Most cited papers from Health Sciences Authority

Health Sciences Authority

What are the most cited papers from Health Sciences Authority?

The most cited paper from Health Sciences Authority is "Defining mesenchymal stromal cell (MSC)‐derived small extracellular vesicles for therapeutic applications" (Kenneth Whitaker Witwer, Bas W. M. van Balkom, Stefania Bruno et al., 2019), with 693 citations. Next come "Human platelet lysate: Replacing fetal bovine serum as a gold standard for human cell propagation?" (544) and "International Society for Cellular Therapy perspective on immune functional assays for mesenchymal stromal cells as potency release criterion for advanced phase clinical trials" (534).

Published TypeFieldAccessCitations

Showing 50 of 57 papers. Every paper with more than 67 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Defining mesenchymal stromal cell (MSC)‐derived small extracellular vesicles for therapeutic applications Kenneth Whitaker Witwer, Bas W. M. van Balkom, Stefania Bruno et al. · Journal of Extracellular Vesicles Open access	29 Apr 2019	693
2	Human platelet lysate: Replacing fetal bovine serum as a gold standard for human cell propagation? Thierry Burnouf, Dirk Strunk, Mickey Koh et al. · Biomaterials	2 Nov 2015	544
3	International Society for Cellular Therapy perspective on immune functional assays for mesenchymal stromal cells as potency release criterion for advanced phase clinical trials Jacques Galipeau et al. · Cytotherapy Open access	23 Dec 2015	534
4	Lung pathology of severe acute respiratory syndrome (SARS): a study of 8 autopsy cases from Singapore Teri J. Franks, Pek Yoon Chong, Paul Chui et al. · Human Pathology Open access	Aug 2003	434
5	Epidemic Hand, Foot and Mouth Disease Caused by Human Enterovirus 71, Singapore Kwai Peng Chan, Kee Tai Goh, Chia Yin Chong et al. · Emerging infectious diseases Open access	2003	389
6	Ethical and regulatory challenges of large language models in medicine Jasmine Chiat Ling Ong, Yin‐Hsi Chang, William Wasswa et al. · The Lancet Digital Health Open access	23 Apr 2024	328
7	Identification of Circulating MicroRNA Signatures for Breast Cancer Detection Maurice Chan, Chiew Suan Liaw, Shen Ji et al. · Clinical Cancer Research	24 Jun 2013	277
8	Adaptive Licensing: Taking the Next Step in the Evolution of Drug Approval H.-G. Eichler et al. · Clinical Pharmacology & Therapeutics	15 Feb 2012	276
9	One and a half million hematopoietic stem cell transplants: continuous and differential improvement in worldwide access with the use of non-identical family donors Dietger W. Niederwieser et al. · Haematologica Open access	12 Aug 2021	250
10	Analysis of Deaths During the Severe Acute Respiratory Syndrome (SARS) Epidemic in Singapore: Challenges in Determining a SARS Diagnosis Pek Yoon Chong, Paul Chui, Ai Ee Ling et al. · Archives of Pathology & Laboratory Medicine Open access	Feb 2004	238
11	Evolutionarily Conserved Protein Sequences of Influenza A Viruses, Avian and Human, as Vaccine Targets A. T. Heiny, Olivo Miotto, Kellathur N. Srinivasan et al. · PLoS ONE Open access	20 Nov 2007	197
12	From adaptive licensing to adaptive pathways: Delivering a flexible life‐span approach to bring new drugs to patients H‐G Eichler et al. · Clinical Pharmacology & Therapeutics Open access	4 Feb 2015	194
13	SJS/TEN 2017: Building Multidisciplinary Networks to Drive Science and Translation Katie D. White et al. · The Journal of Allergy and Clinical Immunology In Practice Open access	2018	182
14	Screening of synthetic PDE-5 inhibitors and their analogues as adulterants: Analytical techniques and challenges Dhavalkumar Narendrabhai Patel, Lin Li, Chee‐Leong Kee et al. · Journal of Pharmaceutical and Biomedical Analysis	6 May 2013	161
15	Circulating microRNAs as Potential Diagnostic and Prognostic Biomarkers in Hepatocellular Carcinoma Jin Hui Yu, Ye Shen Wong, Brian K. P. Goh et al. · Scientific Reports Open access	18 Jul 2019	153
16	Drug‐induced liver injury at an Asian center: a prospective study Chun‐Tao Wai, Bee‐Him Tan, Cheng‐Leng Chan et al. · Liver International	14 Mar 2007	151
17	Analysis of saponins in raw and steamed Panax notoginseng using high-performance liquid chromatography with diode array detection Aik Jiang Lau, Soo-On Woo, Hwee‐Ling Koh · Journal of Chromatography A	8 Aug 2003	148
18	Simultaneous determination of synthetic phosphodiesterase-5 inhibitors found in a dietary supplement and pre-mixed bulk powders for dietary supplements using high-performance liquid chromatography with diode array detection and liquid chromatography–electrospray ionization tandem mass spectrometry Peng Zou, Sharon Sze‐Yin Oh, Peiling Hou et al. · Journal of Chromatography A	22 Dec 2005	148
19	Production and Quality Requirements of Human Platelet Lysate: A Position Statement from the Working Party on Cellular Therapies of the International Society of Blood Transfusion Katharina Schallmoser, Reinhard Henschler, Christian Gabriel et al. · Trends in biotechnology Review	17 Jul 2019	140
20	Nanomedicine: An unresolved regulatory issue Vivian S. W. Chan · Regulatory Toxicology and Pharmacology	2 Nov 2006	136
21	Cost-effectiveness of HLA-B1502 genotyping in adult patients with newly diagnosed epilepsy in Singapore Di Dong, Cynthia Sung, Eric Andrew Finkelstein · Neurology*	6 Sep 2012	131
22	Pressurized hot water extraction of berberine, baicalein and glycyrrhizin in medicinal plants Eng Shi Ong, Shea Mei Len · Analytica Chimica Acta	Apr 2003	128
23	Hand, foot and mouth disease in Singapore: a comparison of fatal and non‐fatal cases C‐Y Chong, K‐P Chan, VA Shah et al. · Acta Paediatrica Open access	Oct 2003	122
24	Pressurized liquid extraction of berberine and aristolochic acids in medicinal plants Eng-Shi Ong, Soo-On Woo, Yuk-Lin Yong · Journal of Chromatography A	Dec 2000	120
25	Data mining spontaneous adverse drug event reports for safety signals in Singapore – a comparison of three different disproportionality measures Pei San Ang, Zhaojin Chen, Cheng Leng Chan et al. · Expert Opinion on Drug Safety	21 Mar 2016	116
26	Is dengue a threat to the blood supply? D. Teo, Lee Ching Ng, Sally Lam · Transfusion Medicine Open access	Apr 2009	114
27	Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients Say Li Kong, Paul Chui, Bing Lim et al. · Virus Research Open access	26 Jul 2009	113
28	Cell, tissue and gene products with marketing authorization in 2018 worldwide Natividad Cuende, John E.J. Rasko, Mickey Koh et al. · Cytotherapy Open access	24 Oct 2018	111
29	Nanomedicines - Tiny particles and big challenges Margareth R. C. Marques, Qiuyi Choo, Mukul Ashtikar et al. · Advanced Drug Delivery Reviews Review	18 Jun 2019	108
30	Occult hepatitis B infection in blood donors from South East Asia: molecular characterisation and potential mechanisms of occurrence Daniel Candotti, Che Kit Lin, Dalila Belkhiri et al. · Gut Open access	20 Jan 2012	108
31	Addressing gaps in international blood availability and transfusion safety in low‐ and middle‐income countries: a NHLBI workshop Brian Custer, Shimian Zou, Simone A. Glynn et al. · Transfusion Open access	14 Mar 2018	106
32	Conservation and Variability of Dengue Virus Proteins: Implications for Vaccine Design Asif M. Khan, Olivo Miotto, Eduardo J. M. Nascimento et al. · PLoS neglected tropical diseases Open access	12 Aug 2008	106
33	MorA Defines a New Class of Regulators Affecting Flagellar Development and Biofilm Formation in Diverse Pseudomonas Species Weng-Keong Choy, Lian Zhou, Chris Kiu-Choong Syn et al. · Journal of Bacteriology Open access	15 Oct 2004	105
34	Regulatory control of Chinese Proprietary Medicines in Singapore Shen-Kuan Yee, Swee-Seng Chu, Yimin Xu et al. · Health Policy	27 Aug 2004	99
35	Identification of Novel Functional Differences in Monocyte Subsets Using Proteomic and Transcriptomic Methods Changqing Zhao, Huoming Zhang, Wing‐Cheong Wong et al. · Journal of Proteome Research	10 Jun 2009	98
36	A systematic bioinformatics approach for selection of epitope-based vaccine targets Asif M. Khan, Olivo Miotto, A. T. Heiny et al. · Cellular Immunology Open access	Dec 2006	92
37	Accelerated Access to Innovative Medicines for Patients in Need L G Baird, Reiner Banken, H‐G Eichler et al. · Clinical Pharmacology & Therapeutics Open access	9 Jul 2014	90
38	Dengue Virus Activates Polyreactive, Natural IgG B Cells after Primary and Secondary Infection Thavamalar Balakrishnan, Dennis Bela-Ong, Ying Xiu Toh et al. · PLoS ONE Open access	22 Dec 2011	88
39	A review of synthetic phosphodiesterase type 5 inhibitors (PDE-5i) found as adulterants in dietary supplements Chee‐Leong Kee, Xiaowei Ge, Véronique Gilard et al. · Journal of Pharmaceutical and Biomedical Analysis	9 Aug 2017	83
40	Human platelet lysate current standards and future developments Reinhard Henschler, Christian Gabriel, Katharina Schallmoser et al. · Transfusion	11 Feb 2019	80
41	Electronic nicotine delivery systems: regulatory and safety challenges: Singapore perspective Nuan Ping Cheah, Norman Wee Lin Chong, Jing Tan et al. · Tobacco Control	Dec 2012	80
42	Association of Sirtuin 1 (SIRT1) Gene SNPs and Transcript Expression Levels With Severe Obesity Stephen J. Clark, Mario Falchi, Bob Olsson et al. · Obesity Open access	14 Jul 2011	80
43	The anti-tumour activity of allogeneic cytokine-induced killer cells in patients who relapse after allogeneic transplant for haematological malignancies Y-C Linn, Madelaine Niam, Shu‐Hsun Chu et al. · Bone Marrow Transplantation	10 Oct 2011	79
44	SJS/TEN 2019: From science to translation Wan-Chun Chang et al. · Journal of Dermatological Science Open access	7 Mar 2020	77
45	Adverse events associated with the use of complementary medicine and health supplements: An analysis of reports in the Singapore Pharmacovigilance database from 1998 to 2009 Dhavalkumar Narendrabhai Patel, Wai-Ling Low, L L Tan et al. · Clinical Toxicology	27 Jun 2012	76
46	IRF8 and IRF3 cooperatively regulate rapid interferon-β induction in human blood monocytes Peng Li, Joyce Jing-Yi Wong, Calvin Sum et al. · Blood	13 Jan 2011	76
47	Evaluation of DNA methylation-based age prediction on blood Zhonghui Thong, Xavier Liang Shun Chan, Jolena Ying Ying Tan et al. · Forensic science international. Genetics supplement series Open access	19 Sep 2017	75
48	Regulatory Experiences with Root Causes and Risk Factors for Nitrosamine Impurities in Pharmaceuticals Stephen Horne, Matthew D. Vera, Laxma R. Nagavelli et al. · Journal of Pharmaceutical Sciences Open access	2023	74
49	Extended Evaluation of Virological, Immunological and Pharmacokinetic Endpoints of CELADEN: A Randomized, Placebo-Controlled Trial of Celgosivir in Dengue Fever Patients Cynthia Sung et al. · PLoS neglected tropical diseases Open access	10 Aug 2016	73
50	Isolation and identification of thiohomosildenafil and thiosildenafil in health supplements Peng Zou, Peiling Hou, Sharon Sze‐Yin Oh et al. · Journal of Pharmaceutical and Biomedical Analysis	20 Jan 2008	73

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.