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Institution · Hokkaido Pharmaceutical University

Most cited papers from Hokkaido Pharmaceutical University

Hokkaido Pharmaceutical University

What are the most cited papers from Hokkaido Pharmaceutical University?

The most cited paper from Hokkaido Pharmaceutical University is "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)" (Daniel J. Klionsky et al., 2016), with 6,023 citations. Next come "A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: A strategy for overcoming the PEG dilemma" (646) and "A Liver-Derived Secretory Protein, Selenoprotein P, Causes Insulin Resistance" (582).

Showing 50 of 60 papers. Every paper with more than 137 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) Daniel J. Klionsky et al. · Autophagy Open access2,467 authors 2 Jan 2016 6,023
2 A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: A strategy for overcoming the PEG dilemma Hiroto Hatakeyama, Hidetaka Akita, Hideyoshi Harashima · Advanced Drug Delivery Reviews Review 16 Sep 2010 646
3 A Liver-Derived Secretory Protein, Selenoprotein P, Causes Insulin Resistance Hirofumi Misu et al. · Cell Metabolism Open access Nov 2010 582
4 Atg8‐family interacting motif crucial for selective autophagy Nobuo N. Noda, Yoshinori Ohsumi, Fuyuhiko Inagaki · FEBS Letters 17 Jan 2010 569
5 γ-Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of β-Carboxyl Terminal Fragment Mako Takami, Yu Nagashima, Y Sano et al. · Journal of Neuroscience Open access 14 Oct 2009 519
6 Nucleosides and Nucleotides Kazunobu Miura, Masatoshi SHIGA, Tohru Ueda · The Journal of Biochemistry Jun 1973 487
7 Paraspeckles: Where Long Noncoding RNA Meets Phase Separation Archa H. Fox, Shinichi Nakagawa, Tetsuro Hirose et al. · Trends in Biochemical Sciences ReviewOpen access 27 Dec 2017 473
8 Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid Hiroto Hatakeyama, Hidetaka Akita, Kentaro Kogure et al. · Gene Therapy 17 Aug 2006 396
9 Genetic Polymorphism in the 5'-Flanking Region of HumanCYP1A2 Gene: Effect on the CYP1A2 Inducibility in Humans Mitsutoshi Nakajima, Tsuyoshi Yokoi, Mayumi Mizutani et al. · The Journal of Biochemistry Apr 1999 348
10 Microglial activation and amyloid‐β clearance induced by exogenous heat‐shock proteins Jun‐ichi Kakimura, Yoshihisa Kitamura, Kazuyuki Takata et al. · The FASEB Journal 25 Feb 2002 331
11 DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity Yuichi Kitai, Takumi Kawasaki, Takuya Sueyoshi et al. · The Journal of Immunology 9 Jan 2017 316
12 A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo Yusuke Sato, Hiroto Hatakeyama, Yu Sakurai et al. · Journal of Controlled Release Open access 20 Sep 2012 310
13 Cp*CoIII Catalyzed Site‐Selective CH Activation of Unsymmetrical O‐Acyl Oximes: Synthesis of Multisubstituted Isoquinolines from Terminal and Internal Alkynes Bo Sun, Tatsuhiko Yoshino, Motomu Kanai et al. · Angewandte Chemie International Edition Open access 28 Sep 2015 306
14 Dehydrative Direct CH Allylation with Allylic Alcohols under [Cp*CoIII] Catalysis Yudai Suzuki, Bo Sun, Ken Sakata et al. · Angewandte Chemie International Edition Jul 2015 301
15 Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease Yoshihisa Kitamura, Shun Shimohama, Wataru Kamoshima et al. · Brain Research 1998 271
16 Atomic model of a pyrimidine dimer excision repair enzyme complexed with a dna substrate: Structural basis for damaged DNA recognition Dmitry G. Vassylyev, Tatsuki Kashiwagi, Yuriko Mikami et al. · Cell Open access Dec 1995 268
17 Structure of the measles virus hemagglutinin bound to its cellular receptor SLAM Takao Hashiguchi, Toyoyuki Ose, Marie Kubota et al. · Nature Structural & Molecular Biology Open access 9 Jan 2011 266
18 STING agonist loaded lipid nanoparticles overcome anti-PD-1 resistance in melanoma lung metastasis via NK cell activation Takashi Nakamura, Takanori Sato, Rikito Endo et al. · Journal for ImmunoTherapy of Cancer Open access Jul 2021 258
19 Multiple Mechanisms Linked to Platelet Activation Result in Lysophosphatidic Acid and Sphingosine 1-Phosphate Generation in Blood Takamitsu Sano, Daniel L. Baker, Tamás Virág et al. · Journal of Biological Chemistry Open access Jun 2002 256
20 ROS-induced ROS release orchestrated by Nox4, Nox2, and mitochondria in VEGF signaling and angiogenesis Young-Mee Kim, Seok-Jo Kim, Ryosuke Tatsunami et al. · American Journal of Physiology-Cell Physiology Open access 19 Apr 2017 250
21 Identification of alpha 2-macroglobulin as a carrier protein for IL-6. Tetsushi Matsuda, T. Hirano, Shigeharu Nagasawa et al. · The Journal of Immunology 1989 211
22 Gene structure of CYP3A4 , an adult‐specific form of cytochrome P 450 in human livers, and its transcriptional control Hisashi Hashimoto, Kenji TOIDE, Ryuji Kitamura et al. · European Journal of Biochemistry Dec 1993 211
23 Creation of CRISPR-based germline-genome-engineered mice without ex vivo handling of zygotes by i-GONAD Channabasavaiah B. Gurumurthy, Masahiro Sato, Ayaka Nakamura et al. · Nature Protocols 24 Jul 2019 210
24 Increased Expression of Cyclooxygenases and Peroxisome Proliferator-Activated Receptor-γ in Alzheimer's Disease Brains Yoshihisa Kitamura, Shun Shimohama, Hideyasu Koike et al. · Biochemical and Biophysical Research Communications 1999 210
25 UGT1A1 genotypes and glucuronidation of SN-38, the active metabolite of irinotecan Yukio Ando, Hideo Saka, Gyo Asai et al. · Annals of Oncology Open access Aug 1998 207
26 Fetus-specific expression of a form of cytochrome P-450 in human livers Masayuki Komori, Kanako Nishio, Mitsukazu Kitada et al. · Biochemistry 8 May 1990 203
27 Loss of HRD1-Mediated Protein Degradation Causes Amyloid Precursor Protein Accumulation and Amyloid-β Generation Masayuki Kaneko, Hiroshi Koike, Ryo Saito et al. · Journal of Neuroscience Open access 17 Mar 2010 201
28 Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma Takashi Nakamura, Hiroko Miyabe, Mamoru Hyodo et al. · Journal of Controlled Release Open access 14 Aug 2015 199
29 DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex. Takeshi Niki, Kazuko Takahashi-Niki, Takahiro Taira et al. · PubMed Feb 2003 198
30 Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450 Shigeharu Muto, Ken‐ichi Fujita, Yoshiyuki Yamazaki et al. · Mutation research. Fundamental and molecular mechanisms of mutagenesis Aug 2001 195
31 Islet-activating protein. Enhanced insulin secretion and cyclic AMP accumulation in pancreatic islets due to activation of native calcium ionophores. Toshiaki Katada, M Ui · Journal of Biological Chemistry Open access 1979 194
32 Uptake characteristics of liposomes by rat alveolar macrophages: influence of particle size and surface mannose modification Sumio Chono, Tomoharu Tanino, Toshinobu Seki et al. · Journal of Pharmacy and Pharmacology Open access 2007 192
33 Mesodermal subdivision along the mediolateral axis in chicken controlled by different concentrations of BMP-4 Akane Tonegawa, Noriko Funayama, Naoto Ueno et al. · Development 15 May 1997 191
34 Changes of p53 in the Brains of Patients with Alzheimer's Disease Yoshihisa Kitamura, Shun Shimohama, Wataru Kamoshima et al. · Biochemical and Biophysical Research Communications Mar 1997 188
35 Multifunctional envelope-type nano device (MEND) as a non-viral gene delivery system Kentaro Kogure, Hidetaka Akita, Yuma Yamada et al. · Advanced Drug Delivery Reviews Review 27 Nov 2007 187
36 Suppression of Alzheimer's Disease-Related Phenotypes by Expression of Heat Shock Protein 70 in Mice Tatsuya Hoshino, Naoya Murao, Takushi Namba et al. · Journal of Neuroscience Open access 6 Apr 2011 183
37 Zinc suppresses Th17 development via inhibition of STAT3 activation Chika Kitabayashi, Toshiyuki Fukada, Minoru Kanamoto et al. · International Immunology 9 Mar 2010 176
38 A Sialylated Voltage-Dependent Ca2+ Channel Binds Hemagglutinin and Mediates Influenza A Virus Entry into Mammalian Cells Yoichiro Fujioka, Shinya Nishide, Toyoyuki Ose et al. · Cell Host & Microbe Open access 17 May 2018 175
39 The Host Protease TMPRSS2 Plays a Major Role in In Vivo Replication of Emerging H7N9 and Seasonal Influenza Viruses Kouji Sakai et al. · Journal of Virology Open access 6 Mar 2014 175
40 DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation Hiroyuki Oshiumi, Moeko Miyashita, Masaaki Okamoto et al. · Cell Reports Open access May 2015 174
41 Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F Kotaro Shide, Haruko K. Shimoda, Takashi Kumano et al. · Leukemia Open access 22 Nov 2007 171
42 Induction of Reactive Oxygen Species by Bisphenol A and Abrogation of Bisphenol A-Induced Cell Injury by DJ-1 Hiromasa Ooe, Takahiro Taira, Sanae M.M. Iguchi‐Ariga et al. · Toxicological Sciences 10 Aug 2005 167
43 Controlled release of plasmid DNA from cationized gelatin hydrogels based on hydrogel degradation Yasunori Fukunaka, Kazunori Iwanaga, Kazuhiro Morimoto et al. · Journal of Controlled Release Apr 2002 167
44 Efficient drug targeting to rat alveolar macrophages by pulmonary administration of ciprofloxacin incorporated into mannosylated liposomes for treatment of respiratory intracellular parasitic infections Sumio Chono, Tomoharu Tanino, Toshinobu Seki et al. · Journal of Controlled Release 28 Dec 2007 166
45 Studies on Absorption of Eutectic Mixture. II. Absorption of fused Conglomerates of Chloramphenicol and Urea in Rabbits. Keiji Sekiguchi, Noboru Obi, Yoshio Ueda · Chemical and Pharmaceutical Bulletin Open access 1964 165
46 High Catalytic Activity of Human Cytochrome P450 Co-expressed with Human NADPH-Cytochrome P450 Reductase in Escherichia coli Hiroshi Iwata, Ken‐ichi Fujita, Hirotaka Kushida et al. · Biochemical Pharmacology Apr 1998 163
47 Changes in expressions of proinflammatory cytokines IL-1β, TNF-α and IL-6 in the brain of senescence accelerated mouse (SAM) P8 Kyi Kyi Tha, Yasunobu Okuma, Hiroyuki Miyazaki et al. · Brain Research Dec 2000 162
48 Effects and mechanisms of prolongevity induced by Lactobacillus gasseri SBT2055 in Caenorhabditis elegans Hisako Nakagawa, Takuya Shiozaki, Eiji Kobatake et al. · Aging Cell Open access 29 Dec 2015 160
49 Influence of particle size on drug delivery to rat alveolar macrophages following pulmonary administration of ciprofloxacin incorporated into liposomes Sumio Chono, Tomoharu Tanino, Toshinobu Seki et al. · Journal of drug targeting 2006 158
50 Primary Structure of Human Plasma Glutathione Peroxidase Deduced from eDNA Sequences1 Kazuhiko Takahashi, Masami Akasaka, Yutaka Yamamoto et al. · The Journal of Biochemistry Aug 1990 153

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.