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Institution · GlycoMimetics (United States)

Most cited papers from GlycoMimetics (United States)

GlycoMimetics (United States)

What are the most cited papers from GlycoMimetics (United States)?

The most cited paper from GlycoMimetics (United States) is "Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance" (Ingrid G. Winkler, Valérie Barbier, Bianca Nowlan et al., 2012), with 434 citations. Next come "Bone vascular niche E-selectin induces mesenchymal–epithelial transition and Wnt activation in cancer cells to promote bone metastasis" (269) and "Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone" (244).

Showing 50 of 99 papers. Every paper is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance Ingrid G. Winkler, Valérie Barbier, Bianca Nowlan et al. · Nature Medicine 21 Oct 2012 434
2 Bone vascular niche E-selectin induces mesenchymal–epithelial transition and Wnt activation in cancer cells to promote bone metastasis Mark Esposito, Nandini Mondal, Todd M. Greco et al. · Nature Cell Biology Open access 15 Apr 2019 269
3 Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone Trevor T. Price, Monika Leigh Burness, Ayelet Sivan et al. · Science Translational Medicine Open access 25 May 2016 244
4 GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice Jungshan Chang, John T. Patton, Arun K. Sarkar et al. · Blood Open access 27 May 2010 238
5 Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use Marilyn J. Telen, Ted Wun, Timothy L. McCavit et al. · Blood Open access 2 Mar 2015 208
6 Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance Valérie Barbier, Johanna M Erbani, Corrine E. Fiveash et al. · Nature Communications Open access 27 Apr 2020 195
7 The discovery, biology, and drug development of sialyl Lea and sialyl Lex John L. Magnani · Archives of Biochemistry and Biophysics 11 May 2004 141
8 P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment Abdel Kareem Azab, Phong Quang, Feda Azab et al. · Blood Open access 18 Nov 2011 125
9 Phase 1/2 study of uproleselan added to chemotherapy in patients with relapsed or refractory acute myeloid leukemia Daniel J. DeAngelo, Brian Andrew Jonas, Jane L. Liesveld et al. · Blood Open access 20 Sep 2021 101
10 Selectin catch-bonds mechanotransduce integrin activation and neutrophil arrest on inflamed endothelium under shear flow Vasilios Aris Morikis, Shannon Chase, Ted Wun et al. · Blood Open access 16 Aug 2017 100
11 E-Selectin Ligands as Mechanosensitive Receptors on Neutrophils in Health and Disease Shannon Chase, J L Magnani, Scott Irwin Simon · Annals of Biomedical Engineering Open access 24 Jan 2012 72
12 Phase 1 Study of the E-Selectin Inhibitor GMI 1070 in Patients with Sickle Cell Anemia Ted Wun, Lori Appel Styles, Laura M DeCastro et al. · PLoS ONE Open access 2 Jul 2014 69
13 Glycomimetic drugs--a new source of therapeutic opportunities. John L. Magnani, Beat Ernst · PubMed Dec 2009 54
14 Evolution of host adaptation in the Salmonella typhoid toxin Xiang Ming Gao, Lingquan Deng, Gabrielle Stack et al. · Nature Microbiology Open access 6 Oct 2017 52
15 Reflection on the Discovery of Carcinoembryonic Antigen, Prostate-Specific Antigen, and Cancer Antigens CA125 and CA19-9 Eleftherios P. Diamandis, Robert C. Bast, Phil Gold et al. · Clinical Chemistry Open access Dec 2012 48
16 Clinical Trials and Applications of Galectin Antagonists Armand Girard, John L. Magnani · Trends in Glycoscience and Glycotechnology Open access 24 May 2018 46
17 E-selectin ligands recognised by HECA452 induce drug resistance in myeloma, which is overcome by the E-selectin antagonist, GMI-1271 Alessandro Natoni, Theodore A Smith, Niamh Keane et al. · Leukemia Open access 25 Apr 2017 43
18 Pre‐organization of the Core Structure of E‐Selectin Antagonists Daniel Schwizer, John T. Patton, Brian Cutting et al. · Chemistry - A European Journal 30 Dec 2011 43
19 A randomized clinical trial of the efficacy and safety of rivipansel for sickle cell vaso-occlusive crisis Carlton Dampier, Marilyn J. Telen, Ted Wun et al. · Blood 18 Aug 2022 42
20 E-selectin inhibition with GMI-1271 decreases venous thrombosis without profoundly affecting tail vein bleeding in a mouse model Dorian L Culmer, Misha L. Dunbar, Angela E. Hawley et al. · Thrombosis and Haemostasis 2017 37
21 Training the next generation of biomedical investigators in glycosciences Peter C. Agre et al. · Journal of Clinical Investigation Open access 31 Jan 2016 37
22 Adhesion Of Acute Myeloid Leukemia Blasts To E-Selectin In The Vascular Niche Enhances Their Survival By Mechanisms Such As Wnt Activation Sylvia S Chien, Siraj U. Haq, Matthew R. Pawlus et al. · Blood 15 Nov 2013 36
23 E-Selectin Inhibition Mitigates Splenic HSC Activation and Myelopoiesis in Hypercholesterolemic Mice With Myocardial Infarction Partha Dutta, Friedrich Felix Hoyer, Yuan Ming Sun et al. · Arteriosclerosis Thrombosis and Vascular Biology Open access 29 Jul 2016 34
24 Dual CXCR4 and E-Selectin Inhibitor, GMI-1359, Shows Anti-Bone Metastatic Effects and Synergizes with Docetaxel in Prostate Cancer Cell Intraosseous Growth Claudio Festuccia, Andrea Mancini, Giovanni Luca Gravina et al. · Cells Open access 20 Dec 2019 32
25 Inhibition of E-Selectin (GMI-1271) or E-selectin together with CXCR4 (GMI-1359) re-sensitizes multiple myeloma to therapy Barbara Muz, Feda Azab, Mark Aaron Fiala et al. · Blood Cancer Journal Open access 20 Aug 2019 26
26 P‐ and E‐selectin receptor antagonism prevents human leukocyte adhesion to activated porcine endothelial monolayers and attenuates porcine endothelial damage Christopher T. Laird, Wessam Hassanein, Natalie A. O’Neill et al. · Xenotransplantation Open access 23 Jan 2018 26
27 Vascular Niche E-Selectin Protects Acute Myeloid Leukaemia Stem Cells from Chemotherapy Ingrid G. Winkler, Valérie Barbier, Diwakar Ram Pattabiraman et al. · Blood 6 Dec 2014 26
28 Targeting Neutrophil Adhesive Events to Address Vaso-Occlusive Crisis in Sickle Cell Patients Vasilios Aris Morikis, Alfredo Alexander Hernandez, John L. Magnani et al. · Frontiers in Immunology Open access 28 Apr 2021 22
29 A new way to treat proximal deep venous thrombosis using E-selectin inhibition Daniel Durant Myers, Patrick A. Lester, Reheman Adili et al. · Journal of Vascular Surgery Venous and Lymphatic Disorders Open access 14 Feb 2020 22
30 Use of GMI‐1271, an E‐selectin antagonist, in healthy subjects and in 2 patients with calf vein thrombosis Sumana Devata, Dana Elizabeth Angelini, Susan A. Blackburn et al. · Research and Practice in Thrombosis and Haemostasis Open access Feb 2020 22
31 FLT3 inhibitors upregulate CXCR4 and E-selectin ligands via ERK suppression in AML cells and CXCR4/E-selectin inhibition enhances anti-leukemia efficacy of FLT3-targeted therapy in AML Yannan Jia, Weiguo Zhang, Mahesh Basyal et al. · Leukemia Open access 21 Apr 2023 19
32 31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two Casey R. Ager et al. · Journal for ImmunoTherapy of Cancer Open access1,802 authors Nov 2016 17
33 First in Human Phase 1 Single Dose Escalation Studies of the E-Selectin Antagonist GMI-1271 Show a Favorable Safety, Pharmacokinetic, and Biomarker Profile Sumana Devata, Suman L. Sood, Martina V Hemmer et al. · Blood 3 Dec 2015 17
34 Probing the carbohydrate recognition domain of E-selectin: The importance of the acid orientation in sLex mimetics Alexander Titz, John T. Patton, Martin Smieško et al. · Bioorganic & Medicinal Chemistry 14 Nov 2009 17
35 Selectins in Biology and Human Disease: Opportunity in E-selectin Antagonism John M. Peterson, Theodore A Smith, Edwin P. Rock et al. · Cureus Open access 9 Jun 2024 15
36 E-selectin inhibitor is superior to low-molecular-weight heparin for the treatment of experimental venous thrombosis Daniel Durant Myers, Junjie Ning, Patrick A. Lester et al. · Journal of Vascular Surgery Venous and Lymphatic Disorders Open access 19 Apr 2021 12
37 Early Initiation of Treatment with Rivipansel for Acute Vaso-Occlusive Crisis in Sickle Cell Disease (SCD) Achieves Earlier Discontinuation of IV Opioids and Shorter Hospital Stay: Reset Clinical Trial Analysis Carlton Dampier, Marilyn J. Telen, Ted Wun et al. · Blood 5 Nov 2020 12
38 Acceptor-influenced and donor-tuned base-promoted glycosylation Stephan Boettcher, Martin Matwiejuk, Joachim Thiem · Beilstein Journal of Organic Chemistry Open access 20 Mar 2012 12
39 Dual E-Selectin/CXCR4 Antagonist GMI-1359 Exerts Efficient Anti-Leukemia Effects in a FLT3 ITD Mutated Acute Myeloid Leukemia Patient-Derived Xenograft Murine Model Weiguo Zhang, Charlie Ly, Qi Zhang et al. · Blood 2 Dec 2016 10
40 Targeting hematologic malignancies by inhibiting E-selectin: A sweet spot for AML therapy? Geoffrey L. Uy, Daniel J. DeAngelo, Jay Nelson Lozier et al. · Blood Reviews Open access 28 Feb 2024 9
41 E-selectin-targeting lipid nanoparticles improve therapeutic efficacy and reduce side effects of bortezomib in multiple myeloma Mina Maksimos, Barbara Muz, John L. Magnani et al. · Blood Cancer Journal Open access 7 Apr 2023 9
42 Protein kinase C‐δ interacts with and phosphorylates ARD1 Kwang‐Hoon Chun, Seung‐Ju Cho, Ji‐Won Lee et al. · Journal of Cellular Physiology 15 Jun 2020 9
43 GMI-1070, a Pan-Selectin Inhibitor: Safety and PK In a Phase 1/2 Study In Adults with Sickle Cell Disease Lori Appel Styles, Ted Wun, Laura M. De Castro et al. · Blood 19 Nov 2010 9
44 De Novo Synthesis of Biofunctional Carbohydrate-Encapsulated Quantum Dots Sergei A. Svarovsky, Joseph J. Barchi · ACS symposium series Conference paper 13 Mar 2007 9
45 A Novel Small Molecule E-Selectin Inhibitor GMI-1271 Blocks Adhesion of AML Blasts to E-Selectin and Mobilizes Blood Cells in Nodscid IL2Rgc−/− Mice Engrafted with Human AML Sylvia S Chien, Xin Zhao, Margaret Brown et al. · Blood 16 Nov 2012 9
46 Administration Of E-Selectin Antagonist GMI-1271 Improves Survival After High-Dose Chemotherapy By Alleviating Mucositis and Accelerating Neutrophil Recovery Ingrid G. Winkler, Valérie Barbier, H Nutt et al. · Blood 15 Nov 2013 9
47 Vascular E-Selectin Protects Leukemia Cells from Chemotherapy By Directly Activating Pro-Survival NF-Kb Signalling - Therapeutic Blockade of E-Selectin Dampens NF-Kb Activation Ingrid G. Winkler, Valérie Barbier, Micheal S. Ward et al. · Blood 2 Dec 2016 8
48 The Dual E-Selectin/CXCR4 Inhibitor, GMI-1359, Enhances Efficacy of Anti-Leukemia Chemotherapy in FLT3-ITD Mutated Acute Myeloid Leukemia Weiguo Zhang, Nalini B. Patel, William E. Fogler et al. · Blood 3 Dec 2015 8
49 Effects of GMI-1070, a Pan-Selectin Inhibitor, on Leukocyte Adhesion In Sickle Cell Disease: Results From a Phase 1/2 Study Ted Wun, Laura M. De Castro, Lori Appel Styles et al. · Blood 19 Nov 2010 8
50 GMI 1070: Reduction In Time To Resolution Of Vaso-Occlusive Crisis and Decreased Opioid Use In a Prospective, Randomized, Multi-Center Double Blind, Adaptive Phase 2 Study In Sickle Cell Disease Marilyn J. Telen, Ted Wun, Timothy L. McCavit et al. · Blood 15 Nov 2013 8

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.