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Starting the fight in the tumor: expert recommendations for the development of human intratumoral immunotherapy (HIT-IT)
Aurélien Marabelle et al. · Annals of Oncology
Open access |
6 Oct 2018 |
216 |
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Evaluating the Efficiency of Hyaluronic Acid for Tumor Targeting via CD44
Alice Spadea, Julio M. Rios De La Rosa, Annalisa Tirella et al. · Molecular Pharmaceutics
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23 Apr 2019 |
145 |
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Uncoupling interferon signaling and antigen presentation to overcome immunotherapy resistance due to JAK1 loss in melanoma
Anusha K. Kalbasi, Mito Tariveranmoshabad, Kevin N. Hakimi et al. · Science Translational Medicine
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14 Oct 2020 |
138 |
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Immunotherapeutic effects of intratumoral nanoplexed poly I:C
Maria Angela Aznar, Lourdes Planelles, Mercedes Pérez‐Olivares et al. · Journal for ImmunoTherapy of Cancer
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2 May 2019 |
134 |
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Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells
Clara Gomez‐Aleza et al. · Nature Communications
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10 Dec 2020 |
93 |
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Intratumoral nanoplexed poly I:C BO-112 in combination with systemic anti–PD-1 for patients with anti–PD-1–refractory tumors
Iván Márquez‐Rodas et al. · Science Translational Medicine
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14 Oct 2020 |
86 |
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Rational optimization of a transcription factor activation domain inhibitor
Shaon Basu et al. · Nature Structural & Molecular Biology
Open access |
Dec 2023 |
78 |
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Intratumoral co-injection of the poly I:C-derivative BO-112 and a STING agonist synergize to achieve local and distant anti-tumor efficacy
Maite Álvarez, Carmen Fernandez Molina, Carlos E. de Andrea et al. · Journal for ImmunoTherapy of Cancer
Open access |
Nov 2021 |
42 |
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Mobile integrons encode phage defense systems
Nicolas Kieffer, Alberto Hipólito, Laura Ortiz-Miravalles et al. · Science
Open access |
8 May 2025 |
36 |
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Intravitreal Injection of Proinsulin-Loaded Microspheres Delays Photoreceptor Cell Death and Vision Loss in therd10Mouse Model of Retinitis Pigmentosa
Carolina Isiegas, Jorge A. Marinich-Madzarevich, Miguel Marchena et al. · Investigative Ophthalmology & Visual Science
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8 Jul 2016 |
28 |
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Intratumoral BO-112 in combination with radiotherapy synergizes to achieve CD8 T-cell-mediated local tumor control
Maria Esperanza Rodriguez-Ruiz, Irantzu Serrano-Mendioroz, Eneko Garate-Soraluze et al. · Journal for ImmunoTherapy of Cancer
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2023 |
25 |
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Composite resin inlays: a study of marginal adaptation.
Carmen Llena, L Forner Navarro, Faus Llacer Vj et al. · PubMed
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25 |
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Intratumoral neoadjuvant immunotherapy based on the BO-112 viral RNA mimetic
Maite Álvarez, Carmen Fernandez Molina, Saray Garasa et al. · OncoImmunology
Open access |
5 Apr 2023 |
14 |
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BO-112 Plus Pembrolizumab for Patients With Anti–PD-1–Resistant Advanced Melanoma: Phase II Clinical Trial SPOTLIGHT-203
Iván Márquez‐Rodas et al. · Journal of Clinical Oncology
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27 Jun 2025 |
13 |
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Intratumoral BO-112, a double-stranded RNA (dsRNA), alone and in combination with systemic anti-PD-1 in solid tumors
Iván Márquez‐Rodas, Federico Longo, Maria Esperanza Rodriguez-Ruiz et al. · Annals of Oncology
Open access |
Oct 2018 |
12 |
| 16 |
Efficacy of LCMV-based cancer immunotherapies is unleashed by intratumoral injections of polyI:C
Celia Gomar, Claudia Augusta Di Trani, Ángela Bella et al. · Journal for ImmunoTherapy of Cancer
Open access |
Apr 2024 |
8 |
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961 Preliminary results of a phase 2 study of intratumoral administration of BO-112 with pembrolizumab in patients with advanced melanoma that have progressive disease on anti-PD-1-based therapy
Iván Márquez‐Rodas et al.
Conference paperOpen access |
Nov 2021 |
8 |
| 18 |
Evaluation of the potential therapeutic effects of a double-stranded RNA mimic complexed with polycations in an experimental mouse model of endometriosis
Carmen María García-Pascual, Jessica Martínez, Paula Calvo et al. · Fertility and Sterility
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18 Aug 2015 |
8 |
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ZebraReg—a novel platform for discovering regulators of cardiac regeneration using zebrafish
Kateřina Apolínová, Ferran Arqué Pérez, Sylvia Dyballa et al. · Frontiers in Cell and Developmental Biology
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10 May 2024 |
7 |
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A Phase 1 randomized study on the safety and pharmacokinetics of OCS-05, a neuroprotective disease modifying treatment for Acute Optic Neuritis and Multiple Sclerosis
Pablo Villoslada, Mar Masso, Stéphane Paris et al. · Scientific Reports
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29 Mar 2023 |
7 |
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In vivo genome editing of human hematopoietic stem cells for treatment of blood disorders by mRNA delivery
Saijuan Xu, Dan Liang, Qiudao Wang et al. · bioRxiv (Cold Spring Harbor Laboratory)
PreprintOpen access |
Nov 2024 |
6 |
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In vivo photocontrol of orexin receptors with a nanomolar light-regulated analogue of orexin-B
Davia Prischich, Rosalba Sortino, Alexandre M. J. Gomila et al. · Cellular and Molecular Life Sciences
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6 Jul 2024 |
6 |
| 23 |
Evaluation of the antiproliferative, proapoptotic, and antiangiogenic effects of a double-stranded RNA mimic complexed with polycations in an experimental mouse model of leiomyoma
Carmen María García-Pascual, Hortensia Ferrero, Irene Juarez et al. · Fertility and Sterility
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24 Nov 2015 |
4 |
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GTX-11 improves portal hypertension, liver fibrosis, and sinusoidal cells phenotype in experimental MASH
María Andrés‐Rozas, Zoe Boyer‐Díaz, Eugènia Ruiz-Cánovas et al. · JHEP Reports
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15 Jul 2025 |
3 |
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GT-02287, a brain-penetrant structurally targeted allosteric regulator for glucocerebrosidase show evidence of pharmacological efficacy in models of Parkinson’s disease
Blanca Erika Gutiérrez-Guzmán, N. Gómez Pérez, Ana María García et al. · Parkinsonism & Related Disorders
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Aug 2023 |
3 |
| 26 |
Safety and immunobiological activity of intratumoral (IT) double-stranded RNA (dsRNA) BO-112 in solid malignancies: First in human clinical trial
Iván Márquez‐Rodas, Marta Ester Ruíz, S. Lopez-Tarruella Cobo et al. · Annals of Oncology
Open access |
Sep 2017 |
3 |
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Mesothelioma, a Review of Current Guidelines
Sonia Maciá · IntechOpen eBooks
Book chapterOpen access |
17 Sep 2020 |
2 |
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Combination of intratumoural double-stranded RNA (dsRNA) BO-112 with systemic anti-PD-1 in patients with anti-PD-1 refractory cancer
Iván Márquez‐Rodas, Federico Longo, Santiago Ponce Aix et al. · Annals of Oncology
Open access |
Dec 2019 |
2 |
| 29 |
Bayesian model of disease progression in mucopolysaccaridosis IIIA
Joe Marion, Juan Manuel Garcı́a-Ruiz, Benjamin R. Saville · Statistics in Medicine
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13 May 2022 |
1 |
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Interim results of Transpher A, a multicentre, single-dose, phase 1/2 clinical trial of ABO-102 investigational gene therapy for Sanfilippo syndrome type A (mucopolysaccharidosis IIIA)
Kevin M. Flanigan, Nicholas J.N. Smith, María Luz Couce et al. · Molecular Genetics and Metabolism
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Feb 2022 |
1 |
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Hyaluronic acid carrier-cell interactions: a tri-culture model of the tumour microenvironment to study siRNA delivery under flow conditions
Julio M. Rios De La Rosa, Nicola Tirelli, Annalisa Tirella · International Journal of Nano and Biomaterials
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2019 |
1 |
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Cross-immunity to therapeutic Kayvirus staphylophages reveals conserved immunogenic epitopes in patients
Mireia Bernabéu-Gimeno, Alonso Felipe-Ruíz, Pilar García et al. · Clinical Microbiology and Infection
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Apr 2026 |
0 |
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Predictors of clinical and pathological response in patients with basal cell carcinoma treated with BO-112, a novel intralesional treatment
J. Cañueto, A. Toll Abelló, D. Egozi et al. · EJC Skin Cancer
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2026 |
0 |
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Neoadjuvant BO-112 and Hypofractionated Radiation Therapy with or without Nivolumab in Soft-Tissue Sarcoma: Preclinical and Phase I Results
J. Deng et al. · Cancer Discovery
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5 Mar 2026 |
0 |
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Intratumoral dsRNA Sensor Activation Redirects Radiation-Associated Myeloid Cells to Ignite Local and Systemic Anti-Tumor Immunity in Undifferentiated Pleomorphic Sarcoma
Jun Deng, S. Chin, Mito Tariveranmoshabad et al. · International Journal of Radiation Oncology*Biology*Physics
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22 Oct 2022 |
0 |
| 36 |
Hyaluronic acid carrier-cell interactions: a tri-culture model of the tumour microenvironment to study siRNA delivery under flow conditions
Annalisa Tirella, Julio M. Rios De La Rosa, Nicola Tirelli · International Journal of Nano and Biomaterials
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2019 |
0 |
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Satisfaction with grass pollen sublingual immunotherapy assessed by ESPIA questionnaire – first results from Bulgaria
Plamena Ivanova Novakova, José Luis Justicia, Maria Toncheva Staevska et al. · World Allergy Organization Journal
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Aug 2020 |
0 |
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Brain penetrant structurally targeted allosteric regulators for treating GLB1-related disorders
Manolo Bellotto, Roberto Maj, Ana María García-Collazo et al. · Molecular Genetics and Metabolism
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30 Jan 2020 |
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BO-110, a dsRNA-Based Anticancer Agent
Mercedes Pozuelo-Rubio, Damiá Tormo Carulla, Andrés P. Gagete et al. · Advances in delivery science and technology
Book chapter |
2014 |
0 |