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Most cited papers from Janelia Research Campus

What are the most cited papers from Janelia Research Campus?

The most cited paper from Janelia Research Campus is "Imaging Intracellular Fluorescent Proteins at Nanometer Resolution" (Eric Betzig, George H. Patterson, Rachid Sougrat et al., 2006), with 9,061 citations. Next come "Accelerated Profile HMM Searches" (7,781) and "Ultrasensitive fluorescent proteins for imaging neuronal activity" (7,242).

Showing 50 of 60 papers. Every paper with more than 998 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Imaging Intracellular Fluorescent Proteins at Nanometer Resolution Eric Betzig, George H. Patterson, Rachid Sougrat et al. · Science 10 Aug 2006 9,061
2 Accelerated Profile HMM Searches Sean R. Eddy · PLoS Computational Biology Open access 20 Oct 2011 7,781
3 Ultrasensitive fluorescent proteins for imaging neuronal activity Tsai‐Wen Chen, Trevor J. Wardill, Yi Sun et al. · Nature Open access 16 Jul 2013 7,242
4 Pfam: the protein families database ROBERT FINN, Alex Bateman, Jody Clements et al. · Nucleic Acids Research Open access 27 Nov 2013 6,604
5 HMMER web server: interactive sequence similarity searching ROBERT FINN, Jody Clements, Sean R. Eddy · Nucleic Acids Research Open access 18 May 2011 6,555
6 CTFFIND4: Fast and accurate defocus estimation from electron micrographs Alexis L. Rohou, Nikolaus Grigorieff · Journal of Structural Biology Open access 13 Aug 2015 5,758
7 An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea Daniel T. McDonald, Morgan N. Price, Julia K. Goodrich et al. · The ISME Journal Open access Dec 2011 5,371
8 Cellpose: a generalist algorithm for cellular segmentation Carsen Stringer, Tim Wang, Michalis Michaelos et al. · Nature Methods 14 Dec 2020 4,662
9 Infernal 1.1: 100-fold faster RNA homology searches Eric P. Nawrocki, Sean R. Eddy · Bioinformatics Open access 4 Sep 2013 4,029
10 ilastik: interactive machine learning for (bio)image analysis Stuart Berg, Dominik Kutra, Thorben Kroeger et al. · Nature Methods Open access 30 Sep 2019 3,760
11 Predicting the Functional Effect of Amino Acid Substitutions and Indels Yongwook Choi, Gregory E. Sims, Sean V. Murphy et al. · PLoS ONE Open access 8 Oct 2012 3,048
12 The Pfam protein families database ROBERT FINN, Jaina Mistry, John G. Tate et al. · Nucleic Acids Research Open access 17 Nov 2009 2,733
13 Trainable Weka Segmentation: a machine learning tool for microscopy pixel classification Ignacio Arganda‐Carreras, Verena Kaynig, Curtis Rueden et al. · Bioinformatics 28 Mar 2017 2,553
14 Fully integrated silicon probes for high-density recording of neural activity James Jaeyoon Jun et al. · Nature Open access 7 Nov 2017 2,453
15 Opportunities and obstacles for deep learning in biology and medicine Travers H. Ching et al. · Journal of The Royal Society Interface Open access Apr 2018 2,322
16 Evolution of genes and genomes on the Drosophila phylogeny Andrew G. Clark et al. · Nature Open access415 authors Nov 2007 2,132
17 Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution Bi‐Chang Chen et al. · Science Open access 23 Oct 2014 2,103
18 Shared and distinct transcriptomic cell types across neocortical areas Bosiljka Tasic et al. · Nature Open access 25 Oct 2018 2,028
19 Experience-dependent structural synaptic plasticity in the mammalian brain Anthony J. D. G. Holtmaat, Karel Svoboda · Nature reviews. Neuroscience ReviewOpen access 20 Aug 2009 2,009
20 Challenges in homology search: HMMER3 and convergent evolution of coiled-coil regions Jaina Mistry, ROBERT FINN, Sean R. Eddy et al. · Nucleic Acids Research Open access 17 Apr 2013 1,924
21 Neuromorphic Silicon Neuron Circuits Giacomo Indiveri, B. Linares-Barranco, Tara Julia Hamilton et al. · Frontiers in Neuroscience Open access 2011 1,844
22 Spontaneous behaviors drive multidimensional, brainwide activity Carsen Stringer, Marius Pachitariu, Nicholas A. Steinmetz et al. · Science Open access 19 Apr 2019 1,768
23 Reconstruction and Simulation of Neocortical Microcircuitry Henry Markram et al. · Cell Open access Oct 2015 1,703
24 A GAL4-Driver Line Resource for Drosophila Neurobiology Arnim Jenett et al. · Cell Reports Open access Oct 2012 1,670
25 A general method to improve fluorophores for live-cell and single-molecule microscopy Jonathan B. Grimm, Brian P. English, Jiji Chen et al. · Nature Methods Open access 19 Jan 2015 1,668
26 Nanoscale architecture of integrin-based cell adhesions Pakorn Kanchanawong, Gleb E. Shtengel, Ana M. Pasapera et al. · Nature Open access Nov 2010 1,625
27 Hidden Markov model speed heuristic and iterative HMM search procedure L. Steven Johnson, Sean R. Eddy, Elon Portugaly · BMC Bioinformatics Open access 18 Aug 2010 1,554
28 A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing Linda Madisen et al. · Nature Neuroscience Open access 25 Mar 2012 1,547
29 Infernal 1.0: inference of RNA alignments Eric P. Nawrocki, Diana L. Kolbe, Sean R. Eddy · Bioinformatics Open access 23 Mar 2009 1,508
30 Cellpose 2.0: how to train your own model Marius Pachitariu, Carsen Stringer · Nature Methods Open access 7 Nov 2022 1,507
31 Whole-brain functional imaging at cellular resolution using light-sheet microscopy Misha B. Ahrens, Michael B. Orger, Drew N. Robson et al. · Nature Methods 18 Mar 2013 1,502
32 A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons D. Gowanlock R. Tervo, Bum‐Yeol Hwang, Sarada Viswanathan et al. · Neuron Open access Oct 2016 1,350
33 High-performance calcium sensors for imaging activity in neuronal populations and microcompartments Hod Dana, Yi Sun, Boaz Mohar et al. · Nature Methods 17 Jun 2019 1,347
34 Refinement of Tools for Targeted Gene Expression in Drosophila Barret D. Pfeiffer, Teri-T B Ngo, Karen L Hibbard et al. · Genetics Open access 9 Aug 2010 1,311
35 Optimization of a GCaMP Calcium Indicator for Neural Activity Imaging Jasper Akerboom et al. · Journal of Neuroscience Open access 3 Oct 2012 1,302
36 Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection Alexandra East-Seletsky, Mitchell R. O’Connell, Spencer C. Knight et al. · Nature Open access 23 Sep 2016 1,276
37 A connectome and analysis of the adult Drosophila central brain Louis K. Scheffer et al. · eLife Open access108 authors 3 Sep 2020 1,264
38 High-density mapping of single-molecule trajectories with photoactivated localization microscopy Suliana Manley, Jennifer M. Gillette, George H. Patterson et al. · Nature Methods Open access 13 Jan 2008 1,264
39 Optimized CRISPR/Cas tools for efficient germline and somatic genome engineering in Drosophila Fillip Port, Hui-Min Chen, Tzumin Lee et al. · Proceedings of the National Academy of Sciences Open access 7 Jul 2014 1,224
40 Simultaneous Denoising, Deconvolution, and Demixing of Calcium Imaging Data Eftychios A. Pnevmatikakis, Daniel Soudry, Yuanjun Gao et al. · Neuron Open access 2016 1,205
41 The neuronal architecture of the mushroom body provides a logic for associative learning Yoshinori Aso, Daisuke Hattori, Yang Yu et al. · eLife Open access 22 Dec 2014 1,194
42 A Complete Electron Microscopy Volume of the Brain of Adult Drosophila melanogaster Zhihao Zheng et al. · Cell Open access Jul 2018 1,191
43 AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training Yexica Aponte, Deniz Atasoy, Scott M. Sternson · Nature Neuroscience Open access 5 Jan 2011 1,189
44 Applying systems-level spectral imaging and analysis to reveal the organelle interactome Alex M. Valm, Sarah Cohen, Wesley R. Legant et al. · Nature Open access 23 May 2017 1,180
45 Rfam 12.0: updates to the RNA families database Eric P. Nawrocki, Sarah Burge, Alex Bateman et al. · Nucleic Acids Research Open access 11 Nov 2014 1,167
46 Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings Nicholas A. Steinmetz et al. · Science Open access 15 Apr 2021 1,165
47 Sensitive red protein calcium indicators for imaging neural activity Hod Dana, Boaz Mohar, Yi Sun et al. · eLife Open access 24 Mar 2016 1,163
48 Rapid three-dimensional isotropic imaging of living cells using Bessel beam plane illumination Thomas A. Planchon, Liang Gao, Daniel E. Milkie et al. · Nature Methods Open access 4 Mar 2011 1,150
49 The subcellular organization of neocortical excitatory connections Leopoldo Petreanu, Tianyi Mao, Scott M. Sternson et al. · Nature Open access 18 Jan 2009 1,137
50 A new generation of homology search tools based on probabilistic inference. Sean R. Eddy · PubMed Conference paper Oct 2009 1,116

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.