| 1 |
Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe
Sélidji Todagbé Agnandji et al. · New England Journal of Medicine
Open access |
2 Apr 2015 |
417 |
| 2 |
Outer membrane vesicles as platform vaccine technology
Leo van der Pol, Michiel Stork, Peter van der Ley · Biotechnology Journal
Open access |
Sep 2015 |
382 |
| 3 |
Current and next generation influenza vaccines: Formulation and production strategies
Peter Christiaan Soema, Ronald Kompier, Jean‐Pierre Amorij et al. · European Journal of Pharmaceutics and Biopharmaceutics
Open access |
5 Jun 2015 |
333 |
| 4 |
Bioengineering bacterial outer membrane vesicles as vaccine platform
Matthias J. H. Gerritzen, Dirk E. Martens, René H. Wijffels et al. · Biotechnology Advances
Open access |
15 May 2017 |
293 |
| 5 |
PLGA particulate delivery systems for subunit vaccines: Linking particle properties to immunogenicity
Ana L Silva, Peter Christiaan Soema, Bram Slütter et al. · Human Vaccines & Immunotherapeutics
Open access |
11 Jan 2016 |
256 |
| 6 |
Dissolving Microneedle Patches for Dermal Vaccination
Mara Leone, Juha Mönkäre, Joke A. Bouwstra et al. · Pharmaceutical Research
Open access |
17 Jul 2017 |
218 |
| 7 |
Buccal and sublingual vaccine delivery
Heleen Kraan, Hilde Vrieling, Cecil C. Czerkinsky et al. · Journal of Controlled Release
Open access |
6 Jun 2014 |
205 |
| 8 |
Expanding the detectable HLA peptide repertoire using electron-transfer/higher-energy collision dissociation (EThcD)
Geert P. M. Mommen, Christian Karl Frese, Hugo D. Meiring et al. · Proceedings of the National Academy of Sciences
Open access |
10 Mar 2014 |
195 |
| 9 |
Predicting the influence of liposomal lipid composition on liposome size, zeta potential and liposome-induced dendritic cell maturation using a design of experiments approach
Peter Christiaan Soema, Geert-Jan Willems, Wim Jiskoot et al. · European Journal of Pharmaceutics and Biopharmaceutics
Open access |
4 Jul 2015 |
154 |
| 10 |
Comparative gut microbiota and resistome profiling of intensive care patients receiving selective digestive tract decontamination and healthy subjects
Elena Buelow, Teresita d. J. Bello Gonzalez, Susana Fuentes et al. · Microbiome
Open access |
27 Jul 2017 |
136 |
| 11 |
Negative Epistasis and Evolvability in TEM-1 β-Lactamase—The Thin Line between an Enzyme's Conformational Freedom and Disorder
Eynat Dellus-Gur, Mikael H. Elias, Emilia Caselli et al. · Journal of Molecular Biology
Open access |
22 May 2015 |
127 |
| 12 |
An Intranasal OMV-Based Vaccine Induces High Mucosal and Systemic Protecting Immunity Against a SARS-CoV-2 Infection
Peter A. van der Ley, Afshin Zariri, Elly van Riet et al. · Frontiers in Immunology
Open access |
17 Dec 2021 |
126 |
| 13 |
Microneedle-based drug and vaccine delivery via nanoporous microneedle arrays
Koen van der Maaden, Regina Lüttge, Pieter Jan Vos et al. · Drug Delivery and Translational Research
Open access |
4 Jun 2015 |
123 |
| 14 |
Safety and immunogenicity of a synthetic carbohydrate conjugate vaccine against Shigella flexneri 2a in healthy adult volunteers: a phase 1, dose-escalating, single-blind, randomised, placebo-controlled study
Dani Cohen, Jacob Atsmon, Cécile Artaud et al. · The Lancet Infectious Diseases
|
10 Nov 2020 |
100 |
| 15 |
Developments in the formulation and delivery of spray dried vaccines
Gaurav Kanojia, Rimko ten Have, Peter Christiaan Soema et al. · Human Vaccines & Immunotherapeutics
Open access |
19 Sep 2017 |
95 |
| 16 |
Large‐scale production of extracellular vesicles: Report on the “massivEVs” ISEV workshop
Lucia Paolini et al. · Journal of Extracellular Biology
Open access |
Oct 2022 |
94 |
| 17 |
Layer-by-Layer Assembly of Inactivated Poliovirus and N -Trimethyl Chitosan on pH-Sensitive Microneedles for Dermal Vaccination
Koen van der Maaden, Emine Şekerdağ, P. R. T. Schipper et al. · Langmuir
|
5 Jul 2015 |
93 |
| 18 |
SARS-CoV-2 host diversity: An update of natural infections and experimental evidence
Md. Golzar Hossain, Aneela Javed, Sharmin Akter et al. · Journal of Microbiology Immunology and Infection
Open access |
25 Jun 2020 |
90 |
| 19 |
Novel Hollow Microneedle Technology for Depth-Controlled Microinjection-Mediated Dermal Vaccination: A Study with Polio Vaccine in Rats
Koen van der Maaden, Sebastiaan J. Trietsch, Heleen Kraan et al. · Pharmaceutical Research
|
27 Jan 2014 |
90 |
| 20 |
The composition and initial evaluation of a grimace scale in ferrets after surgical implantation of a telemetry probe
Marsinah L. Reijgwart, Nico J. Schoemaker, Riccardo Pascuzzo et al. · PLoS ONE
Open access |
13 Nov 2017 |
87 |
| 21 |
Extended O-GlcNAc on HLA Class-I-Bound Peptides
Fabio Marino, Marshall W. Bern, Geert P. M. Mommen et al. · Journal of the American Chemical Society
Open access |
17 Aug 2015 |
85 |
| 22 |
Influenza Vaccine Manufacturing: Effect of Inactivation, Splitting and Site of Manufacturing. Comparison of Influenza Vaccine Production Processes
Theone C. Kon, Adrian Onu, Laurentiu Berbecila et al. · PLoS ONE
Open access |
9 Mar 2016 |
84 |
| 23 |
Immunoproteomic Profiling of Bordetella pertussis Outer Membrane Vesicle Vaccine Reveals Broad and Balanced Humoral Immunogenicity
René H. M. Raeven, Larissa van der Maas, Wichard Tilstra et al. · Journal of Proteome Research
Open access |
19 May 2015 |
83 |
| 24 |
Systems vaccinology and big data in the vaccine development chain
René H. M. Raeven, Elly van Riet, Hugo D. Meiring et al. · Immunology
Open access |
14 Oct 2018 |
82 |
| 25 |
A Synthetic Carbohydrate Conjugate Vaccine Candidate against Shigellosis: Improved Bioconjugation and Impact of Alum on Immunogenicity
Robert M. F. van der Put, Tae Hee Kim, Catherine Guerreiro et al. · Bioconjugate Chemistry
|
26 Feb 2016 |
79 |
| 26 |
Intranasal immunization with outer membrane vesicle pertussis vaccine confers broad protection through mucosal IgA and Th17 responses
René H. M. Raeven, Dedeke Rockx-Brouwer, Gaurav Kanojia et al. · Scientific Reports
Open access |
30 Apr 2020 |
78 |
| 27 |
Diphtheria toxoid and N -trimethyl chitosan layer-by-layer coated pH-sensitive microneedles induce potent immune responses upon dermal vaccination in mice
P. R. T. Schipper, Koen van der Maaden, Vincent Groeneveld et al. · Journal of Controlled Release
Open access |
11 Jul 2017 |
72 |
| 28 |
Meningococcal Outer Membrane Vesicle Composition-Dependent Activation of the Innate Immune Response
Afshin Zariri, Joep Beskers, Bas van de Waterbeemd et al. · Infection and Immunity
Open access |
Aug 2016 |
72 |
| 29 |
Sampling From the Proteome to the Human Leukocyte Antigen-DR (HLA-DR) Ligandome Proceeds Via High Specificity
Geert P. M. Mommen, Fabio Marino, Hugo D. Meiring et al. · Molecular & Cellular Proteomics
Open access |
13 Jan 2016 |
72 |
| 30 |
A Design of Experiment approach to predict product and process parameters for a spray dried influenza vaccine
Gaurav Kanojia, Geert-Jan Willems, Henderik Willem Frijlink et al. · International Journal of Pharmaceutics
Open access |
12 Aug 2016 |
69 |
| 31 |
Improved Production Process for Native Outer Membrane Vesicle Vaccine against Neisseria meningitidis
Bas van de Waterbeemd, G. Zomer, Patricia Kaaijk et al. · PLoS ONE
Open access |
31 May 2013 |
69 |
| 32 |
Quantitative Proteomics Reveals Distinct Differences in the Protein Content of Outer Membrane Vesicle Vaccines
Bas van de Waterbeemd, Geert P. M. Mommen, Jeroen L. A. Pennings et al. · Journal of Proteome Research
Open access |
15 Feb 2013 |
67 |
| 33 |
Definition of Proteasomal Peptide Splicing Rules for High-Efficiency Spliced Peptide Presentation by MHC Class I Molecules
Celia R. Berkers, Annemieke de Jong, Karianne G. Schuurman et al. · The Journal of Immunology
Open access |
24 Sep 2015 |
67 |
| 34 |
Evaluation of the immune response to RTS,S/AS01 and RTS,S/AS02 adjuvanted vaccines
Geert G Leroux-Roels, Isabel Leroux‐Roels, Frédéric Clément et al. · Human Vaccines & Immunotherapeutics
Open access |
24 Jun 2014 |
67 |
| 35 |
Development of inactivated poliovirus vaccine from Sabin strains: A progress report
Hiromasa Okayasu, Carolyn Sein, Ahd Hamidi et al. · Biologicals
|
9 Oct 2016 |
66 |
| 36 |
Neutralizing Antibodies Elicited by a Novel Detoxified Pneumolysin Derivative, PlyD1, Provide Protection against Both Pneumococcal Infection and Lung Injury
Danielle Salha, Jason Szeto, Lisa E. Myers et al. · Infection and Immunity
Open access |
3 Apr 2012 |
65 |
| 37 |
Deletion of accessory genes 3a, 3b, 5a or 5b from avian coronavirus infectious bronchitis virus induces an attenuated phenotype both in vitro and in vivo
Andrea Laconi, Steven J. van Beurden, Alinda J. Berends et al. · Journal of General Virology
Open access |
Aug 2018 |
64 |
| 38 |
Biosynthetically engineered lipopolysaccharide as vaccine adjuvant
Afshin Zariri, Peter van der Ley · Expert Review of Vaccines
|
22 Mar 2015 |
64 |
| 39 |
Hyaluronan-based dissolving microneedles with high antigen content for intradermal vaccination: Formulation, physicochemical characterization and immunogenicity assessment
Mara Leone, Marjolein I. Priester, Stefan G. Romeijn et al. · European Journal of Pharmaceutics and Biopharmaceutics
Open access |
16 Nov 2018 |
63 |
| 40 |
Spontaneously released Neisseria meningitidis outer membrane vesicles as vaccine platform: production and purification
Matthias J. H. Gerritzen, Merijn L.M. Salverda, Dirk E. Martens et al. · Vaccine
Open access |
2 Aug 2019 |
61 |
| 41 |
High dissolved oxygen tension triggers outer membrane vesicle formation by Neisseria meningitidis
Matthias J. H. Gerritzen, Ronald H. W. Maas, Jan van den IJssel et al. · Microbial Cell Factories
Open access |
3 Oct 2018 |
61 |
| 42 |
Improved storage stability and immunogenicity of hepatitis B vaccine after spray-freeze drying in presence of sugars
Wouter F. Tonnis, Jean‐Pierre Amorij, M.A. Vreeman et al. · European Journal of Pharmaceutical Sciences
Open access |
25 Jan 2014 |
59 |
| 43 |
Universal Applicator for Digitally-Controlled Pressing Force and Impact Velocity Insertion of Microneedles into Skin
Mara Leone, Bart H. Van Oorschot, M. Reza Nejadnik et al. · Pharmaceutics
Open access |
Nov 2018 |
58 |
| 44 |
Animal testing for vaccines. Implementing replacement, reduction and refinement: challenges and priorities
Arnoud M. Akkermans et al. · Biologicals
Open access |
8 Oct 2020 |
57 |
| 45 |
The crystal structure of titanium dioxide nanoparticles influences immune activity in vitro and in vivo
Rob J. Vandebriel, Jolanda P. Vermeulen, Laurens B. van Engelen et al. · Particle and Fibre Toxicology
Open access |
30 Jan 2018 |
57 |
| 46 |
Comprehensive Analysis of the Naturally Processed Peptide Repertoire: Differences between HLA-A and B in the Immunopeptidome
Ingrid M. M. Schellens, Ilka Hoof, Hugo D. Meiring et al. · PLoS ONE
Open access |
16 Sep 2015 |
57 |
| 47 |
Skin delivery of trivalent Sabin inactivated poliovirus vaccine using dissolvable microneedle patches induces neutralizing antibodies
Agnese Donadei, Heleen Kraan, Olga J.A.E Ophorst et al. · Journal of Controlled Release
|
Sep 2019 |
56 |
| 48 |
Next Generation Inactivated Polio Vaccine Manufacturing to Support Post Polio-Eradication Biosafety Goals
Yvonne E. Thomassen, Aart G. van ’t Oever, Monique G.C.T. van Oijen et al. · PLoS ONE
Open access |
12 Dec 2013 |
54 |
| 49 |
Development of Cross-Protective Influenza A Vaccines Based on Cellular Responses
Peter Christiaan Soema, Elly van Riet, Gideon F. A. Kersten et al. · Frontiers in Immunology
Open access |
15 May 2015 |
54 |
| 50 |
Combatting infectious diseases; nanotechnology as a platform for rational vaccine design
Elly van Riet, Akira Ainai, Tadaki Suzuki et al. · Advanced Drug Delivery Reviews
ReviewOpen access |
23 May 2014 |
53 |