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Biotransformation: Impact and Application of Metabolism in Drug Discovery
Julia Shanu-Wilson, Liam Evans, Stephen K. Wrigley et al. · ACS Medicinal Chemistry Letters
Open access |
28 Aug 2020 |
110 |
| 2 |
Quest for a COVID-19 Cure by Repurposing Small-Molecule Drugs: Mechanism of Action, Clinical Development, Synthesis at Scale, and Outlook for Supply
Chris De Savi, David L. Hughes, Lisbet Kværnø · Organic Process Research & Development
Open access |
2 Jun 2020 |
108 |
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Aurora A and B kinases as targets for cancer: will they be selective for tumors?
Nick C. Matthews, Cristina Visintin, Basil Hartzoulakis et al. · Expert Review of Anticancer Therapy
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2006 |
76 |
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Further studies on the iodine concentration of conventional, organic and UHT semi-skimmed milk at retail in the UK
Melissa C. Stevenson, Chris Drake, David Ian Givens · Food Chemistry
Open access |
30 Jun 2017 |
55 |
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A phase 2 randomized, double-blind, placebo-controlled, proof-of-concept study of oral seletalisib in primary Sjögren’s syndrome
Maria Juárez et al. · Lara D. Veeken
Open access |
27 Aug 2020 |
49 |
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γ-Heptalactone is an endogenously produced quorum-sensing molecule regulating growth and secondary metabolite production by Aspergillus nidulans
Headley Williams, Jonathan C. P. Steele, Mark O. Clements et al. · Applied Microbiology and Biotechnology
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27 Apr 2012 |
37 |
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Adding a temporal dimension to the study of Friedreich's ataxia: the effect of frataxin overexpression in a human cell model
Tommaso Vannocci, Roberto Notario Manzano, Ombretta Beccalli et al. · Disease Models & Mechanisms
Open access |
2018 |
34 |
| 8 |
Establishing the Secondary Metabolite Profile of the Marine Fungus: Tolypocladium geodes sp. MF458 and Subsequent Optimisation of Bioactive Secondary Metabolite Production
Bethlehem Kebede, Stephen K. Wrigley, Anjali Prashar et al. · Marine Drugs
Open access |
23 Mar 2017 |
30 |
| 9 |
Microbial biotransformation – an important tool for the study of drug metabolism
Rhys Salter, Douglas C. Beshore, Steven L. Colletti et al. · Xenobiotica
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17 Aug 2018 |
25 |
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Ivermectin metabolites reduce Anopheles survival
Kevin C. Kobylinski, Phornpimon Tipthara, Narenrit Wamaket et al. · Scientific Reports
Open access |
19 May 2023 |
22 |
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Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform
Carolina Borsoi Moraes et al. · SLAS DISCOVERY
Open access |
20 Feb 2019 |
22 |
| 12 |
Structure elucidation of some highly unusual tricyclic cis-caryophyllane sesquiterpenes from Marasmiellus troyanus
Liam Evans, J.N. Hedger, Gemma O’Donnell et al. · Tetrahedron Letters
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18 Aug 2010 |
16 |
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Mining for natural product antileishmanials in a fungal extract library
Alison J. Mbekeani, Rebecca Jones, M. Bassas Llorens et al. · International Journal for Parasitology Drugs and Drug Resistance
Open access |
10 Jun 2019 |
15 |
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RESULTS OF SELFMONITORING ON GLUCOMETER SYSTEMS ADVANCE AND OPTIUM IN DAILY ROUTINE
Rudolf Chlup, Martin Payne, Jana Zapletalová et al. · Biomedical Papers
Open access |
Jul 2005 |
15 |
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Building supply chain capacity for neglected tropical diseases: experience from the Ascend West and Central Africa programme
Rocío Villacorta Linaza, Timothy Garner, Chantelle Genovezos · Transactions of the Royal Society of Tropical Medicine and Hygiene
Open access |
23 Apr 2021 |
12 |
| 16 |
Small molecule drug metabolite synthesis and identification: why, when and how?
Julia Shanu-Wilson, Samuel Coe, Liam Evans et al. · Drug Discovery Today
Open access |
5 Mar 2024 |
9 |
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A Phenotypic Screening Approach to Identify Anticancer Compounds Derived from Marine Fungi
Bernhard Ellinger, Johanna Silber, Anjali Prashar et al. · Assay and Drug Development Technologies
Open access |
Apr 2014 |
9 |
| 18 |
Open Source Antibiotics: Simple Diarylimidazoles Are Potent against Methicillin-Resistant Staphylococcus aureus
Dana M. Klug et al. · ACS Infectious Diseases
Open access |
22 Nov 2023 |
7 |
| 19 |
Discovery of Unprecedented Human Stercobilin Conjugates
Sungjoon Cho, Lionel Cheruzel, Jingwei Cai et al. · Drug Metabolism and Disposition
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11 Jul 2024 |
5 |
| 20 |
Methods for metabolite generation and characterization by NMR
Liam Evans, Richard P. Phipps, Julia Shanu-Wilson et al. · Elsevier eBooks
Book chapter |
2020 |
4 |
| 21 |
Use of P450 Enzymes for Late-Stage Functionalization in Drug Discovery
Vincent Kwok‐Man Poon, Christopher Bailey, Sandra Carvalho et al. · Journal of Medicinal Chemistry
Open access |
12 Oct 2025 |
3 |
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Global antimicrobial stewardship and the need for pharmaceutical system strengthening for antimicrobials within a One Health approach
Rocío Villacorta Linaza, Chantelle Genovezos, Timothy Garner et al. · International Journal of Pharmacy Practice
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7 Feb 2022 |
3 |
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In vitro cytochrome P450‐ and transporter‐mediated drug interaction potential of 6β‐hydroxy‐21‐desacetyl deflazacort—A major human metabolite of deflazacort
Jiyuan Ma, Brian Beers, Ravi Manohar et al. · Pharmacology Research & Perspectives
Open access |
21 Mar 2021 |
3 |
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Human metabolites of bosentan produced by enzymes in Hypha's Polycyps™ cytochrome P450 kit
Jonathan C. P. Steele, Antonio De Riso, Headley Williams et al. · Drug Metabolism and Pharmacokinetics
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2018 |
3 |
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New pregaliellalactonoids from Galiella rufa
Zilma Escobar, Headley Williams, Richard P. Phipps et al. · Phytochemistry Letters
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29 Mar 2015 |
3 |
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Identification and Biosynthesis of an N-Glucuronide Metabolite of Camonsertib
Robert Papp, Laird A. Trimble, Adrian J. Fretland et al. · Drug Metabolism and Disposition
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20 Feb 2024 |
1 |
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3-D depth migration in the Diapir Province of the Central North Sea
D. G. Rockliff, M. J. Sugrue, Mike Cooper et al.
Conference paper |
1992 |
1 |
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Gut Microbiota Mediate the Metabolism of Colonic Prostaglandins
Guodong Zhang et al. · Research Square
PreprintOpen access |
20 Feb 2026 |
0 |
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Identification, synthesis, and characterization of a unique N-glucuronide of an acid metabolite of camizestrant (AZD9833) in humans
Zhoupeng Zhang, Stephen Wilkinson, Peter W. A. Howe et al. · Drug Metabolism and Disposition
Open access |
5 Feb 2026 |
0 |
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Biosynthesis and structure assignment of a hydroxylated metabolite of the orexin-1 receptor antagonist JNJ-61393215
Fengbin Song, Jie Chen, Shannon Dallas et al. · Bioorganic & Medicinal Chemistry
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23 Feb 2025 |
0 |
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Synthesis and characterization of human metabolites of the echinocandid drug rezafungin by microbial biotransformation
Julia Shanu-Wilson, Ravi Manohar, Adriana Mederos Gómez et al. · Drug Metabolism and Pharmacokinetics
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Apr 2024 |
0 |
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Correlations between a Shintergy synchronized brain and a laser field; a possible fractal structure of Consciousness (Part 2 of 7 – Local measure in time, and distant in space)
Ortiz Bueno · Zenodo (CERN European Organization for Nuclear Research)
PreprintOpen access |
28 May 2023 |
0 |
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Functional molecules from natural sources: Organized by the Royal Society of Chemistry Biotechnology Group, Magdalen College, Oxford, UK, 6–8 July 2009
Stephen K. Wrigley · The Journal of Antibiotics
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2 Oct 2009 |
0 |