| 1 |
First-in-human phase I study of ISTH0036, an antisense oligonucleotide selectively targeting transforming growth factor beta 2 (TGF-β2), in subjects with open-angle glaucoma undergoing glaucoma filtration surgery
Norbert Pfeiffer, Bogomil Voykov, Giulia Renieri et al. · PLoS ONE
Open access |
30 Nov 2017 |
69 |
| 2 |
TGF-β1 and TGF-β2 abundance in liver diseases of mice and men
Anne Dropmann, Tatjana Dediulia, Katja Breitkopf‐Heinlein et al. · Oncotarget
Open access |
21 Jan 2016 |
62 |
| 3 |
Biological Role and Therapeutic Targeting of TGF-β3 in Glioblastoma
Katharina Seystahl, Alexandros Papachristodoulou, Isabel Burghardt et al. · Molecular Cancer Therapeutics
Open access |
4 Apr 2017 |
60 |
| 4 |
Therapeutic Targeting of TGFβ Ligands in Glioblastoma Using Novel Antisense Oligonucleotides Reduces the Growth of Experimental Gliomas
Alexandros Papachristodoulou, Manuela Silginer, Michael Weller et al. · Clinical Cancer Research
Open access |
17 Sep 2019 |
51 |
| 5 |
TGF-β2 silencing to target biliary-derived liver diseases
Anne Dropmann et al. · Gut
Open access |
28 Jan 2020 |
43 |
| 6 |
An antisense oligonucleotide targeting TGF-β2 inhibits lung metastasis and induces CD86 expression in tumor-associated macrophages
Isabel Huber‐Ruano, C. Raventós, Isabel Cuartas et al. · Annals of Oncology
Open access |
21 Jul 2017 |
30 |
| 7 |
Design and Selection of Antisense Oligonucleotides Targeting Transforming Growth Factor Beta (TGF-β) Isoform mRNAs for the Treatment of Solid Tumors
Frank Jaschinski, Hanna Korhonen, Michel Janicot · Methods in molecular biology
Book chapter |
2015 |
15 |
| 8 |
Nanoparticle platform preferentially targeting liver sinusoidal endothelial cells induces tolerance in CD4+ T cell-mediated disease models
Shu-Hung Wang et al. · Frontiers in Immunology
Open access |
17 Mar 2025 |
13 |
| 9 |
TGF-β isoforms in cancer: Immunohistochemical expression and Smad-pathway-activity-analysis in thirteen major tumor types with a critical appraisal of antibody specificity and immunohistochemistry assay validity
Markus J. Riemenschneider, Maria Hirblinger, Arabel Vollmann‐Zwerenz et al. · Oncotarget
Open access |
22 Sep 2015 |
11 |
| 10 |
Potent and selective antisense oligonucleotides targeting the transforming growth factor beta (TGF-β) isoforms in advanced glaucoma: a preclinical evaluation
Kathy Hasenbach, Tine Van Bergen, Evelien Vandewalle et al. · Modeling and Artificial Intelligence in Ophthalmology
Open access |
15 Dec 2016 |
7 |
| 11 |
A Hyperbolic Discrete Diffusion 3D RNA Inverse Folding Model for Functional RNA Design
Dongyue Hou, Shuai Zhang, Mengyao Ma et al. · Journal of Chemical Information and Modeling
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12 Jun 2025 |
5 |
| 12 |
Main results of the First-In Human single ascending dose phase I study of ISTH0036, an antisense oligonucleotide selectively targeting transforming growth factor beta 2 (TGF-β2) in glaucoma filtration surgery
Bogomil Voykov, Hagen Thieme, Katharina Cornelia Bell et al. · Investigative Ophthalmology & Visual Science
Open access |
23 Jun 2017 |
3 |
| 13 |
Targeting Transforming Growth Factor beta 2 (TGF-β2) mRNA with ISTH0036 as Novel Therapeutic Intervention in Neovascular Ocular Disease
Katja Wosikowski, Inge van Hoven, Jooseppi Puranen et al. · Lirias (KU Leuven)
Open access |
May 2017 |
1 |
| 14 |
Long-term safety and efficacy of ISTH0036 – a selective TGF-β2 blocking antisense oligonucleotide in preclinical and Phase 1 clinical studies.
René Rückert, Marion Ronit Munk, Katja Wosikowski et al. · Investigative Ophthalmology & Visual Science
Open access |
21 Jun 2021 |
0 |
| 15 |
TGF-beta 2 als therapeutische Zielstruktur bei cholestatischer Leberfibrose
Anne Dropmann, Steven Dooley, Bedair Dewidar et al. · Zeitschrift für Gastroenterologie
Conference paper |
13 Aug 2019 |
0 |
| 16 |
Extended preclinical ocular biodistribution and pharmacodynamic profile of ISTH0036, an antisense oligonucleotide targeting transforming growth factor beta 2 (TGF-β2) for the treatment of ophthalmic diseases
Katja Wosikowski, Birgit Korbmacher, Monika Krampert et al. · Investigative Ophthalmology & Visual Science
Open access |
13 Jul 2018 |
0 |
| 17 |
A phase I First-In Human single ascending dose study of ISTH0036, a potent and selective antisense oligonucleotide targeting transforming growth factor beta 2 (TGF-β2) for the treatment of primary open-angle glaucoma
Bogomil Voykov, Katrin Lorenz, Claudia Schuart et al. · Investigative Ophthalmology & Visual Science
Open access |
26 Sep 2016 |
0 |
| 18 |
Anti-fibrotic and anti-inflammatory consequences of TGF-β2 silencing in biliary liver disease
Anne Dropmann, Bedair Dewidar, Tatjana Dediulia et al. · Zeitschrift für Gastroenterologie
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19 Dec 2016 |
0 |
| 19 |
Targeting TGF-β2 in chronic liver diseases
Anne Dropmann, Hanna Korhonen, Frank Jaschinski et al. · Zeitschrift für Gastroenterologie
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16 Jan 2015 |
0 |
| 20 |
TGF-β2 in Chronic Liver Disease (CLD) and Hepatocellular Carcinoma (HCC)
Anne Dropmann, Albrecht Piiper, E M Alonso et al. · Zeitschrift für Gastroenterologie
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13 Jan 2014 |
0 |
| 21 |
Targeting Transforming Growth Factor beta 2 (TGF-β2) Isoform with ISTH0036 - a Potent and Selective Antisense Oligonucleotide - for the Treatment of Glaucoma
Kathy Hasenbach, Leonie Herrnberger, Sabrina Kuespert et al. · Investigative Ophthalmology & Visual Science
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11 Jun 2015 |
0 |
| 22 |
Efficacy of ISTH0036, a Potent and Selective Antisense Oligonucleotide Targeting Transforming Growth Factor beta 2 (TGF-β2) Isoform, in Different Ocular Disease Preclinical Models
Michel Janicot, Kathy Hasenbach, Tine Van Bergen et al. · Investigative Ophthalmology & Visual Science
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11 Jun 2015 |
0 |