|
Jun 2002 |
482 |
| 17 |
Liraglutide, a Long-Acting Human Glucagon-Like Peptide-1 Analog, Given as Monotherapy Significantly Improves Glycemic Control and Lowers Body Weight Without Risk of Hypoglycemia in Patients With Type 2 Diabetes
Tina Vilsbøll, Milan Zdravkovic, T T Le-Thi et al. · Diabetes Care
Open access |
25 May 2007 |
471 |
| 18 |
Development and validation of PRE-DELIRIC (PREdiction of DELIRium in ICu patients) delirium prediction model for intensive care patients: observational multicentre study
Mark van den Boogaard, Peter Pickkers, Arjen J. C. Slooter et al. · BMJ
Open access |
9 Feb 2012 |
458 |
| 19 |
Comfort and patient-centred care without excessive sedation: the eCASH concept
Jean‐Louis Vincent, Yahya Shehabi, Timothy Simon Walsh et al. · Intensive Care Medicine
Open access |
13 Apr 2016 |
444 |
| 20 |
Iterative reconstruction techniques for computed tomography Part 1: Technical principles
Martin J. Willemink, Pim A. de Jong, Tim Leiner et al. · European Radiology
|
11 Jan 2013 |
439 |
| 21 |
Imaging strategies for detection of urgent conditions in patients with acute abdominal pain: diagnostic accuracy study
Wytze Laméris, Adriënne van Randen, H. Wouter van Es et al. · BMJ
Open access |
26 Jun 2009 |
416 |
| 22 |
A Comparison of On-Pump and Off-Pump Coronary Bypass Surgery in Low-Risk Patients
Hendrik M. Nathoe, Diederik van Dijk, Erik W.L. Jansen et al. · New England Journal of Medicine
Open access |
29 Jan 2003 |
406 |
| 23 |
Occurrence of delirium is severely underestimated in the ICU during daily care
Peter E. Spronk, Bea Riekerk, José G.M. Hofhuis et al. · Intensive Care Medicine
Open access |
6 Apr 2009 |
391 |
| 24 |
Radiotherapy or Surgery of the Axilla After a Positive Sentinel Node in Breast Cancer: 10-Year Results of the Randomized Controlled EORTC 10981-22023 AMAROS Trial
Sanne A. L. Bartels et al. · Journal of Clinical Oncology
Open access |
16 Nov 2022 |
389 |
| 25 |
Same-admission versus interval cholecystectomy for mild gallstone pancreatitis (PONCHO): a multicentre randomised controlled trial
David W. da Costa et al. · The Lancet
|
Sep 2015 |
386 |
| 26 |
Determinants of fruit and vegetable consumption among children and adolescents: a review of the literature. Part II: qualitative studies
Rikke Fredenslund Krølner, Mette Lyberg Rasmussen, Johannes Brug et al. · International Journal of Behavioral Nutrition and Physical Activity
Open access |
2011 |
378 |
| 27 |
Secretion of Tumour Necrosis Factor α and Lymphotoxin α in Relation to Polymorphisms in the TNF Genes and HLA‐DR Alleles. Relevance for Inflammatory Bowel Disease
G. BOUMA, J. Bart A. Crusius, M. Oudkerk Pool et al. · Scandinavian Journal of Immunology
|
Apr 1996 |
378 |
| 28 |
Effect of rivastigmine as an adjunct to usual care with haloperidol on duration of delirium and mortality in critically ill patients: a multicentre, double-blind, placebo-controlled randomised trial
Maarten MJ van Eijk, Kit CB Roes, Marina L. H. Honing et al. · The Lancet
|
Nov 2010 |
371 |
| 29 |
Pregnancy-Adapted YEARS Algorithm for Diagnosis of Suspected Pulmonary Embolism
Liselotte M. van der Pol et al. · New England Journal of Medicine
Open access |
20 Mar 2019 |
358 |
| 30 |
Clopidogrel versus ticagrelor or prasugrel in patients aged 70 years or older with non-ST-elevation acute coronary syndrome (POPular AGE): the randomised, open-label, non-inferiority trial
Marieke E. Gimbel, Khalid Qaderdan, Laura M. Willemsen et al. · The Lancet
Open access |
Apr 2020 |
357 |
| 31 |
Randomized clinical trial of observational versus antibiotic treatment for a first episode of CT-proven uncomplicated acute diverticulitis
Lidewine Daniels et al. · British journal of surgery
Open access |
30 Sep 2016 |
329 |
| 32 |
Chromothripsis as a mechanism driving complex de novo structural rearrangements in the germline†
Wigard P. Kloosterman, Victor Guryev, Mark van Roosmalen et al. · Human Molecular Genetics
Open access |
24 Feb 2011 |
327 |
| 33 |
Laparoscopic Cholecystectomy Versus Percutaneous Catheter Drainage for Acute Cholecystitis in High-Risk Patients (CHOCOLATE): Multicentre Randomised Clinical Trial
Charlotte S. Loozen, Hjalmar C. van Santvoort, Peter van Duijvendijk et al. · BMJ
Open access |
8 Oct 2018 |
317 |
| 34 |
Treatment of hypophosphatemia in the intensive care unit: a review
Daniël A. Geerse, Alexander J. G. H. Bindels, Michael A. Kuiper et al. · Critical Care
Open access |
3 Aug 2010 |
315 |
| 35 |
A Randomized, Blinded, Multicenter Trial of Lipid-Associated Amphotericin B Alone versus in Combination with an Antibody-Based Inhibitor of Heat Shock Protein 90 in Patients with Invasive Candidiasis
Jan Pachl, Petra Svoboda, F. Jacobs et al. · Clinical Infectious Diseases
Open access |
18 Apr 2006 |
307 |
| 36 |
Quantifying bedside-derived imaging of microcirculatory abnormalities in septic patients: a prospective validation study
E. Christiaan Boerma, Keshen R. Mathura, Peter H. J. van der Voort et al. · Critical Care
Open access |
22 Sep 2005 |
307 |
| 37 |
A comparison of the Accuracy of Ultrasound and Computed Tomography in common diagnoses causing acute abdominal pain
on behalf of the OPTIMA study group, Adriënne van Randen, Wytze Laméris et al. · European Radiology
Open access |
Mar 2011 |
299 |
| 38 |
Effect of a Low vs Intermediate Tidal Volume Strategy on Ventilator-Free Days in Intensive Care Unit Patients Without ARDS
Writing Group for the PReVENT Investigators et al. · JAMA
Open access |
25 Oct 2018 |
292 |
| 39 |
Routine Use of the Confusion Assessment Method for the Intensive Care Unit: A Multicenter Study
Maarten M. van Eijk et al. · American Journal of Respiratory and Critical Care Medicine
Open access |
11 May 2011 |
288 |
| 40 |
Repair of Giant Midline Abdominal Wall Hernias: “Components Separation Technique” versus Prosthetic Repair
Tammo S. de Vries Reilingh, Harry van Goor, J. A. Charbon et al. · World Journal of Surgery
Open access |
5 Mar 2007 |
281 |
| 41 |
Effect of Haloperidol on Survival Among Critically Ill Adults With a High Risk of Delirium
Mark van den Boogaard et al. · JAMA
Open access |
20 Feb 2018 |
280 |
| 42 |
Clinical characteristics and outcome of patients with early (4h) presentation treated by primary coronary angioplasty or thrombolytic therapy for acute myocardial infarction
Felix Zijlstra · European Heart Journal
Open access |
Apr 2002 |
280 |
| 43 |
Bench-to-bedside review: sepsis is a disease of the microcirculation.
Peter E. Spronk, Durk Freark Zandstra, Can İnce · Critical Care
Open access |
2004 |
277 |
| 44 |
Immediate versus Postponed Intervention for Infected Necrotizing Pancreatitis
Lotte Boxhoorn et al. · New England Journal of Medicine
Open access |
6 Oct 2021 |
276 |
| 45 |
Iterative reconstruction techniques for computed tomography part 2: initial results in dose reduction and image quality
Martin J. Willemink, Tim Leiner, Pim A. de Jong et al. · European Radiology
|
15 Jan 2013 |
268 |
| 46 |
Effect of Early Surgery vs Endoscopy-First Approach on Pain in Patients With Chronic Pancreatitis
Yama Issa et al. · JAMA
Open access |
21 Jan 2020 |
261 |
| 47 |
The effect of a geriatric evaluation on treatment decisions and outcome for older cancer patients – A systematic review
Marije Emilie Hamaker, Marthe te Molder, Noortje Thielen et al. · Journal of Geriatric Oncology
Review |
7 Apr 2018 |
251 |
| 48 |
Impaired microcirculation predicts poor outcome of patients with acute myocardial infarction complicated by cardiogenic shock
Corstiaan A. den Uil, Wim K. Lagrand, Martin van der Ent et al. · European Heart Journal
Open access |
9 Sep 2010 |
249 |
| 49 |
Neoadjuvant chemoradiotherapy plus surgery versus active surveillance for oesophageal cancer: a stepped-wedge cluster randomised trial
on behalf of the SANO-study group et al. · BMC Cancer
Open access |
6 Feb 2018 |
248 |
| 50 |
Cladribine therapy for systemic mastocytosis
Hanneke C. Kluin‐Nelemans · Blood
|
26 Aug 2003 |
248 |