| 1 |
Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome
Alain Combes et al. · New England Journal of Medicine
Open access |
23 May 2018 |
2,451 |
| 2 |
Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma
Héctor Ortega, Mark C. Liu, Ian Douglas Pavord et al. · New England Journal of Medicine
Open access |
8 Sep 2014 |
2,339 |
| 3 |
Efficacy and Safety of Alirocumab in Reducing Lipids and Cardiovascular Events
Jennifer G. Robinson, Michel Farnier, Michel Krempf et al. · New England Journal of Medicine
Open access |
15 Mar 2015 |
2,316 |
| 4 |
Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial
Ian Douglas Pavord, Stephanie Korn, Peter Hugo Howarth et al. · The Lancet
|
Aug 2012 |
2,238 |
| 5 |
Adjuvant vinorelbine plus cisplatin versus observation in patients with completely resected stage IB–IIIA non-small-cell lung cancer (Adjuvant Navelbine International Trialist Association [ANITA]): a randomised controlled trial
Jean‐Yves Douillard et al. · The Lancet Oncology
|
18 Aug 2006 |
1,600 |
| 6 |
Instability of a 550-Base Pair DNA Segment and Abnormal Methylation in Fragile X Syndrome
Isabelle Oberlé, F. Rousseau, Dominique Heitz et al. · Science
|
24 May 1991 |
1,505 |
| 7 |
Human Hypertension Caused by Mutations in WNK Kinases
Frederick Hugh Wilson, Sandra Disse-Nicodème, Keith A. Choate et al. · Science
|
10 Aug 2001 |
1,499 |
| 8 |
A Trial of Intraoperative Low-Tidal-Volume Ventilation in Abdominal Surgery
Emmanuel Futier, Jean‐Michel Constantin, Cathérine Paugam‐Burtz et al. · New England Journal of Medicine
|
31 Jul 2013 |
1,468 |
| 9 |
The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification
A Working Group of the International IgA Nephropathy Network and the Renal Patho et al. · Kidney International
Open access |
Jul 2009 |
1,246 |
| 10 |
First-line nivolumab plus ipilimumab in unresectable malignant pleural mesothelioma (CheckMate 743): a multicentre, randomised, open-label, phase 3 trial
Paul Baas et al. · The Lancet
Open access |
2021 |
1,226 |
| 11 |
Consensus and Future Directions on the Definition of High On-Treatment Platelet Reactivity to Adenosine Diphosphate
Laurent Bonello et al. · Journal of the American College of Cardiology
Open access |
Sep 2010 |
1,152 |
| 12 |
DALI: Defining Antibiotic Levels in Intensive Care Unit Patients: Are Current -Lactam Antibiotic Doses Sufficient for Critically Ill Patients?
Jason A. Roberts et al. · Clinical Infectious Diseases
Open access177 authors |
14 Jan 2014 |
1,111 |
| 13 |
Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial
Julián Panés, Damián García‐Olmo, Gert Van Assche et al. · The Lancet
|
29 Jul 2016 |
1,098 |
| 14 |
Ultrasonographic heel measurements to predict hip fracture in elderly women: the EPIDOS prospective study
D. Hans, Patricia Dargent‐Molina, Anne‐Marie Schott et al. · The Lancet
|
Aug 1996 |
1,064 |
| 15 |
Ventilator-associated pneumonia in adults: a narrative review
Laurent Papazian, Michael Klompas, Charles‐Édouard Luyt · Intensive Care Medicine
ReviewOpen access |
10 Mar 2020 |
1,062 |
| 16 |
The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility
A Working Group of the International IgA Nephropathy Network and the Renal Patho et al. · Kidney International
Open access |
Jul 2009 |
1,050 |
| 17 |
Routine molecular profiling of patients with advanced non-small-cell lung cancer: results of a 1-year nationwide programme of the French Cooperative Thoracic Intergroup (IFCT)
Fabrice Barlési et al. · The Lancet
Open access |
15 Jan 2016 |
1,011 |
| 18 |
Markers of bone resorption predict hip fracture in elderly women: The EPIDOS prospective study
Patrick Garnero, E. Hausherr, M. C. Chapuy et al. · Journal of Bone and Mineral Research
|
Oct 1996 |
1,002 |
| 19 |
Single versus Double Autologous Stem-Cell Transplantation for Multiple Myeloma
Michel Attal, Jean-Luc Harousseau, Thierry T.F. Facon et al. · New England Journal of Medicine
|
24 Dec 2003 |
979 |
| 20 |
Increased Mortality after Dronedarone Therapy for Severe Heart Failure
Lars Køber, Christian Tobias Torp-Pedersen, John J.V. McMurray et al. · New England Journal of Medicine
Open access |
18 Jun 2008 |
974 |
| 21 |
Mapping of a susceptibility locus for Crohn's disease on chromosome 16
Jean‐Pierre Hugot, Pierre Laurent‐Puig, Corinne Gower‐Rousseau et al. · Nature
|
Feb 1996 |
957 |
| 22 |
Effect of Individualized vs Standard Blood Pressure Management Strategies on Postoperative Organ Dysfunction Among High-Risk Patients Undergoing Major Surgery
Emmanuel Futier, Jean‐Yves Lefrant, Pierre‐Grégoire Guinot et al. · JAMA
Open access |
3 Oct 2017 |
947 |
| 23 |
Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial
François Chollet, Jean Tardy, Jean‐François Albucher et al. · The Lancet Neurology
|
8 Jan 2011 |
938 |
| 24 |
Consensus and Update on the Definition of On-Treatment Platelet Reactivity to Adenosine Diphosphate Associated With Ischemia and Bleeding
Udaya S. Tantry et al. · Journal of the American College of Cardiology
Open access |
27 Sep 2013 |
908 |
| 25 |
Dabrafenib plus trametinib in patients with previously treated BRAFV600E-mutant metastatic non-small cell lung cancer: an open-label, multicentre phase 2 trial
David Planchard, Benjamin Besse, Harry J.M. Groen et al. · The Lancet Oncology
Open access |
6 Jun 2016 |
897 |
| 26 |
Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study
Bertrand Cariou et al. · Diabetologia
Open access |
29 May 2020 |
845 |
| 27 |
Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome
Catherine Dodé et al. · Nature Genetics
|
10 Mar 2003 |
834 |
| 28 |
Atrial fibrillation management: a prospective survey in ESC Member Countries
Robby Nieuwlaat, Alessandro Capucci, A. John Camm et al. · European Heart Journal
Open access |
4 Oct 2005 |
832 |
| 29 |
Formal guidelines: management of acute respiratory distress syndrome
Laurent Papazian, Cécile Aubron, Laurent Brochard et al. · Annals of Intensive Care
Open access |
2019 |
829 |
| 30 |
A Randomized, Controlled Trial of Oral Propranolol in Infantile Hemangioma
Christine Léauté-Labrèze et al. · New England Journal of Medicine
Open access |
18 Feb 2015 |
804 |
| 31 |
Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study
Philippe Gautret et al. · Travel Medicine and Infectious Disease
Open access |
Mar 2020 |
791 |
| 32 |
Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism
Jeffrey Ian Weitz, Anthonie W.A. Lensing, Martin H. Prins et al. · New England Journal of Medicine
Open access |
18 Mar 2017 |
791 |
| 33 |
Endoscopic management of common bile duct stones: European Society of Gastrointestinal Endoscopy (ESGE) guideline
Gianpiero Manes et al. · Endoscopy
Open access |
3 Apr 2019 |
782 |
| 34 |
Survival and Morbidity of Preterm Children Born at 22 Through 34 Weeks’ Gestation in France in 2011
Pierre‐Yves Ancel et al. · Archives of Pediatrics and Adolescent Medicine
Open access |
26 Jan 2015 |
767 |
| 35 |
Burnout Syndrome in Critical Care Nursing Staff
Marie Cécile Poncet, Philippe Toullic, Laurent Papazian et al. · American Journal of Respiratory and Critical Care Medicine
|
16 Nov 2006 |
759 |
| 36 |
Early detection of pulmonary arterial hypertension in systemic sclerosis: A French nationwide prospective multicenter study
Eric HACHULLA, Virginie Gressin, Loı̈c Guillevin et al. · Arthritis & Rheumatism
|
30 Nov 2005 |
747 |
| 37 |
Hybrid Minimally Invasive Esophagectomy for Esophageal Cancer
C. Mariette, Sheraz Rehan Markar, Tienhan Sandrine Dabakuyo‐Yonli et al. · New England Journal of Medicine
|
9 Jan 2019 |
738 |
| 38 |
Factors associated with COVID-19-related death in people with rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance physician-reported registry
Anja Strangfeld et al. · Annals of the Rheumatic Diseases
Open access |
27 Jan 2021 |
698 |
| 39 |
Interfacial activation of the lipase–procolipase complex by mixed micelles revealed by X-ray crystallography
Herman van Tilbeurgh, Marie-Pierre Egloff, Chrislaine Martinez et al. · Nature
|
Apr 1993 |
684 |
| 40 |
Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection
Yanick Joseph Crow et al. · Nature Genetics
|
16 Jul 2006 |
683 |
| 41 |
A human homologue of the Drosophila eyes absent gene underlies Branchio-Oto-Renal (BOR) syndrome and identifies a novel gene family
Sonia Abdelhak, Vasiliki Kalatzis, Roland Heilig et al. · Nature Genetics
|
Feb 1997 |
682 |
| 42 |
Azathioprine or Methotrexate Maintenance for ANCA-Associated Vasculitis
Christian Pagnoux, Alfred Mahr, Mohamed Amine Hamidou et al. · Yearbook of Medicine
|
24 Dec 2008 |
674 |
| 43 |
Ciclosporin versus infliximab in patients with severe ulcerative colitis refractory to intravenous steroids: a parallel, open-label randomised controlled trial
David Laharie et al. · The Lancet
|
25 Oct 2012 |
653 |
| 44 |
Withdrawal of Inhaled Glucocorticoids and Exacerbations of COPD
HELGO MAGNUSSEN, Bernd G. Disse, Roberto Rodríguez-Roisin et al. · New England Journal of Medicine
Open access |
8 Sep 2014 |
624 |
| 45 |
Should Adolescents With Acute Lymphoblastic Leukemia Be Treated as Old Children or Young Adults? Comparison of the French FRALLE-93 and LALA-94 Trials
Nicolas Boissel, Marie-Françoise Auclerc, Véronique Lhéritier et al. · Journal of Clinical Oncology
|
Mar 2003 |
608 |
| 46 |
Immune Checkpoint Inhibitor Rechallenge After Immune-Related Adverse Events in Patients With Cancer
Charles Dolladille, Stéphane Éderhy, Marion Sassier et al. · JAMA Oncology
Open access |
16 Apr 2020 |
601 |
| 47 |
Maintenance of Remission Among Patients With Crohn's Disease on Antimetabolite Therapy After Infliximab Therapy Is Stopped
Edouard J. Louis, Jean‐Yves Mary, Gwénola Vernier-Massouille et al. · Gastroenterology
Open access |
22 Sep 2011 |
601 |
| 48 |
Natural History of Pediatric Crohn's Disease: A Population-Based Cohort Study
Gwénola Vernier-Massouille, Mamadou Baldé, Julia Salleron et al. · Gastroenterology
Open access |
4 Jul 2008 |
600 |
| 49 |
Even a low-dose of moderate-to-vigorous physical activity reduces mortality by 22% in adults aged ≥60 years: a systematic review and meta-analysis
David Hupin, Frédéric Roche, Vincent Grémeaux et al. · British Journal of Sports Medicine
ReviewOpen access |
3 Aug 2015 |
579 |
| 50 |
Norepinephrine plus dobutamine versus epinephrine alone for management of septic shock: a randomised trial
Djillali Annane, Philippe Vignon, Alain Renault et al. · The Lancet
|
Aug 2007 |
569 |