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Most cited papers from KAN Research Institute

What are the most cited papers from KAN Research Institute?

The most cited paper from KAN Research Institute is "Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice" (Takehiro Nitta, Masaki Hata, Shimpei Gotoh et al., 2003), with 1,942 citations. Next come "Claudin-based tight junctions are crucial for the mammalian epidermal barrier" (1,515) and "Genome sequencing and analysis of Aspergillus oryzae" (1,272).

Showing 50 of 60 papers. Every paper with more than 130 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice Takehiro Nitta, Masaki Hata, Shimpei Gotoh et al. · The Journal of Cell Biology Open access 12 May 2003 1,942
2 Claudin-based tight junctions are crucial for the mammalian epidermal barrier Mikio Furuse, Masaki Hata, Kyoko Furuse et al. · The Journal of Cell Biology Open access 11 Mar 2002 1,515
3 Genome sequencing and analysis of Aspergillus oryzae Masayuki Machida et al. · Nature Open access Dec 2005 1,272
4 Complex Phenotype of Mice Lacking Occludin, a Component of Tight Junction Strands Mitinori Saitou, Mikio Furuse, Hiroyuki Sasaki et al. · Molecular Biology of the Cell Open access Dec 2000 1,199
5 A Single Gene Product, Claudin-1 or -2, Reconstitutes Tight Junction Strands and Recruits Occludin in Fibroblasts Mikio Furuse, Hiroyuki Sasaki, Kazushi Fujimoto et al. · The Journal of Cell Biology Open access 19 Oct 1998 969
6 Endothelial Claudin Kazumasa Morita, Hiroyuki Sasaki, Mikio Furuse et al. · The Journal of Cell Biology Open access 4 Oct 1999 870
7 Integrated molecular analysis of adult T cell leukemia/lymphoma Keisuke Kataoka et al. · Nature Genetics 5 Oct 2015 862
8 ZO-1 and ZO-2 Independently Determine Where Claudins Are Polymerized in Tight-Junction Strand Formation Kazuaki Umeda, Junichi Ikenouchi, Sayaka Katahira-Tayama et al. · Cell Open access Aug 2006 837
9 Manner of Interaction of Heterogeneous Claudin Species within and between Tight Junction Strands Mikio Furuse, Hiroyuki Sasaki, Shöichiro Tsukita · The Journal of Cell Biology Open access 15 Nov 1999 748
10 Conversion of Zonulae Occludentes from Tight to Leaky Strand Type by Introducing Claudin-2 into Madin-Darby Canine Kidney I Cells Mikio Furuse, Kyoko Furuse, Hiroyuki Sasaki et al. · The Journal of Cell Biology Open access 9 Apr 2001 721
11 Splicing factor SF3b as a target of the antitumor natural product pladienolide Yoshihiko Kotake, Koji Sagane, Takashi Owa et al. · Nature Chemical Biology Open access 22 Jul 2007 675
12 CH5424802, a Selective ALK Inhibitor Capable of Blocking the Resistant Gatekeeper Mutant Hiroshi Sakamoto, Toshiyuki Tsukaguchi, Sayuri Hiroshima et al. · Cancer Cell Open access May 2011 636
13 Clostridium perfringens Enterotoxin Fragment Removes Specific Claudins from Tight Junction Strands Noriyuki Sonoda, Mikio Furuse, Hiroyuki Sasaki et al. · The Journal of Cell Biology Open access 4 Oct 1999 616
14 Claudin-11/OSP-based Tight Junctions of Myelin Sheaths in Brain and Sertoli Cells in Testis Kazumasa Morita, Hiroyuki Sasaki, Kazushi Fujimoto et al. · The Journal of Cell Biology Open access 3 May 1999 448
15 Isolation of Human Induced Pluripotent Stem Cell-Derived Dopaminergic Progenitors by Cell Sorting for Successful Transplantation Daisuke Doi, Bumpei Samata, Mitsuko Katsukawa et al. · Stem Cell Reports Open access Mar 2014 445
16 CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex Yuko Mimori‐Kiyosue, Ilya Grigoriev, Gideon W.A. Lansbergen et al. · The Journal of Cell Biology Open access 3 Jan 2005 433
17 Chemokines in Immunity Osamu Yoshie, Toshio Imai, Hisayuki Nomiyama · Advances in immunology Book chapter 2001 429
18 Junctional adhesion molecule (JAM) binds to PAR-3 Masahiko Itoh, Hiroyuki Sasaki, Mikio Furuse et al. · The Journal of Cell Biology Open access 6 Aug 2001 388
19 Dual Functions of Fractalkine/CX3C Ligand 1 in Trafficking of Perforin+/Granzyme B+ Cytotoxic Effector Lymphocytes That Are Defined by CX3CR1 Expression Miyuki Nishimura, Hisanori Umehara, Takashi Nakayama et al. · The Journal of Immunology Jun 2002 339
20 Differences in neurogenic potential in floor plate cells along an anteroposterior location: midbrain dopaminergic neurons originate from mesencephalic floor plate cells Yuichi Ono, Tomoya Nakatani, Yoshimasa Sakamoto et al. · Development 2 Aug 2007 337
21 Fractalkine in Vascular Biology Hisanori Umehara, Eda T. Bloom, Toshiro Okazaki et al. · Arteriosclerosis Thrombosis and Vascular Biology 16 Sep 2003 330
22 The reconstituted ‘humanized liver’ in TK-NOG mice is mature and functional Masami Hasegawa, Kenji Kawai, T Mitsui et al. · Biochemical and Biophysical Research Communications Open access 20 Jan 2011 320
23 CLASPs Attach Microtubule Plus Ends to the Cell Cortex through a Complex with LL5β Gideon W.A. Lansbergen, Ilya Grigoriev, Yuko Mimori‐Kiyosue et al. · Developmental Cell Open access Jul 2006 318
24 Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes Shojiro Kikuchi, Masaki Hata, Kanehisa Fukumoto et al. · Nature Genetics 17 Jun 2002 311
25 Cast Toshihisa Ohtsuka, Etsuko Takao‐Rikitsu, Eiji Inoue et al. · The Journal of Cell Biology Open access 5 Aug 2002 302
26 Deficiency of Zonula Occludens-1 Causes Embryonic Lethal Phenotype Associated with Defected Yolk Sac Angiogenesis and Apoptosis of Embryonic Cells Tatsuya Katsuno, Kazuaki Umeda, Takeshi Matsui et al. · Molecular Biology of the Cell Open access 20 Mar 2008 301
27 Claudin-2–deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules Shigeaki Muto, Masaki Hata, Junichi Taniguchi et al. · Proceedings of the National Academy of Sciences Open access 12 Apr 2010 301
28 Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells Yuko Yamaguchi‐Iwai, Eiichiro Sonoda, Masao S. Sasaki et al. · The EMBO Journal Open access Dec 1999 284
29 Centriolar Satellites Akiharu Kubo, Hiroyuki Sasaki, Akiko Yuba-Kubo et al. · The Journal of Cell Biology Open access 29 Nov 1999 273
30 Establishment and Characterization of Cultured Epithelial Cells Lacking Expression of ZO-1 Kazuaki Umeda, Takeshi Matsui, Mayumi Nakayama et al. · Journal of Biological Chemistry Open access 30 Jul 2004 263
31 Structure and Activity of Angiotensin I Converting Enzyme Inhibitory Peptides from Sake and Sake Lees Yoshiyuki Saito, Keiko Wanezaki, Akitsugu Kawato et al. · Bioscience Biotechnology and Biochemistry 1994 242
32 Implications of Nectin-like Molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in Cell-Cell Adhesion and Transmembrane Protein Localization in Epithelial Cells Tatsushi Shingai, Wataru Ikeda, Shigeki Kakunaga et al. · Journal of Biological Chemistry Open access Sep 2003 231
33 Dynamic behavior of paired claudin strands within apposing plasma membranes Hiroyuki Sasaki, Chiyuki Matsui, Kyoko Furuse et al. · Proceedings of the National Academy of Sciences Open access 21 Mar 2003 226
34 Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release Etsuko Takao‐Rikitsu, Sumiko Mochida, Eiji Inoue et al. · The Journal of Cell Biology Open access 19 Jan 2004 224
35 Cell–matrix interface regulates dormancy in human colon cancer stem cells Yuki Ohta, Masayuki Fujii, Sirirat Takahashi et al. · Nature 7 Jul 2022 214
36 GPR31-dependent dendrite protrusion of intestinal CX3CR1+ cells by bacterial metabolites Naoki Morita, Eiji Umemoto, Setsuko Fujita et al. · Nature 23 Jan 2019 211
37 Ca2+-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions Kôji Kubota, Mikio Furuse, Hiroyuki Sasaki et al. · Current Biology Open access Sep 1999 199
38 GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose Yusaku Iwasaki, Sendo Mio, Katsuya Dezaki et al. · Nature Communications Open access 3 Jan 2018 198
39 LIS1 and NDEL1 coordinate the plus‐end‐directed transport of cytoplasmic dynein Masami Yamada, Shiori Toba, Yuko Yoshida et al. · The EMBO Journal Open access 11 Sep 2008 196
40 Single-cell gene profiling defines differential progenitor subclasses in mammalian neurogenesis Ayano Kawaguchi, Tomoko Ikawa, Takeya Kasukawa et al. · Development Open access 25 Aug 2008 195
41 Endocytosis of E-cadherin regulated by Rac and Cdc42 small G proteins through IQGAP1 and actin filaments Genkichi Izumi, Toshiaki Sakisaka, Takeshi Baba et al. · The Journal of Cell Biology Open access 19 Jul 2004 187
42 Studies on anticancer treatment with an oily anticancer drug injected into the ligated feeding hepatic artery for liver cancer Kenichiro Nakakuma, Seiki Tashiro, Takehisa Hiraoka et al. · Cancer 15 Dec 1983 185
43 Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown Shuntaro Ogura et al. · JCI Insight Open access 8 Feb 2017 178
44 Direct Binding of Cell Polarity Protein PAR-3 to Cell-Cell Adhesion Molecule Nectin at Neuroepithelial Cells of Developing Mouse Kyoji Takekuni, Wataru Ikeda, Tsutomu Fujito et al. · Journal of Biological Chemistry Open access Feb 2003 178
45 Compartmentalization established by claudin-11-based tight junctions in stria vascularis is required for hearing through generation of endocochlear potential Shin‐ichiro Kitajiri, Tatsuo Miyamoto, Akihito Mineharu et al. · Journal of Cell Science 29 Sep 2004 172
46 Carbohydrate Binding Specificity of a Fucose-specific Lectin from Aspergillus oryzae Kengo Matsumura, Katsuya Higashida, Hiroki Ishida et al. · Journal of Biological Chemistry Open access 23 Mar 2007 171
47 Tight junctions in Schwann cells of peripheral myelinated axons Tatsuo Miyamoto, Kazumasa Morita, Daisuke Takemoto et al. · The Journal of Cell Biology Open access 9 May 2005 167
48 Involvement of LMO7 in the Association of Two Cell-Cell Adhesion Molecules, Nectin and E-cadherin, through Afadin and α-Actinin in Epithelial Cells Takako Ooshio, Kenji Irie, Koji Morimoto et al. · Journal of Biological Chemistry Open access Jul 2004 166
49 Ontogeny-recapitulating generation and tissue integration of ES cell–derived Purkinje cells Keiko Muguruma, Ayaka Nishiyama, Yūichi Ono et al. · Nature Neuroscience 12 Sep 2010 162
50 Migration of CX3CR1‐positive T cells producing type 1 cytokines and cytotoxic molecules into the synovium of patients with rheumatoid arthritis Toshihiro Nanki, Toshio Imai, Kenji Nagasaka et al. · Arthritis & Rheumatism Nov 2002 159

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.