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Most cited papers from Harvard University

What are the most cited papers from Harvard University?

The most cited paper from Harvard University is "The PRISMA 2020 statement: an updated guideline for reporting systematic reviews" (Matthew James Page et al., 2021), with 105,915 citations. Next come "Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2" (104,335) and "The Sequence Alignment/Map format and SAMtools" (69,061).

Showing 50 of 59 papers. Every paper with more than 14,012 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 The PRISMA 2020 statement: an updated guideline for reporting systematic reviews Matthew James Page et al. · BMJ ReviewOpen access 29 Mar 2021 105,915
2 Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 Michael I. Love, Wolfgang K. Huber, Simon Anders · Genome biology Open access 5 Dec 2014 104,335
3 The Sequence Alignment/Map format and SAMtools Heng Li, Bob Handsaker, Alec Wysoker et al. · Bioinformatics Open access 8 Jun 2009 69,061
4 Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles Aravind N. Subramanian, Pablo Tamayo, Vamsi Krishna Mootha et al. · Proceedings of the National Academy of Sciences Open access 30 Sep 2005 58,060
5 Maximum Likelihood from Incomplete Data Via the EM Algorithm A. P. Dempster, N. M. Laird, Donald B. Rubin · Journal of the Royal Statistical Society Series B (Statistical Methodology) Sep 1977 50,034
6 limma powers differential expression analyses for RNA-sequencing and microarray studies Matthew E. Ritchie, Belinda Phipson, Di Wu et al. · Nucleic Acids Research Open access 20 Jan 2015 44,530
7 SciPy 1.0: fundamental algorithms for scientific computing in Python Pauli Virtanen et al. · Nature Methods Open access112 authors 3 Feb 2020 40,161
8 Meta-analysis in clinical trials Rebecca DerSimonian, Nan M. Laird · Controlled Clinical Trials Sep 1986 40,073
9 PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses Shaun Purcell, Benjamin M. Neale, Katherine EO Todd-Brown et al. · The American Journal of Human Genetics Open access 8 Aug 2007 36,890
10 Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology Sue M. Richards, Nazneen Aziz, Sherri J. Bale et al. · Genetics in Medicine Open access 5 Mar 2015 33,443
11 RoB 2: a revised tool for assessing risk of bias in randomised trials Jonathan A C Sterne et al. · BMJ Open access 28 Aug 2019 33,250
12 Dynamic capabilities and strategic management David J. Teece, Gary Paul Pisano, Amy Shuen · Strategic Management Journal Aug 1997 32,830
13 The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data Aaron McKenna, Matthew G. Hanna, Eric Banks et al. · Genome Research Open access 19 Jul 2010 30,696
14 Measuring the efficiency of decision making units A. Charnes, William White Cooper, Edwardo L. Rhodes · European Journal of Operational Research Open access Nov 1978 29,033
15 Principles and Practice of Structural Equation Modeling Nassim Tabri, Corinna Marie Elliott · Canadian Graduate Journal of Sociology and Criminology Open access 12 Jul 2012 26,069
16 Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2 Evan K Bolyen et al. · Nature Biotechnology Open access112 authors 24 Jul 2019 25,165
17 THE USE OF LEAD CITRATE AT HIGH pH AS AN ELECTRON-OPAQUE STAIN IN ELECTRON MICROSCOPY Edward S. Reynolds · The Journal of Cell Biology Open access Apr 1963 25,107
18 Soft self-consistent pseudopotentials in a generalized eigenvalue formalism David Vanderbilt · Physical review. B, Condensed matter 15 Apr 1990 23,211
19 Full-length transcriptome assembly from RNA-Seq data without a reference genome Manfred G. Grabherr et al. · Nature Biotechnology Open access 15 May 2011 23,028
20 Lifetime Prevalence and Age-of-Onset Distributions of DSM-IV Disorders in the National Comorbidity Survey Replication Ronald C. Kessler, Patricia A. Berglund, Olga Demler et al. · Archives of General Psychiatry Jun 2005 20,746
21 Model-based Analysis of ChIP-Seq (MACS) Yong Zhang, Tao Liu, Clifford A. Meyer et al. · Genome biology Open access 17 Sep 2008 20,527
22 A global reference for human genetic variation Corresponding authors et al. · Nature Open access815 authors 29 Sep 2015 20,444
23 The Reliability of Molecular Weight Determinations by Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis Karolin Weber, Mary Osborn · Journal of Biological Chemistry Open access Aug 1969 20,350
24 ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions Jonathan A C Sterne et al. · BMJ Open access 12 Oct 2016 20,199
25 The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis Frank C. Arnett, Steven M. Edworthy, Daniel A. Bloch et al. · Arthritis & Rheumatism Mar 1988 19,994
26 Observational Evidence from Supernovae for an Accelerating Universe and a Cosmological Constant Adam G. Riess, A. V. Filippenko, P. Challis et al. · The Astronomical Journal Open access Sep 1998 19,814
27 An integrated encyclopedia of DNA elements in the human genome Ian Dunham et al. · Nature Open access442 authors Sep 2012 19,751
28 The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease Guy M. McKhann, David S. Knopman, Howard Mark Chertkow et al. · Alzheimer s & Dementia Open access 22 Apr 2011 19,132
29 Recommendations for Cardiac Chamber Quantification by Echocardiography in Adults: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging Roberto Miguel Lang, Luigi Paolo Badano, Victor Mor‐Avi et al. · Journal of the American Society of Echocardiography Open access 2015 18,398
30 Law and Finance Rafael La Porta, Florencio López‐de‐Silanes, Andrei Shleifer et al. · Journal of Political Economy Dec 1998 18,396
31 The variant call format and VCFtools Petr Danecek, Adam Auton, Gonçalo R. Abecasis et al. · Bioinformatics Open access 7 Jun 2011 18,317
32 Proceedings of the National Academy of Sciences of the United States of America John E. Dowling, George Wald · Nutrition Reviews 27 Apr 2009 18,068
33 The magical number seven, plus or minus two: Some limits on our capacity for processing information. George Miller · Psychological Review Mar 1956 17,806
34 Minimap2: pairwise alignment for nucleotide sequences Heng Li · Bioinformatics Open access 4 May 2018 17,673
35 Metagenomic biomarker discovery and explanation Nicola Segata, Jacques Izard, Levi D. Waldron et al. · Genome biology Open access 24 Jun 2011 17,136
36 Twelve years of SAMtools and BCFtools Petr Danecek, James Bonfield, Jennifer Liddle et al. · GigaScience Open access 29 Jan 2021 17,094
37 Integrative genomics viewer James Theodore Robinson, Helga Thorvaldsdóttir, Wendy Winckler et al. · Nature Biotechnology Open access 2011 16,977
38 Competitive Strategy: Techniques for Analyzing Industries and Competitors Michael E. Porter 1980 16,808
39 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer Bryan R. Haugen, Erik Karl Alexander, Keith Christopher Bible et al. · Thyroid Open access 14 Oct 2015 16,719
40 Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation Matthew G. Vander Heiden, Lewis C. Cantley, Craig B. Thompson · Science Open access 21 May 2009 16,511
41 Job Market Signaling Michael J. Spence · The Quarterly Journal of Economics Aug 1973 16,197
42 The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary David N. Louis, Arie Perry, Guido Reifenberger et al. · Acta Neuropathologica Open access 7 May 2016 16,152
43 Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness Michiru Nishita, Seung‐Yeol Park, Tadashi Nishio et al. · Scientific Reports Open access 24 Jan 2017 16,101
44 Multiplex Genome Engineering Using CRISPR/Cas Systems Le Dinh Công, F. Ann Ran, David B. T. Cox et al. · Science Open access 4 Jan 2013 16,026
45 UCHIME improves sensitivity and speed of chimera detection R. C. Edgar, Brian J. Haas, José Carlos Clemente et al. · Bioinformatics Open access 23 Jun 2011 15,726
46 Improved Survival with Ipilimumab in Patients with Metastatic Melanoma Frank Stephen Hodi et al. · New England Journal of Medicine Open access 5 Jun 2010 15,337
47 A Contribution to the Empirics of Economic Growth N. Gregory Mankiw, Daniel Römer, David Nathan Weil · The Quarterly Journal of Economics May 1992 15,301
48 The Molecular Signatures Database Hallmark Gene Set Collection Arthur Liberzon, Chet Birger, Helga Thorvaldsdóttir et al. · Cell Systems Open access Dec 2015 15,167
49 CHARMM : A program for macromolecular energy, minimization, and dynamics calculations Bernard R. Brooks, Robert E. Bruccoleri, Barry D. Olafson et al. · Journal of Computational Chemistry Jun 1983 15,019
50 Haploview: analysis and visualization of LD and haplotype maps Jeffrey C. Barrett, Ben N. Fry, Julian Maller et al. · Bioinformatics Open access 5 Aug 2004 14,838

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.