Most cited papers from IRBM Science Park

IRBM Science Park

What are the most cited papers from IRBM Science Park?

The most cited paper from IRBM Science Park is "Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice" (Drew E. Cressman, Linda E. Greenbaum, Robert A. DeAngelis et al., 1996), with 1,533 citations. Next come "The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus" (1,163) and "Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases" (589).

Published TypeFieldAccessCitations

Showing 50 of 61 papers. Every paper with more than 102 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice Drew E. Cressman, Linda E. Greenbaum, Robert A. DeAngelis et al. · Science	22 Nov 1996	1,533
2	The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus Elisa Scarselli, Helenia Ansuini, Raffaele Cerino et al. · The EMBO Journal Open access	30 Sep 2002	1,163
3	Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases Armin Lahm, Chantal Paolini, Michele Pallaoro et al. · Proceedings of the National Academy of Sciences Open access	23 Oct 2007	589
4	Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation. Fabrizio De Benedetti, Tonino Alonzi, Antonia Moretta et al. · Journal of Clinical Investigation Open access	15 Feb 1997	534
5	hMutSβ, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA Fabio Palombo, Ingram Iaccarino, Eiitsu Nakajima et al. · Current Biology Open access	Sep 1996	373
6	Aggregates from mutant and wild‐type α‐synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β‐sheet and amyloid‐like filaments Omar M. A. El‐Agnaf, Ross Jakes, Martin D. Curran et al. · FEBS Letters	27 Nov 1998	367
7	PINK1 and BECN1 relocalize at mitochondria-associated membranes during mitophagy and promote ER-mitochondria tethering and autophagosome formation Vania Gelmetti, Priscilla De Rosa, Liliana Torosantucci et al. · Autophagy Open access	17 Feb 2017	364
8	CAJAL BODIES: A Long History of Discovery Mario Cioce, Angus I. Lamond · Annual Review of Cell and Developmental Biology Review	16 May 2005	362
9	The crystal structure of the quorum sensing protein TraR bound to its autoinducer and target DNA Alessandro Vannini, Cinzia Volpari, Cesare Gargioli et al. · The EMBO Journal Open access	28 Aug 2002	358
10	Histone deacetylase and Cullin3–RENKCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation Gianluca Canettieri et al. · Nature Cell Biology	17 Jan 2010	326
11	Genome-wide expression profile of sporadic gastric cancers with microsatellite instability Mariarosaria D’Errico, Emanuele de Rinaldis, Monica Francesca Blasi et al. · European Journal of Cancer	9 Dec 2008	320
12	Discovery of 2-{4-[(3S)-Piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): A Novel Oral Poly(ADP-ribose)polymerase (PARP) Inhibitor Efficacious in BRCA-1 and -2 Mutant Tumors PHILIP G. JONES, Sergio Altamura, Julia K. Boueres et al. · Journal of Medicinal Chemistry Open access	29 Oct 2009	318
13	A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees Antonella Folgori, Stefania Capone, Lionello Ruggeri et al. · Nature Medicine	Feb 2006	315
14	Vaccine Vectors Derived from a Large Collection of Simian Adenoviruses Induce Potent Cellular Immunity Across Multiple Species Stefano Colloca et al. · Science Translational Medicine Open access	4 Jan 2012	306
15	Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington’s disease patients Edward J. Wild, Roberto Boggio, Douglas R. Langbehn et al. · Journal of Clinical Investigation Open access	5 Apr 2015	285
16	Structure of unliganded HSV gD reveals a mechanism for receptor‐mediated activation of virus entry Claude Krummenacher, Vinit M. Supekar, J. Charles Whitbeck et al. · The EMBO Journal Open access	17 Nov 2005	269
17	Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH Paola Lo Surdo, Matthew J. Bottomley, Alessandra Calzetta et al. · EMBO Reports Open access	11 Nov 2011	246
18	Identification of Amino Acid Residues in CD81 Critical for Interaction with Hepatitis C Virus Envelope Glycoprotein E2 Adrian Higginbottom, Elizabeth R. Quinn, Chiung-Chi Kuo et al. · Journal of Virology Open access	15 Apr 2000	221
19	A new class of uracil-DNA glycosylases related to human thymine-DNA glycosylase Paola Gallinari, Josef Jiricny · Nature	Oct 1996	217
20	Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor Steven J. Harper et al. · ACS Medicinal Chemistry Letters Open access	2 Mar 2012	202
21	Comparative expression pathway analysis of human and canine mammary tumors Paolo Uva, Luigi Aurisicchio, James Watters et al. · BMC Genomics Open access	27 Mar 2009	199
22	A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease Frank Narjes, Konrad F. Koehler, Uwe Koch et al. · Bioorganic & Medicinal Chemistry Letters Open access	Feb 2002	187
23	Structure of Herpes Simplex Virus Glycoprotein D Bound to the Human Receptor Nectin-1 Paolo Di Giovine, Ethan C. Settembre, Arjun K. Bhargava et al. · PLoS Pathogens Open access	29 Sep 2011	186
24	hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSα Ingram Iaccarino, Giancarlo Marra, Fabio Palombo et al. · The EMBO Journal Open access	May 1998	172
25	Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor Douglas G. Johns et al. · Circulation Open access	May 2023	168
26	Hepatitis C Virus Nonstructural Proteins Are Localized in a Modified Endoplasmic Reticulum of Cells Expressing Viral Subgenomic Replicons Giovanna Mottola, Giorgia Cardinali, Alessandra Ceccacci et al. · Virology Open access	Feb 2002	166
27	A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors Thomas J. Tucker et al. · Journal of Medicinal Chemistry Open access	27 Oct 2021	160
28	Adipogenesis of skeletal muscle fibro/adipogenic progenitors is affected by the WNT5a/GSK3/β-catenin axis Alessio Reggio, Marco Rosina, Alessandro Palma et al. · Cell Death and Differentiation Open access	7 May 2020	153
29	An overview of the ONIONS project: Applying ontologies to the integration of medical terminologies Aldo Gangemi, Domenico M. Pisanelli, Geri Steve · Data & Knowledge Engineering	Sep 1999	152
30	Towards a solution for hepatitis C virus hypervariability: mimotopes of the hypervariable region 1 can induce antibodies cross‐reacting with a large number of viral variants Giulia Puntoriero, Annalisa Meola, Armin Lahm et al. · The EMBO Journal Open access	Jul 1998	148
31	Structural and Biochemical Characterization of the Wild Type PCSK9-EGF(AB) Complex and Natural Familial Hypercholesterolemia Mutants Matthew J. Bottomley, Agostino Cirillo, Laura Orsatti et al. · Journal of Biological Chemistry Open access	11 Nov 2008	138
32	Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design Candice Alleyne et al. · Journal of Medicinal Chemistry Open access	10 Nov 2020	136
33	Gene therapy progress and prospects: transcription regulatory systems Carlo Toniatti, Hermann Bujard, Roberto Cortese et al. · Gene Therapy	26 Feb 2004	135
34	Structural Analysis of the Epitope of the Anti-HIV Antibody 2F5 Sheds Light into Its Mechanism of Neutralization and HIV Fusion Gaetano Barbato, Elisabetta Bianchi, Paolo Ingallinella et al. · Journal of Molecular Biology	Jul 2003	135
35	PP2A Regulates HDAC4 Nuclear Import Gabriela Paroni, Nadia Cernotta, Claudio Dello Russo et al. · Molecular Biology of the Cell Open access	29 Nov 2007	134
36	Cloning and analysis of Candida cylindracea lipase sequences Marina Lotti, Rita Grandori, Fabrizia Fusetti et al. · Gene	Feb 1993	133
37	Structural basis for HIV-1 neutralization by a gp41 fusion intermediate–directed antibody Micah A. Luftig, Marco Mattu, Paolo Di Giovine et al. · Nature Structural & Molecular Biology	23 Jul 2006	132
38	Evolution of Bacterial and Archaeal Multicomponent Monooxygenases Eugenio Notomista, Armin Lahm, Alberto Di Donato et al. · Journal of Molecular Evolution	27 Mar 2003	131
39	Coexpression of IL‐6 and soluble IL‐6R causes nodular regenerative hyperplasia and adenomas of the liver Domenico Maione, Emma Di Carlo, Wei Li et al. · The EMBO Journal Open access	Oct 1998	130
40	Inhibition of the Hepatitis C Virus NS3/4A Protease Stefania Di Marco, Menico Rizzi, Cinzia Volpari et al. · Journal of Biological Chemistry Open access	Mar 2000	127
41	A Continuous Assay of Hepatitis C Virus Protease Based on Resonance Energy Transfer Depsipeptide Substrates Marina Taliani, Elisabetta Bianchi, Frank Narjes et al. · Analytical Biochemistry	Aug 1996	126
42	Development of progressive kidney damage and myeloma kidney in interleukin-6 transgenic mice Elena Fattori, Carlo Della Rocca, Paula Carvalho Costa et al. · Blood Open access	May 1994	124
43	Discovery of α,γ-Diketo Acids as Potent Selective and Reversible Inhibitors of Hepatitis C Virus NS5b RNA-Dependent RNA Polymerase Vincenzo Summa, Alessia Petrocchi, Paola Pace et al. · Journal of Medicinal Chemistry Open access	9 Dec 2003	123
44	Structure of a proteolytically resistant core from the severe acute respiratory syndrome coronavirus S2 fusion protein Vinit M. Supekar, Chiara Bruckmann, Paolo Ingallinella et al. · Proceedings of the National Academy of Sciences Open access	16 Dec 2004	123
45	Selection of biologically active peptides by phage display of random peptide libraries Roberto Cortese · Current Opinion in Biotechnology	Dec 1996	122
46	Antibody Modeling: Implications for Engineering and Design Veronica Morea, Arthur M. Lesk, Anna Luna Tramontano · Methods	Mar 2000	122
47	Janus Kinase-dependent Activation of Insulin Receptor Substrate 1 in Response to Interleukin-4, Oncostatin M, and the Interferons Mark S. Burfoot, Neil C. Rogers, Diane Watling et al. · Journal of Biological Chemistry Open access	Sep 1997	120
48	In Vitro Selection and Characterization of Hepatitis C Virus Serine Protease Variants Resistant to an Active-Site Peptide Inhibitor Caterina Trozzi, Linda Bartholomew, Alessandra Ceccacci et al. · Journal of Virology Open access	27 Feb 2003	118
49	Identification of biologically active peptides using random libraries displayed on phage Riccardo Cortese, Paolo Monaci, Alfredo Nicosia et al. · Current Opinion in Biotechnology Review	1995	118
50	The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism Gaetano Barbato, Daniel Oscar Cicero, M. Nardi et al. · Journal of Molecular Biology Open access	Jun 1999	115

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.