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Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial
Rafael Rosell et al. · The Lancet Oncology
Open access |
30 Jan 2012 |
5,563 |
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Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis
David H Adams et al. · New England Journal of Medicine
Open access |
4 Jul 2018 |
3,046 |
| 3 |
Screening for Epidermal Growth Factor Receptor Mutations in Lung Cancer
Rafael Rosell et al. · New England Journal of Medicine
Open access |
19 Aug 2009 |
2,388 |
| 4 |
Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study
Tudor–Eliade Ciuleanu, Thomas Brodowicz, Christoph Carl Zielinski et al. · The Lancet
Open access |
19 Sep 2009 |
1,122 |
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Effect of CPAP on Blood Pressure in Patients With Obstructive Sleep Apnea and Resistant Hypertension
Miguel Ángel Martínez‐García et al. · JAMA
Open access |
11 Dec 2013 |
668 |
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Effect of Postextubation High-Flow Nasal Cannula vs Conventional Oxygen Therapy on Reintubation in Low-Risk Patients
Gonzalo Hernández, Concepción Vaquero, Paloma González Arenas et al. · JAMA
Open access |
15 Mar 2016 |
564 |
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Cervical pessary in pregnant women with a short cervix (PECEP): an open-label randomised controlled trial
María Goya, Laia Pratcorona, Carme Merced et al. · The Lancet
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3 Apr 2012 |
465 |
| 8 |
Bortezomib, melphalan, and prednisone versus bortezomib, thalidomide, and prednisone as induction therapy followed by maintenance treatment with bortezomib and thalidomide versus bortezomib and prednisone in elderly patients with untreated multiple myeloma: a randomised trial
María‐Victoria Mateos et al. · The Lancet Oncology
Open access |
24 Aug 2010 |
463 |
| 9 |
Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain
Jordi Rello et al. · Critical Care
Open access |
11 Sep 2009 |
451 |
| 10 |
Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza
Jesús F. Bermejo-Martín et al. · Critical Care
Open access |
11 Dec 2009 |
383 |
| 11 |
Microplastic ingestion by Mullus surmuletus Linnaeus, 1758 fish and its potential for causing oxidative stress
Carme Alomar, A. Sureda, Xavier Capó et al. · Environmental Research
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8 Aug 2017 |
379 |
| 12 |
Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the hypertensive response
Santos E. Perez-Pozo, Jesse D. Schold, Takahiko Nakagawa et al. · International Journal of Obesity
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22 Dec 2009 |
347 |
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Efficacy and safety of patisiran for familial amyloidotic polyneuropathy: a phase II multi-dose study
Ole Bernt Suhr, Teresa Coelho, Juan Buades et al. · Orphanet Journal of Rare Diseases
Open access |
2 Sep 2015 |
327 |
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Validity, reproducibility, and responsiveness of a twelve‐joint simplified power doppler ultrasonographic assessment of joint inflammation in rheumatoid arthritis
Esperanza Naredo et al. · Arthritis Care & Research
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27 Mar 2008 |
293 |
| 15 |
Favorable outcome of patients with acute myeloid leukemia harboring a low-allelic burden FLT3-ITD mutation and concomitant NPM1 mutation: relevance to post-remission therapy
Marta Pratcorona, Salut Brunet, Josep F. Nomdedeu et al. · Blood
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Feb 2013 |
286 |
| 16 |
Measurable Residual Disease by Next-Generation Flow Cytometry in Multiple Myeloma
Bruno Paiva et al. · Journal of Clinical Oncology
Open access |
26 Nov 2019 |
282 |
| 17 |
Optimal management therapy for Pseudomonas aeruginosa ventilator-associated pneumonia: An observational, multicenter study comparing monotherapy with combination antibiotic therapy*
José Garnacho‐Montero, Marcio Sa-Borges, Jordi Solé‐Violán et al. · Critical Care Medicine
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20 Jun 2007 |
281 |
| 18 |
Defining the Asthma-COPD Overlap Syndrome in a COPD Cohort
Borja G. Cosío et al. · CHEST Journal
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20 Aug 2015 |
278 |
| 19 |
Prevalence and impact of fibromyalgia on function and quality of life in individuals from the general population: results from a nationwide study in Spain.
Antonio Juan Más, Loreto Carmona, Marta Valverde et al. · PubMed
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5 Feb 2009 |
262 |
| 20 |
Aorto-cavitary fistulous tract formation in infective endocarditis: clinical and echocardiographic features of 76 cases and risk factors for mortality
Ignasi Anguera et al. · European Heart Journal
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30 Nov 2004 |
251 |
| 21 |
Update of the treatment of nosocomial pneumonia in the ICU
Rafael Zaragoza, Pablo Vidal, Gerardo Aguilar et al. · Critical Care
Open access |
29 Jun 2020 |
250 |
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Awareness with recall during general anaesthesia: a prospective observational evaluation of 4001 patients
Carlos Luis Errando, Jeffrey C. Sigl, Matías Robles et al. · British Journal of Anaesthesia
Open access |
31 May 2008 |
246 |
| 23 |
Low Serum Mannose‐Binding Lectin Level Increases the Risk of Death due to Pneumococcal Infection
Damon P. Eisen, Melinda Margaret Dean, Marja A. Boermeester et al. · Clinical Infectious Diseases
Open access |
8 Jul 2008 |
245 |
| 24 |
Cutaneous reactions after SARS-CoV-2 vaccination: a cross-sectional Spanish nationwide study of 405 cases
Ana Crespo Catalá et al. · British Journal of Dermatology
Open access |
13 Jul 2021 |
244 |
| 25 |
Association ofEGFRL858R Mutation in Circulating Free DNA With Survival in the EURTAC Trial
Niki Karachaliou et al. · JAMA Oncology
Open access |
26 Feb 2015 |
239 |
| 26 |
Efficacy of long‐term continuous subcutaneous apomorphine infusion in advanced Parkinson's disease with motor fluctuations: A multicenter study
Pedro Ruiz et al. · Movement Disorders
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28 Apr 2008 |
234 |
| 27 |
Bortezomib, lenalidomide, and dexamethasone as induction therapy prior to autologous transplant in multiple myeloma
Laura Rosiñol et al. · Blood
Open access |
4 Sep 2019 |
220 |
| 28 |
Cervical pessary to prevent preterm birth in women with twin gestation and sonographic short cervix: a multicenter randomized controlled trial (PECEP-Twins)
María Goya et al. · American Journal of Obstetrics and Gynecology
Open access |
25 Nov 2015 |
219 |
| 29 |
First-Line XELOX Plus Bevacizumab Followed by XELOX Plus Bevacizumab or Single-Agent Bevacizumab as Maintenance Therapy in Patients with Metastatic Colorectal Cancer: The Phase III MACRO TTD Study
Eduardo Díaz‐Rubio et al. · The Oncologist
Open access |
2012 |
213 |
| 30 |
A simplified scoring system in de novo follicular lymphoma treated initially with immunochemotherapy
Emmanuel Bachy et al. · Blood
Open access |
17 Apr 2018 |
211 |
| 31 |
Mortality comparison between the first and second/third waves among 3,795 critical COVID-19 patients with pneumonia admitted to the ICU: A multicentre retrospective cohort study
Raquel Carbonell et al. · The Lancet Regional Health - Europe
Open access |
4 Nov 2021 |
207 |
| 32 |
What Is New in Listeriosis?
Almudena Hernández-Milián, Antoni Payeras · BioMed Research International
Open access |
2014 |
197 |
| 33 |
Concordance of blood- and tumor-based detection of RAS mutations to guide anti-EGFR therapy in metastatic colorectal cancer
Julieta Grasselli et al. · Annals of Oncology
Open access |
13 Mar 2017 |
195 |
| 34 |
Lenalidomide plus dexamethasone versus observation in patients with high-risk smouldering multiple myeloma (QuiRedex): long-term follow-up of a randomised, controlled, phase 3 trial
María‐Victoria Mateos, Miguel-Teodoro Hernández, Pilar Giraldo et al. · The Lancet Oncology
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9 Jul 2016 |
194 |
| 35 |
Dermoscopy of Dermatofibromas
Pedro Diego Zaballos, Susana Puig, Álex Llambrich et al. · Archives of Dermatology
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2008 |
188 |
| 36 |
Prevalence of persistent blood eosinophilia: relation to outcomes in patients with COPD
Ciro Casanova et al. · European Respiratory Journal
Open access |
Nov 2017 |
187 |
| 37 |
Potential Anti-inflammatory Effects of Hesperidin from the Genus Citrus
Silvia Tejada, Samuel Pinya, Miquel Martorell et al. · Current Medicinal Chemistry
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19 Jul 2017 |
186 |
| 38 |
Host adaptive immunity deficiency in severe pandemic influenza
Jesús F. Bermejo-Martín et al. · Critical Care
Open access |
14 Sep 2010 |
185 |
| 39 |
Determinants of Severity in Acute Pancreatitis
Hanna Sternby et al. · Annals of Surgery
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18 Apr 2018 |
180 |
| 40 |
Resveratrol and Alzheimer’s Disease: Mechanistic Insights
Touqeer Ahmed, Sehrish Javed, Sana Javed et al. · Molecular Neurobiology
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19 Mar 2016 |
180 |
| 41 |
Management of invasive candidiasis and candidemia in adult non-neutropenic intensive care unit patients: Part I. Epidemiology and diagnosis
Benoit P. Guery, Maiken Cavling Arendrup, Georg M. Auzinger et al. · Intensive Care Medicine
Open access |
29 Oct 2008 |
174 |
| 42 |
Corticosteroid treatment in critically ill patients with severe influenza pneumonia: a propensity score matching study
Antonio Albaya Moreno et al. · Intensive Care Medicine
Open access471 authors |
3 Aug 2018 |
170 |
| 43 |
Phase III trial comparing paclitaxel poliglumex vs docetaxel in the second-line treatment of non-small-cell lung cancer
Luis G Paz-Ares, Helen J. Ross, Mary E.R. O'Brien et al. · British Journal of Cancer
Open access |
May 2008 |
169 |
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Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology
Jean Bousquet et al. · Journal of Allergy and Clinical Immunology
Open access542 authors |
28 Sep 2018 |
168 |
| 45 |
Clinical impact of pneumonia caused by Acinetobacter baumannii in intubated patients: A matched cohort study*
José Garnacho, Jordi Solé‐Violán, Marcio Sa-Borges et al. · Critical Care Medicine
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Oct 2003 |
163 |
| 46 |
Incidence, associated factors and clinical impact of severe infections in a large, multicentric cohort of patients with systemic lupus erythematosus
Íñigo Rúa‐Figueroa et al. · Seminars in Arthritis and Rheumatism
Open access |
27 Jan 2017 |
162 |
| 47 |
Immunogenomic identification and characterization of granulocytic myeloid-derived suppressor cells in multiple myeloma
Cristina Pérez et al. · Blood
Open access |
23 Apr 2020 |
161 |
| 48 |
Prognostic value of minimal residual disease (MRD) in acute myeloid leukemia (AML) with favorable cytogenetics [t(8;21) and inv(16)]
G Perea et al. · Leukemia
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10 Nov 2005 |
161 |
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Dilated Cardiomyopathy Due to BLC2-Associated Athanogene 3 (BAG3) Mutations
Fernándo Domínguez et al. · Journal of the American College of Cardiology
Open access |
Nov 2018 |
160 |
| 50 |
Addition of Bevacizumab to XELOX Induction Therapy Plus Concomitant Capecitabine-Based Chemoradiotherapy in Magnetic Resonance Imaging–Defined Poor-Prognosis Locally Advanced Rectal Cancer: The AVACROSS Study
Miguel Nogué, Antonieta Salud, Pilar Vicente et al. · The Oncologist
Open access |
5 Apr 2011 |
158 |