Most cited papers from GTx (United States)

GTx (United States)

What are the most cited papers from GTx (United States)?

The most cited paper from GTx (United States) is "The selective androgen receptor modulator GTx‐024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double‐blind, placebo‐controlled phase II trial" (James T. Dalton, K. Gary Barnette, Casey E. Bohl et al., 2011), with 402 citations. Next come "Study Design and Rationale for the Phase 3 Clinical Development Program of Enobosarm, a Selective Androgen Receptor Modulator, for the Prevention and Treatment of Muscle Wasting in Cancer Patients (POWER Trials)" (177) and "Adenosine triphosphate-binding cassette transporter genes up-regulation in untreated hepatocellular carcinoma is mediated by cellular microRNAs" (157).

Published TypeFieldAccessCitations

Showing 50 of 60 papers. Every paper with more than 14 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	The selective androgen receptor modulator GTx‐024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double‐blind, placebo‐controlled phase II trial James T. Dalton, K. Gary Barnette, Casey E. Bohl et al. · Journal of Cachexia Sarcopenia and Muscle Open access	Aug 2011	402
2	Study Design and Rationale for the Phase 3 Clinical Development Program of Enobosarm, a Selective Androgen Receptor Modulator, for the Prevention and Treatment of Muscle Wasting in Cancer Patients (POWER Trials) Jeffrey Crawford, Carla Marques Maia Prado, Mary Ann Johnston et al. · Current Oncology Reports Open access	2 May 2016	177
3	Adenosine triphosphate-binding cassette transporter genes up-regulation in untreated hepatocellular carcinoma is mediated by cellular microRNAs Florie Borel, Ruiqi Han, Allerdien Visser et al. · Hepatology	19 Sep 2011	157
4	Pharmacodynamics of Selective Androgen Receptor Modulators Donghua Yin, Wenqing Gao, Jeffrey D. Kearbey et al. · Journal of Pharmacology and Experimental Therapeutics	27 Feb 2003	154
5	Estrogen Receptor-β-selective Ligands Alleviate High-fat Diet- and Ovariectomy-induced Obesity in Mice Muralimohan Yepuru, Jeetendra R. Eswaraka, Jeffrey D. Kearbey et al. · Journal of Biological Chemistry Open access	25 Jul 2010	129
6	A review of occupational physical activity and sedentary behaviour correlates Lee H. Smith, Orla McCourt, Alexia D. M. Sawyer et al. · Occupational Medicine Open access	26 Mar 2016	127
7	Immediate intraportal transplantation of human bone marrow mesenchymal stem cells prevents death from fulminant hepatic failure in pigs Jun Li, Liyuan Zhang, Jiaojiao Xin et al. · Hepatology Open access	16 Mar 2012	119
8	The Upregulation of PI3K/Akt and MAP Kinase Pathways is Associated with Resistance of Microtubule‐Targeting Drugs in Prostate Cancer Zhi Liu, Guangjing Zhu, Robert H. Getzenberg et al. · Journal of Cellular Biochemistry	31 Jan 2015	115
9	Selective Androgen Receptor Modulator (SARM) Treatment Prevents Bone Loss and Reduces Body Fat in Ovariectomized Rats Jeffrey D. Kearbey, Wenqing Gao, Ramesh Narayanan et al. · Pharmaceutical Research Open access	24 Oct 2006	111
10	Pharmacokinetics and Pharmacodynamics of Nonsteroidal Androgen Receptor Ligands Wenqing Gao, Juhyun Kim, James T. Dalton · Pharmaceutical Research Open access	13 Jul 2006	109
11	Design, Synthesis, and Biological Evaluation of Stable Colchicine Binding Site Tubulin Inhibitors as Potential Anticancer Agents Yan Lü, Jianjun Chen, Jin Wang et al. · Journal of Medicinal Chemistry Open access	14 Aug 2014	96
12	Toremifene for Breast Cancer: A Review of 20 Years of Data Charles L. Vogel, Mary Ann Johnston, Christi Capers et al. · Clinical Breast Cancer Open access	31 Oct 2013	95
13	Brown rot on nuts of Castanea sativa Mill: an emerging disease and its causal agent G. Maresi, Claudia Maria Oliveira Longa, Tullio Turchetti · iForest - Biogeosciences and Forestry Open access	16 Jul 2013	89
14	Recent and emerging anti‐diabetes targets Michael L. Mohler, Yali He, Zhongzhi Wu et al. · Medicinal Research Reviews	14 Oct 2008	87
15	Estrogen regulates histone deacetylases to prevent cardiac hypertrophy Ali Pedram, Mahnaz Razandi, Ramesh Narayanan et al. · Molecular Biology of the Cell Open access	24 Oct 2013	84
16	Spectral characterization of acousto-optic filters used in imaging spectroscopy Georgi As. Georgiev, David A. Glenar, J. J. Hillman · Applied Optics	2002	77
17	Steroidal Androgens and Nonsteroidal, Tissue-Selective Androgen Receptor Modulator, S-22, Regulate Androgen Receptor Function through Distinct Genomic and Nongenomic Signaling Pathways Ramesh Narayanan, Christopher Charles Coss, Muralimohan Yepuru et al. · Molecular Endocrinology Open access	19 Sep 2008	76
18	Selective Androgen Receptor Modulators (SARMs) Negatively Regulate Triple-Negative Breast Cancer Growth and Epithelial:Mesenchymal Stem Cell Signaling Ramesh Narayanan, Sunjoo Ahn, Misty D. Cheney et al. · PLoS ONE Open access	29 Jul 2014	70
19	Pharmacologic activation of estrogen receptor α increases mitochondrial function, energy expenditure, and brown adipose tissue Suriyan Ponnusamy, Quynh T. Tran, Innocence C. Harvey et al. · The FASEB Journal Open access	12 Oct 2016	66
20	Antagonism of peripheral hepatic cannabinoid receptor-1 improves liver lipid metabolism in mice: Evidence from cultured explants Tony Jourdan, Laurent Demizieux, Joseph Gresti et al. · Hepatology	10 Oct 2011	63
21	Novel Tubulin Polymerization Inhibitors Overcome Multidrug Resistance and Reduce Melanoma Lung Metastasis Zhao Wang, Jianjun Chen, Jin Wang et al. · Pharmaceutical Research Open access	12 Mar 2012	62
22	MicroRNAs Are Mediators of Androgen Action in Prostate and Muscle Ramesh Narayanan, Jinmai Jiang, Yuriy Gusev et al. · PLoS ONE Open access	27 Oct 2010	62
23	Discovery of 4-Aryl-2-benzoyl-imidazoles as Tubulin Polymerization Inhibitor with Potent Antiproliferative Properties Min Xiao, Sunjoo Ahn, Jin Wang et al. · Journal of Medicinal Chemistry Open access	2 Apr 2013	60
24	Oxidized CaMKII (Ca 2+ /Calmodulin-Dependent Protein Kinase II) Is Essential for Ventricular Arrhythmia in a Mouse Model of Duchenne Muscular Dystrophy Qiongling Wang, Ann P. Quick, Shuyi Cao et al. · Circulation Arrhythmia and Electrophysiology Open access	Apr 2018	56
25	17-β Estradiol Protects ARPE-19 Cells from Oxidative Stress through Estrogen Receptor-β Anand Giddabasappa, Matthew N. Bauler, Muralimohan Yepuru et al. · Investigative Ophthalmology & Visual Science	13 May 2010	54
26	Predicting Mixture Effects over Time with Toxicokinetic–Toxicodynamic Models (GUTS): Assumptions, Experimental Testing, and Predictive Power Sylvain Bart, Tjalling Jager, Alex Robinson et al. · Environmental Science & Technology Open access	26 Jan 2021	45
27	Role of Nuclear Receptors in Lipid Dysfunction and Obesity-Related Diseases Hollie I. Swanson, Taira Wada, Wen Li Xie et al. · Drug Metabolism and Disposition Open access	6 Oct 2012	44
28	Ockham's Razor and Selective Androgen Receptor Modulators (SARMs): Are We Overlooking the Role of 5 -Reductase? Wenqing Gao, James T. Dalton · Molecular Interventions Open access	Feb 2007	44
29	Mass spectrometric characterization of urinary metabolites of the selective androgen receptor modulator S‐22 to identify potential targets for routine doping controls Mario Thevis, Andreas Thomas, Ines Möller et al. · Rapid Communications in Mass Spectrometry	27 Jun 2011	44
30	Therapeutic potential of the SARMs: revisiting the androgen receptor for drug discovery Scott Segal, Ramesh Narayanan, James T. Dalton · Expert Opinion on Investigational Drugs	21 Mar 2006	43
31	The political economy of US aid to Pakistan Katharina Michaelowa, Mumtaz Anwar · Zurich Open Repository and Archive (University of Zurich) Open access	2006	39
32	Effects of Selective Androgen Receptor Modulator (SARM) Treatment in Osteopenic Female Rats Jeffrey D. Kearbey, Wenqing Gao, Scott J. Fisher et al. · Pharmaceutical Research	31 Aug 2009	35
33	Tissue Selective Androgen Receptor Modulators (SARMs) Increase Pelvic Floor Muscle Mass in Ovariectomized Mice Suriyan Ponnusamy, Ryan D. Sullivan, Thirumagal Thiyagarajan et al. · Journal of Cellular Biochemistry Open access	28 Sep 2016	34
34	Pharmacokinetic Optimization of 4-Substituted Methoxybenzoyl-aryl-thiazole and 2-Aryl-4-benzoyl-imidazole for Improving Oral Bioavailability Chien-Ming Li, Jianjun Chen, Yan Lü et al. · Drug Metabolism and Disposition Open access	8 Jul 2011	33
35	Dissociated non-steroidal glucocorticoids: tuning out untoward effects Michael L. Mohler, Yali He, Zhongzhi Wu et al. · Expert Opinion on Therapeutic Patents	2007	33
36	Selective androgen receptor modulators as improved androgen therapy for advanced breast cancer Christopher Charles Coss, Amanda Jane Jones, James T. Dalton · Steroids	16 Jun 2014	33
37	Nonsteroidal Selective Androgen Receptor Modulators Enhance Female Sexual Motivation Amanda Jane Jones, Dong‐Jin Hwang, C. B. Duke et al. · Journal of Pharmacology and Experimental Therapeutics Open access	6 May 2010	31
38	Orally Bioavailable Tubulin Antagonists for Paclitaxel-Refractory Cancer Chien-Ming Li, Yan Lü, Jianjun Chen et al. · Pharmaceutical Research Open access	3 Jul 2012	30
39	Toremifene – a promising therapy for the prevention of prostate cancer and complications of androgen deprivation therapy Samir S. Taneja, Matthew R. Smith, James T. Dalton et al. · Expert Opinion on Investigational Drugs	27 Feb 2006	29
40	Estrogen receptor β selective nonsteroidal estrogens: seeking clinical indications Michael L. Mohler, Ramesh Narayanan, Christopher Charles Coss et al. · Expert Opinion on Therapeutic Patents	20 Mar 2010	29
41	Cancer cachexia therapy: a key weapon in the fight against cancer Christopher Charles Coss, Casey E. Bohl, James T. Dalton · Current Opinion in Clinical Nutrition & Metabolic Care	17 Mar 2011	27
42	Discovery and Mechanistic Characterization of a Novel Selective Nuclear Androgen Receptor Exporter for the Treatment of Prostate Cancer Ramesh Narayanan, Muralimohan Yepuru, Adam T. Szafran et al. · Cancer Research	13 Jan 2010	25
43	Androgen receptor antagonists: a patent review (2008 – 2011) Michael L. Mohler, Christopher Charles Coss, C. B. Duke et al. · Expert Opinion on Therapeutic Patents	May 2012	24
44	A novel bis-indole destabilizes microtubules and displays potent in vitro and in vivo antitumor activity in prostate cancer Sunjoo Ahn, Dong‐Jin Hwang, Christina M. Barrett et al. · Cancer Chemotherapy and Pharmacology	10 Apr 2010	23
45	Discovery and Preclinical Characterization of Novel Small Molecule TRK and ROS1 Tyrosine Kinase Inhibitors for the Treatment of Cancer and Inflammation Ramesh Narayanan, Muralimohan Yepuru, Christopher Charles Coss et al. · PLoS ONE Open access	26 Dec 2013	23
46	Hydroxysteroid Dehydrogenase (17β -HSD3, 17β-HSD5, and 3α-HSD3) Inhibitors:Extragonadal Regulation of Intracellular Sex Steroid Hormone Levels Michael L. Mohler, Ramesh Narayanan, Yali He et al. · Recent Patents on Endocrine Metabolic & Immune Drug Discovery	Jun 2007	22
47	In Vivo Metabolism and Final Disposition of a Novel Nonsteroidal Androgen in Rats and Dogs Minoli A. Perera, Donghua Yin, Di Wu et al. · Drug Metabolism and Disposition	Jul 2006	22
48	New Risk-Based Capital Standards in the EU: A Proposal Based on Empirical Data Hato Schmeiser · Alexandria (UniSG) (University of St.Gallen)	2004	21
49	Diclofenac epolamine topical patch relieves pain associated with ankle sprain Melissa LoSchiavo, Lionberger, Yanchick et al. · Journal of Pain Research Open access	Mar 2011	19
50	Non-steroidal glucocorticoid receptor antagonists: the race to replace RU-486 for anti-glucocorticoid therapy Michael L. Mohler, Yali He, Zhongzhi Wu et al. · Expert Opinion on Therapeutic Patents	2007	18

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.