| 1 |
Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010
Rafael Lozano et al. · The Lancet
Open access191 authors |
Dec 2012 |
14,344 |
| 2 |
Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
Christopher J L Murray et al. · The Lancet
Open access362 authors |
Dec 2012 |
9,055 |
| 3 |
Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
Theo Vos et al. · The Lancet
Open access358 authors |
Dec 2012 |
8,461 |
| 4 |
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial
Rafael Rosell et al. · The Lancet Oncology
Open access |
30 Jan 2012 |
5,563 |
| 5 |
Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus
Michelle Petri et al. · Arthritis & Rheumatism
Open access |
2 May 2012 |
5,385 |
| 6 |
The new mutation, E46K, of α‐synuclein causes parkinson and Lewy body dementia
Juan Jose Zarranz, Javier Alegre, Juan Carlos Gómez‐Esteban et al. · Annals of Neurology
|
30 Dec 2003 |
2,780 |
| 7 |
2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus
Martin Aringer et al. · Arthritis & Rheumatology
Open access |
6 Aug 2019 |
2,644 |
| 8 |
Screening for Epidermal Growth Factor Receptor Mutations in Lung Cancer
Rafael Rosell et al. · New England Journal of Medicine
Open access |
19 Aug 2009 |
2,388 |
| 9 |
2016 updated EULAR evidence-based recommendations for the management of gout
Pascal Richette et al. · Annals of the Rheumatic Diseases
Open access |
25 Jul 2016 |
1,712 |
| 10 |
2012 American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia
Dinesh Khanna et al. · Arthritis Care & Research
Open access |
28 Sep 2012 |
1,542 |
| 11 |
EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee For International Clinical Studies Including Therapeutics (ESCISIT)
Weiya Zhang, M Doherty, T Bardin et al. · Annals of the Rheumatic Diseases
Open access |
17 May 2006 |
1,420 |
| 12 |
Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial
Jesús Villar et al. · The Lancet Respiratory Medicine
|
7 Feb 2020 |
1,263 |
| 13 |
EULAR recommendations for the management of antiphospholipid syndrome in adults
Maria G. Tektonidou et al. · Annals of the Rheumatic Diseases
Open access |
15 May 2019 |
1,254 |
| 14 |
Gitelman's variant of Barter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na–Cl cotransporter
David B. Simon, Carol J. Nelson-Williams, MARGARET JOHNSON BIA et al. · Nature Genetics
|
1996 |
1,225 |
| 15 |
Prevalence of diabetes mellitus and impaired glucose regulation in Spain: the Di@bet.es Study
Federico Soriguer et al. · Diabetologia
Open access |
10 Oct 2011 |
1,160 |
| 16 |
Paracellin-1, a Renal Tight Junction Protein Required for Paracellular Mg 2+ Resorption
David B. Simon, Yin Lu, Keith A. Choate et al. · Science
|
2 Jul 1999 |
1,141 |
| 17 |
Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: a systematic review
Guillermo Ruiz‐Irastorza, Manuel Ramos‐Casals, Pilar Brito‐Zerón et al. · Annals of the Rheumatic Diseases
Review |
22 Dec 2008 |
990 |
| 18 |
Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal
Samra Turajlic et al. · Cell
Open access |
Apr 2018 |
892 |
| 19 |
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease
Gosia Trynka et al. · Nature Genetics
Open access |
6 Nov 2011 |
878 |
| 20 |
Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III
David B. Simon et al. · Nature Genetics
|
Oct 1997 |
873 |
| 21 |
Polyalanine expansion and frameshift mutations of the paired-like homeobox gene PHOX2B in congenital central hypoventilation syndrome
Jeanne Amiel, Béatrice Laudier, Tania Attié‐Bitach et al. · Nature Genetics
|
17 Mar 2003 |
870 |
| 22 |
Neoadjuvant chemotherapy and nivolumab in resectable non-small-cell lung cancer (NADIM): an open-label, multicentre, single-arm, phase 2 trial
Mariano Provencio et al. · The Lancet Oncology
|
24 Sep 2020 |
855 |
| 23 |
Genetic heterogeneity of Barter's syndrome revealed by mutations in the K+ channel, ROMK
David B. Simon, Fiona E. Karet, Juan Rodríguez‐Soriano et al. · Nature Genetics
|
Oct 1996 |
830 |
| 24 |
Antiphospholipid syndrome
Guillermo Ruiz‐Irastorza, Mark Andrew Crowther, Ware D. Branch et al. · The Lancet
|
7 Sep 2010 |
829 |
| 25 |
2012 American College of Rheumatology guidelines for management of gout. Part 2: Therapy and antiinflammatory prophylaxis of acute gouty arthritis
Dinesh Khanna et al. · Arthritis Care & Research
Open access |
28 Sep 2012 |
736 |
| 26 |
Gout
Nicola Dalbeth, Hyon K. Choi, Leo A. B. Joosten et al. · Nature Reviews Disease Primers
Review |
26 Sep 2019 |
712 |
| 27 |
Langerhans cell histiocytosis (LCH): Guidelines for diagnosis, clinical work‐up, and treatment for patients till the age of 18 years
Riccardo Haupt, Milen Minkov, Itziar Astigarraga et al. · Pediatric Blood & Cancer
Open access |
25 Oct 2012 |
701 |
| 28 |
Mutations in the gene encoding B1 subunit of H+-ATPase cause renal tubular acidosis with sensorineural deafness
Fiona E. Karet et al. · Nature Genetics
|
1999 |
699 |
| 29 |
Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response
Gillian Rice et al. · Nature Genetics
Open access |
14 Jun 2009 |
697 |
| 30 |
Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal
Samra Turajlic et al. · Cell
Open access |
Apr 2018 |
693 |
| 31 |
Clinical Predictors for Fatal Pulmonary Embolism in 15 520 Patients With Venous Thromboembolism
Silvy Laporte, Patrick Mismetti, Hervé Decousus et al. · Circulation
Open access |
17 Mar 2008 |
673 |
| 32 |
Predicting Nonmuscle Invasive Bladder Cancer Recurrence and Progression in Patients Treated With Bacillus Calmette-Guerin: The CUETO Scoring Model
J.M. Fernández Gómez, Rosário Madero, Eduardo Solsona et al. · The Journal of Urology
Open access |
17 Sep 2009 |
667 |
| 33 |
Geographic Variations in Prevalence and Underdiagnosis of COPD
Victor Sobradillo Penña, Marc Miravitlles, Rafael Gabriel et al. · CHEST Journal
|
Oct 2000 |
663 |
| 34 |
Prevalence of COPD in Spain: impact of undiagnosed COPD on quality of life and daily life activities
Marc Miravitlles, Joan Bautista Soriano, Francisco Garcia Rio et al. · Thorax
Open access |
23 Jun 2009 |
645 |
| 35 |
Suggested guidelines for the diagnosis and management of urea cycle disorders
Johannes Häberle, Nathalie Boddaert, Alberto Burlina et al. · Orphanet Journal of Rare Diseases
Open access |
2012 |
636 |
| 36 |
Morbidity and mortality in Cushing's disease: an epidemiological approach
Julen Etxabe, Federico Vázquez · Clinical Endocrinology
|
Apr 1994 |
624 |
| 37 |
A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation
Patrick S. Tarpey et al. · Nature Genetics
Open access |
19 Apr 2009 |
622 |
| 38 |
EULAR evidence based recommendations for gout. Part I: Diagnosis. Report of a task force of the standing committee for international clinical studies including therapeutics (ESCISIT)
Weiya Zhang, M Doherty, E Pascual et al. · Annals of the Rheumatic Diseases
Open access |
18 May 2006 |
587 |
| 39 |
Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal
Thomas J. Mitchell et al. · Cell
Open access |
Apr 2018 |
566 |
| 40 |
Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes
Pierre Fenaux et al. · New England Journal of Medicine
Open access |
8 Jan 2020 |
554 |
| 41 |
European League Against Rheumatism recommendations for calcium pyrophosphate deposition. Part I: terminology and diagnosis
Weiya Zhang, Michael Doherty, Thomas Bardin et al. · Annals of the Rheumatic Diseases
|
7 Jan 2011 |
544 |
| 42 |
Effect of obstructive sleep apnoea and its treatment with continuous positive airway pressure on the prevalence of cardiovascular events in patients with acute coronary syndrome (ISAACC study): a randomised controlled trial
Manuel Sánchez‐de‐la‐Torre et al. · The Lancet Respiratory Medicine
Open access |
12 Dec 2019 |
541 |
| 43 |
Anti-inflammatory and immunosuppressive drugs and reproduction.
Monika Østensen et al. · Arthritis Research & Therapy
Open access |
2006 |
536 |
| 44 |
Mutations in the Tight-Junction Gene Claudin 19 (CLDN19) Are Associated with Renal Magnesium Wasting, Renal Failure, and Severe Ocular Involvement
Martin Konrad et al. · The American Journal of Human Genetics
Open access |
6 Oct 2006 |
530 |
| 45 |
Classification of platelet concentrates (Platelet-Rich Plasma-PRP, Platelet-Rich Fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectives
David M. Dohan Ehrenfest, Isabel Andı́a, Matthias A. Zumstein et al. · Muscles Ligaments and Tendons Journal
Open access |
2019 |
520 |
| 46 |
Association of Type and Location ofBRCA1andBRCA2Mutations With Risk of Breast and Ovarian Cancer
Timothy R. Rebbeck et al. · JAMA
Open access258 authors |
7 Apr 2015 |
517 |
| 47 |
Evidence-based recommendations for the prevention and long-term management of thrombosis in antiphospholipid antibody-positive patients: Report of a Task Force at the 13th International Congress on Antiphospholipid Antibodies
Guillermo Ruiz‐Irastorza, MJ Cuadrado, Ioana Ruiz‐Arruza et al. · Lupus
Open access |
Feb 2011 |
508 |
| 48 |
2018 Annual Report of the European Liver Transplant Registry (ELTR) - 50-year evolution of liver transplantation
René A. Adam et al. · Transplant International
Open access |
27 Sep 2018 |
496 |
| 49 |
Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS
Carlos Ferrando et al. · Intensive Care Medicine
Open access444 authors |
29 Jul 2020 |
482 |
| 50 |
Renal Tubular Acidosis
Juan Rodríguez Soriano · Journal of the American Society of Nephrology
|
Aug 2002 |
479 |