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Institution · Integrated DNA Technologies (United States)

Most cited papers from Integrated DNA Technologies (United States)

Integrated DNA Technologies (United States)

What are the most cited papers from Integrated DNA Technologies (United States)?

The most cited paper from Integrated DNA Technologies (United States) is "Pivotal trial of an autonomous AI-based diagnostic system for detection of diabetic retinopathy in primary care offices" (Michael D. Abràmoff, Philip T. Lavin, Michele Birch et al., 2018), with 1,635 citations. Next come "Identification of preexisting adaptive immunity to Cas9 proteins in humans" (1,028) and "Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy" (887).

Showing 50 of 60 papers. Every paper with more than 114 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Pivotal trial of an autonomous AI-based diagnostic system for detection of diabetic retinopathy in primary care offices Michael D. Abràmoff, Philip T. Lavin, Michele Birch et al. · npj Digital Medicine Open access 21 Aug 2018 1,635
2 Identification of preexisting adaptive immunity to Cas9 proteins in humans Carsten T. Charlesworth, Priyanka S. Deshpande, Daniel P. Dever et al. · Nature Medicine Open access 28 Jan 2019 1,028
3 Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy Dongho Kim, Mark A. Behlke, Scott D. Rose et al. · Nature Biotechnology 26 Dec 2004 887
4 A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells Christopher A. Vakulskas, Daniel P. Dever, Garrett R. Rettig et al. · Nature Medicine Open access 31 Jul 2018 828
5 Progress towards in Vivo Use of siRNAs Mark A. Behlke · Molecular Therapy Open access 15 Feb 2006 676
6 CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy Daniel M. Rosenblum, Anna Gutkin, Ranit Kedmi et al. · Science Advances Open access 19 Nov 2020 616
7 Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins Rolen M. Quadros et al. · Genome biology Open access 16 May 2017 591
8 IDT SciTools: a suite for analysis and design of nucleic acid oligomers Richard Owczarzy, Andrey V. Tataurov, Yanfei Wu et al. · Nucleic Acids Research Open access 26 Apr 2008 561
9 Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases Matthew T. N. Yarnall et al. · Nature Biotechnology Open access 24 Nov 2022 473
10 Cellular localization of long non-coding RNAs affects silencing by RNAi more than by antisense oligonucleotides Kim A. Lennox, Mark A. Behlke · Nucleic Acids Research Open access 17 Nov 2015 469
11 Chemical Modification of siRNAs for In Vivo Use Mark A. Behlke · Oligonucleotides 22 Nov 2008 458
12 Chemical modification and design of anti-miRNA oligonucleotides Kim A. Lennox, Mark A. Behlke · Gene Therapy 14 Jul 2011 432
13 Analysis of microRNA turnover in mammalian cells following Dicer1 ablation Michael Paul Gantier, Claire E. McCoy, Irina Rusinova et al. · Nucleic Acids Research Open access 28 Mar 2011 411
14 A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells João T. Marques, Thalie Devosse, Die Wang et al. · Nature Biotechnology 30 Apr 2006 381
15 Structure and activity of putative intronic miRNA promoters Alex Mas Monteys, Ryan M. Spengler, Ji Wan et al. · RNA Open access 14 Jan 2010 380
16 Predicting Stability of DNA Duplexes in Solutions Containing Magnesium and Monovalent Cations Richard Owczarzy, Bernardo G. Moreira, Yong You et al. · Biochemistry Open access 19 Apr 2008 379
17 Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease Kiran Musunuru et al. · New England Journal of Medicine Open access 15 May 2025 356
18 Design of LNA probes that improve mismatch discrimination Y. You · Nucleic Acids Research Open access 28 Apr 2006 348
19 Effects of Sodium Ions on DNA Duplex Oligomers: Improved Predictions of Melting Temperatures Richard Owczarzy, Yong You, Bernardo G. Moreira et al. · Biochemistry Mar 2004 346
20 A modular platform for targeted RNAi therapeutics Ranit Kedmi, Nuphar Veiga, Srinivas Ramishetti et al. · Nature Nanotechnology 29 Jan 2018 321
21 Functional polarity is introduced by Dicer processing of short substrate RNAs Scott D. Rose · Nucleic Acids Research Open access 21 Jul 2005 313
22 Highly Efficient CRISPR-Cas9-Based Methods for Generating Deletion Mutations and F0 Embryos that Lack Gene Function in Zebrafish Kazuyuki Hoshijima, Michael J. Jurynec, Dana Klatt Shaw et al. · Developmental Cell Open access 7 Nov 2019 308
23 Targeting a cytokine checkpoint enhances the fitness of armored cord blood CAR-NK cells May Daher et al. · Blood Open access 9 Sep 2020 299
24 Chitosan/siRNA Nanoparticle–mediated TNF-α Knockdown in Peritoneal Macrophages for Anti-inflammatory Treatment in a Murine Arthritis Model Kenneth Alan Howard, Søren R. Paludan, Mark A. Behlke et al. · Molecular Therapy Open access 30 Sep 2008 299
25 miRNAs control insulin content in pancreatic β‐cells via downregulation of transcriptional repressors Tal Melkman-Zehavi, Roni Oren, Sharon Kredo‐Russo et al. · The EMBO Journal Open access Feb 2011 286
26 Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology Ira W. Deveson et al. · Nature Biotechnology Open access 12 Apr 2021 285
27 Predicting ultraviolet spectrum of single stranded and double stranded deoxyribonucleic acids Andrey V. Tataurov, Yong You, Richard Owczarzy · Biophysical Chemistry 28 Dec 2007 281
28 Current Challenges and Barriers to Real-World Artificial Intelligence Adoption for the Healthcare System, Provider, and the Patient Rishi P. Singh, Grant L. Hom, Michael D. Abràmoff et al. · Translational Vision Science & Technology Open access 11 Aug 2020 266
29 Unique, dual-indexed sequencing adapters with UMIs effectively eliminate index cross-talk and significantly improve sensitivity of massively parallel sequencing Laura E. MacConaill, Robert Thomas Burns, Anwesha Nag et al. · BMC Genomics Open access 8 Jan 2018 253
30 Small Nucleolar RNAs U32a, U33, and U35a Are Critical Mediators of Metabolic Stress Carlos I. Michel, Christopher L. Holley, Benjamin S. Scruggs et al. · Cell Metabolism Open access Jul 2011 249
31 Genetics of fitness and physical performance Eric Jeffrey Devor · American Journal of Human Biology 1998 239
32 Progress Toward In Vivo Use of siRNAs-II Garrett R. Rettig, Mark A. Behlke · Molecular Therapy Open access 20 Dec 2011 217
33 In vivo SELEX for Identification of Brain-penetrating Aptamers Congsheng Cheng, Yong Hong Chen, Kim A. Lennox et al. · Molecular Therapy — Nucleic Acids Open access 2013 211
34 Global role of the bacterial post-transcriptional regulator CsrA revealed by integrated transcriptomics Anastasia H. Potts, Christopher A. Vakulskas, Archana Pannuri et al. · Nature Communications Open access 13 Nov 2017 194
35 Hypersensitive substrate for ribonucleases Bradley R. Kelemen, Tony A. Klink, M. A. Behike et al. · Nucleic Acids Research Open access Sep 1999 194
36 RNase H-dependent PCR (rhPCR): improved specificity and single nucleotide polymorphism detection using blocked cleavable primers Joseph R. Dobosy, Scott D. Rose, Kristin R Beltz et al. · BMC Biotechnology Open access 10 Aug 2011 188
37 A Direct Comparison of Anti-microRNA Oligonucleotide Potency Kim A. Lennox, Mark A. Behlke · Pharmaceutical Research 27 Apr 2010 181
38 AsCas12a ultra nuclease facilitates the rapid generation of therapeutic cell medicines Liyang Zhang et al. · Nature Communications Open access 23 Jun 2021 177
39 Development of β-globin gene correction in human hematopoietic stem cells as a potential durable treatment for sickle cell disease Annalisa Lattanzi et al. · Science Translational Medicine Open access 16 Jun 2021 170
40 Simplified CRISPR tools for efficient genome editing and streamlined protocols for their delivery into mammalian cells and mouse zygotes Ashley M. Jacobi, Garrett R. Rettig, Rolf Turk et al. · Methods Open access 27 Mar 2017 167
41 Stability and Mismatch Discrimination of Locked Nucleic Acid–DNA Duplexes Richard Owczarzy, Yong You, Christopher L. Groth et al. · Biochemistry Open access 6 Oct 2011 167
42 Respiratory syncytial virus nonstructural protein 2 specifically inhibits type I interferon signal transduction Murali Ramaswamy, Lei Shi, Steven M. Varga et al. · Virology Open access 11 Oct 2005 166
43 Deficiency of microRNA miR-34a expands cell fate potential in pluripotent stem cells Yong Jin Choi, Chao‐Po Lin, Davide Risso et al. · Science Open access 12 Jan 2017 163
44 TLR7 Is Involved in Sequence-Specific Sensing of Single-Stranded RNAs in Human Macrophages Michael Paul Gantier, Stephen Y. C. Tong, Mark A. Behlke et al. · The Journal of Immunology Feb 2008 162
45 Effects of fluorescent dyes, quenchers, and dangling ends on DNA duplex stability Bernardo G. Moreira, Yong You, Mark A. Behlke et al. · Biochemical and Biophysical Research Communications 16 Dec 2004 161
46 Engineered transfer RNAs for suppression of premature termination codons John D. Lueck, Jae Seok Yoon, Alfredo Perales‐Puchalt et al. · Nature Communications Open access 18 Feb 2019 157
47 Nox2-containing NADPH oxidase and Akt activation play a key role in angiotensin II-induced cardiomyocyte hypertrophy Shawn Hingtgen, Xin Tian, Jusan Yang et al. · Physiological Genomics 3 May 2006 155
48 Molecular Basis of Reduced Potency of Underacylated Endotoxins Athmane Teghanemt, Desheng Zhang, Erika N. Levis et al. · The Journal of Immunology Oct 2005 147
49 Improved Performance of Anti-miRNA Oligonucleotides Using a Novel Non-Nucleotide Modifier Kim A. Lennox, Richard Owczarzy, Derek M Thomas et al. · Molecular Therapy — Nucleic Acids Open access 2013 147
50 Lessons Learned About Autonomous AI: Finding a Safe, Efficacious, and Ethical Path Through the Development Process Michael D. Abràmoff, Danny Tobey, Danton S. Char · American Journal of Ophthalmology Open access 12 Mar 2020 143

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.