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Institution · Grünenthal Group (Germany)

Most cited papers from Grünenthal Group (Germany)

Grünenthal Group (Germany)

What are the most cited papers from Grünenthal Group (Germany)?

The most cited paper from Grünenthal Group (Germany) is "REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade" (Thomas Tzschentke, 2007), with 1,360 citations. Next come "Pharmacology and behavioral pharmacology of the mesocortical dopamine system" (480) and "Characterization of the mouse cold‐menthol receptor TRPM8 and vanilloid receptor type‐1 VR1 using a fluorometric imaging plate reader (FLIPR) assay" (459).

Showing 50 of 60 papers. Every paper with more than 112 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade Thomas Tzschentke · Addiction Biology 30 Jul 2007 1,360
2 Pharmacology and behavioral pharmacology of the mesocortical dopamine system Thomas Tzschentke · Progress in Neurobiology Feb 2001 480
3 Characterization of the mouse cold‐menthol receptor TRPM8 and vanilloid receptor type‐1 VR1 using a fluorometric imaging plate reader (FLIPR) assay H‐J Behrendt, Tieno Germann, Clemens Gillen et al. · British Journal of Pharmacology Open access Feb 2004 459
4 Thalidomide in the Treatment of the Mucocutaneous Lesions of the Behcet Syndrome Vedat Hamuryudan, Cem Mat, Sebahattin Saip et al. · Annals of Internal Medicine 15 Mar 1998 457
5 (–)-(1 R,2 R)-3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)-phenol Hydrochloride (Tapentadol HCl): a Novel μ-Opioid Receptor Agonist/Norepinephrine Reuptake Inhibitor with Broad-Spectrum Analgesic Properties Thomas Tzschentke, Thomas Christoph, Babette Y. Kögel et al. · Journal of Pharmacology and Experimental Therapeutics 26 Jul 2007 397
6 Physiologically Based Pharmacokinetic Model Qualification and Reporting Procedures for Regulatory Submissions: A Consortium Perspective Mohamad Shebley et al. · Clinical Pharmacology & Therapeutics Open access 10 Jan 2018 390
7 Cathepsin B efficiently activates the soluble and the tumor cell receptor-bound form of the proenzyme urokinase-type plasminogen activator (Pro-uPA). Hiroshi Kobayashi, Manfred Schmitt, Lothar Goretzki et al. · Journal of Biological Chemistry Open access Mar 1991 346
8 Considerations for improving assay sensitivity in chronic pain clinical trials: IMMPACT recommendations Robert H. Dworkin et al. · Pain 9 Apr 2012 293
9 Thalidomide selectively modulates the density of cell surface molecules involved in the adhesion cascade Hartmut Geitz, Stefan Handt, K. Zwingenberger · Immunopharmacology Mar 1996 291
10 Affinity, potency and efficacy of tramadol and its metabolites at the cloned human µ-opioid receptor Clemens Gillen, Michael Haurand, Dieter Johannes Kobelt et al. · Naunyn-Schmiedeberg s Archives of Pharmacology 18 Jul 2000 289
11 Cobalt( I )‐Catalyzed Asymmetric [2+2+2] Cycloaddition of Alkynes and Nitriles: Synthesis of Enantiomerically Enriched Atropoisomers of 2‐Arylpyridines Andrey V. Gutnov, Bárbara Heller, Christine Fischer et al. · Angewandte Chemie International Edition 26 May 2004 286
12 Nicotine activates the chemosensory cation channel TRPA1 Karel Talavera, Maarten Gees, Yuji Karashima et al. · Nature Neuroscience Open access 13 Sep 2009 259
13 Safety and efficacy of tapentadol ER in patients with painful diabetic peripheral neuropathy: results of a randomized-withdrawal, placebo-controlled trial Sherwyn Leon Schwartz, Mila S. Etropolski, Douglas Y. Shapiro et al. · Current Medical Research and Opinion 17 Dec 2010 256
14 Efficacy and safety of tapentadol extended release for the management of chronic low back pain: results of a prospective, randomized, double-blind, placebo- and active-controlled Phase III study Robert J. Buynak, Douglas Y. Shapiro, Akiko Okamoto et al. · Expert Opinion on Pharmacotherapy 25 Jun 2010 252
15 Human Experimental Pain Models for Assessing the Therapeutic Efficacy of Analgesic Drugs Anne Estrup Olesen, Trine Andresen, Camilla Staahl et al. · Pharmacological Reviews Jul 2012 248
16 Interaction of the central analgesic, tramadol, with the uptake and release of 5‐hydroxytryptamine in the rat brain in vitro Bernd Driessen, Wolfgang Reimann · British Journal of Pharmacology Open access 1992 244
17 Validity and responsiveness of EuroQol-5 dimension (EQ-5D) versus Short Form-6 dimension (SF-6D) questionnaire in chronic pain Marko O. Obradović, Arun Lal, Hiltrud Liedgens · Health and Quality of Life Outcomes Open access Jul 2013 238
18 Efficacy and Safety of Tapentadol Extended Release Compared with Oxycodone Controlled Release for the Management of Moderate to Severe Chronic Pain Related to Osteoarthritis of the Knee Marc Afilalo, Mila S. Etropolski, Brigitte Kuperwasser et al. · Clinical Drug Investigation 30 Jun 2010 228
19 Nonsteroidal anti-inflammatory drugs and hormonal contraceptives for pain relief from dysmenorrhea: a review Hans-Peter Zahradnik, Aida Hanjalic-Beck, Klaus Groth · Contraception 7 Nov 2009 227
20 Functional Relationship Among Medial Prefrontal Cortex, Nucleus Accumbens, and Ventral Tegmental Area in Locomotion and Reward Thomas Tzschentke, Werner Schmidt · Critical Reviews in Neurobiology 2000 221
21 NMDA receptor antagonists as analgesics: focus on the NR2B subtype Boris A. Chizh, P. Max Headley, Thomas Tzschentke · Trends in Pharmacological Sciences Review Dec 2001 208
22 The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach Suryaprakash Raichur, Bodo Brunner, Maximilian Bielohuby et al. · Molecular Metabolism Open access 2 Jan 2019 200
23 Phospholipid-hydroperoxide glutathione peroxidase. Genomic DNA, cDNA, and deduced amino acid sequence. R. Brigelius‐Flohé, Klaus-Dieter Aumann, Helmut Blöcker et al. · Journal of Biological Chemistry Open access Mar 1994 200
24 The medial prefrontal cortex as a part of the brain reward system Thomas Tzschentke · Amino Acids 31 Aug 2000 195
25 Effects of the central analgesic tramadol on the uptake and release of noradrenaline and dopaminein vitro Bernd Driessen, Wolfgang Reimann, Hubert Giertz · British Journal of Pharmacology Open access Mar 1993 190
26 5% lidocaine medicated plaster versus pregabalin in post-herpetic neuralgia and diabetic polyneuropathy: an open-label, non-inferiority two-stage RCT study Ralf Baron, Victor Mayoral, Göran Leijon et al. · Current Medical Research and Opinion Jun 2009 190
27 Effects of the cognition impairer MK-801 on learning and memory in mice and rats Franz Josef van der Staay, Kris Rutten, Christina Erb et al. · Behavioural Brain Research 9 Feb 2011 188
28 Efficacy and tolerability of tapentadol immediate release and oxycodone HCl immediate release in patients awaiting primary joint replacement surgery for end-stage joint disease: A 10-day, phase III, randomized, double-blind, active- and placebo-controlled study Craig T. Hartrick, Ilse Van Hove, Jens‐Ulrich Stegmann et al. · Clinical Therapeutics Feb 2009 181
29 Long-term Safety and Tolerability of Tapentadol Extended Release for the Management of Chronic Low Back Pain or Osteoarthritis Pain James E. Wild, Stefan Grond, Brigitte Kuperwasser et al. · Pain Practice 29 Jun 2010 180
30 Efficacy and safety of tapentadol prolonged release for chronic osteoarthritis pain and low back pain Bernd Lange, Brigitte Kuperwasser, Akiko Okamoto et al. · Advances in Therapy Jun 2010 173
31 Mechanistic and functional differentiation of tapentadol and tramadol Robert B. Raffa, Helmut Buschmann, Thomas Christoph et al. · Expert Opinion on Pharmacotherapy 15 Jun 2012 168
32 Role of Macrophages in the Pathogenesis of Atopic Dermatitis Sadaf Kasraie, Thomas Werfel · Mediators of Inflammation Open access 2013 164
33 Aconitum sp. alkaloids: the modulation of voltage-dependent Na+ channels, toxicity and antinociceptive properties Jutta Friese, Johannes Gleitz, Ulrike T. Gutser et al. · European Journal of Pharmacology Oct 1997 162
34 Effective activation of the proenzyme form of the urokinase‐type plasminogen activator (pro‐uPA) by the cysteine protease cathepsin L Lothar Goretzki, Manfred Schmitt, Karlheinz Mann et al. · FEBS Letters 3 Feb 1992 160
35 Polymorphic CYP2D6 mediates O -demethylation of the opioid analgesic tramadol W. D. Paar, S. Poche, Joachim Gerloff et al. · European Journal of Clinical Pharmacology 15 Dec 1997 155
36 Assessing real-world gait with digital technology? Validation, insights and recommendations from the Mobilise-D consortium M. Encarna Micó-Amigo et al. · Journal of NeuroEngineering and Rehabilitation Open access 14 Jun 2023 154
37 Broad analgesic profile of buprenorphine in rodent models of acute and chronic pain Thomas Christoph, Babette Y. Kögel, Klaus Schiene et al. · European Journal of Pharmacology 31 Dec 2004 153
38 The crystal structure of the catalytic domain of human urokinase-type plasminogen activator Glen Spraggon, Christopher Phillips, Ursula K Nowak et al. · Structure Open access Jul 1995 150
39 Phospholipid Hydroperoxide Glutathione Peroxidase is a Seleno-Enzyme Distinct from the Classical Glutathione Peroxidase as Evident from Cdna and Amino Acid Sequencing Rainer Schuckelt, R. Brigelius‐Flohé, Matilde Maiorino et al. · Free Radical Research Communications 1991 149
40 Chemotherapy-induced peripheral neuropathy (CIPN): current therapies and topical treatment option with high-concentration capsaicin Christian Maihöfner, Ingo Diel, Hans Tesch et al. · Supportive Care in Cancer Open access 23 Feb 2021 146
41 Research design considerations for chronic pain prevention clinical trials Jennifer S. Gewandter et al. · Pain Open access 16 Apr 2015 145
42 A randomized, double-blind, phase III study comparing multiple doses of tapentadol IR, oxycodone IR, and placebo for postoperative (bunionectomy) pain Stephen E. Daniels, David H. Upmalis, Akiko Okamoto et al. · Current Medical Research and Opinion 9 Feb 2009 143
43 Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo Thomas Christoph, Arnold Grünweller, Joanna Mika et al. · Biochemical and Biophysical Research Communications 19 Sep 2006 143
44 The experimental toxicology of tramadol: an overview Th. Matthiesen, Thomas Wöhrmann, Timothy P. Coogan et al. · Toxicology Letters Mar 1998 140
45 Topical 5% Lidocaine (Lignocaine) Medicated Plaster Treatment for Post-Herpetic Neuralgia Andreas Binder, Jean-François Bruxelle, Peter D. Rogers et al. · Clinical Drug Investigation May 2009 138
46 A Randomized Withdrawal, Placebo-Controlled Study Evaluating the Efficacy and Tolerability of Tapentadol Extended Release in Patients With Chronic Painful Diabetic Peripheral Neuropathy Aaron I. Vinik, Douglas Y. Shapiro, Christine Rauschkolb et al. · Diabetes Care 22 May 2014 135
47 Phosphorus‐Bearing Axially Chiral Biaryls by Catalytic Asymmetric Cross‐Cyclotrimerization and a First Application in Asymmetric Hydrosilylation Bárbara Heller, Andrey V. Gutnov, Christine Fischer et al. · Chemistry - A European Journal Open access 27 Oct 2006 134
48 Tolerability of tapentadol immediate release in patients with lower back pain or osteoarthritis of the hip or knee over 90 days: a randomized, double-blind study Martin E Hale, David H. Upmalis, Akiko Okamoto et al. · Current Medical Research and Opinion 20 Mar 2009 134
49 A randomized, double-blind, placebo-controlled phase 3 study of the relative efficacy and tolerability of tapentadol IR and oxycodone IR for acute pain Stephen Daniels, Ed Casson, Jens‐Ulrich Stegmann et al. · Current Medical Research and Opinion 18 May 2009 132
50 Differential contribution of opioid and noradrenergic mechanisms of tapentadol in rat models of nociceptive and neuropathic pain Wolfgang Schröder, Jean De Vry, Thomas Tzschentke et al. · European Journal of Pain 12 Jun 2010 130

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.