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GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts
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GM-CSF Neutralization With Lenzilumab in Severe COVID-19 Pneumonia
Zelalem Temesgen et al. · Mayo Clinic Proceedings
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GM-CSF disruption in CART cells modulates T cell activation and enhances CART cell anti-tumor activity
Michelle J. Cox et al. · Leukemia
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19 Apr 2022 |
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Association of a Remote Patient Monitoring (RPM) Program With Reduced Hospitalizations in Cancer Patients With COVID-19
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4 Jun 2021 |
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Zelalem Temesgen, Charles D. Burger, Jason V. Baker et al. · medRxiv
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ZUMA-19: A Phase 1/2 Study of Axicabtagene Ciloleucel Plus Lenzilumab in Patients With Relapsed or Refractory Large B-Cell Lymphoma
Olalekan O. Oluwole, Saad S. Kenderian, Parveen Shiraz et al. · Blood
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15 |
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4 Nov 2020 |
12 |
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C reactive protein utilisation, a biomarker for early COVID-19 treatment, improves lenzilumab efficacy: results from the randomised phase 3 ‘LIVE-AIR’ trial
Zelalem Temesgen, Colleen Frances Kelley, Frank Cerasoli et al. · Thorax
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6 Jul 2022 |
11 |
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Clinical and economic benefits of lenzilumab plus standard of care compared with standard of care alone for the treatment of hospitalized patients with COVID-19 in the United States from the hospital perspective
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17 Jan 2022 |
7 |
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GM-CSF Blockade during Chimeric Antigen Receptor T-Cell (CART) Therapy Reduces Cytokine Release Syndrome and Neurotoxicity and May Enhance CART Effector Functions
Rosalie M. Sterner et al. · Transplantation and Cellular Therapy
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31 Jan 2019 |
6 |
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Clinical and Economic Benefits of Lenzilumab Plus Standard of Care Compared with Standard of Care Alone for the Treatment of Hospitalized Patients with Coronavirus Disease 19 (COVID-19) from the Perspective of National Health Service England
Adrian Kilcoyne, Edward Jordan, Kimberly Thomas et al. · ClinicoEconomics and Outcomes Research
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Phase I safety and bioimaging trial of KB004 (ifabotuzumab) in patients with glioblastoma
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4 |
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Improved Anti-Tumor Response of Chimeric Antigen Receptor T Cell (CART) Therapy after GM-CSF Inhibition Is Mechanistically Supported By a Novel Direct Interaction of GM-CSF with Activated Carts
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23 Jan 2020 |
3 |
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2 |
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P737: LENZILUMAB AND AZACITIDINE IMPROVE HEMATOLOGIC ALTERATIONS OF CHRONIC MYELOMONOCYTIC LEUKEMIA IN THE PREACH-M TRIAL
David M. Ross, Devendra Hiwase, Steven Lane et al. · HemaSphere
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Aug 2023 |
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1134. Lenzilumab Treatment in COVID-19 Pneumonia Reduces Circulating Cytokines and Markers of Systemic Inflammation
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21 Aug 2022 |
0 |
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ICLAS LAQ Network for the Promotion of Animal Quality in Research
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0 |
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Zelalem Temesgen, Charles D. Burger, Claudia R. Libertin et al. · Critical Care Medicine
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S51 Evaluation of treatment approaches for hospitalized Covid-19 patients
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Clinical Benefits and Budget Impact of Lenzilumab plus Standard of Care Compared with Standard of Care Alone for the Treatment of Hospitalized Patients with COVID-19 in the United States from the Hospital Perspective
Adrian Kilcoyne, E. O. Jordan, Allen S. Zhou et al. · medRxiv
PreprintOpen access |
10 Oct 2021 |
0 |
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GM-CSF disruption in cart cells ameliorates cart cell activation and reduces activation-induced cell death
Michelle J. Cox, Claudia Manriquez Roman, Reona Leo Sakemura et al. · Cytotherapy
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May 2021 |
0 |