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Institution · Institute for In Vitro Sciences

Most cited papers from Institute for In Vitro Sciences

Institute for In Vitro Sciences

What are the most cited papers from Institute for In Vitro Sciences?

The most cited paper from Institute for In Vitro Sciences is "Current characterization methods for cellulose nanomaterials" (Earl Johan Foster et al., 2018), with 1,036 citations. Next come "Interleukin 20" (552) and "Screening for human ADME/Tox drug properties in drug discovery" (541).

Showing 50 of 60 papers. Every paper with more than 52 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Current characterization methods for cellulose nanomaterials Earl Johan Foster et al. · Chemical Society Reviews ReviewOpen access 2018 1,036
2 Interleukin 20 Hal Blumberg et al. · Cell Open access 2001 552
3 Screening for human ADME/Tox drug properties in drug discovery Albert P. Li · Drug Discovery Today Apr 2001 541
4 Discovery of the Dual Orexin Receptor Antagonist [(7 R )-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2 H -1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia Christopher D. Cox et al. · Journal of Medicinal Chemistry Open access 21 Jun 2010 379
5 Interleukins 19, 20, and 24 Signal through Two Distinct Receptor Complexes Julia E. Parrish-Novak, Wenfeng Xu, Ty Brender et al. · Journal of Biological Chemistry Open access 28 Nov 2002 270
6 The ECVAM International Validation Study on in Vitro Tests for Acute Skin Irritation: Report on the Validity of the EPISKIN and EpiDerm Assays and on the Skin Integrity Function Test Horst Spielmann et al. · Alternatives to Laboratory Animals Dec 2007 230
7 The ECVAM International Validation Study on In Vitro Tests for Skin Corrosivity. 2. Results and Evaluation by the Management Team Julia H. Fentem, G.E.B. Archer, Michael Balls et al. · Toxicology in Vitro Aug 1998 212
8 Species comparison in P450 induction: effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague–Dawley rat, minipig, and beagle dog Chuang Lu, Albert P. Li · Chemico-Biological Interactions May 2001 205
9 Re‐evaluation of silicon dioxide (E 551) as a food additive EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) et al. · EFSA Journal Open access 2018 190
10 Phase I and II enzyme characterization of two sources of HepG2 cell lines Nicola J. Hewitt, Philip G. Hewitt · Xenobiotica Mar 2004 179
11 Summary of FDA Antibody-Mediated Rejection Workshop Patrick Archdeacon, Marieta Chan, Carolyn Y. Neuland et al. · American Journal of Transplantation Open access 26 Apr 2011 176
12 Primary human hepatocytes as a tool for the evaluation of structure—activity relationship in cytochrome P450 induction potential of xenobiotics: evaluation of rifampin, rifapentine and rifabutin Albert P. Li, Margaret Reith, Asenath Rasmussen et al. · Chemico-Biological Interactions Nov 1997 172
13 Structures of Astaxanthin and Their Consequences for Therapeutic Application Tatas Hardo Panintingjati Brotosudarmo, Leenawaty Limantara, Edi Setiyono et al. · International Journal of Food Science Open access 21 Jul 2020 169
14 Apicoplast translation, transcription and genome replication: targets for antimalarial antibiotics Erica L. Dahl, Philip Jon Rosenthal · Trends in Parasitology Review 30 Apr 2008 164
15 A prevalidation study on in vitro tests for acute skin irritation Julia H. Fentem, David G. Briggs, Christophe Chesné et al. · Toxicology in Vitro Feb 2001 153
16 Present status of the application of cryopreserved hepatocytes in the evaluation of xenobiotics: consensus of an international expert panel Albert P. Li, Peter D. Gorycki, Jan Georg Hengstler et al. · Chemico-Biological Interactions Jun 1999 149
17 Preclinical evaluation of drug—drug interaction potential: present status of the application of primary human hepatocytes in the evaluation of cytochrome P450 induction Albert P. Li, Patrick Maurel, Marı́a José Gómez-Lechón et al. · Chemico-Biological Interactions Nov 1997 146
18 Prevalidation of the Embryonic Stem Cell Test (EST)—A New In Vitro Embryotoxicity Test Gabriele Scholz, Elke Genschow, Ingeborg Pohl et al. · Toxicology in Vitro Aug 1999 142
19 The intra- and inter-laboratory reproducibility and predictivity of the KeratinoSens assay to predict skin sensitizers in vitro: Results of a ring-study in five laboratories Andreas Natsch, Caroline Bauch, Foertsch Leslie et al. · Toxicology in Vitro 31 Dec 2010 131
20 Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver Jocelyn Trottier, Mélanie Verreault, Susan Grepper et al. · Hepatology Open access 20 Oct 2006 122
21 Function of Uptake Transporters for Taurocholate and Estradiol 17β-D-Glucuronide in Cryopreserved Human Hepatocytes Yoshihisa Shitara, Albert P. Li, Yukio Kato et al. · Drug Metabolism and Pharmacokinetics 2003 116
22 In vitro genotoxicity test approaches with better predictivity: Summary of an IWGT workshop Stefan Pfuhler, Mick D. Fellows, Jan van Benthem et al. · Mutation Research/Genetic Toxicology and Environmental Mutagenesis 7 May 2011 113
23 Trends in Regenerative Medicine: Repigmentation in Vitiligo Through Melanocyte Stem Cell Mobilization Stanca Ariana Birlea, Gertrude‐E. Costin, Dennis R. Roop et al. · Medicinal Research Reviews Open access 28 Dec 2016 109
24 Development of a method for assessing micronucleus induction in a 3D human skin model (EpiDerm™) Rodger D. Curren, Greg C. Mun, David P. Gibson et al. · Mutation Research/Genetic Toxicology and Environmental Mutagenesis 15 Jun 2006 103
25 Human and animal hepatocytes in vitro with extrapolation in vivo Peter James O'Brien, Katie Chan, Paul M. Silber · Chemico-Biological Interactions 21 Oct 2004 102
26 Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity Amy J. Clippinger et al. · Toxicology in Vitro Open access 20 Jun 2018 99
27 Cell Transformation Assays as Predictors of Human Carcinogenicity Robert D. Combes, Michael Balls, Rodger Curren et al. · Alternatives to Laboratory Animals Sep 1999 87
28 Activation of TRPV4 by mechanical, osmotic or pharmaceutical stimulation is anti-inflammatory blocking IL-1β mediated articular cartilage matrix destruction Shuhua Fu, Huan Meng, Sheetal R. Inamdar et al. · Osteoarthritis and Cartilage Open access 2021 77
29 Approaches to target tractability assessment – a practical perspective Kristin K. Brown, Michael M. Hann, Ami S. Lakdawala et al. · MedChemComm Open access 2018 77
30 Allele-specific methylation of the human c-Ha-ras-1 gene Lois A. Chandler, Hamid Ghazi, Peter Anthony Jones et al. · Cell Aug 1987 75
31 Re‐evaluation of xanthan gum (E 415) as a food additive EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) et al. · EFSA Journal Open access Jul 2017 74
32 Cytokine—chemokine and apoptotic signatures in patients with hepatitis C Manuela G. Neuman, Jean‐Pierre Benhamou, Patrick Marcellin et al. · Translational research 22 Feb 2007 74
33 Effects of cytochrome P450 inducers on 17α‐ethinyloestradiol (EE2) conjugation by primary human hepatocytes Albert P. Li, Hartman, Lu et al. · British Journal of Clinical Pharmacology Open access Nov 1999 72
34 Determination of cytochrome P450 1A2 and cytochrome P450 3A4 induction in cryopreserved human hepatocytes Dirk Roymans, Cis Van Looveren, Angelique M. Leone et al. · Biochemical Pharmacology 12 Dec 2003 69
35 Acute health risks related to the presence of cyanogenic glycosides in raw apricot kernels and products derived from raw apricot kernels EFSA Panel on Contaminants in the Food Chain (CONTAM) · EFSA Journal Open access Apr 2016 68
36 Use of in vitro 3D tissue models in genotoxicity testing: Strategic fit, validation status and way forward. Report of the working group from the 7th International Workshop on Genotoxicity Testing (IWGT) Stefan Pfuhler, Jan van Benthem, Rodger Curren et al. · Mutation Research/Genetic Toxicology and Environmental Mutagenesis Open access 15 Jan 2020 67
37 Scientifically unfounded precaution drives European Commission’s recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles Daniel Reto Dietrich, Sonja von Aulock, Hans W.J. Marquardt et al. · Chemico-Biological Interactions Open access 4 Jul 2013 67
38 The emerging role of Piezo1 in the musculoskeletal system and disease Lei Lei, Zhenkang Wen, Mingde Cao et al. · Theranostics Open access 2024 66
39 Fractal Design Boosts Extrusion-Based 3D Printing of Bone-Mimicking Radial-Gradient Scaffolds Huawei Qu, Zhenyu Han, Zhi‐Gang Chen et al. · Research Open access 2021 65
40 The Second ECVAM Workshop on Phototoxicity Testing Horst Spielmann, Lutz Müller, Dietrich Averbeck et al. · Alternatives to Laboratory Animals Nov 2000 65
41 Metabolic regulation by p53 prevents R-loop-associated genomic instability Emanuele Panatta, Alessio Butera, Eleonora Mammarella et al. · Cell Reports Open access Nov 2022 64
42 Prediction of ocular irritancy of prototype shampoo formulations by the isolated rabbit eye (IRE) test and bovine corneal opacity and permeability (BCOP) assay Karen J. Cooper, Lesley K. Earl, John W. Harbell et al. · Toxicology in Vitro Apr 2001 64
43 Prediction of hepatic clearance using cryopreserved human hepatocytes: a comparison of serum and serum-free incubations Nadège Blanchard, Nicola J. Hewitt, Paul M. Silber et al. · Journal of Pharmacy and Pharmacology 23 Apr 2006 64
44 Discovery of MK-3207: A Highly Potent, Orally Bioavailable CGRP Receptor Antagonist Ian M. Bell, Steven N. Gallicchio, Michael R. Wood et al. · ACS Medicinal Chemistry Letters Open access 12 Jan 2010 63
45 The Generation and Characterization of Antagonist RNA Aptamers to Human Oncostatin M Andrew Rhodes, Angela M. Deakin, John R. Spaull et al. · Journal of Biological Chemistry Open access Sep 2000 63
46 Construction of Dual-Biofunctionalized Chitosan/Collagen Scaffolds for Simultaneous Neovascularization and Nerve Regeneration Guicai Li, Qi Han, Panjian Lu et al. · Research Open access 2020 62
47 Trends in Wound Repair: Cellular and Molecular Basis of Regenerative Therapy Using Electromagnetic Fields G-E Costin, Stanca Ariana Birlea, David Albert Norris · Current Molecular Medicine 5 Dec 2011 62
48 A comparison of aroclor 1254-induced and uninduced rat liver microsomes to human liver microsomes in phenytoin O-deethylation, coumarin 7-hydroxylation, tolbutamide 4-hydroxylation, S-mephenytoin 4′-hydroxylation, chloroxazone 6-hydroxylation and testosterone 6β-hydroxylation Judy D. Easterbrook, Drew Fackett, Albert P. Li · Chemico-Biological Interactions May 2001 62
49 Intralaboratory and interlaboratory evaluation of the EpiDerm™ 3D human reconstructed skin micronucleus (RSMN) assay Ting Hu, Yulia Kaluzhny, Greg C. Mun et al. · Mutation Research/Genetic Toxicology and Environmental Mutagenesis 10 Jan 2009 62
50 The Principles of Weight of Evidence Validation of Test Methods and Testing Strategies Michael Balls et al. · Alternatives to Laboratory Animals Open access Dec 2006 62

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.